Publications

Vasta JD, Choudhary A, Jensen KH, McGrath NA, Raines RT. Prolyl 4-Hydroxylase: Substrate Isosteres in Which an (E)- or (Z)-Alkene Replaces the Prolyl Peptide Bond. Biochemistry. 2017;56:219-227.
Vasta JD, Andersen KA, Deck KM, Nizzi CP, Eisenstein RS, Raines RT. Selective Inhibition of Collagen Prolyl 4-Hydroxylase in Human Cells. ACS Chemical Biology. 2016;11:193-199.
Aronoff MR, Gold B, Raines RT. 1,3-Dipolar Cycloadditions of Diazo Compounds in the Presence of Azides. Organic Letters. 2016;18:1538-1541.
Aronoff MR, Gold B, Raines RT. Rapid cycloaddition of a diazo group with an unstrained dipolarophile. Tetrahedron Letters. 2016;57:2347-2350.
Arnold U, Raines RT. Replacing a single atom accelerates the folding of a protein and increases its thermostability. Organic & Biomolecular Chemistry. 2016;14:6780-6785.
Gold B, Aronoff MR, Raines RT. Decreasing Distortion Energies without Strain: Diazo-Selective 1,3-Dipolar Cycloadditions. Journal of Organic Chemistry. 2016;81:5998-6006.
Newberry RW, Orke SJ, Raines RT. n ->pi* Interactions Are Competitive with Hydrogen Bonds. Organic Letters. 2016;18:3614-3617.
Gold B, Aronoff MR, Raines RT. 1,3-Dipolar Cycloaddition with Diazo Groups: Noncovalent Interactions Overwhelm Strain. Organic Letters. 2016;18:4466-4469.
Thomas SP, Kim E, Kim JS, Raines RT. Knockout of the Ribonuclease Inhibitor Gene Leaves Human Cells Vulnerable to Secretory Ribonucleases. Biochemistry. 2016;55:6359-6362.
Tanrikulu IC, Forticaux A, Jin S, Raines RT. Peptide tessellation yields micrometre-scale collagen triple helices. Nature Chemistry. 2016;8:1008-1014.
Johnston SB, Raines RT. PTENpred: A Designer Protein Impact Predictor for PTEN-related Disorders. Journal of Computational Biology. 2016;23:969-975.
Chattopadhyay S, Guthrie KM, Teixeira L, Murphy CJ, Dubielzig RR, McAnulty JF, et al.. Anchoring a cytoactive factor in a wound bed promotes healing. Journal of Tissue Engineering and Regenerative Medicine. 2016;10:1012-1020.
Mix KA, Aronoff MR, Raines RT. Diazo Compounds: Versatile Tools for Chemical Biology. ACS Chemical Biology. 2016;11:3233-3244.
McGrath NA, Andersen KA, Davis AKF, Lomax JE, Raines RT. Diazo compounds for the bioreversible esterification of proteins. Chemical Science. 2015;6:752-755.
Johnston SB, Raines RT. Catalysis by the Tumor-Suppressor Enzymes PTEN and PTEN-L. Plos One. 2015;10.
Andersen KA, Martin LJ, Prince JM, Raines RT. Intrinsic site-selectivity of ubiquitin dimer formation. Protein Science. 2015;24:182-189.
Marshall CJ, Grosskopf VA, Moehling TJ, Tillotson BJ, Wiepz GJ, Abbott NL, et al.. An Evolved Mxe GyrA Intein for Enhanced Production of Fusion Proteins. ACS Chemical Biology. 2015;10:527-538.
Andersen KA, Aronoff MR, McGrath NA, Raines RT. Diazo Groups Endure Metabolism and Enable Chemoselectivity in Cellulo. Journal of the American Chemical Society. 2015;137:2412-2415.
Johnston SB, Raines RT. Conformational Stability and Catalytic Activity of PTEN Variants Linked to Cancers and Autism Spectrum Disorders. Biochemistry. 2015;54:1576-1582.
Tonelli M, Eller CH, Singarapu KK, Lee W, Bahrami A, Westler WM, et al.. Assignments of RNase A by ADAPT-NMR and enhancer. Biomolecular NMR Assignments. 2015;9:81-88.
Underkofler KA, Teixeira RE, Pietsch SA, Knapp KG, Raines RT. Separation of Lignin from Corn Stover Hydrolysate with Quantitative Recovery of Ionic Liquid. Acs Sustainable Chemistry & Engineering. 2015;3:606-613.
Newberry RW, VanVeller B, Raines RT. Thioamides in the collagen triple helix. Chemical Communications. 2015;51:9624-9627.
Vasta JD, Raines RT. Selective inhibition of prolyl 4-hydroxylases by bipyridinedicarboxylates. Bioorganic & Medicinal Chemistry. 2015;23:3081-3090.
Mix KA, Raines RT. Optimized Diazo Scaffold for Protein Esterification. Organic Letters. 2015;17:2358-2361.
Windsor IW, Raines RT. Fluorogenic Assay for Inhibitors of HIV-1 Protease with Sub-picomolar Affinity. Scientific Reports. 2015;5.
Choudhary A, Kamer KJ, Shoulders MD, Raines RT. 4-Ketoproline: An Electrophilic Proline Analog for Bioconjugation. Biopolymers. 2015;104:110-115.
Checco JW, Lee EF, Evangelista M, Sleebs NJ, Rogers K, Pettikiriarachchi A, et al.. alpha/beta-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells. Journal of the American Chemical Society. 2015;137:11365-11375.
Caes BR, Teixeira RE, Knapp KG, Raines RT. Biomass to Furanics: Renewable Routes to Chemicals and Fuels. Acs Sustainable Chemistry & Engineering. 2015;3:2591-2605.
Desai KK, Beltrame AL, Raines RT. Coevolution of RtcB and Archease created a multiple-turnover RNA ligase. RNA. 2015;21:1866-1872.
Porter DF, Koh YY, VanVeller B, Raines RT, Wickens M. Target selection by natural and redesigned PUF proteins. Proceedings of the National Academy of Sciences of the United States of America. 2015;112:15868-15873.
Ellison AJ, Van Veller B, Raines RT. Convenient synthesis of collagen-related tripeptides for segment condensation. Biopolymers. 2015;104:674-681.
Zasadil LM, Andersen KA, Yeum D, Rocque GB, Wilke LG, Tevaarwerk AJ, et al.. Cytotoxicity of Paclitaxel in Breast Cancer Is due to Chromosome Missegregation on Multipolar Spindles. Science Translational Medicine. 2014;6.
Newberry RW, Raines RT. A Key n ->pi* Interaction in N-Acyl Homoserine Lactones. ACS Chemical Biology. 2014;9:880-883.
Newberry RW, Bartlett GJ, VanVeller B, Woolfson DN, Raines RT. Signatures of n ->pi* interactions in proteins. Protein Science. 2014;23:284-288.
Lavis LD, Raines RT. Bright Building Blocks for Chemical Biology. ACS Chemical Biology. 2014;9:855-866.
D'Avino C, Paciello R, Riccio G, Coppola M, Laccetti P, Maurea N, et al.. Effects of a second-generation human anti-ErbB2 ImmunoRNase on trastuzumab-resistant tumors and cardiac cells. Protein Engineering Design & Selection. 2014;27:83-88.
Chattopadhyay S, Raines RT. Collagen-Based Biomaterials for Wound Healing. Biopolymers. 2014;101:821-833.
Lomax JE, Bianchettl CM, Chang A, Phillips GN, Fox BG, Raines RT. Functional Evolution of Ribonuclease Inhibitor: Insights from Birds and Reptiles. Journal of Molecular Biology. 2014;426:3041-3056.
Choudhary A, Newberry RW, Raines RT. n ->pi* Interactions Engender Chirality in Carbonyl Groups. Organic Letters. 2014;16:3421-3423.
Lukesh JC, Wallin KK, Raines RT. Pyrazine-derived disulfide-reducing agent for chemical biology. Chemical Communications. 2014;50:9591-9594.
