Burke Group

---

 

Home

Research

 

Group Members

 

Publications

 

Photo Gallery

 

Links

 

 

 

 

 

Publications

 

Lucas, Brian S.; Luther, Laura M.; Burke, Steven D..  A Catalytic Enantioselective Hetero Diels-Alder Approach to the C20-C32 Segment of the Phorboxazoles.    Journal of Organic Chemistry  2005,  70,  3757-3760

 

 

Lambert, William T.; Hanson, Gregory H.; Benayoud, Farid; Burke, Steven D..  Halichondrin B: Synthesis of the C1-C22 Subunit.    Journal of Organic Chemistry  2005,  70,  9382-9398

 

 

Keller, Valerie A.; Kim, Ikyon; Burke, Steven D..  Synthetic Efforts toward the C22-C36 Subunit of Halichondrin B Utilizing Local and Imposed Symmetry.    Organic Letters  2005,  7,  737-740

 

 

Voight, Eric A.; Roethle, Paul A.; Burke, Steven D..  Concise Formal Synthesis of the Bryostatin Southern Hemisphere (C17-C27).    Journal of Organic Chemistry  2004,  69,  4534-4537

 

 

Jiang, Yueheng; Hong, Jian; Burke, Steven D..  Stereoselective Total Synthesis of Antitumor Macrolide (+)-Rhizoxin D.    Organic Letters  2004,  6,  1445-1448

 

 

Voight, Eric A.; Seradj, Hassan; Roethle, Paul A.; Burke, Steven D..  Synthesis of the Bryostatin 1 Northern Hemisphere (C1-C16) via Desymmetrization by Ketalization/Ring-Closing Metathesis.    Organic Letters  2004,  6,  4045-4048

 

 

Lucas, Brian S.; Luther, Laura M.; Burke, Steven D..  Synthesis of the C1-C17 Segment of Phorboxazole B.    Organic Letters  2004,  6,  2965-2968

 

 

Guzei, Ilia A.; Clark, Robert W.; Burke, Steven D.; Lambert, William T.  A comparison of the ring conformational properties of two derivatives prepared from the same diene diacetate precursor.    Acta Crystallographica, Section C: Crystal Structure Communications  2003,  C59,  o721-o723

 

 

Jiang Lei; Martinelli Joseph R; Burke Steven D  A practical synthesis of the F-ring of halichondrin B via ozonolytic desymmetrization of a C(2)-symmetric dihydroxycyclohexene.    The Journal of organic chemistry  2003,  68,  1150-3

 

 

Lambert, William T.; Burke, Steven D..  Halichondrin B: Synthesis of a C1-C14 Model via Desymmetrization of (+)-Conduritol E.    Organic Letters  2003,  5,  515-518

 

 

Lucas, Brian S.; Burke, Steven D..  Palladium(0)-Mediated Desymmetrization of Meso Tetraols: An Approach to the C3-C17 Bis-oxane Segment of Phorboxazoles A and B.    Organic Letters  2003,  5,  3915-3918

 

 

Jiang Lei; Burke Steven D  A novel route to the F-ring of halichondrin B. Diastereoselection in Pd(0)-mediated meso and C(2) biol desymmetrization.    Organic letters  2002,  4,  3411-4

 

 

Keller, Valerie A.; Martinelli, Joseph R.; Streiter, Eric R.; Burke, Steven D..  Dioxolane-to-Bridged Acetal-to-Spiroketal via Ring-Closing Metathesis and Rearrangement: A Novel Route to 1,7-Dioxaspiro[5.5]undecanes.    Organic Letters  2002,  4,  467-470

 

 

Austad, Brian C.; Hart, Amy C.; Burke, Steven D..  Halichondrin B: synthesis of the C(37)-C(54) subunit.    Tetrahedron  2002,  58,  2011-2026

 

 

Campbell John E; Englund Erikah E; Burke Steven D  Synthesis and structure of preorganized, C(3)-symmetric trilactam scaffolds with convergently oriented (S)-acetylthiomethyl appendages.    Organic letters  2002,  4,  2273-5

