Publications

Chen YS, Powell CT, Yu L. Tensile Fracture of Molecular Glasses Studied by Differential Scanning Calorimetry: Reduction of Heat Capacity by Lateral Constraint. Journal of Physical Chemistry B. 2017;121:444-449.
Gujral A, Gomez J, Jiang J, Huang CB, O'Hara KA, Toney MF, et al.. Highly Organized Smectic-like Packing in Vapor-Deposited Glasses of a Liquid Crystal. Chemistry of Materials. 2017;29:849-858.
Gomez J, Gujral A, Huang CB, Bishop C, Yu L, Ediger MD. Nematic-like stable glasses without equilibrium liquid crystal phases. Journal of Chemical Physics. 2017;146.
Huang CB, Powell CT, Sung Y, Cai T, Yu L. Effect of Low-Concentration Polymers on Crystal Growth in Molecular Glasses: A Controlling Role for Polymer Segmental Mobility Relative to Host Dynamics. Journal of Physical Chemistry B. 2017;121:1963-1971.
Ruan SG, Musumeci D, Zhang W, Gujral A, Ediger MD, Yu L. Surface transport mechanisms in molecular glasses probed by the exposure of nano-particles. Journal of Chemical Physics. 2017;146.
Cavallo D, Galli F, Yu L, Alfonso GC. Cross-Nucleation between Concomitantly Crystallizing alpha- and gamma-Phases in Polypivalolactone: Secondary Nucleation of One Polymorph on Another. Crystal Growth & Design. 2017;17:2639-2645.
Zhu M, Yu L. Polyamorphism of D-mannitol. Journal of Chemical Physics. 2017;146.
Chen YS, Zhu M, Laventure A, Lebel O, Ediger MD, Yu L. Influence of Hydrogen Bonding on the Surface Diffusion of Molecular Glasses: Comparison of Three Triazines. Journal of Physical Chemistry B. 2017;121:7221-7227.
Shi CY, Teerakapibal R, Yu L, Zhang GGZ. Pair distribution functions of amorphous organic thin films from synchrotron X-ray scattering in transmission mode. Iucrj. 2017;4:555-559.
Huang CB, Ruan SG, Cai T, Yu L. Fast Surface Diffusion and Crystallization of Amorphous Griseofulvin. Journal of Physical Chemistry B. 2017;121:9463-9468.
Zhang W, Yu L. Surface Diffusion of Polymer Glasses. Macromolecules. 2016;49:731-735.
Gomez J, Jiang J, Gujral A, Huang CB, Yu L, Ediger MD. Vapor deposition of a smectic liquid crystal: highly anisotropic, homogeneous glasses with tunable molecular orientation. Soft Matter. 2016;12:2942-2947.
Musumeci D, Hasebe M, Yu L. Crystallization of Organic Glasses: How Does Liquid Flow Damage Surface Crystal Growth?. Crystal Growth & Design. 2016;16:2931-2936.
Yu L. Surface mobility of molecular glasses and its importance in physical stability. Advanced Drug Delivery Reviews. 2016;100:3-9.
Zhang W, Teerakapibal R, Yu L. Surface Mobility of Amorphous o-Terphenyl: A Strong Inhibitory Effect of Low-Concentration Polystyrene. Journal of Physical Chemistry B. 2016;120:6842-6847.
Chen YS, Zhang W, Yu L. Hydrogen Bonding Slows Down Surface Diffusion of Molecular Glasses. Journal of Physical Chemistry B. 2016;120:8007-8015.
Ruan S, Zhang W, Sun Y, Ediger MD, Yu L. Surface diffusion and surface crystal growth of tris-naphthyl benzene glasses. Journal of Chemical Physics. 2016;145.
Hasebe M, Musumeci D, Yu L. Fast Surface Crystallization of Molecular Glasses: Creation of Depletion Zones by Surface Diffusion and Crystallization Flux. Journal of Physical Chemistry B. 2015;119:3304-3311.
Zhang W, Brian CW, Yu L. Fast Surface Diffusion of Amorphous o-Terphenyl and Its Competition with Viscous Flow in Surface Evolution. Journal of Physical Chemistry B. 2015;119:5071-5078.
Zhu M, Wang JQ, Perepezko JH, Yu L. Possible existence of two amorphous phases of D-mannitol related by a first-order transition. Journal of Chemical Physics. 2015;142.
