Publications

Hines JP, Smith AT, Jacob JP, Lukat-Rodgers GS, Barr I, Rodgers KR, et al.. CO and NO bind to Fe(II) DiGeorge critical region 8 heme but do not restore primary microRNA processing activity. Journal of Biological Inorganic Chemistry. 2016;21:1021-1035.
Bowman HE, Dent MR, Burstyn JN. Met104 is the CO-replaceable ligand at Fe(II) heme in the CO-sensing transcription factor BxRcoM-1. Journal of Biological Inorganic Chemistry. 2016;21:559-569.
Tanimura N, Miller E, Igarashi K, Yang D, Burstyn JN, Dewey CN, et al.. Mechanism governing heme synthesis reveals a GATA factor/heme circuit that controls differentiation. Embo Reports. 2016;17:249-265.
Smith AT, Pazicni S, Marvin KA, Stevens DJ, Paulsen KM, Burstyn JN. Functional Divergence of Heme-Thiolate Proteins: A Classification Based on Spectroscopic Attributes. Chemical Reviews. 2015;115:2532-2558.
Su Y, Majtan T, Freeman KM, Linck R, Ponter S, Kraus JP, et al.. Comparative Study of Enzyme Activity and Heme Reactivity in Drosophila melanogaster and Homo sapiens Cystathionine beta-Synthases. Biochemistry. 2013;52:741-751.
Cintron MS, Green O, Burstyn JN. Ethylene Sensing by Silver(I) Salt-Impregnated Luminescent Films. Inorganic Chemistry. 2012;51:2737-2746.
Barr I, Smith AT, Chen YQ, Senturia R, Burstyn JN, Guo F. Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing. Proceedings of the National Academy of Sciences of the United States of America. 2012;109:1919-1924.
Smith AT, Su Y, Stevens DJ, Majtan T, Kraus JP, Burstyn JN. Effect of the Disease-Causing R266K Mutation on the Heme and PLP Environments of Human Cystathionine beta-Synthase. Biochemistry. 2012;51:6360-6370.
Smith AT, Marvin KA, Freeman KM, Kerby RL, Roberts GP, Burstyn JN. Identification of Cys(94) as the distal ligand to the Fe(III) heme in the transcriptional regulator RcoM-2 from Burkholderia xenovorans. Journal of Biological Inorganic Chemistry. 2012;17:1071-1082.
Smith AT, Majtan T, Freeman KM, Su Y, Kraus JP, Burstyn JN. Cobalt Cystathionine beta-Synthase: A Cobalt-Substituted Heme Protein with a Unique Thiolate Ligation Motif. Inorganic Chemistry. 2011;50:4417-4427.
Majtan T, Freeman KM, Smith AT, Burstyn JN, Kraus JP. Purification and characterization of cystathionine beta-synthase bearing a cobalt protoporphyrin. Archives of Biochemistry and Biophysics. 2011;508:25-30.
Barr I, Smith AT, Senturia R, Chen Y, Scheidemantle BD, Burstyn JN, et al.. DiGeorge Critical Region 8 (DGCR8) Is a Double-cysteine-ligated Heme Protein. Journal of Biological Chemistry. 2011;286:16716-16725.
Ostrowski AD, Deakin SJ, Azhar B, Miller TW, Franco N, Cherney MM, et al.. Nitric Oxide Photogeneration from trans-Cr(cyclam)(ONO)(2)(+) in a Reducing Environment. Activation of Soluble Guanylyl Cyclase and Arterial Vasorelaxation. Journal of Medicinal Chemistry. 2010;53:715-722.
Miller TW, Cherney MM, Lee AJ, Francoleon NE, Farmer PJ, King SB, et al.. The Effects of Nitroxyl (HNO) on Soluble Guanylate Cyclase Activity INTERACTIONS AT FERROUS HEME AND CYSTEINE THIOLS. Journal of Biological Chemistry. 2009;284:21788-21796.
