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Broderick AH, Carter MCD, Lockett MR, Smith LM, Lynn DM. Fabrication of Oligonucleotide and Protein Arrays on Rigid and Flexible Substrates Coated with Reactive Polymer Multilayers. ACS Applied Materials & Interfaces. 2013;5:351-359. |
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Broderick AH, Breitbach AS, Frei R, Blackwell HE, Lynn DM. Surface-Mediated Release of a Small-Molecule Modulator of Bacterial Biofilm Formation: A Non-Bactericidal Approach to Inhibiting Biofilm Formation in Pseudomonas aeruginosa. Advanced Healthcare Materials. 2013;:n/a–n/a. |
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Tocce EJ, Liliensiek SJ, Broderick AH, Jiang Y, Murphy KC, Murphy CJ, et al. The influence of biomimetic topographical features and the extracellular matrix peptide RGD on human corneal epithelial contact guidance. Acta Biomater. 2013;9(2):5040-51. |
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Bechler SL, Si Y, Yu Y, Ren J, Liu B, Lynn DM. Reduction of intimal hyperplasia in injured rat arteries promoted by catheter balloons coated with polyelectrolyte multilayers that contain plasmid DNA encoding PKCδ. Biomaterials. 2013;34(1):226-36. |
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Lynn DM. A ‘Multilayered’ Approach to the Delivery of DNA: Exploiting the Structure of Polyelectrolyte Multilayers to Promote Surface-Mediated Cell Transfection and Multi-Agent Delivery. In: Multilayer Thin Films. Wiley-VCH; 2012. p. 731-748. |
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Broderick AH, Lynn DM. Covalent Layer-by-Layer Assembly Using Reactive Polymers. In: Functional Polymers by Post-Polymerization Modification: Concepts, Practical Guidelines, and Applications. Wiley-VCH; 2012. p. 371-406. |
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Aytar BS, Muller JPE, Golan S, Kondo Y, Talmon Y, Abbott NL, et al. Chemical oxidation of a redox-active, ferrocene-containing cationic lipid: Influence on interactions with DNA and characterization in the context of cell transfection. Journal of Colloid and Interface Science. 2012;387:56-64. |
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Bechler SL, Lynn DM. Characterization of Degradable Polyelectrolyte Multilayers Fabricated Using DNA and a Fluorescently-Labeled Poly(beta-amino ester): Shedding Light on the Role of the Cationic Polymer in Promoting Surface-Mediated Gene Delivery. Biomacromolecules. 2012;13:542-552. |
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Broderick AH, Lockett MR, Buck ME, Yuan Y, Smith LM, Lynn DM, et al. In situ Synthesis of Oligonucleotide Arrays on Surfaces Coated with Crosslinked Polymer Multilayers. Chemistry of Materials. 2012;24:938-945. |
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Manna U, Broderick AH, Lynn DM. Chemical Patterning and Physical Refinement of Reactive Superhydrophobic Surfaces. Advanced Materials. 2012;24:4291-+. |
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Muller JPE, Aytar BS, Kondo Y, Lynn DM, Abbott NL. Incorporation of DOPE into lipoplexes formed from a ferrocenyl lipid leads to inverse hexagonal nanostructures that allow redox-based control of transfection in high serum. Soft Matter. 2012;8:2608-2619. |
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Aytar BS, Muller JPE, Golan S, Hata S, Takahashi H, Kondo Y, et al. Addition of ascorbic acid to the extracellular environment activates lipoplexes of a ferrocenyl lipid and promotes cell transfection. Journal of Controlled Release. 2012;157:249-259. |
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Aytar BS, Prausnitz MR, Lynn DM. Rapid Release of Plasmid DNA from Surfaces Coated with Polyelectrolyte Multilayers Promoted by the Application of Electrochemical Potentials. ACS Applied Materials & Interfaces. 2012;4:2726-2734. |
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Bechler SL, Lynn DM. Reactive Polymer Multi layers Fabricated by Covalent Layer-by-Layer Assembly: 1,4-Conjugate Addition-Based Approaches to the Design of Functional Biointerfaces. Biomacromolecules. 2012;13:1523-1532. |
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Broderick AH, Manna U, Lynn DM. Covalent Layer-by-Layer Assembly of Water-Permeable and Water-Impermeable Polymer Multilayers on Highly Water-Soluble and Water-Sensitive Substrates. Chemistry of Materials. 2012;24:1786-1795. |