Powell CT, Xi HM, Sun Y, Gunn E, Chen YS, Ediger MD, et al.. Fast Crystal Growth in o-Terphenyl Glasses: A Possible Role for Fracture and Surface Mobility. Journal of Physical Chemistry B. 2015;119:10124-10130.
Powell CT, Chen YS, Yu L. Fracture of molecular glasses under tension and increasing their fracture resistance with polymer additives. Journal of Non-Crystalline Solids. 2015;429:122-128.
Lin PH, Lyubimov I, Yu L, Ediger MD, de Pablo JJ. Molecular modeling of vapor-deposited polymer glasses. Journal of Chemical Physics. 2014;140.
Hasebe M, Musumeci D, Powell CT, Cai T, Gunn E, Zhu L, et al.. Fast Surface Crystal Growth on Molecular Glasses and Its Termination by the Onset of Fluidity. Journal of Physical Chemistry B. 2014;118:7638-7646.
Zhang S-W, Yu L, Huang J, Hussain MA, Derdour L, Qian F, et al.. A method to evaluate the effect of contact with excipients on the surface crystallization of amorphous drugs. AAPS PharmSciTech. 2014;15:1516-26.
Musumeci D, Powell CT, Ediger MD, Yu L. Termination of Solid-State Crystal Growth in Molecular Glasses by Fluidity. Journal of Physical Chemistry Letters. 2014;5:1705-1710.
Brian CW, Zhu L, Yu L. Effect of bulk aging on surface diffusion of glasses. Journal of Chemical Physics. 2014;140.
Powell CT, Paeng K, Chen Z, Richert R, Yu L, Ediger MD. Fast Crystal Growth from Organic Glasses: Comparison of o-Terphenyl with its Structural Analogs. Journal of Physical Chemistry B. 2014;118:8203-8209.
Zhang SW, Kendrick J, Leusen FJJ, Yu L. Co-crystallization with Nicotinamide in Two Conformations Lowers Energy but Expands Volume. Journal of Pharmaceutical Sciences. 2014;103:2896-2903.
Powell CT, Cai T, Hasebe M, Gunn EM, Gao P, Zhang G, et al.. Low-Concentration Polymers Inhibit and Accelerate Crystal Growth in Organic Glasses in Correlation with Segmental Mobility. Journal of Physical Chemistry B. 2013;117:10334-10341.
Brian CW, Yu L. Surface Self-Diffusion of Organic Glasses. Journal of Physical Chemistry A. 2013;117:13303-13309.
Zhang SW, Harasimowicz MT, de Villiers MM, Yu L. Cocrystals of Nicotinamide and (R)-Mandelic Acid in Many Ratios with Anomalous Formation Properties. Journal of the American Chemical Society. 2013;135:18981-18989.
Zhang SW, Guzei IA, de Villiers MM, Yu L, Krzyzaniak JF. Formation Enthalpies and Polymorphs of Nicotinamide-R-Mandelic Acid Co-Crystals. Crystal Growth & Design. 2012;12:4090-4097.
Paeng K, Powell CT, Yu L, Ediger MD. Fast Crystal Growth Induces Mobility and Tension in Supercooled o-Terphenyl. Journal of Physical Chemistry Letters. 2012;3:2562-2567.
Gunn E, Guzei IA, Cai T, Yu L. Polymorphism of Nifedipine: Crystal Structure and Reversible Transition of the Metastable beta Polymorph. Crystal Growth & Design. 2012;12:2037-2043.
Ediger MD, Yu L. POLYMER GLASSES From gas to nanoglobular glass. Nature Materials. 2012;11:267-268.
Dawson K, Kopff LA, Zhu L, McMahon RJ, Yu L, Richert R, et al.. Molecular packing in highly stable glasses of vapor-deposited tris-naphthylbenzene isomers. Journal of Chemical Physics. 2012;136.
Adrjanowicz K, Kaminski K, Paluch M, Ngai KL, Yu L. Study of dynamics and crystallization kinetics of 5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile at ambient and elevated pressure. Journal of Chemical Physics. 2012/07/12th ed. 2012;136:234509.