Marvin KA, Reinking JL, Lee AJ, Pardee K, Krause HM, Burstyn JN. Nuclear Receptors Homo sapiens Rev-erb beta and Drosophila melanogaster E75 Are Thiolate-Ligated Heme Proteins Which Undergo Redox-Mediated Ligand Switching and Bind CO and NO. Biochemistry. 2009;48:7056-7071.
Lee AJ, Clark RW, Youn H, Ponter S, Burstyn JN. Guanidine Hydrochloride-Induced Unfolding of the Three Heme Coordination States of the CO-Sensing Transcription Factor, CooA. Biochemistry. 2009;48:6585-6597.
Green O, Gandhi BA, Burstyn JN. Photophysical Characteristics and Reactivity of Bis(2,9-di-tert-butyl-1,10-phenanthroline) copper(I). Inorganic Chemistry. 2009;48:5704-5714.
Bodsgard BR, Clark RW, Ehrbar AW, Burstyn JN. Silica-bound copper(II) triazacyclononane as a phosphate esterase: effect of linker length and surface hydrophobicity. Dalton Transactions. 2009;:2365-2373.
Tseng TSA, Burstyn JN. Synthesis and DNA cleavage activity of a bifunctional intercalator-linked copper(II) macrocycle. Chemical Communications. 2008. pp. 6209-6211.
Marvin KA, Kerby RL, Youn H, Roberts GP, Burstyn JN. The transcription regulator RcoM-2 from Burkholderia xenovorans is a cysteine-ligated hemoprotein that undergoes a redox-mediated ligand switch. Biochemistry. 2008;47:9016-9028.
Gandhi BA, Green O, Burstyn JN. Facile oxidation-based synthesis of sterically encumbered four-coordinate bis(2,9-di-tert-butyl-1,10-phenanthroline)copper(I) and related three-coordinate copper(I) complexes. Inorganic Chemistry. 2007;46:3816-3825.
Clark RW, Youn H, Lee AJ, Roberts GP, Burstyn JN. DNA binding by an imidazole-sensing CooA variant is dependent on the heme redox state. Journal of Biological Inorganic Chemistry. 2007;12:139-146.
Cherney MM, Pazicni S, Frank N, Marvin KA, Kraus JP, Burstyn JN. Ferrous human cystathionine beta-synthase loses activity during enzyme assay due to a ligand switch process. Biochemistry. 2007;46:13199-13210.
Pinkert JC, Clark RW, Burstyn JN. Modeling proline ligation in the heme-dependent CO sensor, CooA, using small-molecule analogs. Journal of Biological Inorganic Chemistry. 2006;11:642.
Clark RW, Lanz ND, Lee AJ, Kerby RL, Roberts GP, Burstyn JN. Unexpected NO-dependent DNA binding by the CooA homolog from Carboxydothermus hydrogenoformans. Proceedings of the National Academy of Sciences of the United States of America. 2006;103:891-896.
Pazicni S, Cherney MM, Lukat-Rodgers GS, Oliveriusova J, Rodgers KR, Kraus JP, et al.. The heme of cystathionine beta-synthase likely undergoes a thermally induced redox-mediated ligand switch. Biochemistry. 2005;44:16785-16795.
Green O, Smith NA, Ellis AB, Burstyn JN. AgBF4-Impregnated poly(vinyl phenyl ketone): An ethylene sensing film. Journal of the American Chemical Society. 2004;126:5952-5953.
Pazicni S, Lukat-Rodgers GS, Oliveriusova J, Rees KA, Parks RB, Clark RW, et al.. The redox behavior of the heme in cystathionine beta-synthase is sensitive to pH. Biochemistry. 2004;43:14684-14695.
Clark RW, Youn H, Parks RB, Cherney MM, Roberts GP, Burstyn JN. Investigation of the role of the N-terminal proline, the distal heme ligand in the CO sensor CooA. Biochemistry. 2004;43:14149-14160.
Youn H, Kerby RL, Thorsteinsson MV, Clark RW, Burstyn JN, Roberts GP. Analysis of the L116K variant of CooA, the heme-containing CO sensor, suggests the presence of an unusual heme ligand resulting in novel activity. Journal of Biological Chemistry. 2002;277:33616-33623.