 

 

Voight, Eric A.; Rein, Christian; Burke, Steven D..  Synthesis of Sialic Acids via Desymmetrization by Ring-Closing Metathesis.    Journal of Organic Chemistry  2002,  67,  8489-8499

 

 

Burke, Steven D.; Voight, Eric A.  Formal Synthesis of (+)-3-Deoxy-D-glycero-D-galacto-2-nonulosonic Acid (KDN) via Desymmetrization by Ring-Closing Metathesis.    Organic Letters  2001,  3,  237-240

 

 

Voight, Eric A.; Rein, Christian; Burke, Steven D..  Formal synthesis of (-)-N-acetylneuraminic acid (Neu5Ac) via desymmetrization by ring-closing metathesis.    Tetrahedron Letters  2001,  42,  8747-8749

 

 

Burke, Steven D.; Jiang, Lei.  Formal Synthesis of Uvaricin via Palladium-Mediated Double Cyclization.    Organic Letters  2001,  3,  1953-1955

 

 

Clark, Robert W.; Guzei, Ilia A.; Ivanov, Sergei A.; Burke, Steven D.; Lambert, William T.  The lack of C2 molecular symmetry in (1R,2R,3S,6S)-3,6-dibenzyloxycyclohex-4-ene-1,2-diol.    Acta Crystallographica, Section C: Crystal Structure Communications  2001,  C57,  844-845

 

 

Hans, Jeremy J.; Driver, Russell W.; Burke, Steven D..  Direct Transacylation of 2,2,2-Trihaloethyl Esters with Amines and Alcohols Using Phosphorus(III) Reagents for Reductive Fragmentation and in Situ Activation.    Journal of Organic Chemistry  2000,  65,  2114-2121

 

 

Burke, Steven D.; Jung, Kyung Woon; Lambert, William T.; Phillips, Jeannie R.; Klovning, Jason J.  Halichondrin B: Synthesis of the C(1)-C(15) Subunit.    Journal of Organic Chemistry  2000,  65,  4070-4087

 

 

Burke, Steven D.; Zhao, Qian; Schuster, Michael C.; Kiessling, Laura L.  Synergistic Formation of Soluble Lectin Clusters by a Templated Multivalent Saccharide Ligand.    Journal of the American Chemical Society  2000,  122,  4518-4519

 

 

Burke, Steven D.; Zhao, Qian.  Synthesis and Study of C3-Symmetric Hydropyran Cyclooligolides with Oriented Aryl and Alcohol Appendages at 10 .ANG. Spacing.    Journal of Organic Chemistry  2000,  65,  1489-1500

 

 

Burke, Steven D.; Mueller, Norbert; Beaudry, Christopher M.  Desymmetrization by Ring-Closing Metathesis Leading to 6,8-Dioxabicyclo[3.2.1]octanes: A New Route for the Synthesis of (+)-exo- and endo-Brevicomin.    Organic Letters  1999,  1,  1827-1829

 

 

Hans, Jeremy J.; Driver, Russell W.; Burke, Steven D..  One-Pot Synthesis of Amides and Esters from 2,2,2-Trihaloethyl Esters Using Phosphorus(III) Reagents.    Journal of Organic Chemistry  1999,  64,  1430-1431

 

 

Burke, Steven D.; Letourneau, Jeffrey J.; Matulenko, Mark A.  Total synthesis of (+)-breynolide.    Tetrahedron Letters  1999,  40,  9-12

 

 

Burke, Steven D.; Sametz, Geoffrey M.  Total Synthesis of 3-Deoxy-D-manno-2-octulosonic Acid (KDO) and 2-Deoxy-b-KDO.    Organic Letters  1999,  1,  71-74

 

 

Burke, Steven D.; Austad, Brian C.; Hart, Amy C.  An Expeditious Synthesis of the C(38)-C(54) Halichondrin B Subunit.    Journal of Organic Chemistry  1998,  63,  6770-6771

 

 

