All Department Publications

Found 332 results
Author Title Type [ Year(Asc)]
Filters: Author is Raines, R. T.  [Clear All Filters]
2000
Sweeney RY, Kelemen BR, Woycechowsky KJ, Raines RT. A highly active immobilized ribonuclease. Anal Biochem. 2000;286(2):312-4.
Park C, Raines RT. Origin of the 'inactivation' of ribonuclease A at low salt concentration. FEBS Lett. 2000;468(2-3):199-202.
Messmore JM, Raines RT. Pentavalent Organo-Vanadates as Transition State Analogues for Phosphoryl Transfer Reactions. J Am Chem Soc. 2000;122(41):9911-9916.
Friedman L, Higgin JJ, Moulder G, Barstead R, Raines RT, Kimble J. Prolyl 4-hydroxylase is required for viability and morphogenesis in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2000;97(9):4736-41.
Bretscher LE, Abel RL, Raines RT. A ribonuclease A variant with low catalytic activity but high cytotoxicity. J Biol Chem. 2000;275(14):9893-6.
Nilsson BL, Kiessling LL, Raines RT. Staudinger Ligation:  A Peptide from a Thioester and Azide. Organic Letters [Internet]. 2000;2:1939-1941. Available from: http://pubs.acs.org/doi/abs/10.1021/ol0060174
Messmore JM, Holmgren SK, Grilley JE, Raines RT. Sulfur shuffle: modulating enzymatic activity by thiol-disulfide interchange. Bioconjug Chem. 2000;11(3):408-13.
Leland PA, Staniszewski KE, Kim B, Raines RT. A synapomorphic disulfide bond is critical for the conformational stability and cytotoxicity of an amphibian ribonuclease. FEBS Lett. 2000;477(3):203-7.
1999
Mannino SJ, Jenkins CL, Raines RT. Chemical mechanism of DNA cleavage by the homing endonuclease I-PpoI. Biochemistry. 1999;38:16178-16186.
Schultz LW, Chivers PT, Raines RT. The CXXC motif: crystal structure of an active-site variant of Escherichia coli thioredoxin. Acta Crystallographica Section D-Biological Crystallography. 1999;55:1533-1538.
Kelemen BR, Raines RT. Extending the limits to enzymatic catalysis: Diffusion of ribonuclease A in one dimension. Biochemistry. 1999;38:5302-5307.
Quirk DJ, Raines RT. His - Asp catalytic dyad of ribonuclease A: Histidine pK(a) values in the wild-type, D121N, and D121A enzymes. Biophysical Journal. 1999;76:1571-1579.
Kelemen BR, Klink TA, Behlke MA, Eubanks SR, Leland PA, Raines RT. Hypersensitive substrate for ribonucleases. Nucleic Acids Research. 1999;27:3696-3701.
Holmgren SK, Bretscher LE, Taylor KM, Raines RT. A hyperstable collagen mimic. Chemistry & Biology. 1999;6:63-70.
Woycechowsky KJ, Wittrup KD, Raines RT. A small-molecule catalyst of protein folding in vitro and in vivo. Chemistry & Biology. 1999;6:871-879.
Soucek J, Raines RT, Haugg M, Raillard-Yoon SA, Benner SA. Structural changes to ribonuclease A and their effects on biological activity. Comparative Biochemistry and Physiology C-Pharmacology Toxicology & Endocrinology. 1999;123:103-111.
Kim BM, Schultz LW, Raines RT. Variants of ribonuclease inhibitor that resist oxidation. Protein Science. 1999;8:430-434.
1998
Holmgren SK, Taylor KM, Bretscher LE, Raines RT. Code for collagen's stability deciphered. Nature. 1998;392:666-667.
Fisher BM, Schultz LW, Raines RT. Coulombic effects of remote subsites on the active site of ribonuclease A. Biochemistry. 1998;37:17386-17401.
Fisher BM, Ha JH, Raines RT. Coulombic forces in protein-RNA interactions: Binding and cleavage by ribonuclease A and variants at Lys7, Arg10, and Lys66. Biochemistry. 1998;37:12121-12132.
Wittmayer PK, McKenzie JL, Raines RT. Degenerate DNA recognition by I-PpoI endonuclease. Gene. 1998;206:11-21.
Quirk DJ, Park C, Thompson JE, Raines RT. His - Asp catalytic dyad of ribonuclease A: Conformational stability of the wild-type, D121N, D121A, and H119A enzymes. Biochemistry. 1998;37:17958-17964.
Schultz LW, Quirk DJ, Raines RT. His - Asp catalytic dyad of ribonuclease A: Structure and function of the wild-type, D121N, and D121A enzymes. Biochemistry. 1998;37:8886-8898.
Shusta EV, Raines RT, Pluckthun A, Wittrup KD. Increasing the secretory capacity of Saccharomyces cerevisiae for production of single-chain antibody fragments. Nature Biotechnology. 1998;16:773-777.
Fisher BM, Grilley JE, Raines RT. A new remote subsite in ribonuclease A. Journal of Biological Chemistry. 1998;273:34134-34138.