Deck KM, Tseng TA, Burstyn JN. Triisopropyltriazacyclononane copper(II): An efficient phosphodiester hydrolysis catalyst and DNA cleavage agent. Inorganic Chemistry. 2002;41:669-677.
Amin S, Chappell LL, Morrow JR, Tseng AT, Bodsgard BR, Burstyn JN. Compounds of general interest. Preparation of a synthetic ribonuclease: the europium(III) complex of 1-(4-nitrobenzyl)-4,7,10-tris(carbamoylmethyl)-1,4,7,10-tetraazac yclodod ecane. Inorganic Syntheses. 2002;33:213-218.
Richter-Addo GB, Legzdins P, Burstyn JN. Introduction: Nitric oxide chemistry. Chemical Reviews. 2002;102:857-859.
Carr HS, Tran D, Reynolds MF, Burstyn JN, Spiro TG. Activation of soluble guanylyl cyclase by four-coordinate metalloporphyrins: Evidence for a role for porphyrin conformation. Biochemistry. 2002;41:10149-10157.
Polzin GM, Burstyn JN. Synthetic Cu(II) and Ni(II) peptidases. In: Sigel A, Sigel H. Probing Of Proteins By Metal Ions And Their Low Molecular Weight Complexes. New York: Marcel Dekker; 2001. pp. 103-143.
Bodsgard BR, Burstyn JN. Silica-bound copper(II) triazacyclononane: a robust material for the heterogeneous hydrolysis of a phosphodiester. Chemical Communications. 2001;:647-648.
Serfass L, Carr HS, Aschenbrenner LM, Burstyn JN. Calcium ion downregulates soluble guanylyl cyclase activity: Evidence for a two-metal ion catalytic mechanism. Archives of Biochemistry and Biophysics. 2001;387:47-56.
Hirsch J, George SD, Solomon EI, Hedman B, Hodgson KO, Burstyn JN. Raman and extended X-ray absorption fine structure characterization of a sulfur-ligated Cu(I) ethylene complex: Modeling the proposed ethylene binding site of Arabidopsis thaliana ETR1. Inorganic Chemistry. 2001;40:2439-+.
Reynolds MF, Parks RB, Burstyn JN, Shelver D, Thorsteinsson MV, Kerby RL, et al.. Electronic absorption, EPR, and resonance raman spectroscopy of CooA, a CO-sensing transcription activator from R-rubrum, reveals a five-coordinate NO-heme. Biochemistry. 2000;39:388-396.
Kavana M, Powell DR, Burstyn JN. Static versus dynamic Jahn-Teller distortions in octahedral-like copper(II) complexes of 1,4,7-triazacyclononane and 1-oxa-4,7-diazacyclononane: implications for hydrolytic reactivity. Inorganica Chimica Acta. 2000;297:351-361.
Ivanisevic A, Reynolds MF, Burstyn JN, Ellis AB. Photoluminescent properties of cadmium selenide in contact with solutions and films of metalloporphyrins: Nitric oxide sensing and evidence for the aversion of an analyte to a buried semiconductor-film interface. Journal of the American Chemical Society. 2000;122:3731-3738.
Carr HS, Serfass L, Aschenbrenner LM, Burstyn JN. Calcium ion down-regulates soluble guanylyl cyclase activity: Evidence for a second metal ion binding site. Biochemistry. 2000;39:1564-1564.
Burstyn JN, Heiger-Bernays WJ, Cohen SM, Lippard SJ. Formation of cis-diamminedichloroplatinum(II) 1,2-intrastrand cross-links on DNA is flanking-sequence independent. Nucleic Acids Research. 2000;28:4237-4243.
Vogel KM, Hu SZ, Spiro TG, Dierks EA, Yu AE, Burstyn JN. Variable forms of soluble guanylyl cyclase: protein-ligand interactions and the issue of activation by carbon monoxide. Journal of Biological Inorganic Chemistry. 1999;4:804-813.
