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Stacy DM, Le Quement ST, Hansen CL, Clausen JW, Tolker-Nielsen T, Brummond JW, et al. Synthesis and biological evaluation of triazole-containing N-acyl homoserine lactones as quorum sensing modulators. Organic & Biomolecular Chemistry. 2013;11:938-954. |
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Frei R, Breitbach AS, Blackwell HE. Expedient construction of small molecule macroarrays via sequential palladium- and copper-mediated reactions and their ex situ biological testing. Chemical Science. 2012;3:1555-1561. |
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Frei R, Breitbach AS, Blackwell HE. 2-Aminobenzimidazole Derivatives Strongly Inhibit and Disperse Pseudomonas aeruginosa Biofilms. Angewandte Chemie-International Edition. 2012;51:5226-5229. |
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Praneenararat T, Palmer AG, Blackwell HE. Chemical methods to interrogate bacterial quorum sensing pathways. Organic & Biomolecular Chemistry. 2012;10:8189-8199. |
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Stacy DM, Welsh MA, Rather PN, Blackwell HE, Jg JOf Bacteri. Attenuation of Quorum Sensing in the Pathogen Acinetobacter baumannii Using Non-native N-Acyl Homoserine Lactones. ACS Chemical Biology. 2012;7:1719-1728. |
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Praneenararat T, Palmer AG, Blackwell HE. Chemical methods to interrogate bacterial quorum sensing pathways. Org. Biomol. Chem. [Internet]. 2012;10:8189-8199. Available from: http://dx.doi.org/10.1039/C2OB26353J |
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Stacy DM, Welsh MA, Rather PN, Blackwell HE. Attenuation of Quorum Sensing in the Pathogen Acinetobacter baumannii Using Non-native N-Acyl Homoserine Lactones. ACS Chemical Biology [Internet]. 2012;7:1719-1728. Available from: http://pubs.acs.org/doi/abs/10.1021/cb300351x |
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Blackwell HE, Fuqua C. Introduction to Bacterial Signals and Chemical Communication. Chemical Reviews. 2011;111:1-3. |
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Crapster AJ, Stringer JR, Guzei IA, Blackwell HE. Design and Conformational Analysis of Peptoids Containing N-Hydroxy Amides Reveals a Unique Sheet-Like Secondary Structure. Biopolymers. 2011;96:604-616. |
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Lindemann A, Pessi G, Schaefer AL, Mattmann ME, Christensen QH, Kessler A, et al. Isovaleryl-homoserine lactone, an unusual branched-chain quorum-sensing signal from the soybean symbiont Bradyrhizobium japonicum. Proceedings of the National Academy of Sciences of the United States of America. 2011;108:16765-16770. |
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Mattmann ME, Shipway PM, Heth NJ, Blackwell HE. Potent and Selective Synthetic Modulators of a Quorum Sensing Repressor in Pseudomonas aeruginosa Identified from Second-Generation Libraries of N-Acylated L-Homoserine Lactones. Chembiochem. 2011;12:942-949. |
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McInnis CE, Blackwell HE. Design, synthesis, and biological evaluation of abiotic, non-lactone modulators of LuxR-type quorum sensing. Bioorganic & Medicinal Chemistry. 2011;19:4812-4819. |
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McInnis CE, Blackwell HE. Thiolactone modulators of quorum sensing revealed through library design and screening. Bioorganic & Medicinal Chemistry. 2011;19:4820-4828. |
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Palmer AG, Streng E, Jewell KA, Blackwell HE. Quorum Sensing in Bacterial Species that Use Degenerate Autoinducers Can Be Tuned by Using Structurally Identical Non-native Ligands. Chembiochem. 2011;12:138-147. |
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Praneenararat T, Beary TMJ, Breitbach AS, Blackwell HE. Synthesis and application of an N-acylated L-homoserine lactone derivatized affinity matrix for the isolation of quorum sensing signal receptors. Bioorganic & Medicinal Chemistry Letters. 2011;21:5054-5057. |
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Stringer JR, Bowman MD, Weisblum B, Blackwell HE. Improved Small-Molecule Macroarray Platform for the Rapid Synthesis and Discovery of Antibacterial Chalcones. ACS Combinatorial Science. 2011;13:175-180. |
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Breitbach AS, Broderick AH, Jewell CM, Gunasekaran S, Lin Q, Lynn DM, et al. Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: Gradual release enhances activity. Chem. Commun. [Internet]. 2011;47:370-372. Available from: http://dx.doi.org/10.1039/C0CC02316G |
