Burke Group

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Bryostatin 1

Didemniserinolipid B

Dictyostatin

Halichondrin B

Kendomycin

Phorboxazole B

Spicamycin

Trilobin & Trilobacin

Thromboxane B2

 

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The synthetic strategy at the heart of each Burke group project is that of symmetry.

 

 Hidden symmetry within each of our targets is exploited in order to complete the total synthesis of these molecules quickly and efficiently.

 

Key steps in the synthetic routes include:

 

  1. Ketalization/Ring Closing Metathesis
  2. Pd mediated cycloetherification
  3. Double asymmetric Hetero-Diels-Alder

 

Click on a natural product on the left to learn more about that compound!