Shelver D, Thorsteinsson MV, Kerby RL, Chung SY, Roberts GP, Reynolds MF, et al.. Identification of two important heme site residues (cysteine 75 and histidine 77) in CooA, the CO-sensing transcription factor of Rhodospirillum rubrum. Biochemistry. 1999;38:2669-2678.
Reynolds MF, Parks RB, Shelver D, Thorsteinsson MV, Kerby RB, Roberts GP, et al.. Spectroscopy of CO-sensing CooA reveals a ligand displacement mechanism for CO activation. Journal of Inorganic Biochemistry. 1999;74:276-276.
Hegg EL, Mortimore SH, Cheung CL, Huyett JE, Powell DR, Burstyn JN. Structure-reactivity studies in copper(II)-catalyzed phosphodiester hydrolysis. Inorganic Chemistry. 1999;38:2961-2968.
Burstyn JN. Regulation of NO-sensing soluble guanylyl cyclase and CO-sensing CooA. Journal of Inorganic Biochemistry. 1999;74:15-15.
Serfas L, Burstyn JN. Effect of heme oxygenase inhibitors on soluble guanylyl cyclase activity. Archives of Biochemistry and Biophysics. 1998;359:8-16.
Reynolds MF, Shelver D, Kerby RL, Parks RB, Roberts GP, Burstyn JN. EPR and electronic absorption spectroscopies of the CO-sensing CooA protein reveal a cysteine-ligated low-spin ferric heme. Journal of the American Chemical Society. 1998;120:9080-9081.
Hegg EL, Burstyn JN. Toward the development of metal-based synthetic nucleases and peptidases: a rationale and progress report in applying the principles of coordination chemistry. Coordination Chemistry Reviews. 1998;173:133-165.
Dierks EA, Burstyn JN. The deactivation of soluble guanylyl cyclase by redox-active agents. Archives of Biochemistry and Biophysics. 1998;351:1-7.
Sisemore MF, Selke M, Burstyn JN, Valentine JS. Metalloporphyrin peroxo complexes of iron(III), manganese(III), and titanium(IV). Comparative studies demonstrating that the iron(III) complex is extremely nucleophilic. Inorganic Chemistry. 1997;36:979-984.
Hegg EL, Deal KA, Kiessling LL, Burstyn JN. Hydrolysis of double-stranded and single-stranded RNA in hairpin structures by the copper(II) macrocycle Cu( 9 aneN(3))Cl-2. Inorganic Chemistry. 1997;36:1715-1718.
Dierks EA, Hu SZ, Vogel KM, Yu AE, Spiro TG, Burstyn JN. Demonstration of the role of scission of the proximal histidine-iron bond in the activation of soluble guanylyl cyclase through metalloporphyrin substitution studies. Journal of the American Chemical Society. 1997;119:7316-7323.
Sisemore MF, Burstyn JN, Valentine JS. Epoxidation of electron-deficient olefins by a nucleophilic iron(III) peroxo porphyrinato complex, peroxo(tetramesitylporphyrinato)ferrate(1-). Angewandte Chemie-International Edition. 1996;35:206-208.
Hegg EL, Burstyn JN. Copper(II) macrocycles cleave single-stranded and double-stranded DNA under both aerobic and anaerobic conditions. Inorganic Chemistry. 1996;35:7474-7481.
Dierks EA, Burstyn JN. Nitric oxide (NO center dot), the only nitrogen monoxide redox form capable of activating soluble guanylyl cyclase. Biochemical Pharmacology. 1996;51:1593-1600.
Deal KA, Hengge AC, Burstyn JN. Characterization of transition states in dichloro(1,4,7-triazacyclononane)copper(II)-catalyzed activated phosphate diester hydrolysis. Journal of the American Chemical Society. 1996;118:1713-1718.
Deal KA, Burstyn JN. Mechanistic studies of dichloro(1,4,7-triazacyclononane)copper(II)-catalyzed phosphate diester hydrolysis. Inorganic Chemistry. 1996;35:2792-2798.
Hegg EL, Burstyn JN. HYDROLYSIS OF UNACTIVATED PEPTIDE-BONDS BY A MACROCYCLIC COPPER(II) COMPLEX - CU( 9 ANEN(3))CL-2 HYDROLYZES BOTH DIPEPTIDES AND PROTEINS. Journal of the American Chemical Society. 1995;117:7015-7016.
