Publications

Wangkanont K, Wesener DA, Vidani JA, Kiessling LL, Forest KT. Structures of Xenopus Embryonic Epidermal Lectin Reveal a Conserved Mechanism of Microbial Glycan Recognition. Journal of Biological Chemistry. 2016;291:5596-5610.
Yamatsugu K, Splain RA, Kiessling LL. Fidelity and Promiscuity of a Mycobacterial Glycosyltransferase. Journal of the American Chemical Society. 2016;138:9205-9211.
Winton VJ, Aldrich C, Kiessling LL. Carboxylate Surrogates Enhance the Antimycobacterial Activity of UDP-Galactopyranose Mutase Probes. Acs Infectious Diseases. 2016;2:538-543.
Wrighton PJ, Kiessling LL. Forces of Change: Mechanics Underlying Formation of Functional 3D Organ Buds. Cell Stem Cell. 2015;16:453-454.
Wesener DA, Wangkanont K, McBride R, Song XZ, Kraft MB, Hodges HL, et al.. Recognition of microbial glycans by human intelectin-1. Nature Structural & Molecular Biology. 2015;22:603-610.
Bennett NR, Zwick DB, Courtney AH, Kiessling LL. Multivalent Antigens for Promoting B and T Cell Activation. ACS Chemical Biology. 2015;10:1817-1824.
Wangkanont K, Forest KT, Kiessling LL. The non-detergent sulfobetaine-201 acts as a pharmacological chaperone to promote folding and crystallization of the type II TGF-beta receptor extracellular domain. Protein Expression and Purification. 2015;115:19-25.
Kincaid VA, London N, Wangkanont K, Wesener DA, Marcus SA, Heroux A, et al.. Virtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial Agents. ACS Chemical Biology. 2015;10:2209-2218.
Hudson KL, Bartlett GJ, Diehl RC, Agirre J, Gallagher T, Kiessling LL, et al.. Carbohydrate-Aromatic Interactions in Proteins. Journal of the American Chemical Society. 2015;137:15152-15160.
Soares JA, Kiessling LL. A Symposium in Honor of Peter B. Dervan, the 2014 ACS Chemical Biology Lectureship Award Winner. ACS Chemical Biology. 2014;9:1221-1223.
Sheridan RTC, Hudon J, Hank JA, Sondel PM, Kiessling LL. Rhamnose Glycoconjugates for the Recruitment of Endogenous Anti-Carbohydrate Antibodies to Tumor Cells. Chembiochem. 2014;15:1393-1398.
Musah S, Wrighton PJ, Zaltsman Y, Zhong XF, Zorn S, Parlato MB, et al.. Substratum-induced differentiation of human pluripotent stem cells reveals the coactivator YAP is a potent regulator of neuronal specification. Proceedings of the National Academy of Sciences of the United States of America. 2014;111:13805-13810.
Wrighton PJ, Klim JR, Hernandez BA, Koonce CH, Kamp TJ, Kiessling LL. Signals from the surface modulate differentiation of human pluripotent stem cells through glycosaminoglycans and integrins. Proceedings of the National Academy of Sciences of the United States of America. 2014;111:18126-18131.
Farias MAM, Kincaid VA, Annamalai VR, Kiessling LL. Isoprenoid Phosphonophosphates as Glycosyltransferase Acceptor Substrates. Journal of the American Chemical Society. 2014;136:8492-8495.
Courtney AH, Bennett NR, Zwick DB, Hudon J, Kiessling LL. Synthetic Antigens Reveal Dynamics of BCR Endocytosis during Inhibitory Signaling. ACS Chemical Biology. 2014;9:202-210.
Briegel A, Wong ML, Hodges HL, Oikonomou CM, Piasta KN, Harris MJ, et al.. New Insights into Bacterial Chemoreceptor Array Structure and Assembly from Electron Cryotomography. Biochemistry. 2014;53:1575-1585.
Wesener DA, May JF, Huffman EM, Kiessling LL. UDP-Galactopyranose Mutase in Nematodes. Biochemistry. 2013;52:4391-4398.
Kraft MB, Farias MAM, Kiessling LL. Synthesis of Lipid-Linked Arabinofuranose Donors for Glycosyltransferases. Journal of Organic Chemistry. 2013;78:2128-2133.