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Buck ME, Lynn DM. Azlactone-functionalized polymers as reactive platforms for the design of advanced materials: Progress in the last ten years. Polym. Chem. 2012;3:66-80. |
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Tocce EJ, Broderick AH, Murphy KC, Liliensiek SJ, Murphy CJ, Lynn DM, et al. Functionalization of reactive polymer multilayers with RGD and an antifouling motif: RGD density provides control over human corneal epithelial cell-substrate interactions. J Biomed Mater Res A. 2012;100(1):84-93. |
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Bechler SL, Lynn DM. Design and Synthesis of a Fluorescently End-Labeled Poly(beta-amino ester): Application to the Characterization of Degradable Polyelectrolyte Multilayers. Journal of Polymer Science Part a-Polymer Chemistry. 2011;49:1572-1581. |
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Broderick AH, Azarin SM, Buck ME, Palecek SP, Lynn DM. Fabrication and Selective Functionalization of Amine-Reactive Polymer Multi layers on Topographically Patterned Microwell Cell Culture Arrays. Biomacromolecules. 2011;12:1998-2007. |
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Buck ME, Lynn DM. Layer-by-Layer Fabrication of Covalently Crosslinked and Reactive Polymer Multilayers Using Azlactone-Functionalized Copolymers: A Platform for the Design of Functional Biointerfaces. Advanced Engineering Materials. 2011;13:B343-B352. |
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Flessner RM, Jewell CM, Anderson DG, Lynn DM. Degradable Polyelectrolyte Multilayers that Promote the Release of siRNA. Langmuir. 2011;27:7868-7876. |
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Golan S, Aytar BS, Muller JPE, Kondo Y, Lynn DM, Abbott NL, et al. Influence of Biological Media on the Structure and Behavior of Ferrocene-Containing Cationic Lipid/DNA Complexes Used for DNA Delivery. Langmuir. 2011;27:6615-6621. |
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Saurer EM, Flessner RM, Buck ME, Lynn DM. Fabrication of covalently crosslinked and amine-reactive microcapsules by reactive layer-by-layer assembly of azlactone-containing polymer multilayers on sacrificial microparticle templates. Journal of Materials Chemistry. 2011;21:1736-1745. |
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Saurer EM, Yamanouchi D, Liu B, Lynn DM. Delivery of plasmid DNA to vascular tissue in vivo using catheter balloons coated with polyelectrolyte multilayers. Biomaterials. 2011;32:610-618. |
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Sun B, Flessner RM, Saurer EM, Jewell CM, Fredin NJ, Lynn DM. Characterization of pH-induced changes in the morphology of polyelectrolyte multilayers assembled from poly(allylamine) and low molecular weight poly(acrylic acid). Journal of Colloid and Interface Science. 2011;355:431-441. |
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Breitbach AS, Broderick AH, Jewell CM, Gunasekaran S, Lin Q, Lynn DM, et al. Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: Gradual release enhances activity. Chem. Commun. [Internet]. 2011;47:370-372. Available from: http://dx.doi.org/10.1039/C0CC02316G |
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Golan S, Aytar BS, Muller JPE, Kondo Y, Lynn DM, Abbott NL, et al. Influence of biological media on the structure and behavior of ferrocene-containing cationic lipid/DNA complexes used for DNA delivery. Langmuir. 2011;27(11):6615-21. |
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Breitbach AS, Broderick AH, Jewell CM, Gunasekaran S, Lin Q, Lynn DM, et al. Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: Gradual release enhances activity. Chemical Communications. 2010;47:370-372. |
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Karlsson AJ, Flessner RM, Gellman SH, Lynn DM, Palecek SP. Polyelectrolyte Multilayers Fabricated from Antifungal beta-Peptides: Design of Surfaces that Exhibit Antifungal Activity Against Candida albicans. Biomacromolecules. 2010;11:2321-2328. |
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Buck ME, Lynn DM. Reactive Layer-by-Layer Assembly of Suspended Thin Films and Semipermeable Membranes at Interfaces Created Between Aqueous and Organic Phases. Advanced Materials. 2010;22:994-+. |