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Stringer JR, Crapster AJ, Guzei IA, Blackwell HE. Extraordinarily Robust Polyproline Type I Peptoid Helices Generated via the Incorporation of α-Chiral Aromatic N-1-Naphthylethyl Side Chains. Journal of the American Chemical Society [Internet]. 2011;133:15559-15567. Available from: http://pubs.acs.org/doi/abs/10.1021/ja204755p |
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Palmer AG, Streng E, Blackwell HE. Attenuation of Virulence in Pathogenic Bacteria Using Synthetic Quorum-Sensing Modulators under Native Conditions on Plant Hosts. ACS Chemical Biology [Internet]. 2011;6:1348-1356. Available from: http://pubs.acs.org/doi/abs/10.1021/cb200298g |
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Borlee BR, Geske GD, Blackwell HE, Handelsman J. Identification of Synthetic Inducers and Inhibitors of the Quorum-Sensing Regulator LasR in Pseudomonas aeruginosa by High-Throughput Screening. Applied and Environmental Microbiology. 2010;76:8255-8258. |
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Breitbach AS, Broderick AH, Jewell CM, Gunasekaran S, Lin Q, Lynn DM, et al. Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: Gradual release enhances activity. Chemical Communications. 2010;47:370-372. |
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Frei R, Blackwell HE. Small Molecule Macroarray Construction via Palladium-Mediated Carbon-Carbon Bond-Forming Reactions: Highly Efficient Synthesis and Screening of Stilbene Arrays. Chemistry-A European Journal. 2010;16:2692-2695. |
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Mattmann ME, Blackwell HE. Small Molecules That Modulate Quorum Sensing and Control Virulence in Pseudomonas aeruginosa. Journal of Organic Chemistry. 2010;75:6737-6746. |
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Stringer JR, Crapster AJ, Guzei IA, Blackwell HE. Construction of Peptoids with All Trans-Amide Backbones and Peptoid Reverse Turns via the Tactical Incorporation of N-Aryl Side Chains Capable of Hydrogen Bonding. Journal of Organic Chemistry. 2010;75:6068-6078. |
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Buck ME, Breitbach AS, Belgrade SK, Blackwell HE, Lynn DM. Chemical Modification of Reactive Multilayered Films Fabricated from Poly(2-alkenyl azlactone)s: Design of Surfaces that Prevent or Promote Mammalian Cell Adhesion and Bacterial Biofilm Growth. Biomacromolecules. 2009;10:1564-1574. |
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Campbell J, Blackwell HE. Efficient Construction of Diketopiperazine Macroarrays Through a Cyclative-Cleavage Strategy and Their Evaluation as Luminescence Inhibitors in the Bacterial Symbiont Vibrio fischeri. Journal of Combinatorial Chemistry. 2009;11:1094-1099. |
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Campbell J, Lin Q, Geske GD, Blackwell HE. New and Unexpected Insights into the Modulation of LuxR-Type Quorum Sensing by Cyclic Dipeptides. ACS Chemical Biology. 2009;4:1051-1059. |
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Fowler SA, Blackwell HE. Structure-function relationships in peptoids: Recent advances toward deciphering the structural requirements for biological function. Organic & Biomolecular Chemistry. 2009;7:1508-1524. |
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Fowler SA, Luechapanichkul R, Blackwell HE. Synthesis and Characterization of Nitroaromatic Peptoids: Fine Tuning Peptoid Secondary Structure through Monomer Position and Functionality. Journal of Organic Chemistry. 2009;74:1440-1449. |
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Praneenararat T, Geske GD, Blackwell HE. Efficient Synthesis and Evaluation of Quorum-Sensing Modulators Using Small Molecule Macroarrays. Organic Letters. 2009;11:4600-4603. |
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Gorske BC, Stringer JR, Bastian BL, Fowler SA, Blackwell HE. New Strategies for the Design of Folded Peptoids Revealed by a Survey of Noncovalent Interactions in Model Systems. Journal of the American Chemical Society [Internet]. 2009;131:16555-16567. Available from: http://pubs.acs.org/doi/abs/10.1021/ja907184g |
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Campbell J, Lin Q, Geske GD, Blackwell HE. New and Unexpected Insights into the Modulation of LuxR-Type Quorum Sensing by Cyclic Dipeptides. ACS Chemical Biology [Internet]. 2009;4:1051-1059. Available from: http://pubs.acs.org/doi/abs/10.1021/cb900165y |
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Borlee BR, Geske GD, Robinson CJ, Blackwell HE, Handelsman J. Quorum-sensing signals in the microbial community of the cabbage white butterfly larval midgut. ISME Journal. 2008;2:1101-1111. |
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Fowler SA, Stacy DM, Blackwell HE. Design and synthesis of macrocyclic peptomers as mimics of a quorum sensing signal from Staphylococcus aureus. Organic Letters. 2008;10:2329-2332. |