Sun Y, Zhu L, Wu T, Cai T, Gunn EM, Yu L. Stability of Amorphous Pharmaceutical Solids: Crystal Growth Mechanisms and Effect of Polymer Additives. Aaps Journal. 2012;14:380-388.
Malshe R, Ediger MD, Yu L, de Pablo JJ. Evolution of glassy gratings with variable aspect ratios under surface diffusion. Journal of Chemical Physics. 2011;134.
Gunn EM, Guzei IA, Yu L. Does Crystal Density Control Fast Surface Crystal Growth in Glasses? A Study with Polymorphs. Crystal Growth & Design. 2011;11:3979-3984.
Dawson KJ, Zhu L, Yu L, Ediger MD. Anisotropic Structure and Transformation Kinetics of Vapor-Deposited Indomethacin Glasses. Journal of Physical Chemistry B. 2011;115:455-463.
Zhu L, Cai T, Huang J, Stringfellow TC, Wall M, Yu L. Water Self-Diffusion in Glassy and Liquid Maltose Measured by Raman Microscopy and NMR. Journal of Physical Chemistry B. American Chemical Society; 2011;115:5849-5855.
Zhu L, Brian CW, Swallen SF, Straus PT, Ediger MD, Yu L. Surface Self-Diffusion of an Organic Glass. Physical Review Letters. 2011;106.
Sun Y, Zhu L, Kearns KL, Ediger MD, Yu L. Glasses crystallize rapidly at free surfaces by growing crystals upward. Proceedings of the National Academy of Sciences of the United States of America. 2011;108:5990-5995.
Shtukenberg A, Freundenthal J, Gunn E, Yu L, Kahr B. Glass-Crystal Growth Mode for Testosterone Propionate. Crystal Growth & Design. American Chemical Society; 2011;11:4458-4462.
Dawson K, Zhu L, Kopff LA, McMahon RJ, Yu L, Ediger MD. Highly Stable Vapor-Deposited Glasses of Four Tris-naphthylbenzene Isomers. Journal of Physical Chemistry Letters. American Chemical Society; 2011;2:2683-2687.
Cai T, Zhu L, Yu L. Crystallization of organic glasses: effects of polymer additives on bulk and surface crystal growth in amorphous nifedipine. Pharmaceutical Research. 2011/06/04th ed. 2011;28:2458-66.
Zhu L, Yu L. Generality of forming stable organic glasses by vapor deposition. Chemical Physics Letters. 2010;499:62-65.
Sun Y, Tao J, Zhang GG, Yu L. Solubilities of crystalline drugs in polymers: an improved analytical method and comparison of solubilities of indomethacin and nifedipine in PVP, PVP/VA, and PVAc. Journal of Pharmaceutical SciencesJournal of Pharmaceutical Sciences. 2010/07/08th ed. 2010;99:4023-31.
Yu L. Polymorphism in Molecular Solids: An Extraordinary System of Red, Orange, and Yellow Crystals. Accounts of Chemical Research. American Chemical Society; 2010;43:1257-1266.
Zhao JS, Ediger MD, Sun Y, Yu L. Two DSC Glass Transitions in Miscible Blends of Polyisoprene/Poly(4-tert-butylstyrene). Macromolecules. 2009;42:6777-6783.
Xi H, Sun Y, Yu L. Diffusion-controlled and diffusionless crystal growth in liquid o-terphenyl near its glass transition temperature. Journal of Chemical Physics. 2009/03/12th ed. 2009;130:094508.
Sun Y, Xi HM, Ediger MD, Richert R, Yu L. Diffusion-controlled and "diffusionless" crystal growth near the glass transition temperature: Relation between liquid dynamics and growth kinetics of seven ROY polymorphs. Journal of Chemical Physics. 2009;131.
Kearns KL, Swallen SF, Ediger MD, Sun Y, Yu L. Calorimetric Evidence for Two Distinct Molecular Packing Arrangements in Stable Glasses of Indomethacin. Journal of Physical Chemistry B. 2009;113:1579-1586.
Dawson KJ, Kearns KL, Yu L, Steffen W, Ediger MD. Physical vapor deposition as a route to hidden amorphous states. Proceedings of the National Academy of Sciences of the United States of America. 2009;106:15165-15170.