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Buck ME, Lynn DM. Functionalization of Fibers Using Azlactone-Containing Polymers: Layer-by-Layer Fabrication of Reactive Thin Films on the Surfaces of Hair and Cellulose-Based Materials. ACS Applied Materials & Interfaces. 2010;2:1421-1429. |
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Buck ME, Lynn DM. Free-Standing and Reactive Thin Films Fabricated by Covalent Layer-by-Layer Assembly and Subsequent Lift-Off of Azlactone-Containing Polymer Multilayers. Langmuir. 2010;26:16134-16140. |
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Buck ME, Schwartz SC, Lynn DM. Superhydrophobic Thin Films Fabricated by Reactive Layer-by-Layer Assembly of Azlactone-Functionalized Polymers. Chemistry of Materials. 2010;22:6319-6327. |
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Flessner RM, Yu Y, Lynn DM. Rapid release of plasmid DNA from polyelectrolyte multilayers: A weak poly(acid) approach. Chemical Communications. 2010;47:550-552. |
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Fredin NJ, Flessner RM, Jewell CM, Bechler SL, Buck ME, Lynn DM. Characterization of Nanoscale Transformations in Polyelectrolyte Multilayers Fabricated From Plasmid DNA Using Laser Scanning Confocal Microscopy in Combination With Atomic Force Microscopy. Microscopy Research and Technique. 2010;73:834-844. |
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Kinsinger MI, Buck ME, Abbott NL, Lynn DM. Immobilization of Polymer-Decorated Liquid Crystal Droplets on Chemically Tailored Surfaces. Langmuir. 2010;26:10234-10242. |
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Kinsinger MI, Buck ME, Meli M-V, Abbott NL, Lynn DM. Langmuir films of flexible polymers transferred to aqueous/liquid crystal interfaces induce uniform azimuthal alignment of the liquid crystal. Journal of Colloid and Interface Science. 2010;341:124-135. |
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Saurer EM, Flessner RM, Sullivan SP, Prausnitz MR, Lynn DM. Layer-by-Layer Assembly of DNA- and Protein-Containing Films on Microneedles for Drug Delivery to the Skin. Biomacromolecules. 2010;11:3136-3143. |
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Sun B, Liu X, Buck ME, Lynn DM. Azlactone-functionalized polymers as reactive templates for parallel polymer synthesis: synthesis and screening of a small library of cationic polymers in the context of DNA delivery. Chemical Communications. 2010;46:2016-2018. |
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Sun B, Lynn DM. Release of DNA from polyelectrolyte multilayers fabricated using 'charge-shifting' cationic polymers: Tunable temporal control and sequential, multi-agent release. Journal of Controlled Release. 2010;148:91-100. |
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Kinsinger MI, Lynn DM, Abbott NL. Nematic ordering drives the phase separation of mixed monolayers containing phospholipids modified with poly(ethylene glycol) at aqueous-liquid crystal interfaces. Soft Matter. 2010;6:4095-4104. |
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Buck ME, Breitbach AS, Belgrade SK, Blackwell HE, Lynn DM. Chemical Modification of Reactive Multilayered Films Fabricated from Poly(2-alkenyl azlactone)s: Design of Surfaces that Prevent or Promote Mammalian Cell Adhesion and Bacterial Biofilm Growth. Biomacromolecules. 2009;10:1564-1574. |
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Fredin NJ, Broderick AH, Buck ME, Lynn DM. Nanoimprinted Thin Films of Reactive, Azlactone-Containing Polymers: Combining Methods for the Topographic Patterning of Cell Substrates with Opportunities for Facile Post-Fabrication Chemical Functionalization. Biomacromolecules. 2009;10:994-1003. |
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Saurer EM, Jewell CM, Kuchenreuther JM, Lynn DM. Assembly of erodible, DNA-containing thin films on the surfaces of polymer microparticles: Toward a layer-by-layer approach to the delivery of DNA to antigen-presenting cells. Acta Biomaterialia. 2009;5:913-924. |
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Jewell CA, Lynn DM. Multilayered polyelectrolyte assemblies as platforms for the delivery of DNA and other nucleic acid-based therapeutics. Advanced Drug Delivery Reviews. 2008;60:979-999. |