O'Donnell, Christopher J.; Burke, Steven D..  Selective Mesylation of Vicinal Diols: A Systematic Case Study.    Journal of Organic Chemistry  1998,  63,  8614-8616

 

 

Burke, Steven D.; Hong, Jian; Mongin, Andrew P.  Stereoselective syntheses of the rhizoxin C(1)-C(9) and C(12)-C(26) subunits.    Tetrahedron Letters  1998,  39,  2239-2242

 

 

Burke, Steven D.; Quinn, Kevin J.; Chen, Victor J.  Synthesis of a C(22)-C(34) Halichondrin B Precursor via Ring Opening-Double Ring Closing Metathesis.    Journal of Organic Chemistry  1998,  63,  8626-8627

 

 

Burke, Steven D.; Hong, Jian; Lennox, Joseph R.; Mongin, Andrew P.  Synthetic Studies of Antitumor Macrolide Rhizoxin: Stereoselective Syntheses of the C(1)-C(9) and C(12)-C(26) Subunits.    Journal of Organic Chemistry  1998,  63,  6952-6967

 

 

Burke, Steven D.; Ng, Raymond A.; Morrison, James A.; Alberti, Michael J.  Tandem Glycolate Claisen Rearrangement/Ring-Closing Metathesis: A Stereochemically General Synthesis of Substituted Dihydropyran-2-carboxylates.    Journal of Organic Chemistry  1998,  63,  3160-3161

 

 

Burke, Steven D.; McDermott, Todd S.; O'Donnell, Christopher J.  Template Macrolactonization of Trichloroethyl Ester Derivatives Catalyzed by Potassium Salts.    Journal of Organic Chemistry  1998,  63,  2715-2718

 

 

Burke, Steven D.; O'donnell, Christopher J.; Hans, Jeremy J.; Moon, Choong Woon; Ng, Raymond A.; Adkins, Thomas W.; Packard, Garrick K.  Synthesis of cyclic hydropyran oligolides with convergent amine, amide, phosphonate and furan appendages.    Tetrahedron Letters  1997,  38, 2593-2596

 

 

Burke, Steven D.; Heap, Charles R.; Porter, Warren J.; Song, Yuntao.  Cyclic hydropyran oligolides as preorganized ligand arrays: modular assembly of 18-, 24-, 36-, 48-, 54- and 72-membered rings via iteration and cyclooligomerization.    Tetrahedron Letters  1996,  37,  343-46

 

 

Burke, Steven D.; O'Donnell, Christopher J.; Porter, Warren J.; Song, Yuntao.  Cyclic Hydropyran Oligolides as Preorganized Ligand Arrays: Cumulative Effects of Structural Elements on Shape and Cation Binding.    Journal of the American Chemical Society  1995,  117,  12649-50

 

 

Burke, Steven D.; Zhang, Gan; Buchanan, John L.  Enantioselective synthesis of a halichondrin B C(20) (r) C(36) precursor.    Tetrahedron Letters  1995,  36,  7023-6

 

 

Burke, Steven D.; Jung, Kyung Woon.  2,3-Disubstituted tetrahydrofuran synthesis via radical and anionic cyclization.    Tetrahedron Letters  1994,  35,  5837-40

 

 

Burke, Steven D.; Jung, Kyung Woon; Perri, Roman E.  A short route to avenaciolide and isoavenaciolide via radical cyclization.    Tetrahedron Letters  1994,  35,  5841-4

 

 

Burke, Steven D.; Jung, Kyung Woon; Phillips, Jeannie R.; Perri, Roman E.  An expeditious synthesis of the C(1)-C(14) subunit of halichondrin B.    Tetrahedron Letters  1994,  35,  703-6

 

 

Burke, Steven D.; Kort, Michael E.; Strickland, Sharon M. S.; Organ, Helen M.; Silks, Louis A., III.  Enantioselective synthesis of nagilactone F via vinylsilane-terminated cationic cyclization.    Tetrahedron Letters  1994,  35,  1503-6

 

 

