All Faculty and Research Staff Publications

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2017
Rank LA, Walsh NM, Liu RH, Lim FY, Bok JW, Huang MW, Keller NP, Gellman SH, Hull CM. A Cationic Polymer That Shows High Antifungal Activity against Diverse Human Pathogens. Antimicrobial Agents and Chemotherapy. 2017 ;61.
Hager MV, Clydesdale L, Gellman SH, Sexton PM, Wootten D. Characterization of signal bias at the GLP-1 receptor induced by backbone modification of GLP-1. Biochemical Pharmacology. 2017 ;136:99-108.
Cheloha RW, Chen BM, Kumar NN, Watanabe T, Thorne RG, Li LJ, Gardella TJ, Gellman SH. Development of Potent, Protease-Resistant Agonists of the Parathyroid Hormone Receptor with Broad beta Residue Distribution. Journal of Medicinal Chemistry. 2017 ;60:8816-8833.
Fisher BF, Hong SH, Gellman SH. Helix Propensities of Amino Acid Residues via Thioester Exchange. Journal of the American Chemical Society. 2017 ;139:13292-13295.
Lee MR, Raman N, Gellman SH, Lynn DM, Palecek SP. Incorporation of beta-Amino Acids Enhances the Antifungal Activity and Selectivity of the Helical Antimicrobial Peptide Aurein 1.2. ACS Chemical Biology. 2017 ;12:2975-2980.
MacDonald MJ, Cornejo NR, Gellman SH. Inhibition of Ice Recrystallization by Nylon-3 Polymers. Acs Macro Letters. 2017 ;6:695-699.
Checco JW, Gellman SH. Iterative Nonproteinogenic Residue Incorporation Yields alpha/beta-Peptides with a Helix-Loop-Helix Tertiary Structure and High Affinity for VEGF. Chembiochem. 2017 ;18:291-299.
Wang CX, Ma CKD, Yeon H, Wang XG, Gellman SH, Abbott NL. Nonadditive Interactions Mediated by Water at Chemically Heterogeneous Surfaces: Nonionic Polar Groups and Hydrophobic Interactions. Journal of the American Chemical Society. 2017 ;139:18536-18544.
Thomas NC, Bartlett GJ, Woolfson DN, Gellman SH. Toward a Soluble Model System for the Amyloid State. Journal of the American Chemical Society. 2017 ;139:16434-16437.
2016
Hager MV, Johnson LM, Wootten D, Sexton PM, Gellman SH. beta-Arrestin-Biased Agonists of the GLP-1 Receptor from beta-Amino Acid Residue Incorporation into GLP-1 Analogues. Journal of the American Chemical Society. 2016 ;138:14970-14979.
Walsh PS, Dean JC, McBurney C, Kang H, Gellman SH, Zwier TS. Conformation-specific spectroscopy of capped glutamine-containing peptides: role of a single glutamine residue on peptide backbone preferences. Physical Chemistry Chemical Physics. 2016 ;18:11306-11322.
Kreitler DF, Mortenson DE, Forest KT, Gellman SH. Effects of Single alpha-to-beta Residue Replacements on Structure and Stability in a Small Protein: Insights from Quasiracemic Crystallization. Journal of the American Chemical Society. 2016 ;138:6498-6505.
MacDonald MJ, Lavis LD, Hilvert D, Gellman SH. Evaluation of the Ser-His Dipeptide, a Putative Catalyst of Amide and Ester Hydrolysis. Organic Letters. 2016 ;18:3518-3521.
Ma CD, Acevedo-Velez C, Wang C, Gellman SH, Abbott NL. Interaction of the Hydrophobic Tip of an Atomic Force Microscope with Oligopeptides Immobilized Using Short and Long Tethers. Langmuir. 2016 ;32:2985-95.
Choi H, Chakraborty S, Liu RH, Gellman SH, Weisshaar JC. Single-Cell, Time-Resolved Antimicrobial Effects of a Highly Cationic, Random Nylon-3 Copolymer on Live Escherichia coli. ACSChemical Biology. 2016 ;11:113-120.
Checco JW, Gellman SH. Targeting recognition surfaces on natural proteins with peptidic foldamers. Current Opinion in Structural Biology. 2016 ;39:96-105.
