All Faculty and Research Staff Publications

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2009
Buck ME, Breitbach AS, Belgrade SK, Blackwell HE, Lynn DM. Chemical Modification of Reactive Multilayered Films Fabricated from Poly(2-alkenyl azlactone)s: Design of Surfaces that Prevent or Promote Mammalian Cell Adhesion and Bacterial Biofilm Growth. Biomacromolecules. 2009 ;10:1564-1574.
Campbell J, Blackwell HE. Efficient Construction of Diketopiperazine Macroarrays Through a Cyclative-Cleavage Strategy and Their Evaluation as Luminescence Inhibitors in the Bacterial Symbiont Vibrio fischeri. Journal of Combinatorial Chemistry. 2009 ;11:1094-1099.
Praneenararat T, Geske GD, Blackwell HE. Efficient Synthesis and Evaluation of Quorum-Sensing Modulators Using Small Molecule Macroarrays. Organic Letters. 2009 ;11:4600-4603.
Campbell J, Lin Q, Geske GD, Blackwell HE. New and Unexpected Insights into the Modulation of LuxR-Type Quorum Sensing by Cyclic Dipeptides. ACS Chemical Biology. 2009 ;4:1051-1059.
Gorske BC, Stringer JR, Bastian BL, Fowler SA, Blackwell HE. New strategies for the design of folded peptoids revealed by a survey of noncovalent interactions in model systems. Journal of the American Chemical SocietyJournal of the American Chemical Society. 2009 ;131:16555-67.
Fowler SA, Blackwell HE. Structure-function relationships in peptoids: Recent advances toward deciphering the structural requirements for biological function. Organic & Biomolecular Chemistry. 2009 ;7:1508-1524.
Fowler SA, Luechapanichkul R, Blackwell HE. Synthesis and Characterization of Nitroaromatic Peptoids: Fine Tuning Peptoid Secondary Structure through Monomer Position and Functionality. Journal of Organic Chemistry. 2009 ;74:1440-1449.
2008
Geske GD, Oneill JC, Miller DM, Wezeman RJ, Mattmann ME, Lin Q, Blackwell HE. Comparative analyses of N-acylated homoserine Lactones reveal unique structural features that dictate their ability to activate or inhibit quorum sensing. Chembiochem. 2008 ;9:389-400.
Palmer AG, Blackwell HE. Deciphering a protolanguage for bacteria-host communication. Nature Chemical Biology. 2008 ;4:452-454.
Fowler SA, Stacy DM, Blackwell HE. Design and synthesis of macrocyclic peptomers as mimics of a quorum sensing signal from Staphylococcus aureus. Organic Letters. 2008 ;10:2329-2332.
Geske GD, Mattmann ME, Blackwell HE. Evaluation of a focused library of N-aryl L-homoserine lactones reveals a new set of potent quorum sensing modulators. Bioorganic & Medicinal Chemistry Letters. 2008 ;18:5978-5981.
Geske GD, O'Neill JC, Blackwell HE. Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria. Chemical Society Reviews. 2008 ;37:1432-1447.
Borlee BR, Geske GD, Robinson CJ, Blackwell HE, Handelsman J. Quorum-sensing signals in the microbial community of the cabbage white butterfly larval midgut. ISME Journal. 2008 ;2:1101-1111.
Mattmann ME, Geske GD, Worzalla GA, Chandler JR, Sappington KJ, Greenberg PE, Blackwell HE. Synthetic ligands that activate and inhibit a quorum-sensing regulator in Pseudomonas aeruginosa. Bioorganic & Medicinal Chemistry Letters. 2008 ;18:3072-3075.
2007
Chan YY, Bian HS, Tan TMC, Mattmann ME, Geske GD, Igarashi J, Hatano T, Suga H, Blackwell HE, Chua KL. Control of quorum sensing by a Burkholderia pseudomallei multidrug efflux pump. Journal of Bacteriology. 2007 ;189:4320-4324.
Gorske BC, Bastian BL, Geske GD, Blackwell HE. Local and tunable n ->pi* interactions regulate amide isomerism in the peptoid backbone. Journal of the American Chemical Society. 2007 ;129:8928-+.
Geske GD, O'Neill JC, Miller DM, Mattmann ME, Blackwell HE. Modulation of bacterial quorum sensing with synthetic ligands: Systematic evaluation of N-acylated homoserine lactones in multiple species and new insights into their mechanisms of action. Journal of the American Chemical Society. 2007 ;129:13613-13625.
Guzei IA, Spencer LC, Lin Q, Blackwell HE. N-{(Aminocarbonyl) (S)-4-nitrobenzyl methyl}-N-{ (R)-cyclohexyl (cyclohe xylaminocarbonyl)methyl}propanamide methanol solvate. Acta Crystallographica Section E-Structure Reports Online. 2007 ;63:O1892-O1894.
Geske GD, O'Neill JC, Blackwell HE. N-phenylacetanoyl-L-homoserine lactones can strongly antagonize or superagonize quorum sensing in. ACS Chemical Biology. 2007 ;2:315-U1.
Bowman MD, O'Neill JC, Stringer JR, Blackwell HE. Rapid identification of antibacterial agents effective against Staphylococcus aureus using small-molecule macroarrays. Chemistry & Biology. 2007 ;14:351-357.
O'Neill JC, Blackwell HE. Solid-phase and microwave-assisted syntheses of 2,5-diketopiperazines: Small molecules with great potential. Combinatorial Chemistry & High Throughput Screening. 2007 ;10:857-876.
2006
Bowman MD, Jacobson MM, Blackwell HE. Discovery of fluorescent cyanopyridine and deazalumazine dyes using small molecule macroarrays. Organic Letters. 2006 ;8:1645-1648.
Bowman MD, Jacobson MM, Pujanauski BG, Blackwell HE. Efficient synthesis of small molecule macroarrays: optimization of the macroarray synthesis platform and examination of microwave and conventional heating methods. Tetrahedron. 2006 ;62:4715-4727.
Gorske BC, Blackwell HE. Interception of quorum sensing in Staphylococcus aureus: a new niche for peptidomimetics (vol 4, pg 1441, 2006). Organic & Biomolecular Chemistry. 2006 ;4:2050.
Guzei IA, Gorske BC, Blackwell HE. N-[1-(Pentafluorophenyl)ethyl]-acetamide. Acta Crystallographica - Section C - Crystal Structure Communications. 2006 ;62:O286-O288.
Hollenbeck JJ, Wixson EN, Geske GD, Dodge MW, Tseng TA, Clauss AD, Blackwell HE. A new model for transitioning students from the undergraduate teaching laboratory to the research laboratory - The evolution of an intermediate organic synthesis laboratory course. Journal of Chemical Education. 2006 ;83:1835.
Lin Q, Blackwell HE. Rapid synthesis of diketopiperazine macroarrays via Ugi four-component reactions on planar solid supports. Chemical Communications. 2006 :2884.
Gorske BC, Blackwell HE. Tuning peptoid secondary structure with pentafluoroaromatic functionality: A new design paradigm for the construction of discretely folded peptoid structures. Journal of the American Chemical Society. 2006 ;128:14378.

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