UW-Madison  
University of Wisconsin-Madison  
  
 
 
 
 

 
 

Cloning and characterization of novel natural product biosynthetic gene clusters and machinery

 

1.   The bleomycin biosynthetic gene cluster from Streptomyces verticillus ATCC15003 (Chem. Biol. 1999,

      6, 507-517; Chem. Biol. 2000, 7, 623-642)

 

 

2.   The C-1027 biosynthetic gene cluster from Streptomyces globisporus (Antimicrob. Agents Chemother.

      2000, 44, 382-392; Science 2002, 297, 1170-1173)

 

 

3.   The macrotetrolide biosynthetic gene cluster from Streptomyces griseus DSM40695 (Antimicrob. Agents

      Chemother. 2000, 44, 1943-1953; J. Am. Che. Soc. 2001, 123, 3385-3386; Science 2002, 297, 1327-

     1330)

 

 

4.   The leinamycin biosynthetic gene cluster from Streptomyces atroolivaceus (J. Bacteriol. 2002, 184,

      7013-7024; Proc. Natl. Acad. Sci. 2003, 100, 3010-3012; Chem. Biol. 2004, 11, 33-45)

 

 

5.   The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC15944 (Nat.

     Biotechnol. 2003, 21, 187-190; Chem. Biol. 2005, 12, 293-302)

 

 

 6.   The maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC39144 (Proc. Natl.

     Acad. Sci. 2003, 100, 11959-11963)

 

 

7.   The fredericamycin biosynthetic gene cluster from Streptomyces griseus (J. Am. Chem. Soc. 2005, 127,

      16442-16452)

 

 

 8.   The tautomycin biosynthetic gene cluster from Streptomyces spiroverticillus (J. Bacteriol. 2006, 198,

     4148-4152)

 

 

 

9.   The oxazolomycin biosynthetic gene cluster from Streptomyces albus (J. Bacteriol. 2006, 198, 4141-

     4147)

 

 

10. The tallysomycin biosynthetic gene cluster from Streptoalloteichus hindustanus E465-94 ATCC31158

     (Mol. BioSyst. 2007, 3, 60-74)

 

 

 
     
             

School of Pharmacy | Department of Chemistry | UW-Madison

Recent Update 2007.2.5.

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