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1999 | 1995-1991 | 1990-1986 | 1986-1982| Patents |
  
2008
Van Lanen, S. G.; Lin, S.; Shen, B. (2008) The
biosynthesis of the antitumor antibiotic C-1027 involves a new
branching point in chorismate metabolism. Proc. Natl. Acad. Sci.
U.S.A. 105:494-499. (Featured in C & E News, January 14,
2008, p36)
Van Lanen, S. G.; Shen, B. (2008) Advances in
polyketide synthase structure and mechanism. Curr. Opinion Drug
Discov. Develop. 11:186-195.
Zhang, J.; Van Lanen, S. G.; Ju,
J.; Liu, W.; Dorrestein, P. C.; Li, W.; Kelleher, N. L.; Shen, B.
(2008) A phosphopantetheinylating polyketide synthase producing a
linear polyene to initiate enediyne antitumor antibiotic
biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 105:1460-1465.
Chen, Y.; Luo, Y.; Ju.; Wendt-Pienkowski,
E.; Rajski, S. R.; Shen, B. (2008) Identification of fredericamycin
E from Streptomyces griseus: insights into fredericamycin A
biosynthesis highlighting carbaspirocycle formation. J. Nat.
Prod. 71:431-437.
Song, D.; Coughlin, J.; Ju, J.;
Zhou, X.; Shen, B.; Zhao, C.; Deng, Z. (2008) Alternative method for
site-directed mutagenesis of complex polyketide synthase in
Streptomyces albus JA3453. Acta Biochim. Biophys. Sinica
40:319-326.
Montavon, T. J.; Christianson, C.
V.; Festin, G. M.; Shen, B.; Bruner, S. D. (2008) Design and
characterization of mechanism-based inhibitors for the tyrosine
aminomutase SgTAM. Bioorg. Med. Chem. Lett. 18:3099-3102.
Lin, S.; Van Lanen, S. G.; Shen,
B. (2008) Characterization of the two-component, FAD-dependent
monooxygenase SgcC that requires carrier protein-tethered substrates
for the biosynthesis of the enediyne antitumor antibiotic C-1027.
J. Am. Chem. Soc. 130:6616-6623.
Jiang, H.; Zirkle, R.; Metz, J.
G.; Braun, L.; Richter, L.; Van Lanen, S. G.; Shen, B. (2008) The
role of tandem acyl carrier protein domains in polyunsaturated fatty
acid biosynthesis. J. Am. Chem. Soc. 130:6336-6337.
(Featured in Nat. Chem. Biol. 2008, 4:340)
Luo, Y.; Lin, S.; Zhang, J.;
Cooke, H. A.; Bruner, S. D.; Shen, B. (2008) Regiospecific O-methylation
of naphthoic acids catalyzed by NcsB1, an O-methyltransferase
involved in the biosynthesis of the enediyne antitumor antibiotic
neocarzinostatin. J. Biol. Chem. 283:14694-14702.
Van Lanen, S. G.; Shen, B. (2008)
Biosynthesis of enediyne antitumor antibiotics. Curr. Topics Med.
Chem. 8:448-459.
Chen, Y.; Wendt-Pienkowski, E.;
Shen, B. (2008) Identification and utilities of FdmR1 as a SARP
activator for fredericamycin production in Streptomyces griseus
ATCC49344 and heterologous hosts. J. Bcateriol. 190:5587-5596.
Li, W.; Ju, J.; Rajski, S. R. ;
Osada, H. ; Shen, B. (2008) Characterization of the tautomycin
biosynthetic gene cluster from Streptomyces spiroverticillatus
unveiling new insights into dialkylmaleic anhydride and polyketide
biosynthesis. J. Biol. Chem. 283:28607-28617.
Galm, U.; Wang, L.; Wendt-Pienkowski,
E.; Tao, M.; Coughlin, J. M.; Shen, B. (2008) In vivo manipulation
of the bleomycin biosynthetic gene cluster in Streptomyces
verticillus ATCC15003 revealing new insights into its
biosynthetic pathway. J. Biol. Chem. 283:28236-28245.
Ju, J.; Rajski, S. R.; Lim,
S.-K. ; Seo, J.-W. ; Peters, N. ; Hoffmann, F. M.; Shen, B. (2008)
Evaluation of new migrastatin and dorrigocin congeners unveils cell
migration inhibitors with dramatically improved potency. Bioorg.
Med. Chem. Lett. 18:5951-5954.
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