Tao J, Sun Y, Zhang GG, Yu L. Solubility of small-molecule crystals in polymers: D-mannitol in PVP, indomethacin in PVP/VA, and nifedipine in PVP/VA. Pharmaceutical Research. 2008/12/05th ed. 2009;26:855-64.
Strydom S, Liebenberg W, Yu L, de Villiers M. The effect of temperature and moisture on the amorphous-to-crystalline transformation of stavudine. International Journal of Pharmaceutics. 2009/06/23th ed. 2009;379:72-81.
Sun Y, Xi H, Ediger MD, Yu L. Diffusionless crystal growth from glass has precursor in equilibrium liquid. Journal of Physical Chemistry B. 2008;112:661-664.
Kearns KL, Swallen SF, Ediger MD, Wu T, Sun Y, Yu L. Hiking down the energy landscape: Progress toward the Kauzmann temperature via vapor deposition. Journal of Physical Chemistry B. 2008;112:4934-4942.
Ediger MD, Harrowell P, Yu L. Crystal growth kinetics exhibit a fragility-dependent decoupling from viscosity. Journal of Chemical Physics. 2008;128.
Zhu L, Wong L, Yu L. Surface-enhanced crystallization of amorphous nifedipine. Mol Pharm. 2009/05/13th ed. 2008;5:921-6.
Sun Y, Xi H, Chen S, Ediger MD, Yu L. Crystallization near Glass Transition:  Transition from Diffusion-Controlled to Diffusionless Crystal Growth Studied with Seven Polymorphs. Journal of Physical Chemistry B. American Chemical Society; 2008;112:5594-5601.
Huang J, Stringfellow TC, Yu L. Glycine Exists Mainly as Monomers, Not Dimers, in Supersaturated Aqueous Solutions: Implications for Understanding Its Crystallization and Polymorphism. Journal of the American Chemical Society. American Chemical Society; 2008;130:13973-13980.
Yu L. Survival of the fittest polymorph: how fast nucleater can lose to fast grower. Crystengcomm. The Royal Society of Chemistry; 2007;9:847-851.
Wu T, Sun Y, Li N, de Villiers MM, Yu L. Inhibiting surface crystallization of amorphous indomethacin by nanocoating. Langmuir. 2007/04/03th ed. 2007;23:5148-53.
Swallen SF, Kearns KL, Mapes MK, Kim YS, McMahon RJ, Ediger MD, et al.. Organic glasses with exceptional thermodynamic and kinetic stability. Science. 2007;315:353-356.
Kearns KL, Swallen SF, Ediger MD, Wu T, Yu L. Influence of substrate temperature on the stability of glasses prepared by vapor deposition. Journal of Chemical Physics. 2007;127.
Tao J, Jones KJ, Yu L. Cross-Nucleation between d-Mannitol Polymorphs in Seeded Crystallization. Crystal Growth & Design. American Chemical Society; 2007;7:2410-2414.
Milton N, Gopalrathnam G, Craig GD, Mishra DS, Roy ML, Yu L. Vial breakage during freeze-drying: crystallization of sodium chloride in sodium chloride-sucrose frozen aqueous solutions. Journal of Pharmaceutical Sciences. 2007/02/15th ed. 2007;96:1848-53.
Ishida H, Wu T, Yu L. Sudden rise of crystal growth rate of nifedipine near T(g) without and with polyvinylpyrrolidone. Journal of Pharmaceutical Sciences. 2007/04/25th ed. 2007;96:1131-8.
Wu T, Yu L. Surface crystallization of indomethacin below T-g. Pharmaceutical Research. 2006;23:2350-2355.
Wu T, Yu L. Origin of enhanced crystal growth kinetics near T-g probed with indomethacin polymorphs. Journal of Physical Chemistry B. 2006;110:15694-15699.
Tao J, Yu L. Kinetics of cross-nucleation between polymorphs. Journal of Physical Chemistry B. 2006;110:7098-7101.
Huang J, Yu L. Effect of molecular chirality on racemate stability: alpha-Amino acids with nonpolar R groups. Journal of the American Chemical Society. 2006;128:1873-1878.
Huang J, Chen S, Guzei IA, Yu L. Discovery of a solid solution of enantiomers in a racemate-forming system by seeding. Journal of the American Chemical Society. 2006;128:11985-11992.