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Jewell CM, Hays ME, Kondo Y, Abbott NL, Lynn DM. Chemical Activation of Lipoplexes Formed from DNA and a Redox-Active, Ferrocene-Containing Cationic Lipid. Bioconjugate Chemistry. 2008;19:2120-2128. |
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Jewell CM, Lynn DM. Surface-mediated delivery of DNA: Cationic polymers take charge. Current Opinion in Colloid & Interface Science. 2008;13:395-402. |
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Kinsinger MI, Buck ME, Campos F, Lynn DM, Abbott NL. Dynamic Ordering Transitions of Liquid Crystals Driven by Interfacial Complexes Formed between Polyanions and Amphiphilic Polyamines. Langmuir. 2008;24:13231-13236. |
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Liu X, Yang JW, Lynn DM. Addition of "Charge-Shifting" side chains to linear poly(ethyleneimine) enhances cell transfection efficiency. Biomacromolecules. 2008;9:2063-2071. |
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Liu XH, Zhang JT, Lynn DM. Polyelectrolyte multilayers fabricated from 'charge-shifting' anionic polymers: a new approach to controlled film disruption and the release of cationic agents from surfaces. Soft Matter. 2008;4:1688-1695. |
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Liu XH, Zhang JT, Lynn DM. Ultrathin Multilayered Films that Promote the Release of Two DNA Constructs with Separate and Distinct Release Profiles. Advanced Materials. 2008;20:4148-+. |
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Pizzey CL, Jewell CM, Hays ME, Lynn DM, Abbott NL, Kondo Y, et al. Characterization of the Nanostructure of Complexes Formed by a Redox-Active Cationic Lipid and DNA. The Journal of Physical Chemistry B. 2008;112:5849-5857. |
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Buck ME, Zhang J, Lynn DM. Layer-by-layer assembly of reactive ultrathin films mediated by click-type reactions of poly(2-alkenyl azlactone)s. Advanced Materials. 2007;19:3951-+. |
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Fredin NJ, Zhang J, Lynn DM. Nanometer-scale decomposition of ultrathin multilayered polyelectrolyte films. Langmuir. 2007;23:2273-2276. |
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Hays ME, Jewell CM, Kondo Y, Lynn DM, Abbott NL. Lipoplexes formed by DNA and ferrocenyl lipids: Effect of lipid oxidation state on size, internal dynamics, and zeta-potential. Biophysical Journal. 2007;93:4414-4424. |
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Hays ME, Jewell CM, Lynn DM, Abbott NL. Reversible condensation of DNA using a redox-active surfactant. Langmuir. 2007;23:5609-5614. |
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Jewell CM, Fuchs SM, Flessner RM, Raines RT, Lynn DM. Multilayered films fabricated from an oligoarginine-conjugated protein promote efficient surface-mediated protein transduction. Biomacromolecules. 2007;8:857-863. |
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Kinsinger ML, Sun B, Abbott NL, Lynn DM. Reversible control of ordering transitions at aqueous/liquid crystal interfaces using functional amphiphilic polymers. Advanced Materials. 2007;19:4208-+. |
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Lynn DM. Peeling back the layers: Controlled erosion and triggered disassembly of multilayered polyelectrolyte thin films. Advanced Materials. 2007;19:4118-4130. |
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Sun B, Jewell CM, Fredin NJ, Lynn DM. Assembly of multilayered films using well-defined, end-labeled poly(acrylic acid): Influence of molecular weight on exponential growth in a synthetic weak polyelectrolyte system. Langmuir. 2007;23:8452-8459. |
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Zhang J, Fredin NJ, Lynn DM. Apparent dewetting of ultrathin multilayered polyelectrolyte films incubated in aqueous environments. Langmuir. 2007;23:11603-11610. |
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Zhang J, Lynn DM. Ultrathin multilayered films assembled from "Charge-Shifting" cationic polymers: Extended, long-term release of plasmid DNA from surfaces. Advanced Materials. 2007;19:4218-+. |