2015
Checco JW, Lee EF, Evangelista M, Sleebs NJ, Rogers K, Pettikiriarachchi A, Kershaw NJ, Eddinger GA, Belair DG, Wilson JL, et al. alpha/beta-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells. Journal of the American Chemical Society. 2015 ;137:11365-11375.
Cheloha RW, Sullivan JA, Wang T, Sand JM, Sidney J, Sette A, Cook ME, Suresh M, Gellman SH. Consequences of Periodic alpha-to-beta(3) Residue Replacement for Immunological Recognition of Peptide Epitopes. ACS Chemical Biology. 2015 ;10:844-854.
Hovakeemian SG, Liu RH, Gellman SH, Heerklotz H. Correlating antimicrobial activity and model membrane leakage induced by nylon-3 polymers and detergents. Soft Matter. 2015 ;11:6840-6851.
Fisher BF, Guo L, Dolinar BS, Guzei IA, Gellman SH. Heterogeneous H-Bonding in a Foldamer Helix. Journal of the American Chemical Society. 2015 ;137:6484-6487.
Mortenson DE, Steinkruger JD, Kreitler DF, Perroni DV, Sorenson GP, Huang L, Mittal R, Yun HG, Travis BR, Mahanthappa MK, et al. High-resolution structures of a heterochiral coiled coil. Proceedings of the National Academy of Sciences of the United States of America. 2015 ;112:13144-13149.
Kung VM, Cornilescu G, Gellman SH. Impact of Strand Number on Parallel beta-Sheet Stability. Angewandte Chemie-International Edition. 2015 ;54:14336-14339.
Ma CD, Wang CX, Acevedo-Velez C, Gellman SH, Abbott NL. Modulation of hydrophobic interactions by proximally immobilized ions. Nature. 2015 ;517:347-U443.
Liu RH, Chen XY, Falk SP, Masters KS, Weisblum B, Gellman SH. Nylon-3 Polymers Active against Drug-Resistant Candida albicans Biofilms. Journal of the American Chemical Society. 2015 ;137:2183-2186.
Demizu Y, Oba M, Okitsu K, Yamashita H, Misawa T, Tanaka M, Kurihara M, Gellman SH. A preorganized beta-amino acid bearing a guanidinium side chain and its use in cell-penetrating peptides. Organic & Biomolecular Chemistry. 2015 ;13:5617-5620.
Cheloha RW, Gellman SH, Vilardaga JP, Gardella TJ. PTH receptor-1 signalling-mechanistic insights and therapeutic prospects. Nature Reviews Endocrinology. 2015 ;11:712-724.
Hayouka Z, Thomas NC, Mortenson DE, Satyshur KA, Weisblum B, Forest KT, Gellman SH. Quasiracemate Crystal Structures of Magainin 2 Derivatives Support the Functional Significance of the Phenylalanine Zipper Motif. Journal of the American Chemical Society. 2015 ;137:11884-7.
Peterson-Kaufman KJ, Haase HS, Boersma MD, Lee EF, Fairlie DW, Gellman SH. Residue-Based Preorganization of BH3-Derived α/β-Peptides: Modulating Affinity, Selectivity and Proteolytic Susceptibility in α-Helix Mimics. ACS Chemical Biology. 2015 ;10:1667-1675.
Nadithe V, Liu RH, Killinger BA, Movassaghian S, Kim NH, Moszczynska AB, Masters KS, Gellman SH, Merkel OM. Screening Nylon-3 Polymers, a New Class of Cationic Amphiphiles, for siRNA Delivery. Mol Pharm. 2015 ;12:362-374.
Checco JW, Kreitler DF, Thomas NC, Belair DG, Rettko NJ, Murphy WL, Forest KT, Gellman SH. Targeting diverse protein-protein interaction interfaces with alpha/beta-peptides derived from the Z-domain scaffold. Proceedings of the National Academy of Sciences of the United States of America. 2015 ;112:4552-4557.
2014
Stephenson NA, Gellman SH, Stahl SS. Ammonolysis of anilides promoted by ethylene glycol and phosphoric acid. Rsc Advances. 2014 ;4:46840-46843.
Cheloha RW, Maeda A, Dean T, Gardella TJ, Gellman SH. Backbone modification of a polypeptide drug alters duration of action in vivo. Nature Biotechnology. 2014 ;32:653-+.
Mayer C, Muller MM, Gellman SH, Hilvert D. Building Proficient Enzymes with Foldamer Prostheses. Angewandte Chemie-International Edition. 2014 ;53:6978-6981.