Burke, Steven D.; Piscopio, Anthony D.; Kort, Michael E.; Matulenko, Mark A.; Parker, Marshall H.; Armistead, David M.; Shankaran, K.  Total synthesis of ionophore antibiotic X-14547 A (indanomycin).    Journal of Organic Chemistry  1994,  59,  332-47

 

 

Burke, Steven D.; Pacofsky, Gregory J.; Piscopio, Anthony D.  Synthesis of ethisolide, isoavenaciolide, and avenaciolide.    Journal of Organic Chemistry  1992,  57,  2228-35

 

 

Burke, Steven D.; Piscopio, Anthony D.; Marron, Brian E.; Matulenko, Mark A.; Pan, Gonghua.  Diastereoselectivity enhancement in vinylcuprate addition to b-alkoxy aldehydes via a vinylsilane.    Tetrahedron Letters  1991,  32,  857-8

 

 

Burke, Steven D.; Lee, Kevin C.; Santafianos, Dinos.  Double dioxanone-to-dihydropyran reorganization.  Construction of a C(1)-C(13) erythronolide template.    Tetrahedron Letters  1991,  32,  3957-60

 

 

Burke, Steven D.; Piscopio, Anthony D.; Kort, Michael E.  Stereoselective synthesis of E-b,b-disubstituted alkenylsilanes from a-(mesyloxy)allylsilanes.    Tetrahedron Letters  1991,  32,  855-6

 

 

Burke, Steven D.; Deaton, David N.  Synthesis of (+)-dihydrocompactin and (+)-compactin via vinylsilane terminated cationic cyclization.    Tetrahedron Letters  1991,  32,  4651-4

 

 

Burke, Steven D.; Shankaran, K.; Helber, Margaret Jones.  Synthesis of (+)-fragolide and (-)-pereniporin B via vinylsilane terminated cationic cyclization.    Tetrahedron Letters  1991,  32,  4655-8

 

 

Burke, Steven D.; Buchanan, John L.; Rovin, Joshua D.  Synthesis of a C(22) (r) C(34) halichondrin precursor via a double dioxanone-to-dihydropyran rearrangement.    Tetrahedron Letters  1991,  32,  3961-4

 

 

Burke, Steven D.; Rancourt, Jean.  Tetrahydropyran synthesis via radical cyclization.  A systematic study of substituent effects.    Journal of the American Chemical Society  1991,  113,  2335-6

 

 

Burke, Steven D.; Porter, Warren J.; Rancourt, Jean; Kaltenbach, Robert F.  Chiral synthetic macrodiolide and macrotriolide ionophores with C2- and C3-symmetry.    Tetrahedron Letters  1990,  31,  5285-8

 

 

Burke, Steven D.; Cobb, Jeffery E.; Takeuchi, Kumiko.  Total synthesis of (+)-phyllanthocin.  Introduction of intramolecular hydroformylation for complex molecule functionalization.    Journal of Organic Chemistry  1990,  55,  2138-51

 

 

Burke, Steven D.; Strickland, Sharon M. S.; Organ, Helen M.; Silks, Louis A., III.  Enantioselective synthesis of the nagilactone ring system via vinylsilane-mediated polyene cyclization.    Tetrahedron Letters  1989,  30,  6303-6

 

 

Burke, Steven D..  Studies in sesquiterpene synthesis: (±)-quadrone and (+)-phyllanthocin.    Strategies Tactics Org. Synth.  1989,  57-89

 

 

Burke, Steven D.; Takeuchi, Kumiko; Murtiashaw, C. W.; Liang, D. W. M.  Synthesis of optically active mevinic acid subunits via acetal initiated/vinylsilane terminated polyene cyclizations.    Tetrahedron Letters  1989,  30, 6299-302

 

 

Burke, Steven D.; Silks, Louis A., III; Strickland, Sharon M. S.  Remote functionalization and molecular modeling.  Observations relevant to the Barton and hypoiodite reactions.    Tetrahedron Letters  1988,  29,  2761-4