Eller CH, Lomax JE, Raines RT. Bovine Brain Ribonuclease Is the Functional Homolog of Human Ribonuclease 1. Journal of Biological Chemistry. 2014;289:25996-26006.
Eller CH, Yang GB, Ouerfelli O, Raines RT. Affinity of monoclonal antibodies for Globo-series glycans. Carbohydrate Research. 2014;397:1-6.
Bingman CA, Cheng CL, Phillips GN, Raines RT. Structure of RNA 3 '-phosphate cyclase bound to substrate RNA AU Desai, KK Bingman, CA Cheng, CL Phillips, GN Raines, RT. RNA-a Publication of the RNA Society. 2014;20:1560-1566.
Tanrikulu IC, Raines RT. Optimal Interstrand Bridges for Collagen-like Biomaterials. Journal of the American Chemical Society. 2014;136:13490-13493.
Lukesh JC, Andersen KA, Wallin KK, Raines RT. Organocatalysts of oxidative protein folding inspired by protein disulfide isomerase. Organic & Biomolecular Chemistry. 2014;12:8598-8602.
Desai KK, Cheng CL, Bingman CA, Phillips GN, Raines RT. A tRNA splicing operon: Archease endows RtcB with dual GTP/ATP cofactor specificity and accelerates RNA ligation. Nucleic Acids Research. 2014;42:3931-3942.
Vasta JD, Higgin JJ, Kersteen EA, Raines RT. Bioavailable affinity label for collagen prolyl 4-hydroxylase. Bioorganic & Medicinal Chemistry. 2013;21:3597-3601.
VanVeller B, Aronoff MR, Raines RT. A divalent protecting group for benzoxaboroles. Rsc Advances. 2013;3:21331-21334.
Rutkoski TJ, Kink JA, Strong LE, Raines RT. Human Ribonuclease with a Pendant Poly(Ethylene Glycol) Inhibits Tumor Growth in Mice. Transl Oncol. 2013;6:392-397.
Riccio G, D'Avino C, Raines RT, De Lorenzo C. A novel fully human antitumor ImmunoRNase resistant to the RNase inhibitor. Protein Engineering Design & Selection. 2013;26:243-248.
Newberry RW, VanVeller B, Guzei IA, Raines RT. n ->pi* Interactions of Amides and Thioamides: Implications for Protein Stability. Journal of the American Chemical Society. 2013;135:7843-7846.
Newberry RW, Raines RT. n ->pi(star) interactions in poly(lactic acid) suggest a role in protein folding. Chemical Communications. 2013;49:7699-7701.
Marshall CJ, Agarwal N, Kalia J, Grosskopf VA, McGrath NA, Abbott NL, et al.. Facile Chemical Functionalization of Proteins through Intein-Linked Yeast Display. Bioconjugate Chemistry. 2013;24:1634-1644.
Lukesh JC, VanVeller B, Raines RT. Thiols and Selenols as Electron-Relay Catalysts for Disulfide-Bond Reduction. Angewandte Chemie-International Edition. 2013;52:12901-12904.
Levine MN, Hoang TT, Raines RT. Fluorogenic Probe for Constitutive Cellular Endocytosis. Chemistry & Biology. 2013;20:614-618.
Arnold U, Huck BR, Gellman SH, Raines RT. Protein prosthesis: beta-peptides as reverse-turn surrogates. Protein Science. 2013;22:274-279.
Sundlass NK, Eller CH, Cui Q, Raines RT. Contribution of Electrostatics to the Binding of Pancreatic-Type Ribonucleases to Membranes. Biochemistry. 2013;52:6304-6312.
Kamer KJ, Choudhary A, Raines RT. Intimate Interactions with Carbonyl Groups: Dipole-Dipole or n ->pi*?. Journal of Organic Chemistry. 2013;78:2099-2103.
Guzei IA, Choudhary A, Raines RT. Pyramidalization of a carbonyl C atom in (2S)-N-(selenoacetyl)proline methyl ester. Acta Crystallographica Section E. 2013;69:o805-o806.
Desai KK, Bingman CA, Phillips GN, Raines RT. Structures of the Noncanonical RNA Ligase RtcB Reveal the Mechanism of Histidine Guanylylation. Biochemistry. 2013;52:2518-2525.
Choudhary A, Fry CG, Kamer KJ, Raines RT. An n -> pi* interaction reduces the electrophilicity of the acceptor carbonyl group. Chemical Communications. 2013;49:8166-8168.
Chou HH, Raines RT. Conversion of Azides into Diazo Compounds in Water. Journal of the American Chemical Society. 2013;135:14936-14939.
Chao TY, Raines RT. Fluorogenic label to quantify the cytosolic delivery of macromolecules. Molecular Biosystems. 2013;9:339-342.
Caes BR, Van Oosbree TR, Lu FC, Ralph J, Maravelias CT, Raines RT. Simulated Moving Bed Chromatography: Separation and Recovery of Sugars and Ionic Liquid from Biomass Hydrolysates. Chemsuschem. 2013;6:2083-2089.
Caes BR, Palte MJ, Raines RT. Organocatalytic conversion of cellulose into a platform chemical. Chemical Science. 2013;4:196-199.
Bartlett GJ, Newberry RW, VanVeller B, Raines RT, Woolfson DN. Interplay of Hydrogen Bonds and n ->pi* Interactions in Proteins. Journal of the American Chemical Society. 2013;135:18682-18688.
Aronoff MR, VanVeller B, Raines RT. Detection of Boronic Acids through Excited-State Intramolecular Proton-Transfer Fluorescence. Organic Letters. 2013;15:5382-5385.
Lomax JE, Eller CH, Raines RT. RATIONAL DESIGN AND EVALUATION OF MAMMALIAN RIBONUCLEASE CYTOTOXINS. In: Wittrup KD, Verdine GL. Methods in Enzymology. San Diego: Elsevier Academic Press Inc; 2012. pp. 273-290.
Palte MJ, Raines RT. Interaction of Nucleic Acids with the Glycocalyx. Journal of the American Chemical Society. 2012;134:6218-6223.
Palte MJ, Davis AKF, McGrath NA, Spiegel CA, Raines RT. Ribonucleoside 3'-Phosphates as Pro-Moieties for an Orally Administered Drug. Chemmedchem. 2012;7:1361-1364.
McGrath NA, Raines RT. Diazo compounds as highly tunable reactants in 1,3-dipolar cycloaddition reactions with cycloalkynes. Chemical Science. 2012;3:3237-3240.
Lukesh JC, Palte MJ, Raines RT. A Potent, Versatile Disulfide-Reducing Agent from Aspartic Acid. Journal of the American Chemical Society. 2012;134:4057-4059.
Levine MN, Raines RT. Trimethyl lock: a trigger for molecular release in chemistry, biology, and pharmacology. Chemical Science. 2012;3:2412-2420.
Krow GR, Shoulders MD, Edupuganti R, Gandla D, Yu F, Sonnet PE, et al.. Synthesis of 5-Fluoro- and 5-Hydroxymethanoprolines via Lithiation of N-BOC-methanopyrrolidines. Constrained C-gamma-Exo and C-gamma-Endo Flp and Hyp Conformer Mimics. Journal of Organic Chemistry. 2012;77:5331-5344.
Ellis GA, Palte MJ, Raines RT. Boronate-Mediated Biologic Delivery. Journal of the American Chemical SocietyJournal of the American Chemical Society. 2012;134:3631-3634.
Ellis GA, McGrath NA, Palte MJ, Raines RT. Ribonuclease-Activated Cancer Prodrug. Acs Medicinal Chemistry Letters. 2012;3:268-272.
Desai KK, Raines RT. tRNA Ligase Catalyzes the GTP-Dependent Ligation of RNA with 3 '-Phosphate and 5 '-Hydroxyl Termini. Biochemistry. 2012;51:1333-1335.
