1.   Discovery and biochemical characterization of BlmI as the first type II peptidyl carrier protein (PCP)

      (Chem. Biol. 1999, 6, 507-517)

2.   Proposal of the bleomycin biosynthetic gene cluster as a model hybrid peptide synthetase (NRPS)-

      polyketide synthase (PKS) for hybrid peptide-polyketide biosynthesis (Chem. Biol. 2000, 7, 623-642;

      Met. Engineer. 2001, 3, 78-95; Curr. Opin. Drug Disco. Decelop. 2001, 4, 215-228)

 3.   Discovery of an oxidation (Ox) domain of NRPS for thiazole biosynthesis (FEMS Microbiol. Lett. 2000,

    189, 171-175; Biochemistry 2003, 42, 9722-9730)

4.   Characterization of triple hydroxylation by TcmG or ElmG (J. Biol. Chem. 1994, 48, 30726-30733; Org.

     Lett. 2000, 2, 3225-3227; J. Nat. Prod. 2001, 64, 444-449)

5.   Discovery of a pair of enantio-complementary pathways for macrotetrolide biosynthesis (Antimicrob.

    Agents Chemther. 2000, 44, 1943-1953; J. Am. Chem. Soc. 2001, 123, 3385-3386)

6.   Discovery of the Svp phosphopantetheinyl transferase with broad substrate specificity for both ACP and

     PCP to activate hybrid NRPS-PKS (Chem. Biol. 2001, 8, 725-738)

7.   Discovery of an iterative PKS for enediyne biosynthesis (Science 2002, 297, 1170-1173; Nat. Biotechnol.

     2003, 21, 187-190)

8.   Discovery of a type II PKS for C-O bond formation (Science 2002, 297, 1327-1330)

9.   Development of a PCR method for NRPS domains (Cy and Ox domains) to clone thiazole-containing

      natural product biosynthetic pathways (J. Bacteriol. 2002, 184, 7013-7024)

10. Discovery of NRPS domain “skipping” (A and Ox domains) in nonribosomal peptide biosynthesis

     (Biochemistry 2003, 42, 9722-9730; Biochemistry 2003, 42, 9731-9740)

11. Discovery of an AT-less PKS (Proc. Natl. Acad. Sci. USA 2003, 100, 3149-3154)

12. Discovery of a 4-methylideneimidazole-5-one (MIO)-containing tyrosine aminomutase (J. Am. Chem.

     Soc. 2003, 125, 6062-6063; Biochemistry 2003, 42, 12708-12718)

13. Development of a PCR method for enediyne PKS to clone enediyne biosynthetic pathways (Proc. Natl.

    Acad. Soc. USA  2003, 100, 11959-11963)

14. Discovery of migrastatin and dorrigocins as shunt metabolites of iso-migrastatin (J. Am. Chem. Soc.

     2005, 127, 1622-1623)

 15. Discovery of an adenylation enzyme (A) of NRPS that activate b-tyrosine (J. Am. Chem. Soc. 2005,

     127, 11594-11595; J. Biol. Chem. 2006, 281, 29633-29640)

16. Discovery of PKS domain “skipping” (ACP domain) in polyketide biosynthesis by type I PKS (J. Nat.

     Prod. 2006, 69, 387-393)

17. Development of a PCR method for cloning methoxymalonate-incorporating polyketide biosynthetic

     pathways (J. Bacteriol. 2006, 198, 4148-4152; J. Bacteriol. 2006, 198, 4141-4147)

18. Discovery of the first holo-ACP synthase-type phosphopantetheinyl transferase for a type II PKS (J. Am.

    Chem. Soc. 2005, 127, 16442-16452; J. Biol. Chem. 2006, 281, 29660-29668)

19. Identification of 1,3-bisphosphoglycerate as the direct precursor for methoxymalonyl-ACP biosynthesis

    (J. Am. Chem. Soc. 2006, 128, 10386-10387)

20. Discovery of a [3,3]-sigmtropic rearrangement for iso-migratsatin to migratsatin (Org. Lett. 2006, 8,

     5865-5868)