 

 

Burke, Steven D.; Piscopio, Anthony D.; Buchanan, John L.  Total synthesis of (±)-pulo'upone.    Tetrahedron Letters  1988,  29,  2757-60

 

 

Burke, Steven D.; Chandler, Arthur C., III; Nair, Mangalam S.; Campopiano, Onorato.  An alternate route to the C(7)-C(13) subunit of erythronolide B via a hydropyran template.    Tetrahedron Letters  1987,  28,  4147-8

 

 

Burke, Steven D.; Deaton, David N.; Olsen, Robert J.; Armistead, David M.; Blough, Bruce E.  Stereocontrolled one-pot conversions of a-alkoxy esters to syn- and anti-1,2-diol derivatives.    Tetrahedron Letters  1987,  28,  3905-6

 

 

Burke, Steven D.; Schoenen, Frank J.; Nair, Mangalam S.  The dioxanone-to-dihydropyran Claisen rearrangement.  Synthesis of C(7)-C(13) fragments of erythronolides A and B.    Tetrahedron Letters  1987,  28, 4143-6

 

 

Burke, Steven D.; Armistead, David M.; Schoenen, Frank J.; Fevig, John M.  An enolate Claisen route to C-pyranosides. Development and application to an ionophore synthon.    Tetrahedron  1986,  42,  2787-801

 

 

Burke, Steven D.; Cobb, Jeffrey E.  Intramolecular phosphine-directed hydroformylation.  Application to the total synthesis of (+)-phyllanthocin.    Tetrahedron Letters  1986,  27,  4237-40

 

 

Burke, Steven D.; Armistead, David M.; Shankaran, K.  Not the enolate Claisen rearrangement.  A surprising route to the "right-wing" of indanomycin (X-14547A).    Tetrahedron Letters  1986,  27,  6295-8.

 

 

Burke, Steven D.; Schoenen, Frank J.; Murtiashaw, Charles W.  The ester enolate Claisen rearrangement.  Synthesis of a C(1)-C(6) erythronolide fragment.    Tetrahedron Letters  1986,  27,  449-52

 

 

Burke, Steven D.; Pacofsky, Gregory J.  The ester enolate Claisen rearrangement.  Total synthesis (±)-ethisolide.    Tetrahedron Letters  1986,  27,  445-8.

 

 

Burke, Steven D.; Pacofsky, Gregory J.; Piscopio, Anthony D.  Total synthesis of (±)-isoavenaciolide and (±)-avenaciolide.    Tetrahedron Letters  1986,  27,  3345-8.

 

 

Burke, Steven D.; Armistead, David M.; Fevig, John M.  Ionophore synthesis.  An enantioselective route to the left-wing of indanomycin (X-14547A).    Tetrahedron Letters  1985,  26,  1163-6

 

 

Burke, Steven D.; Cobb, Jeffery E.; Takeuchi, Kumiko.  Total synthesis of (+)-phyllanthocin.    Journal of Organic Chemistry  1985,  50,  3420-1.

 

 

Burke, Steven D.; Saunders, Jeffrey O.; Oplinger, Jeffrey A.; Murtiashaw, Charles W.  Vinylsilane-mediated polyene cyclization.  Synthesis of the octahydronaphthalenol portion of dihydrocompactin.    Tetrahedron Letters  1985,  26,  1131-4.

 

 

Burke, Steven D.; Magnin, David R.; Oplinger, Jeffrey A.; Baker, Julia P.; Abdelmagid, Ahmed.  A unified approach to prostanoid and corticosteroid synthons.    Tetrahedron Letters  1984,  25,  19-22.

 

 

Burke, Steven D.; Armistead, David M.; Schoenen, Frank J.  Polysubstituted dihydropyrans via the enolate Claisen rearrangement.  A stereocontrolled route to C-pyranosides.    Journal of Organic Chemistry  1984,  49,  4320-2.

