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Bryostatin 1 The bryostatins constitute a family of polyacetate derived natural products originally isolated from the bryozoan Bugula neritina by Pettit and co-workers Their potent antineoplastic activity, low toxicity, and unique mode of action have led to numerous human clinical trials investigating bryostatin 1 alone or in combination with other chemotherapies. Of the 18 naturally occurring bryostatins, only three have thus far been synthesized, bryostatins 2, 3 and 7. The majority of naturally occurring bryostatins have the general structure shown above, differing in only ester functionalities at C7 and C20. Above is excerpted from: Voight, Eric A.; Roethle, Paul A.; Burke, Steven D. Journal of Organic Chemistry 2004, 69, 4534.