Yu L, Huang J, Jones KJ. Measuring free-energy difference between crystal polymorphs through eutectic melting. Journal of Physical Chemistry B. 2005;109:19915-19922.
Martin OM, Yu L, Mecozzi S. Solution self-assembly and solid state properties of fluorinated amphiphilic calix 4 arenes. Chemical Communications. 2005;:4964-4966.
Chen SA, Xi HM, Yu L. Cross-nucleation between ROY polymorphs. Journal of the American Chemical Society. 2005;127:17439-17444.
Chen S, Guzei IA, Yu L. New polymorphs of ROY and new record for coexisting polymorphs of solved structures. Journal of the American Chemical Society. 2005;127:9881-9885.
Telang C, Suryanarayanan R, Yu L. Crystallization of D-mannitol in binary mixtures with NaCl: Phase diagram and polymorphism. Pharmaceutical Research. 2003;20:1939-1945.
Yu L. Nucleation of One Polymorph by Another. Journal of the American Chemical Society. 2003;125:6380-6381.
Yu L. Growth Rings in D-Sorbitol Spherulites: Connection to Concomitant Polymorphs and Growth Kinetics. Crystal Growth & Design. 2003;3:967-971.
Telang C, Yu L, Suryanarayanan R. Effective inhibition of mannitol crystallization in frozen solutions by sodium chloride. Pharmaceutical Research. 2003/05/13rd ed. 2003;20:660-7.
Milton N, Pyne A, Mishra D, Yu L. The exploration and use of thermal analytical technologies during formulation and process development of freeze-dried products. Am. Pharm. Rev. 2003;6:46,48,50-51.
Yu L, Ng K. Glycine crystallization during spray drying: the pH effect on salt and polymorphic forms. Journal of Pharmaceutical Sciences. 2002;91:2367-2375.
Yu L. Color Changes Caused by Conformational Polymorphism: Optical-Crystallography, Single-Crystal Spectroscopy, and Computational Chemistry. Journal of Physical Chemistry A. 2002;106:544-550.
Yu L. Amorphous pharmaceutical solids: preparation, characterization and stabilization. Advanced Drug Delivery Reviews. 2001;48:27-42.
Mitchell CA, Yu L, Ward MD. Selective Nucleation and Discovery of Organic Polymorphs through Epitaxy with Single Crystal Substrates. Journal of the American Chemical Society. 2001;123:10830-10839.
Yu L, Stephenson GA, Mitchell CA, Bunnell CA, Snorek SV, Bowyer JJ, et al.. Thermochemistry and Conformational Polymorphism of a Hexamorphic Crystal System. Journal of the American Chemical Society. 2000;122:585-591.
Yu L, Reutzel-Edens SM, Mitchell CA. Crystallization and polymorphism of conformationally flexible molecules. Problems, patterns, and strategies. Org. Process Res. Dev. 2000;4:396-402.
Reutzel-Edens SM, Russell VA, Yu L. Molecular basis for the stability relationships between homochiral and racemic crystals of tazofelone: a spectroscopic, crystallographic, and thermodynamic investigation. Perkin 2. 2000;:913-924.
Yu L, Milton N, Groleau EG, Mishra DS, Vansickle RE. Existence of a Mannitol Hydrate during Freeze-Drying and Practical Implications. Journal of Pharmaceutical SciencesJournal of Pharmaceutical Sciences. 1999;88:196-198.
Yu L, Reutzel SM, Stephenson GA. Physical characterization of polymorphic drugs: an integrated characterization strategy. Pharmaceutical Science & Technology Today. 1998;1:118-127.
Yu L, Mishra DS, Rigsbee DR. Determination of the glass properties of D-mannitol using sorbitol as an impurity. Journal of Pharmaceutical Sciences. 1998;87:774-777.
Yu L. Inferring Thermodynamic Stability Relationship of Polymorphs from Melting Data. Journal of Pharmaceutical SciencesJournal of Pharmaceutical Sciences. 1995;84:966-74.
Stephenson GA, Borchardt TB, Byrn SR, Bowyer J, Bunnell CA, Snorek SV, et al.. CONFORMATIONAL AND COLOR POLYMORPHISM OF 5-METHYL-2- (2-NITROPHENYL)AMINO -3-THIOPHENECARBONITRILE. Journal of Pharmaceutical Sciences. 1995;84:1385-1386.