Kiessling LL, Kraft MB. A Path to Complex Carbohydrates. Science. 2013;341:357-358.
Kiessling LL, Grim JC. Glycopolymer probes of signal transduction. Chemical Society Reviews. 2013;42:4476-4491.
Hernandez BA, Wrighton PJ, Klim JR, Kiessling LL. A defined glycosaminoglycan-binding surface facilitates endoderm differentiation of human embryonic stem cells. FASEB Journal. 2013;27.
Fishman JM, Kiessling LL. Synthesis of Functionalizable and Degradable Polymers by Ring-Opening Metathesis Polymerization. Angewandte Chemie-International Edition. 2013;52:5061-5064.
Wong ML, Guzei IA, Kiessling LL. An Asymmetric Synthesis of L-Pyrrolysine. Organic Letters. 2012;14:1378-1381.
Prost LR, Grim JC, Tonelli M, Kiessling LL. Noncarbohydrate Glycomimetics and Glycoprotein Surrogates as DC-SIGN Antagonists and Agonists. ACS Chemical Biology. 2012;7:1603-1608.
May JF, Levengood MR, Splain RA, Brown CD, Kiessling LL. A Processive Carbohydrate Polymerase That Mediates Bifunctional Catalysis Using a Single Active Site. Biochemistry. 2012;51:1148-1159.
Mangold SL, Prost LR, Kiessling LL. Quinoxalinone inhibitors of the lectin DC-SIGN. Chemical Science. 2012;3:772-777.
Klim JR, Fowler AJ, Courtney AH, Wrighton PJ, Sheridan RTC, Wong ML, et al.. Small-Molecule-Modified Surfaces Engage Cells through the alpha(v)beta(3) Integrin. ACS Chemical Biology. 2012;7:518-525.
Brown CD, Rusek MS, Kiessling LL. Fluorosugar Chain Termination Agents as Probes of the Sequence Specificity of a Carbohydrate Polymerase. Journal of the American Chemical Society. 2012;134:6552-6555.
Kiessling LL. Recasting Biomolecules for Function. ACS Chemical Biology. 2012;7:1-2.
Musah S, Morin SA, Wrighton PJ, Zwick DB, Jin S, Kiessling LL. Glycosaminoglycan-Binding Hydrogels Enable Mechanical Control of Human Pluripotent Stem Cell Self-Renewal. ACS Nano. 2012;6:10168-10177.
Underbakke ES, Zhu Y, Kiessling LL. Protein Footprinting in a Complex Milieu: Identifying the Interaction Surfaces of the Chemotaxis Adaptor Protein CheW. Journal of Molecular Biology. 2011;409:483-495.
Li L, Klim JR, Derda R, Courtney AH, Kiessling LL. Spatial control of cell fate using synthetic surfaces to potentiate TGF-beta signaling. Proceedings of the National Academy of Sciences of the United States of America. 2011;108:11745-11750.
Levengood MR, Splain RA, Kiessling LL. Monitoring Processivity and Length Control of a Carbohydrate Polymerase. Journal of the American Chemical Society. 2011;133:12758-12766.
Chattopadhyay S, Guthrie KM, Teixeira L, Li L, Kiessling LL, Dubielzig RR, et al.. Collagen Mimetic Peptides Enable Cutaneous Wound Assessment and Expedite Healing. Biopolymers. 2011;96:427-427.
Kiessling LL, Splain RA. Chemical Approaches to Glycobiology. In: Kornberg RD, Raetz CRH, Rothman JE, Thorner JW. 2010. pp. 619-653.
Underbakke ES, Kiessling LL. Classifying chemoreceptors: quantity versus quality. EMBO Journal. 2010;29:3435-3436.
Splain RA, Kiessling LL. Synthesis of galactofuranose-based acceptor substrates for the study of the carbohydrate polymerase GlfT2. Bioorganic & Medicinal Chemistry. 2010;18:3753-3759.
Li L, Orner BP, Huang T, Hinck AP, Kiessling LL. Peptide ligands that use a novel binding site to target both TGF-beta receptors. Molecular Biosystems. 2010;6:2392-2402.