Chattopadhyay S, Murphy CJ, McAnulty JF, Raines RT. Peptides that anneal to natural collagen in vitro and ex vivo. Organic & Biomolecular Chemistry. 2012;10:5892-5897.
Sen SM, Binder JB, Raines RT, Maravelias CT. Conversion of biomass to sugars via ionic liquid hydrolysis: process synthesis and economic evaluation. Biofuels Bioproducts & Biorefining. 2012;6:444-452.
Choudhary A, Kamer KJ, Raines RT. A conserved interaction with the chromophore of fluorescent proteins. Protein Science. 2012;21:171-177.
Watkins RW, Arnold U, Raines RT. Ribonuclease S redux. Chemical Communications. 2011;47:973-975.
Thiyagarajan N, Smith BD, Raines RT, Acharya RK. Functional and structural analyses of N-acylsulfonamide-linked dinucleoside inhibitors of RNase A. FEBS Journal. 2011;278:541-549.
Sundlass NK, Raines RT. Arginine Residues Are More Effective than Lysine Residues in Eliciting the Cellular Uptake of Onconase. Biochemistry. 2011;50:10293-10299.
Smith BD, Higgin JJ, Raines RT. Site-specific folate conjugation to a cytotoxic protein. Bioorganic & Medicinal Chemistry Letters. 2011;21:5029-5032.
Shoulders MD, Raines RT. Interstrand Dipole-Dipole Interactions Can Stabilize the Collagen Triple Helix. Journal of Biological Chemistry. 2011;286:22905-22912.
Rutkoski TJ, Kink JA, Strong LE, Raines RT. Site-specific PEGylation endows a mammalian ribonuclease with antitumor activity. Cancer Biology & Therapy. 2011;12:208-214.
Pinkas DM, Ding S, Raines RT, Barron AE. Tunable, Post-translational Hydroxylation of Collagen Domains in Escherichia coli. ACS Chemical Biology. 2011;6:320-324.
McGrath NA, Raines RT. Chemoselectivity in Chemical Biology: Acyl Transfer Reactions with Sulfur and Selenium. Accounts of Chemical Research. 2011;44:752-761.
Ma L, Sundlass NK, Raines RT, Cui Q. Disruption and Formation of Surface Salt Bridges Are Coupled to DNA Binding by the Integration Host Factor: A Computational Analysis. Biochemistry. 2011;50:266-275.
Levine MN, Raines RT. Sensitive fluorogenic substrate for alkaline phosphatase. Analytical Biochemistry. 2011;418:247-252.
Lavis LD, Chao T-Y, Raines RT. Synthesis and utility of fluorogenic acetoxymethyl ethers. Chemical Science. 2011;2:521-530.
Krow GR, Edupuganti R, Gandla D, Yu F, Sender M, Sonnet PE, et al.. Synthesis of Conformationally Constrained 5-Fluoro- and 5-Hydroxymethanopyrrolidines. Ring-Puckered Mimics of Gauche- and Anti-3-Fluoro- and 3-Hydroxypyrrolidines. Journal of Organic Chemistry. 2011;76:3626-3634.
Ellis GA, Hornung ML, Raines RT. Potentiation of ribonuclease cytotoxicity by a poly(amidoamine) dendrimer. Bioorganic & Medicinal Chemistry Letters. 2011;21:2756-2758.
Cuchillo CM, Victoria Nogues M, Raines RT. Bovine Pancreatic Ribonuclease: Fifty Years of the First Enzymatic Reaction Mechanism. Biochemistry. 2011;50:7835-7841.
Choudhary A, Raines RT. An Evaluation of Peptide-Bond Isosteres. Chembiochem. 2011;12:1801-1807.
Choudhary A, Raines RT. Signature of n ->pi* interactions in alpha-helices. Protein Science. 2011;20:1077-1081.
Choudhary A, Pua KH, Raines RT. Quantum mechanical origin of the conformational preferences of 4-thiaproline and its S-oxides. Amino Acids. 2011;41:181-186.
Chattopadhyay S, Guthrie KM, Teixeira L, Li L, Kiessling LL, Dubielzig RR, et al.. Collagen Mimetic Peptides Enable Cutaneous Wound Assessment and Expedite Healing. Biopolymers. 2011;96:427-427.
Chao T-Y, Raines RT. Mechanism of Ribonuclease A Endocytosis: Analogies to Cell-Penetrating Peptides. Biochemistry. 2011;50:8374-8382.
Caes BR, Raines RT. Conversion of Fructose into 5-(Hydroxymethyl)furfural in Sulfolane. Chemsuschem. 2011;4:353-356.
Caes BR, Binder JB, Blank JJ, Raines RT. Separable fluorous ionic liquids for the dissolution and saccharification of cellulose. Green Chemistry. 2011;13:2719-2722.
Choudhary A, Kamer KJ, Raines RT. An n→π* Interaction in Aspirin: Implications for Structure and Reactivity. Journal of Organic Chemistry. 2011;76:7933-7937.
Shoulders MD, Satyshur KA, Forest KT, Raines RT. Stereoelectronic and steric effects in side chains preorganize a protein main chain. Proceedings of the National Academy of Sciences of the United States of America. 2010;107:559-564.
Shoulders MD, Kotch FW, Choudhary A, Guzei IA, Raines RT. The Aberrance of the 4S Diastereomer of 4-Hydroxyproline. Journal of the American Chemical Society. 2010;132:10857-10865.
Rutkoski TJ, Kink JA, Strong LE, Schilling CI, Raines RT. Antitumor Activity of Ribonuclease Multimers Created by Site-Specific Covalent Tethering. Bioconjugate Chemistry. 2010;21:1691-1702.
Martin LJ, Raines RT. Carpe Diubiquitin. Angewandte Chemie-International Edition. 2010;49:9042-9044.
Krow GR, Liu N, Sender M, Lin G, Centafont R, Sonnet PE, et al.. Oligomers of a 5-Carboxy-methanopyrrolidine beta-Amino Acid. A Search for Order. Organic Letters. 2010;12:5438-5441.
Kalia J, Raines RT. Advances in Bioconjugation. Current Organic Chemistry. 2010;14:138-147.
Jakobsche CE, Choudhary A, Miller SJ, Raines RT. n -> pi(star) Interaction and n)(pi Pauli Repulsion Are Antagonistic for Protein Stability. Journal of the American Chemical Society. 2010;132:6651-+.
Gorres KL, Raines RT. Prolyl 4-hydroxylase. Critical Reviews in Biochemistry and Molecular Biology. 2010;45:106-124.
Choudhary A, Kamer KJ, Powner MW, Sutherland JD, Raines RT. A Stereoelectronic Effect in Prebiotic Nucleotide Synthesis. ACS Chemical Biology. 2010;5:655-657.
Choudhary A, Fry CG, Raines RT. Modulation of an n ->pi* interaction with alpha-fluoro groups. Arkivoc. 2010;:251-262.
Chao T-Y, Lavis LD, Raines RT. Cellular Uptake of Ribonuclease A Relies on Anionic Glycans. Biochemistry. 2010;49:10666-10673.
Binder JB, Raines RT. Fermentable sugars by chemical hydrolysis of biomass. Proceedings of the National Academy of Sciences of the United States of America. 2010;107:4516-4521.
Binder JB, Cefali AV, Blank JJ, Raines RT. Mechanistic insights on the conversion of sugars into 5-hydroxymethylfurfural. Energy & Environmental Science. 2010;3:765-771.
Binder JB, Blank JJ, Cefali AV, Raines RT. Synthesis of Furfural from Xylose and Xylan. Chemsuschem. 2010;3:1268-1272.
Bartlett GJ, Choudhary A, Raines RT, Woolfson DN. n ->pi* interactions in proteins. Nature Chemical Biology. 2010;6:615-620.
Shoulders MD, Satyshur KA, Forest KT, Raines RT. Stereoelectronic and steric effects in side chains preorganize a protein main chain. Proceedings of the National Academy of Sciences of the United States of America. 2010;107:559-564.