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Zhang J, Montanez SI, Jewell CM, Lynn DM. Multilayered films fabricated from plasmid DNA and a side-chain functionalized poly(beta-amino ester): Surface-type erosion and sequential release of multiple plasmid constructs-from surfaces. Langmuir. 2007;23:11139-11146. |
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LaVan DA, Lynn DM, Langer R. Moving smaller in drug discovery and delivery. Nature Reviews. 2006;2:269-273. |
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Wood KC, Chuang HF, Batten RD, Lynn DM, Hammond PT. Controlling interlayer diffusion to achieve sustained, multiagent delivery from layer-by-layer thin films. Proceedings of the National Academy of Sciences of the United States of America. 2006;103:10207. |
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Zhang J, Lynn DM. Multilayered films fabricated from combinations of degradable polyamines: Tunable erosion and release of anionic polyelectrolytes. Macromolecules. 2006;39:8928-8935. |
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Zhang JT, Fredin NJ, Janz JF, Sun B, Lynn DM. Structure/property relationships in erodible multilayered films: Influence of polycation structure on erosion profiles and the release of anionic polyelectrolytes. Langmuir. 2006;22:239-245. |
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Zhang JT, Fredin NJ, Lynn DM. Erosion of multilayered films fabricated from degradable polyamines: Characterization and evidence in support of a mechanism that involves polymer hydrolysis. Journal of Polymer Science Part a-Polymer Chemistry. 2006;44:5161. |
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Lynn DM. Layers of opportunity: nanostructured polymer assemblies for the delivery of macromolecular therapeutics. Soft Matter. 2006;2:269-273. |
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Jewell CM, Hays ME, Kondo Y, Abbott NL, Lynn DM. Ferrocene-containing cationic lipids for the delivery of DNA: oxidation state determines transfection activity. J Control Release. 2006;112(1):129-38. |
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Berry D, Lynn DM, Berry E, Sasisekharan R, Langer R. Heparin localization and fine structure regulate Burkitt's lymphoma growth. Biochem Biophys Res Commun. 2006;348(3):850-6. |
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Jewell CM, Zhang J, Fredin NJ, Wolff MR, Hacker TA, Lynn DM. Release of plasmid DNA from intravascular stents coated with ultrathin multilayered polyelectrolyte films. Biomacromolecules. 2006;7(9):2483-91. |
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Liu X, Yang JW, Miller AD, Nack EA, Lynn DM. Charge-Shifting Cationic Polymers That Promote Self-Assembly and Self-Disassembly with DNA. Macromolecules. 2005;38:7907-7914. |
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Wood KC, Boedicker JQ, Lynn DM, Hammond PT. Tunable drug release from hydrolytically degradable layer-by-layer thin films. Langmuir. 2005;21(4):1603-9. |
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Fredin NJ, Zhang J, Lynn DM. Surface analysis of erodible multilayered polyelectrolyte films: nanometer-scale structure and erosion profiles. Langmuir. 2005;21(13):5803-11. |
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Jewell CM, Zhang J, Fredin NJ, Lynn DM. Multilayered polyelectrolyte films promote the direct and localized delivery of DNA to cells. J Control Release. 2005;106(1-2):214-23. |
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Abbott NL, Jewell CM, Hays ME, Kondo Y, Lynn DM. Ferrocene-containing cationic lipids: influence of redox state on cell transfection. J Am Chem Soc. 2005;127(33):11576-7. |
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Little SR, Lynn DM, Puram SV, Langer R. Formulation and characterization of poly (beta amino ester) microparticles for genetic vaccine delivery. J Control Release. 2005;107(3):449-62. |
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Lynn DM, Anderson DG, Akinc AB, Langer R. Degradable Poly(b-amino ester)s for Gene Delivery. In: Polymeric Gene Delivery: Principles and Applications. CRC Press; 2004. p. 227-241. |
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Gelman MA, Weisblum B, Lynn DM, Gellman SH. Biocidal activity of polystyrenes that are cationic by virtue of protonation. Org Lett. 2004;6(4):557-60. |