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Geske GD, Mattmann ME, Blackwell HE. Evaluation of a focused library of N-aryl L-homoserine lactones reveals a new set of potent quorum sensing modulators. Bioorganic & Medicinal Chemistry Letters. 2008;18:5978-5981. |
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Geske GD, O'Neill JC, Blackwell HE. Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria. Chemical Society Reviews. 2008;37:1432-1447. |
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Geske GD, Oneill JC, Miller DM, Wezeman RJ, Mattmann ME, Lin Q, et al. Comparative analyses of N-acylated homoserine Lactones reveal unique structural features that dictate their ability to activate or inhibit quorum sensing. Chembiochem. 2008;9:389-400. |
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Mattmann ME, Geske GD, Worzalla GA, Chandler JR, Sappington KJ, Greenberg PE, et al. Synthetic ligands that activate and inhibit a quorum-sensing regulator in Pseudomonas aeruginosa. Bioorganic & Medicinal Chemistry Letters. 2008;18:3072-3075. |
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Palmer AG, Blackwell HE. Deciphering a protolanguage for bacteria-host communication. Nature Chemical Biology. 2008;4:452-454. |
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Bowman MD, O'Neill JC, Stringer JR, Blackwell HE. Rapid identification of antibacterial agents effective against Staphylococcus aureus using small-molecule macroarrays. Chemistry & Biology. 2007;14:351-357. |
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Chan YY, Bian HS, Tan TMC, Mattmann ME, Geske GD, Igarashi J, et al. Control of quorum sensing by a Burkholderia pseudomallei multidrug efflux pump. Journal of Bacteriology. 2007;189:4320-4324. |
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Geske GD, O'Neill JC, Blackwell HE. N-phenylacetanoyl-L-homoserine lactones can strongly antagonize or superagonize quorum sensing in. ACS Chemical Biology. 2007;2:315-U1. |
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Geske GD, O'Neill JC, Miller DM, Mattmann ME, Blackwell HE. Modulation of bacterial quorum sensing with synthetic ligands: Systematic evaluation of N-acylated homoserine lactones in multiple species and new insights into their mechanisms of action. Journal of the American Chemical Society. 2007;129:13613-13625. |
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Gorske BC, Bastian BL, Geske GD, Blackwell HE. Local and tunable n ->pi* interactions regulate amide isomerism in the peptoid backbone. Journal of the American Chemical Society. 2007;129:8928-+. |
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O'Neill JC, Blackwell HE. Solid-phase and microwave-assisted syntheses of 2,5-diketopiperazines: Small molecules with great potential. Combinatorial Chemistry & High Throughput Screening. 2007;10:857-876. |
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Guzei IA, Spencer LC, Lin Q, Blackwell HE. {ıt N}-{(Amino{\-}carbon{\-}yl)[(ıt S})-4-nitro{\-}benz{\-}yl]meth{\-}yl}-ıt N}-{[(ıt R})-cyclo{\-}hexyl](cyclo{\-}hexylamino{\-}carbon{\-}yl)meth{\-}yl}propanamide methanol solvate}. Acta Crystallographica Section E [Internet]. 2007;63:o1892–o1894. Available from: http://dx.doi.org/10.1107/S1600536807012299 |
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Blackwell HE. Out of the oil bath and into the oven - microwave-assisted combinatorial chemistry heats up. Organic & Biomolecular Chemistry. 2006;62:O286-O288. |
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Hollenbeck JJ, Wixson EN, Geske GD, Dodge MW, Tseng TA, Clauss AD, et al. A new model for transitioning students from the undergraduate teaching laboratory to the research laboratory - The evolution of an intermediate organic synthesis laboratory course. Journal of Chemical Education. 2006;83:1835. |
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Lin Q, Blackwell HE. Rapid synthesis of diketopiperazine macroarrays via Ugi four-component reactions on planar solid supports. Chemical Communications. 2006;:2884. |
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Guzei IA, Gorske BC, Blackwell HE. N-[1-(Pentafluorophenyl)ethyl]-acetamide. Acta Crystallographica - Section C - Crystal Structure CommunicationsActa Crystallographica - Section C - Crystal Structure Communications. 2006;62:O286-O288. |
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Gorske BC, Blackwell HE. Tuning peptoid secondary structure with pentafluoroaromatic functionality: A new design paradigm for the construction of discretely folded peptoid structures. Journal of the American Chemical Society. 2006;128:14378. |