Watkins RW, Lavis LD, Kung VM, Los GV, Raines RT. Fluorogenic affinity label for the facile, rapid imaging of proteins in live cells. Organic & Biomolecular Chemistry. 2009;7:3969-3975.
Turcotte RF, Lavis LD, Raines RT. Onconase cytotoxicity relies on the distribution of its positive charge. FEBS Journal. 2009;276:4270-4281.
Tam A, Raines RT. Protein Engineering with the Traceless Staudinger Ligation. Methods in Enzymology. 2009;462:25-44.
Tam A, Raines RT. Coulombic effects on the traceless Staudinger ligation in water. Bioorganic & Medicinal Chemistry. 2009;17:1055-1063.
Shoulders MD, Raines RT. Collagen Structure and Stability. Annual Review of Biochemistry. 2009;78:929-958.
Shoulders MD, Raines RT. Modulating Collagen Triple-Helix Stability with 4-Chloro, 4-Fluoro, and 4-Methylprolines. Peptides for Youth. 2009;611:251-252.
Shoulders MD, Kamer KJ, Raines RT. Origin of the stability conferred upon collagen by fluorination. Bioorganic & Medicinal Chemistry Letters. 2009;19:3859-3862.
Myers EL, Raines RT. A Phosphine-Mediated Conversion of Azides into Diazo Compounds. Angewandte Chemie-International Edition. 2009;48:2359-2363.
Krow GR, Edupuganti R, Gandla D, Choudhary A, Lin GL, Sonnet PE, et al.. 5(6)-anti-Substituted-2-azabicyclo[2.1.1]hexanes: A Nucleophilic Displacement Route. Journal of Organic Chemistry. 2009;74:8232-8242.
Gorres KL, Raines RT. Direct and continuous assay for prolyl 4-hydroxylase. Analytical Biochemistry. 2009;386:181-185.
Dickson KA, Raines RT. Silencing an Inhibitor Unleashes a Cytotoxic Enzyme. Biochemistry. 2009;48:5051-5053.
Derewenda U, Boczek T, Gorres KL, Yu M, Hung LW, Cooper D, et al.. Structure and Function of Bacillus subtilis YphP, a Prokaryotic Disulfide Isomerase with a CXC Catalytic Motif. Biochemistry. 2009;48:8664-8671.
Choudhary A, Gandla D, Krow GR, Raines RT. Nature of Amide Carbonyl-Carbonyl Interactions in Proteins. Journal of the American Chemical Society. 2009;131:7244-+.
Binder JB, Raines RT. Simple Chemical Transformation of Lignocellulosic Biomass into Furans for Fuels and Chemicals. Journal of the American Chemical Society. 2009;131:1979-1985.
Allen MJ, Wangkanont K, Raines RT, Kiessling LL. ROMP from ROMP: A New Approach to Graft Copolymer Synthesis. Macromolecules. 2009;42:4023-4027.
Yatzeck MM, Lavis LD, Chao TY, Chandran SS, Raines RT. A highly sensitive fluorogenic probe for cytochrome P450 activity in live cells. Bioorganic & Medicinal Chemistry Letters. 2008;18:5864-5866.
Wennemers H, Raines RT. Peptides and peptidomimetics as prototypes Editorial overview. Current Opinion in Chemical Biology. 2008;12:690-691.
Turcotte RF, Raines RT. Design and Characterization of an HIV-Specific Ribonuclease Zymogen. AIDS Research and Human Retroviruses. 2008;24:1357-1363.
Turcotte RF, Raines RT. Interaction of onconase with the human ribonuclease inhibitor protein. Biochemical and Biophysical Research Communications. 2008;377:512-514.
Tam A, Soellner MB, Raines RT. Electronic and steric effects on the rate of the traceless Staudinger ligation. Organic & Biomolecular Chemistry. 2008;6:1173-1175.
Smith BD, Raines RT. Genetic selection for peptide inhibitors of angiogenin. Protein Engineering Design & Selection. 2008;21:289-294.
Shoulders MD, Guzei IA, Raines RT. 4-chloroprolines: Synthesis, conformational analysis, and effect on the collagen triple helix. Biopolymers. 2008;89:443-454.
Rutkoski TJ, Raines RT. Evasion of ribonuclease inhibitor as a determinant of ribonuclease cytotoxicity. Current Pharmaceutical Biotechnology. 2008;9:185-199.
Raines RT. Jeremy R. Knowles (1935-2006). ACS Chemical Biology. 2008;3:262-264.
Levine MN, Lavis LD, Raines RT. Trimethyl lock: A stable chromogenic substrate for esterases. Molecules. 2008;13:204-211.
Lee EJ, Raines RT. Ribonucleases as novel chemotherapeutics - The ranpirnase example. Biodrugs. 2008;22:53-58.
Lee EJ, Bae E, Bingman CA, Phillips, Jr. GN, Raines RT. Structural basis for catalysis by onconase. Journal of Molecular Biology. 2008;375:165-177.
Lavis LD, Raines RT. Bright ideas for chemical biology. ACS Chemical Biology. 2008;3:142-155.
Kotch FW, Guzei IA, Raines RT. Stabilization of the collagen triple helix by O-methylation of hydroxyproline residues. Journal of the American Chemical Society. 2008;130:2952-2953.
Kalia J, Raines RT. Hydrolytic stability of hydrazones and oximes. Angewandte Chemie-International Edition. 2008;47:7523-7526.
Gottlieb D, Morin SA, Jin S, Raines RT. Self-assembled collagen-like peptide fibers as templates for metallic nanowires. Journal of Materials Chemistry. 2008;18:3865-3870.
Gorres KL, Edupuganti R, Krow GR, Raines RT. Conformational preferences of substrates for human prolyl 4-hydroxylase. Biochemistry. 2008;47:9447-9455.
Chorghade MS, Mohapatra DK, Sahoo G, Gurjar MK, Mandlecha MV, Bhoite N, et al.. Practical syntheses of 4-fluoroprolines. Journal of Fluorine Chemistry. 2008;129:781-784.
Binder JB, Raines RT. Olefin metathesis for chemical biology. Current Opinion in Chemical Biology. 2008;12:767-773.
Tam A, Soellner MB, Raines RT. Water-soluble phosphinothiols for traceless Staudinger ligation and integration with expressed protein ligation. Journal of the American Chemical Society. 2007;129:11421-11430.
Tam A, Arnold U, Soellner MB, Raines RT. Protein prosthesis: 1,5-disubstituted[1,2,3]triazoles as cis-peptide bond surrogates. Journal of the American Chemical Society. 2007;129:12670-+.
Shoulders MD, Raines RT. Modulating collagen triple helix stability with 4-chloro-, 4-fluoro-, and 4-methylprolines. Biopolymers. 2007;88:593-593.
Lavis LD, Rutkoski TJ, Raines RT. Tuning the pK(a) of fluorescein to optimize binding assays. Analytical Chemistry. 2007;79:6775-6782.
Kalia J, Raines RT. Catalysis of imido group hydrolysis in a maleimide conjugate. Bioorganic & Medicinal Chemistry Letters. 2007;17:6286-6289.
Kalia J, Abbott NL, Raines RT. General method for site-specific protein immobilization by staudinger ligation. Bioconjugate Chemistry. 2007;18:1064-1069.
Johnson JR, McCoy JG, Bingman CA, Phillips, Jr. GN, Raines RT. Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein. Journal of Molecular Biology. 2007;368:434-449.
Johnson JR, Lin SR, Raines RT. Genetic selection reveals the role of a buried, conserved polar residue. Protein Science. 2007;16:1609-1616.
Johnson JR, Lavis LD, Raines RT. Intraspecies regulation of ribonucleolytic activity. Biochemistry. 2007;46:13131-13140.
Johnson JR, Chao T-Y, Lavis LD, Raines RT. Cytotoxic ribonucleases: The dichotomy of coulombic forces. Biochemistry. 2007;46:10308-10316.
