Inhibitors of HIV Protease: An Introduction to Carbonyl Chemistry
Introduction
Physical properties
2.0. What does Chemistry have to do with AIDS?
2.1. A Small Piece of HIV Protease
2.2. The Carbonyl Group
2.3. Hybridization Does Not Predict the Structure of a Piece of HIV Protease
2.4 Resonance Considerations Apply to Carboxylic Acids and Esters
2.5 Carbonyls Have Distinctive Spectroscopic Properties
2.6. Carboxylic Acids, Esters, and Amides Are Found in Many Common Materials
2.7. Ionization of Carboxylic Acids Contributes to the Folding of Proteins.
2.8. Acidity is Promoted by Resonance Stabilization
2.9 Salt Bridges Stabilize Protein Folding by Electrostatic Attraction
2.10 Carboxylic Acids are Critical for the Activity of HIV Protease
2.11 Carboxylic Acids Form Strong Intermolecular Bonds
2.12 How Do We Know that Hydrogen Bonds Form?
2.13 Helices and Sheets in HIV Protease
2.14 Does the Nature of the Amino Acids Influence a-Helix and b-Pleated Sheet Formation?
2.15 HIV Protease Comprises Two Strands of Amino Acids
2.16 How Do We Know the Structures of Proteins?
2.17. The Structure of HIV Protease and the Design of Inhibitors
Carbonyl chemistry