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Gorske BC, Blackwell HE. Interception of quorum sensing in Staphylococcus aureus: a new niche for peptidomimetics (vol 4, pg 1441, 2006). Organic & Biomolecular ChemistryOrganic & Biomolecular Chemistry. 2006;4:2050. |
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Bowman MD, Jacobson MM, Pujanauski BG, Blackwell HE. Efficient synthesis of small molecule macroarrays: optimization of the macroarray synthesis platform and examination of microwave and conventional heating methods. TetrahedronTetrahedron. 2006;62:4715-4727. |
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Bowman MD, Jacobson MM, Blackwell HE. Discovery of fluorescent cyanopyridine and deazalumazine dyes using small molecule macroarrays. Organic LettersOrganic Letters. 2006;8:1645-1648. |
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Gorske BC, Blackwell HE. Tuning Peptoid Secondary Structure with Pentafluoroaromatic Functionality: A New Design Paradigm for the Construction of Discretely Folded Peptoid Structures. Journal of the American Chemical Society [Internet]. 2006;128:14378-14387. Available from: http://pubs.acs.org/doi/abs/10.1021/ja065248o |
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Guzei IA, Gorske BC, Blackwell HE. {ıt N}-[1-(Penta{\-}fluoro{\-}phenyl){\-}ethyl]{\-}acetamide}. Acta Crystallographica Section C [Internet]. 2006;62:o286–o288. Available from: http://dx.doi.org/10.1107/S0108270106012121 |
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Bowman MD, Jacobsen M, Pujanauski BG, Blackwell HE. Efficient synthesis of small molecule macroarrays: optimization of the macroarray synthesis platform and examination of microwave and conventional heating methods. Tetrahedron [Internet]. 2006;62:4715 - 4727. Available from: http://www.sciencedirect.com/science/article/pii/S0040402006002699 |
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Bowman MD, Jacobson MM, Blackwell HE. Discovery of Fluorescent Cyanopyridine and Deazalumazine Dyes Using Small Molecule Macroarrays. Organic Letters [Internet]. 2006;8:1645-1648. Available from: http://pubs.acs.org/doi/abs/10.1021/ol0602708 |
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Blackwell HE. Hitting the SPOT: small-molecule macroarrays advance combinatorial synthesis. Current Opinion in Chemical Biology [Internet]. 2006;10:203 - 212. Available from: http://www.sciencedirect.com/science/article/pii/S1367593106000639 |
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Gorske BC, Blackwell HE. Interception of quorum sensing in Staphylococcus aureus: a new niche for peptidomimetics. Org. Biomol. Chem. [Internet]. 2006;4:1441-1445. Available from: http://dx.doi.org/10.1039/B517681F |
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Hollenbeck JJ, Wixson EN, Geske GD, Dodge MW, Tseng AT, Clauss AD, et al. A New Model for Transitioning Students from the Undergraduate Teaching Laboratory to the Research Laboratory. The Evolution of an Intermediate Organic Synthesis Laboratory Course. Journal of Chemical Education [Internet]. 2006;83:1835. Available from: http://pubs.acs.org/doi/abs/10.1021/ed083p1835 |
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Lin Q, O'Neill JC, Blackwell HE. Small molecule macroarray construction via Ugi four-component reactions. Organic LettersOrganic Letters. 2005;7:4455-4458. |
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Gorske BC, Jewell SA, Guerard EJ, Blackwell HE. Expedient synthesis and design strategies for new peptoid construction. Organic LettersOrganic Letters. 2005;7:1521-1524. |
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Geske GD, Wezeman RJ, Siegel AP, Blackwell HE. Small molecule inhibitors of bacterial quorum sensing and biofilm formation. Journal of the American Chemical Society. 2005;127:12762-12763. |
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Blackwell HE. Bacterial crowd control with iron. Chemistry & BiologyChemistry & Biology. 2005;12:721-723. |
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Lin Q, O'Neill JC, Blackwell HE. Small Molecule Macroarray Construction via Ugi Four-Component Reactions. Organic Letters [Internet]. 2005;7:4455-4458. Available from: http://pubs.acs.org/doi/abs/10.1021/ol051684o |
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Geske GD, Wezeman RJ, Siegel AP, Blackwell HE. Small Molecule Inhibitors of Bacterial Quorum Sensing and Biofilm Formation. Journal of the American Chemical Society [Internet]. 2005;127:12762-12763. Available from: http://pubs.acs.org/doi/abs/10.1021/ja0530321 |