Klim JR, Li L, Wrighton PJ, Piekarczyk MS, Kiessling LL. A defined glycosaminoglycan-binding substratum for human pluripotent stem cells. Nature Methods. 2010;7:989-U72.
Jiarpinitnun C, Kiessling LL. Unexpected Enhancement in Biological Activity of a GPCR Ligand Induced by an Oligoethylene Glycol Substituent. Journal of the American Chemical Society. 2010;132:8844-+.
Garber KCA, Wangkanont K, Carlson EE, Kiessling LL. A general glycomimetic strategy yields non-carbohydrate inhibitors of DC-SIGN. Chemical Communications. 2010;46:6747-6749.
Derda R, Musah S, Orner BP, Klim JR, Li L, Kiessling LL. High-Throughput Discovery of Synthetic Surfaces That Support Proliferation of Pluripotent Cells. Journal of the American Chemical Society. 2010;132:1289-1295.
Kiessling LL. Decoding Signals with Chemical Biology. ACS Chemical Biology. 2010;5:1-2.
May JF, Splain RA, Brotschi C, Kiessling LL. A tethering mechanism for length control in a processive carbohydrate polymerization. Proceedings of the National Academy of Sciences of the United States of America. 2009;106:11851-11856.
Lamanna AC, Kiessling LL. Flow Cytometry Reveals that Multivalent Chemoattractants Effect Swarmer Cell Dedifferentiation. ACS Chemical Biology. 2009;4:828-833.
Kolonko EM, Pontrello JK, Mangold SL, Kiessling LL. General Synthetic Route to Cell-Permeable Block Copolymers via ROMP. Journal of the American Chemical Society. 2009;131:7327-7333.
Gruber TD, Westler WM, Kiessling LL, Forest KT. X-ray Crystallography Reveals a Reduced Substrate Complex of UDP-Galactopyranose Mutase Poised for Covalent Catalysis by Flavin. Biochemistry. 2009;48:9171-9173.
Gruber TD, Borrok MJ, Westler WM, Forest KT, Kiessling LL. Ligand Binding and Substrate Discrimination by UDP-Galactopyranose Mutase. Journal of Molecular Biology. 2009;391:327-340.
Dykhuizen EC, Kiessling LL. Potent Ligands for Prokaryotic UDP-Galactopyranose Mutase That Exploit an Enzyme Subsite. Organic Letters. 2009;11:193-196.
Courtney AH, Puffer EB, Pontrello JK, Yang ZQ, Kiessling LL. Sialylated multivalent antigens engage CD22 in trans and inhibit B cell activation. Proceedings of the National Academy of Sciences of the United States of America. 2009;106:2500-2505.
Borrok MJ, Zhu YM, Forest KT, Kiessling LL. Structure-Based Design of a Periplasmic Binding Protein Antagonist that Prevents Domain Closure. ACS Chemical Biology. 2009;4:447-456.
Allen MJ, Wangkanont K, Raines RT, Kiessling LL. ROMP from ROMP: A New Approach to Graft Copolymer Synthesis. Macromolecules. 2009;42:4023-4027.
Underbakke ES, Zhu YM, Kiessling LL. Isotope-Coded Affinity Tags with Tunable Reactivities for Protein Footprinting. Angewandte Chemie-International Edition. 2008;47:9677-9680.
Mangold SL, Carpenter RT, Kiessling LL. Synthesis of fluorogenic polymers for visualizing cellular internalization. Organic Letters. 2008;10:2997-3000.
Dykhuizen EC, May JF, Tongpenyai A, Kiessling LL. Inhibitors of UDP-galactopyranose mutase thwart mycobacterial growth. Journal of the American Chemical Society. 2008;130:6706-+.
Borrok JM, Kolonko EM, Kiessling LL. Chemical probes of bacterial signal transduction reveal that repellents stabilize and attractants destabilize the chemoreceptor array. ACS Chemical Biology. 2008;3:101-109.
Kolonko EM, Kiessling LL. A polymeric domain that promotes cellular internalization. Journal of the American Chemical Society. 2008;130:5626-+.
Puffer EB, Pontrello JK, Hollenbeck JJ, Kink JA, Kiessling LL. Activating B cell signaling with defined multivalent ligands. ACS Chemical Biology. 2007;2:252-262.