Jewell CM, Fuchs SM, Flessner RM, Raines RT, Lynn DM. Multilayered films fabricated from an oligoarginine-conjugated protein promote efficient surface-mediated protein transduction. Biomacromolecules. 2007;8:857-863.
Horng J-C, Kotch FW, Raines RT. Is glycine a surrogate for a D-amino acid in the collagen triple helix?. Protein Science. 2007;16:208-215.
Govindaraju T, Bertics PJ, Raines RT, Abbott NL. Using measurements of anchoring energies of liquid crystals on surfaces to quantify proteins captured by immobilized ligands. Journal of the American Chemical Society. 2007;129:11223-11231.
Fuchs SM, Rutkoski TJ, Kung VM, Groeschl RT, Raines RT. Increasing the potency of a cytotoxin with an arginine graft. Protein Engineering Design & Selection. 2007;20:505-509.
Fuchs SM, Raines RT. Arginine grafting to endow cell permeability. ACS Chemical Biology. 2007;2:167-170.
Binder JB, Guzei IA, Raines RT. Salicylaldimine ruthenium alkylidene complexes: Metathesis catalysts tuned for protic solvents. Advanced Synthesis & Catalysis. 2007;349:395-404.
Binder JB, Blank JJ, Raines RT. Olefin metathesis in homogenous aqueous media catalyzed by conventional ruthenium catalysts. Organic Letters. 2007;9:4885-4888.
Soellner MB, Tam A, Raines RT. Staudinger ligation of peptides at non-glycyl residues. Journal of Organic Chemistry. 2006;71:9824-9830.
Smith BD, Raines RT. Genetic selection for critical residues in ribonucleases. Journal of Molecular Biology. 2006;362:459.
Shoulders MD, Hodges JA, Raines RT. Reciprocity of steric and stereoelectronic effects in the collagen triple helix. Journal of the American Chemical Society. 2006;128:8112.
Liu XS, Jang CH, Zheng F, Jurgensen A, Denlinger JD, Dickson KA, et al.. Characterization of protein immobilization at silver surfaces by near edge X-ray absorption fine structure spectroscopy. Langmuir. 2006;22:7719.
Lavis LD, Chao TY, Raines RT. Fluorogenic label for biomolecular imaging. ACS Chemical Biology. 2006;1:252.
Lavis LD, Chao TY, Raines RT. Latent blue and red fluorophores based on the trimethyl lock. Chembiochem. 2006;7:1151.
Kotch FW, Raines RT. Self-assembly of synthetic collagen triple helices. Proceedings of the National Academy of Sciences of the United States of America. 2006;103:3028-3033.
Kiessling LL, Wedde SG, Raines RT. Symbiosis: Chemical biology at Wisconsin. ACS Chemical Biology. 2006;1:481-484.
Kalia J, Raines RT. Reactivity of intein thioesters: Appending a functional group to a protein. Chembiochem. 2006;7:1375.
Johnson RJ, Lin SR, Raines RT. A ribonuclease zymogen activated by the NS3 protease of the hepatitis C virus. FEBS Journal. 2006;273:5457.
Horng JC, Hawk AJ, Zhao Q, Benedict ES, Burke SD, Raines RT. Macrocyclic scaffold for the collagen triple helix. Organic Letters. 2006;8:4735.
Hodges JA, Raines RT. Energetics of an n ->pi* interaction that impacts protein structure. Organic Letters. 2006;8:4695.
Fuchs SM, Raines RT. Internalization of cationic peptides: the road less (or more?) traveled. Cellular and Molecular Life Sciences. 2006;63:1819.
Allen MJ, Raines RT, Kiessling LL. Contrast agents for magnetic resonance imaging synthesized with ring-opening metathesis polymerization. Journal of the American Chemical Society. 2006;128:6534-6535.
Raines RT. 2005 Emil Thomas Kaiser Award. Protein Science. 2006;15:1219-1225.
Horng JC, Raines RT. Stereoelectronic effects on polyproline conformation. Protein Science. 2006;15:74-83.
Eckenroth B, Harris K, Turanov AA, Gladyshev VN, Raines RT, Hondal RJ. Semisynthesis and characterization of mammalian thioredoxin reductase. Biochemistry. 2006;45:5158-5170.
Hodges JA, Raines RT. Stereoelectronic and steric effects in the collagen triple helix: Toward a code for strand association. Journal of the American Chemical Society. 2005;127:15923-15932.
Dickson KA, Haigis MC, Raines RT. Ribonuclease inhibitor: Structure and function [Review]. Progress in Nucleic Acid Research and Molecular Biology. 2005;80:349-+.
Chandran SS, Dickson KA, Raines RT. Latent fluorophore based on the trimethyl lock. Journal of the American Chemical Society. 2005;127:1652-1653.
Smith BD, Soellner MB, Raines RT. Synthetic surfaces for ribonuclease adsorption. Langmuir. 2005;21:187-190.
Nilsson BL, Soellner MB, Raines RT. Chemical synthesis of proteins [Review]. Annual Review of Biophysics & Biomolecular Structure. 2005;34:91-118.
Miller BG, Raines RT. Reconstitution of a defunct glycolytic pathway via recruitment of ambiguous sugar kinases. Biochemistry. 2005;44:10776-10783.
Lee JE, Raines RT. Cytotoxicity of bovine seminal ribonuclease: Monomer versus dimer. Biochemistry. 2005;44:15760-15767.
Kersteen EA, Barrows SR, Raines RT. Catalysis of protein disulfide bond isomerization in a homogeneous substrate. Biochemistry. 2005;44:12168-12178.
Jenkins CL, Vasbinder MM, Miller SJ, Raines RT. Peptide bond isosteres: Ester or (E)-alkene in the backbone of the collagen triple helix. Organic Letters. 2005;7:2619-2622.
Jenkins CL, Thiyagarajan N, Sweeney RY, Guy MP, Kelemen BR, Acharya KR, et al.. Binding of non-natural 3 '-nucleotides to ribonuclease A. FEBS Journal. 2005;272:744-755.
Jenkins CL, McCloskey AI, Guzei IA, Eberhardt ES, Raines RT. O-acylation of hydroxyproline residues: Effect on peptide-bond isomerization and collagen stability. Biopolymers. 2005;80:1-8.
Fuchs SM, Raines RT. Polyarginine as a multifunctional fusion tag. Protein Science. 2005;14:1538-1544.
Luk YY, Tingey ML, Dickson KA, Raines RT, Abbott NL. Imaging the binding ability of proteins immobilized on surfaces with different orientations by using liquid crystals. Journal of the American Chemical Society. 2004;126:9024-9032.
Jenkins CL, Lin GL, Duo JQ, Rapolu D, Guzei IA, Raines RT, et al.. Substituted 2-azabicyclo[2.1.1]hexanes as constrained proline analogues: Implications for collagen stability. Journal of Organic Chemistry. 2004;69:8565-8573.
Miller BG, Raines RT. Identifying latent enzyme activities: Substrate ambiguity within modern bacterial sugar kinases. Biochemistry. 2004;43:6387-6392.
Makarov AA, Yakovlev GI, Mitkevich VA, Higgin JJ, Raines RT. Zinc(II)-mediated inhibition of ribonuclease Sa by an N-hydroxyurea nucleotide and its basis. Biochemical & Biophysical Research Communications. 2004;319:152-156.
Kim BM, Kim H, Raines RT, Lee Y. Glycosylation of onconase increases its conformational stability and toxicity for cancer cells. Biochemical & Biophysical Research Communications. 2004;315:976-983.
Kersteen EA, Higgin JJ, Raines RT. Production of human prolyl 4-hydroxylase in Escherichia coli. Protein Expression & Purification. 2004;38:279-291.
Fuchs SM, Raines RT. Pathway for polyarginine entry into mammalian cell. Biochemistry. 2004;43:2438-2444.
Wright G, Higgin JJ, Raines RT, Steenbergen C, Murphy E. Activation of the prolyl hydroxylase oxygen-sensor results in induction of GLUT1, heme oxygenase-1, and nitric-oxide synthase proteins and confers protection from metabolic inhibition to cardiomyocytes. Journal of Biological Chemistry. 2003;278:20235-20239.