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Berry D, Lynn DM, Sasisekharan R, Langer R. Poly(beta-amino ester)s promote cellular uptake of heparin and cancer cell death. Chem Biol. 2004;11(4):487-98. |
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Little SR, Lynn DM, Ge Q, Anderson DG, Puram SV, Chen J, et al. Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines. Proc Natl Acad Sci U S A. 2004;101(26):9534-9. |
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Zhang J, Chua LS, Lynn DM. Multilayered thin films that sustain the release of functional DNA under physiological conditions. Langmuir. 2004;20(19):8015-21. |
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Potineni A, Lynn DM, Langer R, Amiji MM. Poly(ethylene oxide)-modified poly(β-amino ester) nanoparticles as a pH-sensitive biodegradable system for paclitaxel delivery. Journal of Controlled Release. 2003;86:223 - 234. |
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Akinc A, Lynn DM, Anderson DG, Langer R. Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery. J Am Chem Soc. 2003;125(18):5316-23. |
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Anderson DG, Lynn DM, Langer R. Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery. Angew Chem Int Ed Engl. 2003;42(27):3153-8. |
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Akinc A, Anderson DG, Lynn DM, Langer R. Synthesis of poly(beta-amino ester)s optimized for highly effective gene delivery. Bioconjug Chem. 2003;14(5):979-88. |
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Vázquez E, Dewitt DM, Hammond PT, Lynn DM. Construction of hydrolytically-degradable thin films via layer-by-layer deposition of degradable polyelectrolytes. J Am Chem Soc. 2002;124(47):13992-3. |
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Zelikin AN, Lynn DM, Farhadi J, Martin I, Shastri V, Langer R. Erodible conducting polymers for potential biomedical applications. Angew Chem Int Ed Engl. 2002;41(1):141-4. |
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Lynn DM, Amiji MM, Langer R. pH-Responsive Polymer Microspheres: Rapid Release of Encapsulated Material within the Range of Intracellular pH. Angew Chem Int Ed Engl. 2001;40(9):1707-1710. |
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Lynn DM, Grubbs RH. Novel reactivity of ruthenium alkylidenes in protic solvents: degenerate alkylidene proton exchange. J Am Chem Soc. 2001;123(14):3187-93. |
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Lynn DM, Anderson DG, Putnam D, Langer R. Accelerated discovery of synthetic transfection vectors: parallel synthesis and screening of a degradable polymer library. J Am Chem Soc. 2001;123(33):8155-6. |
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Lynn DM, Langer R. Degradable poly(beta-amino esters): Synthesis, characterization, and self-assembly with plasmid DNA. Journal of the American Chemical Society. 2000;122:10761-10768. |
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Lynn DM, Mohr B, Grubbs RH, Henling LM, Day MW. Water-soluble ruthenium alkylidenes: Synthesis, characterization, and application to olefin metathesis in protic solvents. Journal of the American Chemical Society. 2000;122:6601-6609. |
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Grubbs DH, Lynn DM. Olefin Metathesis in Water. In: Aqueous-Phase Organometallic Catalysis: Concepts and Applications. Wiley-VCH; 1998. p. 466-476. |
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Kirkland TA, Lynn DM, Grubbs RH. Ring-closing metathesis in methanol and water. Journal of Organic Chemistry. 1998;63:9904-9909. |
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Lynn DM, Mohr B, Grubbs RH. Living ring-opening metathesis polymerization in water. Journal of the American Chemical Society. 1998;120:1627-1628. |
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Lynn DM, Kanaoka S, Grubbs RH. Living ring-opening metathesis polymerization in aqueous media catalyzed by well-defined ruthenium carbene complexes. Journal of the American Chemical Society. 1996;118:784-790. |
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Mohr B, Lynn DM, Grubbs RH. Synthesis of water-soluble, aliphatic phosphines and their application to well-defined ruthenium olefin metathesis catalysts. Organometallics. 1996;15:4317-4325. |