Owen RM, Carlson CB, Xu J, Mowery P, Fasella E, Kiessling LL. Bifunctional ligands that target cells displaying the alpha(v)beta(3) integrin. Chembiochem. 2007;8:68-82.
Derda R, Wherritt DJ, Kiessling LL. Solid-phase synthesis of alkanethiols for the preparation of self-assembled monolayers. Langmuir. 2007;23:11164-11167.
Derda R, Li L, Orner BP, Lewis RL, Thomson JA, Kiessling LL. Defined substrates for human embryonic stem cell growth identified from surface arrays. ACS Chemical Biology. 2007;2:347-355.
Chad JM, Sarathy KP, Gruber TD, Addala E, Kiessling LL, Sanders DAR. Site-directed mutagenesis of UDP-Galactopyranose mutase reveals a critical role for the active-site, conserved arginine residues. Biochemistry. 2007;46:6723-6732.
Carlson CB, Mowery P, Owen RM, Dykhuizen EC, Kiessling LL. Selective tumor cell targeting using low-affinity, multivalent interactions. ACS Chemical Biology. 2007;2:119-127.
Borrok JM, Kiessling LL, Forest KT. Conformational changes of glucose/galactose-binding protein illuminated by open, unliganded, and ultra-high-resolution ligand-bound structures. Protein Science. 2007;16:1032-1041.
Borrok JM, Kiessling LL. Non-carbo hydrate inhibitors of the lectin DC-SIGN. Journal of the American Chemical Society. 2007;129:12780-12785.
Kiessling LL, Doudna JA, Johnsson K, Mapp AK, Marletta MA, Seeberger PH, et al.. A higher degree of difficulty. ACS Chemical Biology. 2007;2:197-199.
Wangkanont K, Allen MJ, Kiessling LL. Graft co-polymers by ring-opening metathesis polymerization from a main chain containing latent monomers. Polymer Preprints. 2007;48:979.
McElroy EE, Pontrello JK, Kiessling LL. General strategy for the synthesis of biologically active block copolymers. Polymer Preprints. 2007;48:219-220.
Orner BP, Liu L, Murphy RM, Kiessling LL. Phage display affords peptides that modulate beta-amyloid aggregation. Journal of the American Chemical Society. 2006;128:11882.
Kiessling LL, Wedde SG, Raines RT. Symbiosis: Chemical biology at Wisconsin. ACS Chemical Biology. 2006;1:481-484.
Kiessling LL. Editor's Letter - Fostering Major Breakthroughs. ACS Chemical Biology. 2006;1:1-2.
Allen MJ, Raines RT, Kiessling LL. Contrast agents for magnetic resonance imaging synthesized with ring-opening metathesis polymerization. Journal of the American Chemical Society. 2006;128:6534-6535.
Carlson EE, May JF, Kiessling LL. Chemical probes of UDP-galactopyranose mutase. Chemistry & Biology. 2006;13:825-837.
Kiessling LL, Gestwicki JE, Strong LE. Synthetic multivalent ligands as probes of signal transduction [Review]. Angewandte Chemie-International Edition. 2006;45:2348-2368.
Derda R, Li L, Orner BP, Lewis RL, Thomson JA, Kiessling LL. High-throughput approach to functional materials supporting human ES cell self-renewal. Polymer Preprints. 2006;47:24-25.
Pontrello JK, Allen MJ, Underbakke ES, Kiessling LL. Solid-phase synthesis of polymers using the ring-opening metathesis polymerization. Journal of the American Chemical Society. 2005;127:14536-14537.
Lamanna AC, Ordal GW, Kiessling LL. Large increases in attractant concentration disrupt the polar localization of bacterial chemoreceptors. Molecular Microbiology. 2005;57:774-785.
Kiessling LL. Biologically active polymeric multivalent ligands. Polymer Preprints. 2005;46:122.
Borrok D, Borrok MJ, Fein JB, Kiessling LL. Link between chemotactic response to Ni2+ and its adsorption onto the Escherichia coli cell surface. Environmental Science & Technology. 2005;39:5227-5233.