Schwier J, Cooke G, Hartauer K, Yu L. Rayon: A Source of Furfural-A Reactive Aldehyde Capable of Insolublizing Gelatin Capsules. Pharm. Technol. 1993;May:78.
Yu L, Cullin DW, Williamson JM, Miller TA. HIGH-RESOLUTION LASER SPECTROSCOPY OF ASYMMETRICALLY DEUTERATED CYCLOPENTADIENYL RADICALS - A STUDY OF VIBRONIC DEGENERACY RESOLUTION AND JAHN-TELLER DISTORTION. Journal of Chemical Physics. 1993;98:2682-2698.
Yu L, Williamson J, Foster SC, Miller TA. HIGH-RESOLUTION LASER SPECTROSCOPY OF FREE RADICAL-INERT GAS COMPLEXES - C5H5.HE, C5H5.HE2, C5H5.NE, AND CH3-C5H4.HE2. Journal of Chemical Physics. 1992;97:5273-5282.
Cullin DW, Yu L, Williamson JM, Miller TA. HIGH-RESOLUTION SPECTROSCOPY OF JET-COOLED SUBSTITUTED CYCLOPENTADIENYL RADICALS. Journal of Physical Chemistry. 1992;96:89-94.
Yu L, Cullin DW, Williamson JM, Miller TA. ROTATIONALLY RESOLVED LASER SPECTROSCOPY OF THE JET-COOLED METHYLCYCLOPENTADIENYL RADICAL (CH3-C5H4 AND CD3-C5H4). Journal of Chemical Physics. 1991;95:804-812.
Chang BC, Yu L, Cullin D, Rehfuss B, Williamson J, Miller TA, et al.. ROTATIONAL, FINE, AND HYPERFINE-STRUCTURE IN THE HIGH-RESOLUTION ELECTRONIC-SPECTRUM OF AROH AND AROD. Journal of Chemical Physics. 1991;95:7086-7098.
Yu L, Foster SC, Williamson JM, Miller TA. HIGH-RESOLUTION ELECTRONIC SPECTROSCOPY OF JET-COOLED HEXAFLUOROBENZENE AND 1,3,5-TRIFLUOROBENZENE CATIONS, C6F6+ AND C6F3H3+. Journal of Chemical Physics. 1990;92:5794-5800.
Liu XM, Yu L, Miller TA. JAHN-TELLER INDUCED CORRECTIONS TO ROTATIONAL AND FINE-STRUCTURE PARAMETERS IN DOUBLY DEGENERATE ELECTRONIC STATES. Journal of Molecular Spectroscopy. 1990;140:112-125.
Liu XM, Foster SC, Williamson JM, Yu L, Miller TA. THE SPIN ROTATION INTERACTIONS IN THE METHOXY RADICAL. Molecular Physics. 1990;69:357-367.
Cullin DW, Yu L, Williamson JM, Platz MS, Miller TA. REINVESTIGATION OF THE ELECTRONIC-SPECTRUM OF THE PHENYLNITRENE RADICAL. Journal of Physical Chemistry. 1990;94:3387-3391.
Yu L, Williamson JM, Miller TA. ROTATIONALLY RESOLVED ELECTRONIC-SPECTRUM OF JET-COOLED DEUTERATED CYCLOPENTADIENYL RADICAL. Chemical Physics Letters. 1989;162:431-436.
Liu XM, Damo CP, Lin TYD, Foster SC, Misra P, Yu L, et al.. FREE JET-COOLED LASER-INDUCED FLUORESCENCE-SPECTRUM OF METHOXY RADICAL .2. ROTATIONAL ANALYSIS OF THE A2A1 -- X2E ELECTRONIC-TRANSITION. Journal of Physical Chemistry. 1989;93:2266-2275.
Yu L, Foster SC, Williamson JM, Heaven MC, Miller TA. ROTATIONALLY RESOLVED ELECTRONIC-SPECTRUM OF JET-COOLED CYCLOPENTADIENYL RADICAL. Journal of Physical Chemistry. 1988;92:4263-4266.
Liu L, Damo C, Lin D, Foster S, Misra P, Yu L, et al.. Free-Jet Cooled Laser-Induced Fluorescence Spectrum of Methoxy Radical. Journal of Physical Chemistry. 1986;93:6766.