Howard Whitlock

Professor, Born 1936

B.S. 1957, University of Maryland

Ph.D. 1960, University of Wisconsin

Room: 5209a
Phone: 608-262-3180
Email: whitlock@chem.wisc.edu
Position: Professor

Research Description

Howard W. Whitlock, Jr. - Description of Research We are currently engaged in the synthesis and study of doughnut-shaped molecules possessing hydrophobic cavities. These molecules may be represented schematically as in structure 1. A particular example recently synthesized is shown as structure 2. The interest in these molecules lies in the observation that they form hydrophobic complexes of appreciable stability (Kassoc 104N-1) with aromatic guest molecules. Exploitation of this cavity binding property as a basis of artificial enzyme construction is under active investigation.

Last updated July 12, 1996

Publications

• Cochran, J.E., Parrott, T.J., Whitlock, B.J. and Whitlock, H.W. "Pi Hydrogen Bonds as a Design Principal in Molecular Recognition," J. Am. Chem. Soc., 114, 2269 (1992).

• Whitlock, H.W., "On the Iconic Nature of Conformational Pictures and Their Recognition," J. Org. Chem., 56, 7297 (1991).

• Brown, A.B. and Whitlock, H.W. "Inversion Topologies of n.8.81(2,1,4) Cyclophanes; Effects on Host Cavity Stereodynamics," J. Am. Chem. Soc., 111, 3640 (1989).

Awards

• NIH Senior Postdoctoral Fellow, Harvard University, 1970
• Alfred P. Sloan Fellow, 1965-67