Soltero-Higgin M, Carlson EE, Phillips JH, Kiessling LL. Identification of inhibitors for UDP-galactopyranose mutase. Journal of the American Chemical Society. 2004;126:10532-10533.
Orner BP, Derda R, Lewis RL, Thomson JA, Kiessling LL. Arrays for the combinatorial exploration of cell adhesion. Journal of the American Chemical Society. 2004;126:10808-10809.
Griffith BR, Allen BL, Rapraeger AC, Kiessling LL. A polymer scaffold for protein oligomerization. Journal of the American Chemical Society. 2004;126:1608-1609.
Carlson EE, Kiessling LL. Improved chemical syntheses of 1-and 5-deazariboflavin. Journal of Organic Chemistry. 2004;69:2614-2617.
Soltero-Higgin M, Carlson EE, Gruber TD, Kiessling LL. A unique catalytic mechanism for UDP-galactopyranose mutase. Nature Structural & Molecular Biology. 2004;11:539-543.
Mowery P, Yang ZQ, Gordon EJ, Dwir O, Spencer AG, Alon R, et al.. Synthetic glycoprotein mimics inhibit L-selectin-mediated rolling and promote L-selectin shedding. Chemistry & Biology. 2004;11:725-732.
He Y, Hinklin RJ, Chang JY, Kiessling LL. Stereoselective N-glycosylation by Staudinger ligation. Organic Letters. 2004;6:4479-4482.
Smith EA, Thomas WD, Kiessling LL, Corn RM. Surface plasmon resonance imaging studies of protein-carbohydrate interactions. Journal of the American Chemical Society. 2003;125:6140-6148.
Kiessling LL, Pontrello JK, Schuster MC. Synthetic multivalent carbohydrate ligands as effectors or inhibitors of biological processes. Carbohydrate-Based Drug Discovery. 2003;2:575-608.
Schuster MC, Mann DA, Buchholz TJ, Johnson KM, Thomas WD, Kiessling LL. Parallel synthesis of glycomimetic libraries: Targeting a C-type lectin. Organic Letters. 2003;5:1407-1410.
Kiessling LL. Synthesis and binding mechanisms of polymeric multivalent ligands. Polymer Preprints. 2003;44:447-448.
Genbacev OD, Prakobphol A, Foulk RA, Krtolica AR, Ilic D, Singer MS, et al.. Trophoblast L-selectin-mediated adhesion at the maternal-fetal interface. Science. 2003;299:405-408.
Yang ZQ, Puffer EB, Pontrello JK, Kiessling LL. Synthesis of a multivalent display of a CD22-binding trisaccharide. Carbohydrate Research. 2002;337:1605-1613.
Lamanna AC, Gestwicki JE, Strong LE, Borchardt SL, Owen RM, Kiessling LL. Conserved amplification of chemotactic responses through chemoreceptor interactions. Journal of Bacteriology. 2002;184:4981-4987.
Gestwicki JE, Cairo CW, Strong LE, Oetjen KA, Kiessling LL. Influencing receptor-ligand binding mechanisms with multivalent ligand architecture. Journal of the American Chemical Society. 2002;124:14922-14933.
Cairo CW, Gestwicki JE, Kanai M, Kiessling LL. Control of multivalent interactions by binding epitope density. Journal of the American Chemical Society. 2002;124:1615-1619.
Young T, Kiessling LL. A strategy for the synthesis of sulfated peptides. Angewandte Chemie-International Edition. 2002;41:3449-3451.
Owen RM, Gestwicki JE, Young T, Kiessling LL. Synthesis and applications of end-labeled neoglycopolymers. Organic Letters. 2002;4:2293-2296.
Kiessling LL, Cairo CW. Hitting the sweet spot. Nature Biotechnology. 2002;20:234-235.
Hinklin RJ, Kiessling LL. p-methoxybenzyl ether cleavage by polymer-supported sulfonamides. Organic Letters. 2002;4:1131-1133.
Gestwicki JE, Strong LE, Cairo CW, Boehm FJ, Kiessling LL. Cell aggregation by scaffolded receptor clusters. Chemistry & Biology. 2002;9:163-169.
Gestwicki JE, Kiessling LL. Inter-receptor communication through arrays of bacterial chemoreceptors. Nature. 2002;415:81-84.
