Publications

Schroeder CE, Neuenswander SA, Yao T, Aube J, Golden JE. One-pot, regiospecific assembly of (E)-benzamidines from delta- and gamma-amino acids via an intramolecular aminoquinazolinone rearrangement. Organic & Biomolecular Chemistry. 2016;14:3950-3955.
Hong L, Guo Y, BasuRay S, Agola JO, Romero E, Simpson DS, et al.. A Pan-GTPase Inhibitor as a Molecular Probe. Plos One. 2015;10:e0134317.
Schreiber SL, Kotz JD, Li M, Aube J, Austin CP, Reed JC, et al.. Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. Cell. 2015;161:1252-1265.
Hong L, Guo YN, BasuRay S, Agola JO, Romero E, Simpson DS, et al.. A Pan-GTPase Inhibitor as a Molecular Probe. Plos One. 2015;10:24.
Schroeder CE, Yao TL, Sotsky J, Smith RA, Roy S, Chu YK, et al.. Development of (E)-2-((1,4-Dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide , ML336: Novel 2-Amidinophenylbenzamides as Potent Inhibitors of Venezuelan Equine Encephalitis Virus. Journal of Medicinal Chemistry. 2014;57:8608-8621.
Matharu DS, Flaherty DP, Simpson DS, Schroeder CE, Chung D, Yan D, et al.. Optimization of Potent and Selective Quinazolinediones: Inhibitors of Respiratory Syncytial Virus That Block RNA-Dependent RNA-Polymerase Complex Activity. Journal of Medicinal Chemistry. 2014;57:10314-10328.
Flaherty DP, Simpson DS, Miller M, Maki BE, Zou BY, Shi J, et al.. Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold. Bioorganic & Medicinal Chemistry Letters. 2014;24:3968-3973.
Flaherty DP, Miller JR, Garshott DM, Hedrick M, Gosalia P, Li YJ, et al.. Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response. Acs Medicinal Chemistry Letters. 2014;5:1278-1283.
Chung DH, Jonsson CB, Tower NA, Chu YK, Sahin E, Golden JE, et al.. Discovery of a Novel Compound with Anti-Venezuelan Equine Encephalitis Virus Activity That Targets the Nonstructural Protein 2. Plos Pathogens. 2014;10:10.
Wender PA, Axtman AD, Golden JE, Kee JM, Sirois LE, Quiroz RV, et al.. Function through bio-inspired, synthesis-informed design: step-economical syntheses of designed kinase inhibitors. Organic Chemistry Frontiers. 2014;1:1166-1171.
Hong L, Kenney SR, Phillips GK, Simpson D, Schroeder CE, Noth J, et al.. Characterization of a Cdc42 Protein Inhibitor and Its Use as a Molecular Probe. Journal of Biological Chemistry. 2013;288:8531-8543.
Harris MT, Walker DM, Drew ME, Mitchell WG, Dao K, Schroeder CE, et al.. Interrogating a Hexokinase-Selected Small-Molecule Library for Inhibitors of Plasmodium falciparum Hexokinase. Antimicrobial Agents and Chemotherapy. 2013;57:3731-3737.
Strouse JJ, Ivnitski-Steele I, Khawaja HM, Perez D, Ricci J, Yao TL, et al.. A Selective ATP-Binding Cassette Subfamily G Member 2 Efflux Inhibitor Revealed via High-Throughput Flow Cytometry. Journal of Biomolecular Screening. 2013;18:26-38.
Chung DH, Moore BP, Matharu DS, Golden JE, Maddox C, Rasmussen L, et al.. A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus. Virology Journal. 2013;10:12.
Seguin SP, Evans CW, Nebane-Akah M, McKellip S, Ananthan S, Tower NA, et al.. High-Throughput Screening Identifies a Bisphenol Inhibitor of SV40 Large T Antigen ATPase Activity. Journal of Biomolecular Screening. 2012;17:194-203.
Moore BP, Chung DH, Matharu DS, Golden JE, Maddox C, Rasmussen L, et al.. (S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolicline-2-carb oxamide as a Small Molecule Inhibitor Probe for the Study of Respiratory Syncytial Virus Infection. Journal of Medicinal Chemistry. 2012;55:8582-8587.
Frohn M, Cee VJ, Lanman BA, Pickrell AJ, Golden JE, Rivenzon-Segal D, et al.. Novel 5-and 6-subtituted benzothiazoles with improved physicochemical properties: Potent S1P(1) agonists with in vivo lymphocyte-depleting activity. Bioorganic & Medicinal Chemistry Letters. 2012;22:628-633.
Chen J, Young SM, Allen C, Seeber A, Peli-Gulli MP, Panchaud N, et al.. Identification of a Small Molecule Yeast TORC1 Inhibitor with a Multiplex Screen Based on Flow Cytometry. ACS Chemical Biology. 2012;7:715-722.
Agola JO, Hong L, Surviladze Z, Ursu O, Waller A, Strouse JJ, et al.. A Competitive Nucleotide Binding Inhibitor: In Vitro Characterization of Rab7 GTPase Inhibition. ACS Chemical Biology. 2012;7:1095-1108.
Lanman BA, Cee VJ, Cheruku SR, Frohn M, Golden JE, Lin JA, et al.. Discovery of a Potent, S1P(3)-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P(1)). Acs Medicinal Chemistry Letters. 2011;2:102-106.
Cee VJ, Frohn M, Lanman BA, Golden JE, Muller K, Neira S, et al.. Discovery of AMG 369, a Thiazolo 5,4-b pyridine Agonist of S1P(1) and S1P(5). Acs Medicinal Chemistry Letters. 2011;2:107-112.
Golden JE, Sanders SD, Muller KM, Burli RW. Modulating N- versus O-arylation in pyrazolone-aryl halide couplings. Tetrahedron Letters. 2008;49:794-798.
Frohn M, Viswanadhan V, Pickrell AJ, Golden JE, Muller KM, Burli RW, et al.. Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1 alpha prolyl hydroxylase-2 inhibitors. Bioorganic & Medicinal Chemistry Letters. 2008;18:5023-5026.
Frankowski KJ, Golden JE, Zeng YB, Lei Y, Aube J. Syntheses of the Stemona alkaloids (+/-)-stenine, (+/-)-neostenine, and (+/-)-13-epineostenine using a stereodivergent Diels-Alder/azido-Schmidt reaction. Journal of the American Chemical Society. 2008;130:6018-6024.
Burli RW, Xu H, Zou XM, Muller K, Golden JE, Frohn M, et al.. Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents. Bioorganic & Medicinal Chemistry Letters. 2006;16:3713-3718.
Lei Y, Wrobleski AD, Golden JE, Powell DR, Aube J. Facile C-N cleavage in a series of bridged lactams. Journal of the American Chemical Society. 2005;127:4552-4553.
Golden JE, Aube J. A combined intramolecular Diels-Alder/intramolecular Schmidt reaction: Formal synthesis of (+/-)-stenine. Angewandte Chemie-International Edition. 2002;41:4316-4318.