Soellner MB, Dickson KA, Nilsson BL, Raines RT. Site-specific protein immobilization by Staudinger ligation. Journal of the American Chemical Society. 2003;125:11790-11791.
Smith BD, Soellner MB, Raines RT. Potent inhibition of ribonuclease A by oligo(vinylsulfonic acid). Journal of Biological Chemistry. 2003;278:20934-20938.
Nilsson BL, Hondal RJ, Soellner MB, Raines RT. Protein assembly by orthogonal chemical ligation methods. Journal of the American Chemical Society. 2003;125:5268-5269.
Jenkins CL, Bretscher LE, Guzei IA, Raines RT. Effect of 3-hydroxyproline residues on collagen stability. Journal of the American Chemical Society. 2003;125:6422-6427.
Hodges JA, Raines RT. Stereoelectronic effects on collagen stability: The dichotomy of 4-fluoroproline diastereomers. Journal of the American Chemical Society. 2003;125:9262-9263.
Higgin JJ, Yakovlev GI, Mitkevich VA, Makarov AA, Raines RT. Zinc(II)-mediated inhibition of a ribonuclease by an N-hydroxyurea nudeotide. Bioorganic & Medicinal Chemistry Letters. 2003;13:409-412.
Haigis MC, Raines RT. Secretory ribonucleases are internalized by a dynamin-independent endocytic pathway. Journal of Cell Science. 2003;116:313-324.
Woycechowsky KJ, Raines RT. The CXC motif: A functional mimic of protein disulfide isomerase. Biochemistry. 2003;42:5387-5394.
Woycechowsky KJ, Hook BA, Raines RT. Catalysis of protein folding by an immobilized small-molecule dithiol. Biotechnology Progress. 2003;19:1307-1314.
Plainkum P, Fuchs SM, Wiyakrutta S, Raines RT. Creation of a zymogen. Nature Structural Biology. 2003;10:115-119.
Park C, Raines RT. Catalysis by ribonuclease A is limited by the rate of substrate association. Biochemistry. 2003;42:3509-3518.
Matousek J, Soucek J, Slavik T, Tomanek M, Lee JE, Raines RT. Comprehensive comparison of the cytotoxic activities of onconase and bovine seminal ribonuclease. Comparative Biochemistry & Physiology. 2003;:343-356.
Lee JE, Raines RT. Contribution of active-site residues to the function of onconase, a ribonuclease with antitumoral activity. Biochemistry. 2003;42:11443-11450.
Hinderaker MP, Raines RT. An electronic effect on protein structure. Protein Science. 2003;12:1188-1194.
Haigis MC, Kurten EL, Raines RT. Ribonuclease inhibitor as an intracellular sentry. Nucleic Acids Research. 2003;31:1024-1032.
Dickson KA, Dahlberg CL, Raines RT. Compensating effects on the cytotoxicity of ribonuclease A variants. Archives of Biochemistry & Biophysics. 2003;415:172-177.
Arnold U, Hinderaker MP, Koditz J, Golbik R, Ulbrich-Hofmann R, Raines RT. Protein prosthesis: A nonnatural residue accelerates folding and increases stability. Journal of the American Chemical Society. 2003;125:7500-7501.
Umezawa N, Gelman MA, Haigis MC, Raines RT, Gellman SH. Translocation of a beta-peptide across cell membranes. Journal of the American Chemical Society. 2002;124:368-369.
Soellner MB, Nilsson BL, Raines RT. Staudinger ligation of alpha-azido acids retains stereochemistry. Journal of Organic Chemistry. 2002;67:4993-4996.
Sevcik J, Urbanikova L, Leland PA, Raines RT. X-ray structure of two crystalline forms of a Streptomycete ribonuclease with cytotoxic activity. Journal of Biological Chemistry. 2002;277:47325-47330.
Haigis MC, Kurten EL, Abel RL, Raines RT. KFERQ sequence in ribonuclease A-mediated cytotoxicity. Journal of Biological Chemistry. 2002;277:11576-11581.
DeRider ML, Wilkens SJ, Waddell MJ, Bretscher LE, Weinhold F, Raines RT, et al.. Collagen stability: Insights from NMR spectroscopic and hybrid density functional computational investigations of the effect of electronegative substituents on prolyl ring conformations. Journal of the American Chemical Society. 2002;124:2497-2505.
Arnold U, Hinderaker MP, Nilsson BL, Huck BR, Gellman SH, Raines RT. Protein prosthesis: A semisynthetic enzyme with a beta-peptide reverse turn. Journal of the American Chemical Society. 2002;124:8522-8523.
Park SH, Raines RT. Genetic screen to dissect protein-protein interactions: ribonuclease inhibitor-ribonuclease A as a model system. Methods. 2002;28:346-352.
Leland PA, Staniszewski KE, Park C, Kelemen BR, Raines RT. The ribonucleolytic activity of angiogenin. Biochemistry. 2002;41:1343-1350.
Jenkins CL, Raines RT. Insights on the conformational stability of collagen. Natural Product Reports. 2002;19:49-59.
Hondal RJ, Raines RT. Semisynthesis of proteins containing selenocysteine. Protein Sensors And Reactive Oxygen Species, Pt A. 2002;347:70-83.
Haigis MC, Haag ES, Raines RT. Evolution of ribonuclease inhibitor by exon duplication. Molecular Biology & Evolution. 2002;19:959-963.
Gellman SH, Raines RT. Model systems - This year's model - Editorial overview. Current Opinion in Chemical Biology. 2002;6:727-728.
Abel RL, Haigis MC, Park C, Raines RT. Fluorescence assay for the binding of ribonuclease A to the ribonuclease inhibitor protein. Analytical Biochemistry. 2002;306:100-107.
Park C, Kelemen BR, Klink TA, Sweeney RY, Behlke MA, Eubanks SR, et al.. Fast, facile, hypersensitive assays for ribonucleolytic activity. In San Diego: Academic Press Inc; 2001. pp. 81-94.
Park C, Raines RT. Quantitative analysis of the effect of salt concentration on enzymatic catalysis. Journal of the American Chemical SocietyJournal of the American Chemical Society. 2001;123:11472-11479.
Nilsson BL, Kiessling LL, Raines RT. High-yielding Staudinger ligation of a phosphinothioester and azide to form a peptide. Organic Letters. 2001;3:9-12.
Plainkum P, Fuchs SM, Raines RT. A ribonuclease zymogen as a chemotherapeutic for malaria. FASEB Journal. 2001;15:A538-A538.
Park C, Schultz LW, Raines RT. Contribution of the active site histidine residues of ribonuclease A to nucleic acid binding. Biochemistry. 2001;40:4949-4956.
Leland PA, Staniszewski KE, Kim BM, Raines RT. Endowing human pancreatic ribonuclease with toxicity for cancer cells. Journal of Biological Chemistry. 2001;276:43095-43102.
Leland PA, Raines RT. Cancer chemotherapy - ribonucleases to the rescue. Chemistry & Biology. 2001;8:405-413.
Lee JWE, Raines RT. Role of lysine residues in the active site of onconase. Biochemistry. 2001;40:8627-8627.
Klink TA, Vicentini AM, Hofsteenge J, Raines RT. High-level soluble production and characterization of porcine ribonuclease inhibitor. Protein Expression & Purification. 2001;22:174-179.
Kersteen EA, Raines RT. Contribution of tertiary amides to the conformational stability of collagen triple helices. Biopolymers. 2001;59:24-28.
Jardine AM, Leonidas DD, Jenkins JL, Park C, Raines RT, Acharya KR, et al.. Cleavage of 3 ',5 '-pyrophosphate-linked dinucleotides by ribonuclease A and angiogenin. Biochemistry. 2001;40:10262-10272.
Hondal RJ, Abel RL, Raines RT. Stereochemical consequences of catalysis by ribonuclease A: Nonnatural variants and phosphorothioate substrates. Biochemistry. 2001;40:8645-8645.