Giuliano MW, Maynard SJ, Almeida AM, Guo L, Guzei IA, Spencer LC, Gellman SH. A gamma-Amino Acid That Favors 12/10-Helical Secondary Structure in alpha/gamma-Peptides. Journal of the American Chemical Society. 2014 ;136:15046-15053.
Chae PS, Cho KH, Wander MJ, Bae HE, Gellman SH, Laible PD. Hydrophobic variants of ganglio-tripod amphiphiles for membrane protein manipulation. Biochimica Et Biophysica Acta-Biomembranes. 2014 ;1838:278-286.
Chae PS, Sadaf A, Gellman SH. Hydrophobic Variations of N-Oxide Amphiphiles for Membrane Protein Manipulation: Importance of Non-hydrocarbon Groups in the Hydrophobic Portion. Chemistry-an Asian Journal. 2014 ;9:110-116.
Lee MR, Raman N, Gellman SH, Lynn DM, Palecek SP. Hydrophobicity and Helicity Regulate the Antifungal Activity of 14-Helical beta-Peptides. ACS Chemical Biology. 2014 ;9:1613-1621.
Cho KH, Bae HE, Das M, Gellman SH, Chae PS. Improved Glucose-Neopentyl Glycol (GNG) Amphiphiles for Membrane Protein Solubilization and Stabilization. Chemistry-an Asian Journal. 2014 ;9:632-638.
Gord JR, Walsh PS, Fisher BF, Gellman SH, Zwier TS. Mimicking the First Turn of an alpha-Helix with an Unnatural Backbone: Conformation-Specific IR and UV Spectroscopy of Cyclically Constrained beta/gamma-Peptides. Journal of Physical Chemistry B. 2014 ;118:8246-8256.
Maynard SJ, Almeida AM, Yoshimi Y, Gellman SH. New Charge-Bearing Amino Acid Residues That Promote beta-Sheet Secondary Structure. Journal of the American Chemical Society. 2014 ;136:16683-16688.
Johnson LM, Barrick S, Hager MV, McFedries A, Homan EA, Rabaglia ME, Keller MP, Attie AD, Saghatelian A, Bisello A, et al. A Potent alpha/beta-Peptide Analogue of GLP-1 with Prolonged Action in Vivo. Journal of the American Chemical Society. 2014 ;136:12848-12851.
Liu RH, Chen XY, Falk SP, Mowery BP, Karlsson AJ, Weisblum B, Palecek SP, Masters KS, Gellman SH. Structure-Activity Relationships among Antifungal Nylon-3 Polymers: Identification of Materials Active against Drug-Resistant Strains of Candida albicans. Journal of the American Chemical Society. 2014 ;136:4333-4342.
Liu RH, Suarez JM, Weisblum B, Gellman SH, McBride SM. Synthetic Polymers Active against Clostridium difficile Vegetative Cell Growth and Spore Outgrowth. Journal of the American Chemical Society. 2014 ;136:14498-14504.
Chakraborty S, Liu RH, Hayouka Z, Chen XY, Ehrhardt J, Lu Q, Burke E, Yan YQ, Weisblum B, Wong GCL, et al. Ternary Nylon-3 Copolymers as Host-Defense Peptide Mimics: Beyond Hydrophobic and Cationic Subunits. Journal of the American Chemical Society. 2014 ;136:14530-14535.
Liu RH, Chen XY, Chakraborty S, Lemke JJ, Hayouka Z, Chow C, Welch RA, Weisblum B, Masters KS, Gellman SH. Tuning the Biological Activity Profile of Antibacterial Polymers via Subunit Substitution Pattern. Journal of the American Chemical Society. 2014 ;136:4410-4418.
Lee MW, Chakraborty S, Schmidt NW, Murgai R, Gellman SH, Wong GCL. Two interdependent mechanisms of antimicrobial activity allow for efficient killing in nylon-3-based polymeric mimics of innate immunity peptides. Biochimica Et Biophysica Acta-Biomembranes. 2014 ;1838:2269-2279.
Laaser JE, Skoff DR, Ho JJ, Joo Y, Serrano AL, Steinkruger JD, Gopalan P, Gellman SH, Zanni MT. Two-Dimensional Sum-Frequency Generation Reveals Structure and Dynamics of a Surface-Bound Peptide. Journal of the American Chemical Society. 2014 ;136:956-962.

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