Kothandaraman S, Hebert MC, Raines RT, Nibert ML. No role for pepstatin-A-sensitive acidic proteinases in reovirus infections of L or MDCK cells. Virology. 1998;251:264-272.
Raines RT. Ribonuclease A. Chemical Reviews. 1998;98:1045-1065.
Leland PA, Schultz LW, Kim BM, Raines RT. Ribonuclease A variants with potent cytotoxic activity. Proceedings of the National Academy of Sciences of the United States of America. 1998;95:10407-10412.
Schultz LW, Hargraves SR, Klink TA, Raines RT. Structure and stability of the P93G variant of ribonuclease A. Protein Science. 1998;7:1620-1625.
1997
Chivers PT, Prehoda KE, Raines RT. The CXXC motif: A rheostat in the active site. Biochemistry. 1997;36:4061-4066.
Chivers PT, Raines RT. General acid/base catalysis in the active site of Escherichia coli thioredoxin. Biochemistry. 1997;36:15810-15816.
Park SH, Raines RT. Green fluorescent protein as a signal for protein-protein interactions. Protein Science. 1997;6:2344-2349.
Chivers PT, Prehoda KE, Volkman BF, Kim BM, Markley JL, Raines RT. Microscopic pK(a) values of Escherichia coli thioredoxin. Biochemistry. 1997;36:14985-14991.
Raines RT. Nature's transitory covalent bond. Nature Structural Biology. 1997;4:424-427.
Laboissiere MCA, Sturley SL, Raines RT. Protein disulfide isomerase in spore germination and cell division. Biological Chemistry. 1997;378:431-437.
Matousek J, Kim JS, Soucek J, Riha J, Ribo M, Leland PA, Raines RT. Ribonucleases endowed with specific toxicity for spermatogenic layers. Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology. 1997;118:881-888.
1996
Eberhardt ES, Wittmayer PK, Templer BM, Raines RT. Contribution of a tyrosine side chain to ribonuclease A catalysis and stability. Protein Science. 1996;5:1697-1703.
Chivers PT, Laboissiere MCA, Raines RT. The CXXC motif: Imperatives for the formation of native disulfide bonds in the cell. EMBO Journal. 1996;15:2659-2667.
Soucek J, Marinov I, Benes J, Hilgert I, Matousek J, Raines RT. Immunosuppressive activity of bovine seminal ribonuclease and its mode of action. Immunobiology. 1996;195:271-285.
Eberhardt ES, Panasik N, Raines RT. Inductive effects on the energetics of prolyl peptide bond isomerization: Implications for collagen folding and stability. Journal of the American Chemical Society. 1996;118:12261-12266.
Ribo M, delCardayre SB, Raines RT, deLlorens R, Cuchillo CM. Production of human pancreatic ribonuclease in Saccharomyces cerevisiae and Escherichia coli. Protein Expression and Purification. 1996;7:253-261.
Wittmayer PK, Raines RT. Substrate binding and turnover by the highly specific I-PpoI endonuclease. Biochemistry. 1996;35:1076-1083.
1995
Attie AD, Raines RT. ANALYSIS OF RECEPTOR-LIGAND INTERACTIONS. Journal of Chemical Education. 1995;72:119-124.
Kim JS, Soucek J, Matousek J, Raines RT. CATALYTIC ACTIVITY OF BOVINE SEMINAL RIBONUCLEASE IS ESSENTIAL FOR ITS IMMUNOSUPPRESSIVE AND OTHER BIOLOGICAL-ACTIVITIES. Biochemical Journal. 1995;308:547-550.
Kim JS, Raines RT. DIBROMOBIMANE AS A FLUORESCENT CROSS-LINKING REAGENT. Analytical Biochemistry. 1995;225:174-176.
delCardayre SB, Ribo M, Yokel EM, Quirk DJ, Rutter WJ, Raines RT. ENGINEERING RIBONUCLEASE-A - PRODUCTION, PURIFICATION AND CHARACTERIZATION OF WILD-TYPE ENZYME AND MUTANTS AT GLN11. Protein Engineering. 1995;8:261-273.
Laboissiere MCA, Sturley SL, Raines RT. THE ESSENTIAL FUNCTION OF PROTEIN-DISULFIDE ISOMERASE IS TO UNSCRAMBLE NONNATIVE DISULFIDE BONDS. Journal of Biological Chemistry. 1995;270:28006-28009.
delCardayre SB, Raines RT. THE EXTENT TO WHICH RIBONUCLEASES CLEAVE RIBONUCLEIC-ACID. Analytical Biochemistry. 1995;225:176-178.
Thompson JE, Kutateladze TG, Schuster MC, Venegas FD, Messmore JM, Raines RT. Limits to catalysis by ribonuclease A. Bioorganic Chemistry. 1995;23:471-481.
Kim JS, Soucek J, Matousek J, Raines RT. Mechanism of ribonuclease cytotoxicity. Journal of Biological Chemistry. 1995;270:31097-31102.

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