All Faculty and Research Staff Publications

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Buller AR, Freeman MF, Wright NT, Schildbach JF, Townsend CA. Insights into cis-autoproteolysis reveal a reactive state formed through conformational rearrangement. Proceedings of the National Academy of Sciences of the United States of America. 2012 ;109:2308-2313.
Buller AR, Labonte JW, Freeman MF, Wright NT, Schildbach JF, Townsend CA. Autoproteolytic Activation of ThnT Results in Structural Reorganization Necessary for Substrate Binding and Catalysis. Journal of Molecular Biology. 2012 ;422:508-518.
Buller AR, Townsend CA. Intrinsic evolutionary constraints on protease structure, enzyme acylation, and the identity of the catalytic triad. Proceedings of the National Academy of Sciences of the United States of America. 2013 ;110:E653-E661.
Buller AR, Freeman MF, Schildbach JF, Townsend CA. Exploring the Role of Conformational Heterogeneity in cis-Autoproteolytic Activation of ThnT. Biochemistry. 2014 ;53:4273-4281.
Buller AR, Brinkmann-Chen S, Romney DK, Herger M, Murciano-Calles J, Arnold FH. Directed evolution of the tryptophan synthase beta-subunit for stand-alone function recapitulates allosteric activation. Proceedings of the National Academy of Sciences of the United States of America. 2015 ;112:14599-14604.
Buller AR, van Roye P, Murciano-Calles J, Arnold FH. Tryptophan Synthase Uses an Atypical Mechanism To Achieve Substrate Specificity. Biochemistry. 2016 ;55:7043-7046.
Buller AR, van Roye P, Cahn JKB, Scheele RA, Herger M, Arnold FH. Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble. Journal of the American Chemical Society. 2018 ;140:7256-7266.