Hinderaker MP, Arnold U, Raines RT. Stabilization of semi-synthetic ribonuclease A with covalent mimics of disulfide bonds. Biochemistry. 2001;40:8628-8628.
Chandran SS, Taylor KM, Raines RT. Contribution of individual modules of a leucine-rich repeat protein to its affinity for other proteins. Biochemistry. 2001;40:8615-8616.
Bretscher LE, Jenkins CL, Taylor KM, DeRider ML, Raines RT. Conformational stability of collagen relies on a stereoelectronic effect. Journal of the American Chemical Society. 2001;123:777-778.
Arnold U, Hinderaker MP, Nilsson BL, Huck BR, Gellman SH, Raines RT. Semisynthesis of proteins containing nonnatural modules. Biochemistry. 2001;40:8627-8628.
Abel R, Hondal RJ, Raines RT. Active-site variants of ribonuclease A. Biochemistry. 2001;40:8647-8647.
Park SH, Raines RT. Green fluorescent protein chimeras to probe protein-protein interactions. In San Diego: Academic Press Inc; 2000. pp. 251-261.
Nilsson BL, Kiessling LL, Raines RT. Staudinger ligation: A peptide from a thioester and azide. Organic Letters. 2000;2:1939-1941.
Woycechowsky KJ, Wittrup KD, Raines RT. A small-molecule catalyst of protein folding in vitro and in vivo. Chemistry & Biology. 1999;6:871-879.
Soucek J, Raines RT, Haugg M, Raillard-Yoon SA, Benner SA. Structural changes to ribonuclease A and their effects on biological activity. Comparative Biochemistry and Physiology C-Pharmacology Toxicology & Endocrinology. 1999;123:103-111.
Schultz LW, Chivers PT, Raines RT. The CXXC motif: crystal structure of an active-site variant of Escherichia coli thioredoxin. Acta Crystallographica Section D-Biological Crystallography. 1999;55:1533-1538.
Quirk DJ, Raines RT. His - Asp catalytic dyad of ribonuclease A: Histidine pK(a) values in the wild-type, D121N, and D121A enzymes. Biophysical Journal. 1999;76:1571-1579.
Mannino SJ, Jenkins CL, Raines RT. Chemical mechanism of DNA cleavage by the homing endonuclease I-PpoI. Biochemistry. 1999;38:16178-16186.
Kim BM, Schultz LW, Raines RT. Variants of ribonuclease inhibitor that resist oxidation. Protein Science. 1999;8:430-434.
Kelemen BR, Raines RT. Extending the limits to enzymatic catalysis: Diffusion of ribonuclease A in one dimension. Biochemistry. 1999;38:5302-5307.
Kelemen BR, Klink TA, Behlke MA, Eubanks SR, Leland PA, Raines RT. Hypersensitive substrate for ribonucleases. Nucleic Acids Research. 1999;27:3696-3701.
Holmgren SK, Bretscher LE, Taylor KM, Raines RT. A hyperstable collagen mimic. Chemistry & Biology. 1999;6:63-70.
Wittmayer PK, McKenzie JL, Raines RT. Degenerate DNA recognition by I-PpoI endonuclease. Gene. 1998;206:11-21.
Shusta EV, Raines RT, Pluckthun A, Wittrup KD. Increasing the secretory capacity of Saccharomyces cerevisiae for production of single-chain antibody fragments. Nature Biotechnology. 1998;16:773-777.
Schultz LW, Quirk DJ, Raines RT. His - Asp catalytic dyad of ribonuclease A: Structure and function of the wild-type, D121N, and D121A enzymes. Biochemistry. 1998;37:8886-8898.
Schultz LW, Hargraves SR, Klink TA, Raines RT. Structure and stability of the P93G variant of ribonuclease A. Protein Science. 1998;7:1620-1625.
Raines RT. Ribonuclease A. Chemical Reviews. 1998;98:1045-1065.
Quirk DJ, Park C, Thompson JE, Raines RT. His - Asp catalytic dyad of ribonuclease A: Conformational stability of the wild-type, D121N, D121A, and H119A enzymes. Biochemistry. 1998;37:17958-17964.
Leland PA, Schultz LW, Kim BM, Raines RT. Ribonuclease A variants with potent cytotoxic activity. Proceedings of the National Academy of Sciences of the United States of America. 1998;95:10407-10412.
Kothandaraman S, Hebert MC, Raines RT, Nibert ML. No role for pepstatin-A-sensitive acidic proteinases in reovirus infections of L or MDCK cells. Virology. 1998;251:264-272.
Holmgren SK, Taylor KM, Bretscher LE, Raines RT. Code for collagen's stability deciphered. Nature. 1998;392:666-667.
Fisher BM, Schultz LW, Raines RT. Coulombic effects of remote subsites on the active site of ribonuclease A. Biochemistry. 1998;37:17386-17401.
Fisher BM, Ha JH, Raines RT. Coulombic forces in protein-RNA interactions: Binding and cleavage by ribonuclease A and variants at Lys7, Arg10, and Lys66. Biochemistry. 1998;37:12121-12132.
Fisher BM, Grilley JE, Raines RT. A new remote subsite in ribonuclease A. Journal of Biological Chemistry. 1998;273:34134-34138.
Raines RT. Nature's transitory covalent bond. Nature Structural Biology. 1997;4:424-427.
Park SH, Raines RT. Green fluorescent protein as a signal for protein-protein interactions. Protein Science. 1997;6:2344-2349.
Matousek J, Kim JS, Soucek J, Riha J, Ribo M, Leland PA, et al.. Ribonucleases endowed with specific toxicity for spermatogenic layers. Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology. 1997;118:881-888.
Laboissiere MCA, Sturley SL, Raines RT. Protein disulfide isomerase in spore germination and cell division. Biological Chemistry. 1997;378:431-437.
Chivers PT, Raines RT. General acid/base catalysis in the active site of Escherichia coli thioredoxin. Biochemistry. 1997;36:15810-15816.
Chivers PT, Prehoda KE, Volkman BF, Kim BM, Markley JL, Raines RT. Microscopic pK(a) values of Escherichia coli thioredoxin. Biochemistry. 1997;36:14985-14991.
Chivers PT, Prehoda KE, Raines RT. The CXXC motif: A rheostat in the active site. Biochemistry. 1997;36:4061-4066.
Wittmayer PK, Raines RT. Substrate binding and turnover by the highly specific I-PpoI endonuclease. Biochemistry. 1996;35:1076-1083.
Soucek J, Marinov I, Benes J, Hilgert I, Matousek J, Raines RT. Immunosuppressive activity of bovine seminal ribonuclease and its mode of action. Immunobiology. 1996;195:271-285.
Ribo M, delCardayre SB, Raines RT, deLlorens R, Cuchillo CM. Production of human pancreatic ribonuclease in Saccharomyces cerevisiae and Escherichia coli. Protein Expression & Purification. 1996;7:253-261.
Eberhardt ES, Wittmayer PK, Templer BM, Raines RT. Contribution of a tyrosine side chain to ribonuclease A catalysis and stability. Protein Science. 1996;5:1697-1703.
Eberhardt ES, Panasik N, Raines RT. Inductive effects on the energetics of prolyl peptide bond isomerization: Implications for collagen folding and stability. Journal of the American Chemical Society. 1996;118:12261-12266.
Chivers PT, Laboissiere MCA, Raines RT. The CXXC motif: Imperatives for the formation of native disulfide bonds in the cell. EMBO Journal. 1996;15:2659-2667.
Thompson JE, Kutateladze TG, Schuster MC, Venegas FD, Messmore JM, Raines RT. Limits to catalysis by ribonuclease A. Bioorganic Chemistry. 1995;23:471-481.
Stowell JK, Widlanski TS, Kutateladze TG, Raines RT. Mechanism-Based Inactivation of Ribonuclease-A. Journal of Organic Chemistry. 1995;60:6930-6936.