Gestwicki JE, Cairo CW, Mann DA, Owen RM, Kiessling LL. Selective immobilization of multivalent ligands for surface plasmon resonance and fluorescence microscopy. Analytical Biochemistry. 2002;305:149-155.
Cairo CW, Strzelec A, Murphy RM, Kiessling LL. Affinity-based inhibition of beta-amyloid toxicity. Biochemistry. 2002;41:8620-8629.
Steinmann JG, Phillips JH, Sanders WJ, Kiessling LL. Synthesis of cyclic sulfates by halocyclization. Organic Letters. 2001;3:3557-3559.
Nilsson BL, Kiessling LL, Raines RT. High-yielding Staudinger ligation of a phosphinothioester and azide to form a peptide. Organic Letters. 2001;3:9-12.
Marlow AL, Kiessling LL. Improved chemical synthesis of UDP-galactofuranose. Organic Letters. 2001;3:2517-2519.
Kiessling LL, Young T, Mortell KH. Multivalency in protein-carbohydrate recognition. Glycoscience. 2001;2:1817-1861.
Lowe TL, Strzelec A, Kiessling LL, Murphy RM. Structure-function relationships for inhibitors of beta-amyloid toxicity containing the recognition sequence KLVFF. Biochemistry. 2001;40:7882-7889.
Lamanna AC, Gestwicki JE, Adler J, Kiessling LL. Effects of multivalent, chemotactically active, saccharide polymers on bacterial swarmer cell dedifferentiation. Biochemistry. 2001;40:8657-8658.
Hinklin RJ, Kiessling LL. Glycosyl sulfonylcarbamates: New glycosyl donors with tunable reactivity. Journal of the American Chemical Society. 2001;123:3379-3380.
Gestwicki JE, Strong LE, Borchardt SL, Cairo CW, Schnoes AM, Kiessling LL. Designed potent multivalent chemoattractants for Escherichia coli. Bioorganic & Medicinal Chemistry. 2001;9:2387-2393.
Bertozzi CR, Kiessling LL. Chemical glycobiology. Science. 2001;291:2357-2364.
Gestwicki JE, Strong LE, Kiessling LL. Visualization of single multivalent receptor-ligand complexes by transmission electron microscopy. Angewandte Chemie-International Edition. 2000;39:4567-+.
Burke SD, Zhao Q, Schuster MC, Kiessling LL. Synergistic formation of soluble lectin clusters by a templated multivalent saccharide ligand. Journal of the American Chemical Society. 2000;122:4518-4519.
Nilsson BL, Kiessling LL, Raines RT. Staudinger ligation: A peptide from a thioester and azide. Organic Letters. 2000;2:1939-1941.
Maki N, Gestwicki JE, Lake EM, Kiessling LL, Adler J. Motility and chemotaxis of filamentous cells of Escherichia coli. Journal of Bacteriology. 2000;182:4337-4342.
Kiessling LL, Strong LE, Gestwicki JE. Principles for multivalent ligand design. Annual Reports in Medicinal Chemistry, Vol 35. 2000;35:321-330.
Kiessling LL, Gestwicki JE, Strong LE. Synthetic multivalent ligands in the exploration of cell-surface interactions. Current Opinion in Chemical Biology. 2000;4:696-703.
Gordon EJ, Gestwicki JE, Strong LE, Kiessling LL. Synthesis of end-labeled multivalent ligands for exploring cell-surface-receptor-ligand interactions. Chemistry & Biology. 2000;7:9-16.
Gestwicki JE, Strong LE, Kiessling LL. Tuning chemotactic responses with synthetic multivalent ligands. Chemistry & Biology. 2000;7:583-591.
Gestwicki JE, Lamanna AC, Harshey RM, McCarter LL, Kiessling LL, Adler J. Evolutionary conservation of methyl-accepting chemotaxis protein location in Bacteria and Archaea. Journal of Bacteriology. 2000;182:6499-6502.
Strong LE, Kiessling LL. A general synthetic route to defined, biologically active multivalent arrays. Journal of the American Chemical Society. 1999;121:6193-6196.
Sanders WJ, Gordon EJ, Dwir O, Beck PJ, Alon R, Kiessling LL. Inhibition of L-selectin-mediated leukocyte rolling by synthetic glycoprotein mimics. Journal of Biological Chemistry. 1999;274:5271-5278.