Burstyn JN, Yu AE, Dierks EA, Hawkins BK, Dawson JH. STUDIES OF THE HEME COORDINATION AND LIGAND-BINDING PROPERTIES OF SOLUBLE GUANYLYL CYCLASE (SGC) - CHARACTERIZATION OF FE(II)SGC AND FE(II)SGC(CO) BY ELECTRONIC ABSORPTION AND MAGNETIC CIRCULAR-DICHROISM SPECTROSCOPIES AND FAILURE OF CO TO ACTIVATE THE EN. Biochemistry. 1995;34:5896-5903.
Yu AE, Hu SZ, Spiro TG, Burstyn JN. RESONANCE RAMAN-SPECTROSCOPY OF SOLUBLE GUANYLYL CYCLASE REVEALS DISPLACEMENT OF DISTAL AND PROXIMAL HEME LIGANDS BY NO. Journal of the American Chemical Society. 1994;116:4117-4118.
Kim TD, Burstyn JN. Identification and partial-purification of an endogenous inhibitor of soluble guanylyl cyclase from bovine lung. Journal of Biological Chemistry. 1994;269:15540-15545.
Hu SZ, Yu AE, Burstyn JN, Spiro TG. RESONANCE RAMAN-SPECTROSCOPY OF GUANYLYL CYCLASE REVEALS DISPLACEMENT OF DISTAL AND PROXIMAL HEME LIGANDS BY NO. Biophysical Journal. 1994;66:A11-A11.
Burstyn JN, Deal KA. SELECTIVE CATALYTIC HYDROLYSIS OF A SIMPLE PHOSPHODIESTER BY A MACROCYCLIC COPPER(II) COMPLEX. Inorganic Chemistry. 1993;32:3585-3586.
Comess KM, Burstyn JN, Essigmann JM, Lippard SJ. REPLICATION INHIBITION AND TRANSLESION SYNTHESIS ON TEMPLATES CONTAINING SITE-SPECIFICALLY PLACED CIS-DIAMMINEDICHLOROPLATINUM(II) DNA ADDUCTS. Biochemistry. 1992;31:3975-3990.
Hollis LS, Sundquist WI, Burstyn JN, Heigerbernays WJ, Bellon SF, Ahmed KJ, et al.. MECHANISTIC STUDIES OF A NOVEL CLASS OF TRISUBSTITUTED PLATINUM(II) ANTITUMOR AGENTS. Cancer Research. 1991;51:1866-1875.
Burstyn JN, Iskandar M, Brady JF, Fukuto JM, Cho AK. COMPARATIVE-STUDIES OF N-HYDROXYLATION AND N-DEMETHYLATION BY MICROSOMAL CYTOCHROME-P-450. Chemical Research in Toxicology. 1991;4:70-76.
Burstyn JN, Roe JA, Miksztal AR, Shaevitz BA, Lang G, Valentine JS. MAGNETIC AND SPECTROSCOPIC CHARACTERIZATION OF AN IRON PORPHYRIN PEROXIDE COMPLEX - PEROXOFERRIOCTAETHYLPORPHYRIN(1-). Journal of the American Chemical Society. 1988;110:1382-1388.
Fukuto JM, Brady JF, Burstyn JN, Vanatta RB, Valentine JS, Cho AK. DIRECT FORMATION OF COMPLEXES BETWEEN CYTOCHROME-P-450 AND NITROSOARENES. Biochemistry. 1986;25:2714-2719.
Fukuto JM, Distefano EW, Burstyn JN, Valentine JS, Cho AK. Mechanism of oxidation of n-hydroxyphentermine by superoxide. Biochemistry. 1985;24:4161-4167.
Quinn R, Mercersmith J, Burstyn JN, Valentine JS. Influence of hydrogen-bonding on the properties of iron porphyrin imidazole complexes - an internally hydrogen-bonded imidazole ligand. Journal of the American Chemical Society. 1984;106:4136-4144.