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Spicamycin
Spicamycin was isolated in 1983
from the culture broth of Streptomyces alanosinicus as a potent antitumor
antibiotic. Structural features
of spicamycin include an aminoheptose, adenine, glycine, and various fatty
acids. An unusual linkage of adenine C-6 amino group as the b-manno anomeric to an aminoheptose moiety as well
as the attachment point of the adenine makes the spicamycin structure
interesting. Naturally occurring
spicamycin exists as a mixture of several congers differing in their fatty
acid moieties. Because of its unusual
structure, alternative mechanism of action, and non-overlapping toxicities,
spicamycin is an interesting target for total synthesis. |