Pohl NL, Kiessling LL. Scope of multivalent ligand function: Lactose-bearing neoglycopolymers by ring-opening metathesis polymerization. Synthesis-Stuttgart. 1999;:1515-1519.
Pallitto MM, Ghanta J, Heinzelman P, Kiessling LL, Murphy RM. Recognition sequence design for peptidyl modulators of beta-amyloid aggregation and toxicity. Biochemistry. 1999;38:3570-3578.
Kiessling LL, DeGrado WF, Eckstein F. Modulation of nucleic acids, carbohydrates and proteins to different task. Current Opinion in Chemical Biology. 1999;3:641-642.
Mann DA, Kanai M, Maly DJ, Kiessling LL. Probing low affinity and multivalent interactions with surface plasmon resonance: Ligands for concanavalin A. Journal of the American Chemical Society. 1998;120:10575-10582.
Kiessling LL, Gordon EJ. Transforming the cell surface through proteolysis. Chemistry & Biology. 1998;5:R49-R62.
Gordon EJ, Strong LE, Kiessling LL. Glycoprotein-inspired materials promote the proteolytic release of cell surface L-selectin. Bioorganic & Medicinal Chemistry. 1998;6:1293-1299.
Gordon EJ, Sanders WJ, Kiessling LL. Synthetic ligands point to cell surface strategies. Nature. 1998;392:30-31.
Schuster MC, Mortell KH, Hegeman AD, Kiessling LL. Neoglycopolymers produced by aqueous ring-opening metathesis polymerization: Decreasing saccharide density increases activity. Journal of Molecular Catalysis A-Chemical. 1997;116:209-216.
Sanders WJ, Manning DD, Koeller KM, Kiessling LL. Synthesis of sulfated trisaccharide ligands for the selectins. Tetrahedron. 1997;53:16391-16422.
Pohl NL, Kiessling LL. Para-chlorobenzyl protecting groups as stabilizers of the glycosidic linkage: Synthesis of the 3'-O-sulfated Lewis X trisaccharide. Tetrahedron Letters. 1997;38:6985-6988.
Manning DD, Strong LE, Hu X, Beck PJ, Kiessling LL. Neoglycopolymer inhibitors of the selectins. Tetrahedron. 1997;53:11937-11952.
Manning DD, Hu X, Beck P, Kiessling LL. Synthesis of sulfated neoglycopolymers: Selective P-selectin inhibitors. Journal of the American Chemical Society. 1997;119:3161-3162.
Kurutz JW, Kiessling LL. Solution conformation of Lewis a-derived selectin ligands is unaffected by anionic substituents at the 3'- and 6'-positions. Glycobiology. 1997;7:337-347.
Kanai M, Mortell KH, Kiessling LL. Varying the size of multivalent ligands: The dependence of concanavalin a binding on neoglycopolymer length. Journal of the American Chemical Society. 1997;119:9931-9932.
Hegg EL, Deal KA, Kiessling LL, Burstyn JN. Hydrolysis of double-stranded and single-stranded RNA in hairpin structures by the copper(II) macrocycle Cu( 9 aneN(3))Cl-2. Inorganic Chemistry. 1997;36:1715-1718.
Weatherman RV, Mortell KI, Chervenak M, Kiessling LL, Toone EJ. Specificity of C-glycoside complexation by mannose glucose specific lectins. Biochemistry. 1996;35:3619-3624.
Weatherman RV, Kiessling LL. Fluorescence anisotropy assays reveal affinities of C- and O-glycosides for concanavalin A. Journal of Organic Chemistry. 1996;61:534-538.
Schueller CM, Manning DD, Kiessling LL. Preparation of (R)-(+)-7-oxabicyclo 2.2.1 hept-5-ene-exo-2-carboxylic acid, a precursor to substrates for the ring opening metathesis polymerization. Tetrahedron Letters. 1996;37:8853-8856.
Sanders WJ, Katsumoto TR, Bertozzi CR, Rosen SD, Kiessling LL. L-selectin-carbohydrate interactions: Relevant modifications of the Lewis x trisaccharide. Biochemistry. 1996;35:14862-14867.