Raines RT, Toscano MP, Nierengarten DM, Ha JH, Auerbach R. Replacing a Surface Loop Endows Ribonuclease-a with Angiogenic Activity. Journal of Biological Chemistry. 1995;270:17180-17184.
Messmore JM, Fuchs DN, Raines RT. Ribonuclease-a - Revealing Structure-Function-Relationships with Semisynthesis. Journal of the American Chemical Society. 1995;117:8057-8060.
Laboissiere MCA, Sturley SL, Raines RT. The Essential Function of Protein-Disulfide Isomerase Is to Unscramble Nonnative Disulfide Bonds. Journal of Biological Chemistry. 1995;270:28006-28009.
Laboissiere MCA, Chivers PT, Raines RT. Production of Rat Protein Disulfide-Isomerase in Saccharomyces-Cerevisiae. Protein Expression & Purification. 1995;6:700-706.
Kim JS, Soucek J, Matousek J, Raines RT. Mechanism of ribonuclease cytotoxicity. Journal of Biological Chemistry. 1995;270:31097-31102.
Kim JS, Soucek J, Matousek J, Raines RT. Catalytic Activity of Bovine Seminal Ribonuclease Is Essential for Its Immunosuppressive and Other Biological-Activities. Biochemical Journal. 1995;308:547-550.
Kim JS, Soucek J, Matousek J, Raines RT. Structural Basis for the Biological-Activities of Bovine Seminal Ribonuclease. Journal of Biological Chemistry. 1995;270:10525-10530.
Kim JS, Raines RT. Dibromobimane as a Fluorescent Cross-Linking Reagent. Analytical Biochemistry. 1995;225:174-176.
delCardayre SB, Ribo M, Yokel EM, Quirk DJ, Rutter WJ, Raines RT. ENGINEERING RIBONUCLEASE-A - PRODUCTION, PURIFICATION AND CHARACTERIZATION OF WILD-TYPE ENZYME AND MUTANTS AT GLN11. Protein Engineering. 1995;8:261-273.
delCardayre SB, Raines RT. A Residue to Residue Hydrogen-Bond Mediates the Nucleotide Specificity of Ribonuclease-A. Journal of Molecular Biology. 1995;252:328-336.
delCardayre SB, Raines RT. The Extent to Which Ribonucleases Cleave Ribonucleic-Acid. Analytical Biochemistry. 1995;225:176-178.
Attie AD, Raines RT. Analysis of Receptor-Ligand Interactions. Journal of Chemical Education. 1995;72:119-124.
Thompson JE, Venegas FD, Raines RT. Energetics of Catalysis by Ribonucleases - Fate of the 2',3'-Cyclic Phosphodiester Intermediate. Biochemistry. 1994;33:7408-7414.
Thompson JE, Raines RT. Value of General Acid-Base Catalysis to Ribonuclease-A. Journal of the American Chemical Society. 1994;116:5467-5468.
Panasik N, Eberhardt ES, Edison AS, Powell DR, Raines RT. Inductive Effects on the Structure of Proline Residues. International Journal of Peptide and Protein Research. 1994;44:262-269.
Kim JS, Raines RT. A Misfolded but Active Dimer of Bovine Seminal Ribonuclease. European Journal of Biochemistry. 1994;224:109-114.
Kim JS, Raines RT. Peptide Tags for a Dual Affinity Fusion System. Analytical Biochemistry. 1994;219:165-166.
Eberhardt ES, Raines RT. Amide-Amide and Amide-Water Hydrogen-Bonds - Implications for Protein-Folding and Stability. Journal of the American Chemical Society. 1994;116:2149-2150.
delCardayre SB, Raines RT. Structural Determinants of Enzymatic Processivity. Biochemistry. 1994;33:6031-6037.
Taylor CB, Bariola PA, delCardayre SB, Raines RT, Green PJ. RNS2 - A SENESCENCE-ASSOCIATED RNASE OF ARABIDOPSIS THAT DIVERGED FROM THE S-RNASES BEFORE SPECIATION. Proceedings of the National Academy of Sciences of the United States of America. 1993;90:5118-5122.
Kim JS, Raines RT. Bovine Seminal Ribonuclease Produced from a Synthetic Gene. Journal of Biological Chemistry. 1993;268:17392-17396.
Kim JS, Raines RT. Ribonuclease S-Peptide as a Carrier in Fusion Proteins. Protein Science. 1993;2:348-356.
Eberhardt ES, Loh SN, Raines RT. Thermodynamic Origin of Prolyl Peptide-Bond Isomers. Tetrahedron Letters. 1993;34:3055-3056.
Eberhardt ES, Loh SN, Hinck AP, Raines RT. Solvent Effects on the Energetics of Prolyl Peptide-Bond Isomerization. Journal of the American Chemical Society. 1992;114:5437-5439.
Ringe D, Bash P, Karplus M, Davenport RC, Giamonna DA, Sugio S, et al.. Triose Phosphate Isomerase Mutants and Mechanism - Computation Vs Experiment. FASEB Journal. 1991;5:A1148-A1148.
Hansen DE, Raines RT. Binding-Energy and Enzymatic Catalysis. Journal of Chemical Education. 1990;67:483-489.
Burbaum JJ, Raines RT, Albery WJ, Knowles JR. Evolutionary Optimization of the Catalytic Effectiveness of an Enzyme. Biochemistry. 1989;28:9293-9305.
Raines RT, Hansen DE. An Intuitive Approach to Steady-State Kinetics. Journal of Chemical Education. 1988;65:757-759.
Blacklow SC, Raines RT, Lim WA, Zamore PD, Knowles JR. TRIOSEPHOSPHATE ISOMERASE CATALYSIS IS DIFFUSION CONTROLLED - APPENDIX - ANALYSIS OF TRIOSE PHOSPHATE EQUILIBRIA IN AQUEOUS-SOLUTION BY P-31 NMR. Biochemistry. 1988;27:1158-1167.
Raines RT, Knowles JR. Enzyme Relaxation in the Reaction Catalyzed by Triosephosphate Isomerase - Detection and Kinetic Characterization of 2 Unliganded Forms of the Enzyme. Biochemistry. 1987;26:7014-7020.
Raines RT, Sutton EL, Straus DR, Gilbert W, Knowles JR. Reaction Energetics of a Mutant Triosephosphate Isomerase in Which the Active-Site Glutamate Has Been Changed to Aspartate. Biochemistry. 1986;25:7142-7154.
Raines RT, Straus DR, Gilbert W, Knowles JR. The Kinetic Consequences of Altering the Catalytic Residues of Triosephosphate Isomerase. Philosophical Transactions of the Royal Society of London Series A-Mathematical Physical & Engineering Sciences. 1986;317:371-&.
Raines RT, Knowles JR. The Mechanistic Pathway of a Mutant Triosephosphate Isomerase. Annals of the New York Academy of Sciences. 1986;471:266-271.
Straus D, Raines RT, Kawashima E, Knowles JR, Gilbert W. Active-Site of Triosephosphate Isomerase - Invitro Mutagenesis and Characterization of an Altered Enzyme. Proceedings of the National Academy of Sciences of the United States of America. 1985;82:2272-2276.
Walsh C, Pascal RA, Johnston M, Raines RT, Dikshit D, Krantz A, et al.. Mechanistic Studies on the Pyridoxal-Phosphate Enzyme 1-Aminocyclopropane-1-Carboxylate Deaminase from Pseudomonas Sp. Biochemistry. 1981;20:7509-7519.
Johnston M, Raines RT, Chang M, Esaki N, Soda K, Walsh C. Mechanistic Studies on Reactions of Bacterial Methionine Gamma-Lyase with Olefinic Amino-Acids. Biochemistry. 1981;20:4325-4333.
Johnston M, Raines RT, Walsh C, Firestone RA. Mechanism-Based Enzyme Inactivation Using an Allyl Sulfoxide-Allyl Sulfenate Ester Rearrangement. Journal of the American Chemical Society. 1980;102:4241-4250.