 

 

Burke, Steven D.; Murtiashaw, Charles William; Saunders, Jeffrey O.; Oplinger, Jeffrey A.; Dike, Meera S.  Total synthesis of (±)-quadrone.    Journal of the American Chemical Society  1984,  106,  4558-66.

 

 

Burke, Steven D.; Powner, Tory H.; Kageyama, Masanori.  A Diels-Alder approach to trans-fused, angularly methylated decalins.    Tetrahedron Letters  1983,  24,  4529-32. 

 

 

Burke, Steven D.; Fobare, William F.; Pacofsky, Gregory J.  Chelation control of enolate geometry.  Acyclic diastereoselection via the enolate Claisen rearrangement.    Journal of Organic Chemistry  1983,  48,  5221-8.

 

 

Burke, Steven D.; Strickland, Sharon M. Smith; Powner, Tory H.  Silicon-substituted dienes in the intramolecular Diels-Alder reaction:  nagilactone model studies.    Journal of Organic Chemistry  1983,  48,  454-9.

 

 

Burke, Steven D.; Murtiashaw, Charles William; Oplinger, Jeffrey A.  Synthetic studies directed at (±)-quadrone.  A new end game.    Tetrahedron Letters  1983,  24,  2949-52.

 

 

Burke, Steven D.; Murtiashaw, Charles William; Saunders, Jeffrey O.; Dike, Meera S.  A novel and efficient entry to (±)-quadrone.    Journal of the American Chemical Society  1982,  104,  872-4.

 

 

Burke, Steven D.; Fobare, William F.; Armistead, David M.  Free-radicals in synthesis.  I.  A two-step carbolactonization procedure.    Journal of Organic Chemistry  1982,  47, 3348-50.

 

 

Burke, Steven D.; Murtiashaw, Charles William; Dike, Meera S.  Ring forming reactions:  adjustable regiocontrol on a polyfunctional substrate.    Journal of Organic Chemistry  1982,  47,  1349-51.

 

 

Burke, Steven D.; Saunders, J. O.; Murtiashaw, C. W.  A novel two-step pyrone to 4-chromanone transformation.    Journal of Organic Chemistry  1981,  46, 2425-6. 

 

 

Burke, Steven D.; Murtiashaw, Charles William; Dike, Meera S.; Strickland, Sharon M. Smith; Saunders, Jeffrey O.  Vinylsilane-mediated spiroannulation.  Synthesis of spiro[4.5]decadienones.    Journal of Organic Chemistry  1981,  46, 2400-2. 

 

 

Burke, Steven D.; Shearouse, Sandra A.; Burch, Daniel J.; Sutton, Randy W.  An efficient and versatile synthesis of b-alkylidene-a,a-disubstituted cyclopentanones.    Tetrahedron Letters  1980,  21,  1285-8.

 

 

Burke, Steven D.; Grieco, Paul A.  Intramolecular reactions of diazocarbonyl compounds.    Organic Reactions (New York)  1979,  26  361-475.

 

 

Nishizawa, Mugio; Grieco, Paul A.; Burke, Steven D.; Metz, William.  Structure and total synthesis of temisin.    Journal of the Chemical Society, Chemical Communications  1978, 76-8.

 

 

Grieco, Paul A.; Nishizawa, Mugio; Oguri, Tomei; Burke, Steven D.; Marinovic, Nebojsa.  Sesquiterpene lactones:  total synthesis of (±)-vernolepin and (±)-vernomenin.    Journal of the American Chemical Society  1977,  99,  5773-80. 

 

 

Grieco, Paul A.; Pogonowski, Chester S.; Burke, Steven D.; Nishizawa, Mugio; Miyashita, Masaaki; Masaki, Yukio; Wang, C. L. J.; Majetich, G.  Total synthesis of racemic 12-methylprostaglandins.    Journal of the American Chemical Society  1977,  99,  4111-18. 

 

 

Grieco, Paul A.; Wang, Chia-Lin J.; Burke, Steven D..  Trimethylsilylacetic acid dianion.  Application to organic synthesis.    Journal of the Chemical Society, Chemical Communications  1975, 537-8.