Mortell KH, Weatherman RV, Kiessling LL. Recognition specificity of neoglycopolymers prepared by ring-opening metathesis polymerization. Journal of the American Chemical Society. 1996;118:2297-2298.
Manning DD, Bertozzi CR, Rosen SD, Kiessling LL. Tin-mediated phosphorylation: Synthesis and selectin binding of a phospho Lewis a analog. Tetrahedron Letters. 1996;37:1953-1956.
Kiessling LL, Pohl NL. Strength in numbers: Non-natural polyvalent carbohydrate derivatives. Chemistry & Biology. 1996;3:71-77.
Ghanta J, Shen CL, Kiessling LL, Murphy RM. A strategy for designing inhibitors of beta-amyloid toxicity. Journal of Biological Chemistry. 1996;271:29525-29528.
Dantzman CL, Kiessling LL. Reactivity of a 2'-thio nucleotide analog. Journal of the American Chemical Society. 1996;118:11715-11719.
Bruning J, Kiessling LL. Convergent synthesis of sulfated bivalent glycopeptides as selectin ligands. Tetrahedron Letters. 1996;37:2907-2910.
Manning DD, Bertozzi CR, Pohl NL, Rosen SD, Kiessling LL. Selectin Saccharide Interactions - Revealing Structure-Function-Relationships with Chemical Synthesis. Journal of Organic Chemistry. 1995;60:6254-6255.
Kiessling LL. Creating molecules: Evolution of randomness. Graven Images: a journal of culture, law, and the sacred. 1995;2:222-228.
Sanders WJ, Kiessling LL. STEREOSELECTIVE, LEWIS ACID-CATALYZED GLYCOSYLATION OF ALCOHOLS BY GLUCOSE 1,2-CYCLIC SULFITES. Tetrahedron Letters. 1994;35:7335-7338.
Mortell KH, Gingras M, Kiessling LL. Synthesis of Cell Agglutination Inhibitors by Aqueous Ring-Opening Metathesis Polymerization. Journal of the American Chemical Society. 1994;116:12053-12054.
Kiessling LL, Griffin LC, Dervan PB. Flanking Sequence Effects within the Pyrimidine Triple-Helix Motif Characterized by Affinity Cleaving. Biochemistry. 1992;31:2829-2834.
Griffin LC, Kiessling LL, Beal PA, Gillespie P, Dervan PB. RECOGNITION OF ALL 4 BASE-PAIRS OF DOUBLE-HELICAL DNA BY TRIPLE-HELIX FORMATION - DESIGN OF NONNATURAL DEOXYRIBONUCLEOSIDES FOR PYRIMIDINE.PURINE BASE PAIR BINDING. Journal of the American Chemical Society. 1992;114:7976-7982.
Schreiber SL, Kiessling LL. FURTHER INVESTIGATIONS OF THE TYPE-II DIELS-ALDER ROUTE TO THE BICYCLIC CORE OF ESPERAMICIN CALICHEMICIN REVEAL A REGIOCHEMICAL MISASSIGNMENT - META-SELECTIVITY VS PARA-SELECTIVITY. Tetrahedron Letters. 1989;30:433-436.
Hawley RC, Kiessling LL, Schreiber SL. MODEL OF THE INTERACTIONS OF CALICHEMICIN-GAMMA-1 WITH A DNA FRAGMENT FROM PBR322. Proceedings of the National Academy of Sciences of the United States of America. 1989;86:1105-1109.
Schreiber SL, Kiessling LL. Synthesis of the Bicyclic Core of the Esperamicin Calichemicin Class of Antitumor Agents. Journal of the American Chemical Society. 1988;110:631-633.
Shambayati S, Kiessling LL, Schreiber SL. Observation of an eclipsed Csp3-CH3 bond in a tricyclic ortho amide: experimental and theoretical evidence for C-H···O hydrogen bonds. Chemtracts Org. Chem. 1988;1:388-91.
Kiessling LL, Schreiber SL. Esperamicins, a novel class of potent antitumor antibiotics. Parts 2 and 3. Calichemicins, a novel family of antitumor antibiotics. Parts 1 and 2. Chemtracts Org. Chem. 1988;1:4-6.
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