Edwin Vedejs

Email address: edved@umich.edu

Group Affiliation: 
Vedejs Group
Position Name: 
Professor Emeritus

B.S. 1962, University of Michigan
Ph.D. 1966, University of Wisconsin-Madison
Postdoctoral Fellow 1966-67, Harvard University

University of Wisconsin-Madison faculty member, 1967-98
University of Michigan faculty member, 1999-2011

evedejs's picture

Research Description

Professor Vedejs is no longer taking students.

Work in the Vedejs lab is designed to develop an understanding of conceptual, stereochemical, mechanistic, and preparative aspects of organic synthesis. The targets can be natural products derived from nitrogen-containing heterocycles, but they can also be complex unnatural heteroelement (boron, nitrogen, phosphorus, etc. ) containing molecules that have been designed to serve as catalysts for enantioselective reactions. The Vedejs group has used total synthesis as a challenging testing ground for the fundamental issues that are under study in our group, and as an extraordinary tool for training that teaches logical analysis and practical mechanistic thinking as well as preparative chemistry. Targets are carefully chosen to combine the investigation of several fundamental questions in connection with a specific structural family and to provide a diverse experience for group members. In some cases, our projects encounter biologically interesting activity and collaborative screening efforts, but our principal focus is on the chemistry and on fundamental questions. The ideal synthesis project in the Vedejs group targets a substance that is needed for a specific purpose, and addresses concepts that have lasting value beyond the specific family of targeted structures.

More recent studies have focused on the investigation of reagents and catalysts based on heteroelements and on methods for enantioselective synthesis via chiral nucleophilic catalysis. In the area of synthetic methodology, we have been especially interested in the development of heteroatom-directed hydroboration for control of relative stereochemistry.

Awards and Honors

Order of the Three Stars, Latvia 2006
Grand Medal, Latvian Academy of Sciences 2005
H. C. Brown Award for Creative Research in Synthetic Methods 2004
ACS Organic Division Chair 2003
Paul Walden Medal, Riga Technical University 1997

Selected Publications

Nothing found