 Associate Professor
B.S., B.A. 1994 University of Rochester
Ph.D. 1999, University of California, Berkeley
Room: 8305I
Phone: 608-262-4783
Email: zanni@chem.wisc.edu
Position: Associate Professor
D. B. Strasfeld, Y. L. Ling, S.–H. Shim and M. T. Zanni, Tracking fibril formation in human islet amyloid polypeptide with automated 2D-IR spectroscopy, JACS, 130, 6698-6699 (2008). E. M. Grumstrup, S.-H. Shim, M. A. Montgomery, N. H. Damrauer, and M. T. Zanni, Facile collection of two-dimensional electronic spectra using femtosecond pulse-shaping technology, Optics Express, 15, 16681 (2007) D. B. Strasfeld, S.-H. Shim and M. T. Zanni, Controlling vibrational excitation with shaped mid-IR pulses, Physical Review Letters, 99, 038102 (2007). S.-H. Shim, D. B. Strasfeld, Yun L. Ling and M. T. Zanni, Automated 2D IR spectroscopy using a mid-IR pulse shaper and application of this technology to the human islet amyloid polypeptide, Proceedings of the National Academy of Sciences, 104, 14197 (2007). P. Mukherjee, I. Kass, I. Arkin, and M. T. Zanni, Picosecond dynamics of membrane protein revealed by 2D IR, PNAS, 103, 3528-3533 (2006). S.-H. Shim, D. B. Strasfeld, E. C. Fulmer, M. T. Zanni, Femtosecond pulse shaping directly in the mid-IR using acousto-optic modulation, Optics Lett., 31, 838-840 (2006). E. C. Fulmer, F. Ding, P. Mukherjee, and M. T. Zanni, Vibrational dynamics of ions in glass from fifth-order two-dimensional infrared spectroscopy, Phys. Rev. Lett., 94 067402 (2005). E. C. Fulmer, F. Ding, and M. T. Zanni, Heterodyned fifth-order 2D IR spectroscopy of the azide ion in an ionic glass, J. Chem. Phys., 034302 (2005). F. Ding, E. C. Fulmer, and M. T. Zanni, Heterodyned fifth-order 2D-IR spectroscopy: Third-quantum states and polarization selectivity, J. Chem. Phys, 123, 094502 (2005). P. Mukherjee, A. T. Krummel, E. C. Fulmer, I. Kass, I. T. Arkin, and M. T. Zanni, Site-specific vibrational dynamics of the CD3zeta membrane peptide using heterodyned 2D IR photon echo spectroscopy, J. Chem. Phys. 120, 10215 (2004).
| Research Description
Research in the Zanni group is aimed at exploring molecular structures and dynamics through vibrational motions and couplings. To accomplish this, sophisticated ultrafast multi-dimensional spectroscopies are being developed that correlate vibrational modes and measure frequency fluctuations. Emphasis is placed on understanding the molecular vibrations of complex biomolecules with regards to structure and function.
We are working towards both advancing the technology behind 2D IR spectroscopies as well as applying these new techniques to study chemistry and biology. For example, we built the first mid-IR pulse shaper that is capable of creating phase and amplitude modulated pulses. This shaper can used to selectively excite specific vibrational modes and to generate phase stable 2D IR pulse sequences. For applications, we are studying the coupling/structure relationship in DNA, membrane peptide environmental heterogeneity from the amide I vibrational dynamics, and peptide folding dynamics. Please see our website for more information.
Last Updated: November 22, 2006.
Coblentz Award, 2006 Alfred P. Sloan Research Fellow, 2006 Benjamin Smith Reynolds Award for Excellence in Teaching Engineers, 2005 Packard Foundation Science and Engineering Fellowship, 2005 Beckman Young Investigators Award, 2004 National Science Foundation CAREER Award, 2003 Research Corporation Innovation Award, 2002 Camille and Henry Dreyfus New Faculty Award, 2002 American Chemical Society Nobel Laureate Signature Award for Graduate Education in Chemistry, 2001 National Institute of Health Postdoctoral Fellow (NRSA), 2000 American Chemical Society Regional Award, Rochester, NY, 1994 - Bausch and Lomb Scholar, University of Rochester, 1990
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