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Gorske BC, Jewell SA, Guerard EJ, Blackwell HE. Expedient Synthesis and Design Strategies for New Peptoid Construction. Organic Letters [Internet]. 2005;7:1521-1524. Available from: http://pubs.acs.org/doi/abs/10.1021/ol0502984 |
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Blackwell HE. Bacterial Crowd Control with Iron. Chemistry & Biology [Internet]. 2005;12:721 - 723. Available from: http://www.sciencedirect.com/science/article/pii/S1074552105002012 |
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Bowman MD, Jeske RC, Blackwell HE. Microwave-accelerated SPOT-synthesis on cellulose supports. Organic LettersOrganic Letters. 2004;6:2019-2022. |
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Bowman MD, Jeske RC, Blackwell HE. Microwave-Accelerated SPOT-Synthesis on Cellulose Supports. Organic Letters [Internet]. 2004;6:2019-2022. Available from: http://pubs.acs.org/doi/abs/10.1021/ol049313f |
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Zhao YD, Dai XH, Blackwell HE, Schreiber SL, Chory J. SIR1, an upstream component in auxin signaling identified by chemical genetics. ScienceScience. 2003;301:1107-1110. |
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Blackwell HE, Zhao YD. Chemical genetic approaches to plant biology. Plant PhysiologyPlant Physiology. 2003;133:448-455. |
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Blackwell HE. Out of the oil bath and into the oven - microwave-assisted combinatorial chemistry heats up. Organic & Biomolecular ChemistryOrganic & Biomolecular Chemistry. 2003;1:1251-1255. |
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Blackwell HE, Zhao YD. Chemical Genetic Approaches to Plant Biology. Plant Physiology [Internet]. 2003;133:448-455. Available from: http://www.plantphysiol.org/content/133/2/448.short |
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Blackwell HE. Out of the oil bath and into the oven-microwave-assisted combinatorial chemistry heats up. Org. Biomol. Chem. [Internet]. 2003;1:1251-1255. Available from: http://dx.doi.org/10.1039/B301432K |
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Spring DR, Krishnan S, Blackwell HE, Schreiber SL. Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform. Journal of the American Chemical Society. 2002;124:1354-1363. |
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Grubbs RH, O'Leary DJ, Blackwell HE. Methods for cross-methathesis of terminal olefins. 2002; |
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Blackwell HE, Clemons PA, Schreiber SL. Exploiting site-site interactions on solid support to generate dimeric molecules. Organic Letters. 2001;3:1185-1188. |
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Blackwell HE, Perez L, Schreiber SL. Decoding products of diversity pathways from stock solutions derived from single polymeric macrobeads. Angewandte Chemie-International Edition. 2001;40:3421-+. |
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Blackwell HE, Perez L, Stavenger RA, Tallarico JA, Eatough EC, Foley MA, et al. A one-bead, one-stock solution approach to chemical genetics: part 1. Chemistry & Biology. 2001;8:1167-1182. |
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Blackwell HE, Sadowsky JD, Howard RJ, Sampson JN, Chao JA, Steinmetz WE, et al. Ring-closing metathesis of olefinic peptides: Design, synthesis, and structural characterization of macrocyclic helical peptides. Journal of Organic Chemistry. 2001;66:5291-5302. |
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Grozinger CM, Chao ED, Blackwell HE, Moazed D, Schreiber SL. Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. Journal of Biological Chemistry. 2001;276:38837-38843. |
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Blackwell HE, O'Leary DJ, Chatterjee AK, Washenfelder RA, Bussmann DA, Grubbs RH. New approaches to olefin cross-metathesis. Journal of the American Chemical Society. 2000;122:58-71. |
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O'Leary DJ, Blackwell HE, Washenfelder RA, Miura K, Grubbs RH. Terminal olefin cross-metathesis with acrolein acetals. Tetrahedron Letters. 1999;40:1091-1094. |
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Blackwell HE, Grubbs RH. Highly efficient synthesis of covalently cross-linked peptide helices by ring-closing metathesis. Angewandte Chemie-International Edition. 1998;37:3281-3284. |
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O'Leary DJ, Blackwell HE, Washenfelder RA, Grubbs RH. A new method for cross-metathesis of terminal olefins. Tetrahedron Letters. 1998;39:7427-7430. |
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Miller SJ, Blackwell HE, Grubbs RH. Application of ring-closing metathesis to the synthesis of rigidified amino acids and peptides. Journal of the American Chemical Society. 1996;118:9606-9614. |
