All Faculty and Research Staff Publications

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2000
Porter EA, Wang X, Lee H-S, Weisblum B, Gellman SH. Antibiotics: Non-hemolytic β-amino-acid oligomers. Nature. 2000 ;404:565.
Fisk JD, Powell DR, Gellman SH. Control of hairpin formation via proline configuration in parallel β-sheet model systems. Journal of the American Chemical Society. 2000 ;122:5443-5447.
Espinosa JF, Gellman SH. A designed β-hairpin containing a natural hydrophobic cluster. Angewandte Chemie-International Edition. 2000 ;39:2330-2333.
Christianson LA, Lucero MJ, Appella DH, Klein DA, Gellman SH. Improved treatment of cyclic β-amino acids and successful prediction of β-peptide secondary structure using a modified force field: AMBER*C. Journal of Computational Chemistry. 2000 ;21:763-773.
Yu SM, McQuade DT, Quinn MA, Hackenberger CPR, Krebs MP, Polans AS, Gellman SH. An improved tripod amphiphile for membrane protein solubilization. Protein Science. 2000 ;9:2518-2527.
Huck BR, Fisk JD, Gellman SH. Promotion of sheet formation in α-peptide strands by a β-peptide reverse turn. Organic Letters. 2000 ;2:2607-2610.
D. McQuade T, Quinn MA, Yu SM, Polans AS, Krebs MP, Gellman SH. Rigid amphiphiles for membrane protein manipulation. Angewandte Chemie-International Edition. 2000 ;39:758-761.
Appella DH, LePlae PR, Raguse TL, Gellman SH. (R,R,R)-2,5-Diaminocylohexanecarboxylic Acid, a Building Block for Water-Soluble, Helix-Forming β-Peptides. Journal of Organic Chemistry. 2000 ;65:4766-4769.
Barchi, Jr. JJ, Huang X, Appella DH, Christianson LA, Durell SR, Gellman SH. Solution conformations of helix-forming β-amino acid homooligomers. Journal of the American Chemical Society. 2000 ;122:2711-2718.
Gardner RR, McKay SL, Gellman SH. Solvent-Dependent Stabilization of the E Configuration of Propargylic Secondary Amides. Organic Letters. 2000 ;2:2335-2338.
Chung YJ, Huck BR, Christianson LA, Stanger HE, Krauthäuser S, Powell DR, Gellman SH. Stereochemical Control of Hairpin Formation in β-Peptides Containing Dinipecotic Acid Reverse Turn Segments. Journal of the American Chemical Society. 2000 ;122:3995-4004.
1999
Gardner RR, Liang GB, Gellman SH. beta-turn and beta-hairpin mimicry with tetrasubstituted alkenes. Journal of the American Chemical Society. 1999 ;121:1806-1816.
Yang JH, Christianson LA, Gellman SH. Comparison of an HXH three-center hydrogen bond with alternative two-center hydrogen bonds in a model system. Organic Letters. 1999 ;1:11-13.
Daugherty DL, Gellman SH. A fluorescence assay for leucine zipper dimerization: Avoiding unintended consequences of fluorophore attachment. Journal of the American Chemical Society. 1999 ;121:4325-4333.
Appella DH, Barchi JJ, Durell SR, Gellman SH. Formation of short, stable helices in aqueous solution by beta-amino acid hexamers. Journal of the American Chemical Society. 1999 ;121:2309-2310.
Syud FA, Espinosa JF, Gellman SH. NMR-based quantification of beta-sheet populations in aqueous solution through use of reference peptides for the folded and unfolded states. Journal of the American Chemical Society. 1999 ;121:11577-11578.
Huck BR, Langenhan JM, Gellman SH. Non-hydrogen-bonded secondary structure in beta-peptides: Evidence from circular dichroism of (S)-pyrrolidine-3-carboxylic acid oligomers and (S)-nipecotic acid oligomers. Organic Letters. 1999 ;1:1717-1720.
Appella DH, Christianson LA, Karle IL, Powell DR, Gellman SH. Synthesis and characterization of trans-2-aminocyclohexanecarboxylic acid oligomers: An unnatural helical secondary structure and implications for beta-peptide tertiary structure. Journal of the American Chemical Society. 1999 ;121:6206-6212.
Appella DH, Christianson LA, Klein DA, Richards MR, Powell DR, Gellman SH. Synthesis and structural characterization of helix-forming beta-peptides: trans-2-aminocyclopentanecarboxylic acid oligomers. Journal of the American Chemical Society. 1999 ;121:7574-7581.
1998
Daugherty DL, Rozema D, Hanson PE, Gellman SH. Artificial chaperone-assisted refolding of citrate synthase. Journal of Biological Chemistry. 1998 ;273:33961-33971.
Chung YJ, Christianson LA, Stanger HE, Powell DR, Gellman SH. A beta-peptide reverse turn that promotes hairpin formation. Journal of the American Chemical Society. 1998 ;120:10555-10556.
Yang JH, Gellman SH. Energetic superiority of two-center hydrogen bonding relative to three-center hydrogen bonding in a model system. Journal of the American Chemical Society. 1998 ;120:9090-9091.
Gellman SH. Foldamers: A manifesto. Accounts of Chemical Research. 1998 ;31:173-180.
Hanson PE, Gellman SH. Mechanistic comparison of artificial-chaperone-assisted and unassisted refolding of urea-denatured carbonic anhydrase B. Folding and Design. 1998 ;3:457-468.
Gellman SH. Minimal model systems for beta sheet secondary structure in proteins. Current Opinion in Chemical Biology. 1998 ;2:717-725.
Stanger HE, Gellman SH. Rules for antiparallel beta-sheet design: D-Pro-Gly is superior to L-Asn-Gly for beta-hairpin nucleation. Journal of the American Chemical Society. 1998 ;120:4236-4237.
Applequist J, Bode KA, Appella DH, Christianson LA, Gellman SH. Theoretical and experimental circular dichroic spectra of the novel helical foldamer poly (1R,2R)-trans-2-aminocyclopentanecarboxylic acid. Journal of the American Chemical Society. 1998 ;120:4891-4892.
Schenck HL, Gellman SH. Use of a designed triple-stranded antiparallel beta-sheet to probe beta-sheet cooperativity in aqueous solution. Journal of the American Chemical Society. 1998 ;120:4869-4870.
1997
Krauthauser S, Christianson LA, Powell DR, Gellman SH. Antiparallel sheet formation in beta-peptide foldamers: Effects of beta-amino acid substitution on conformational preference. Journal of the American Chemical Society. 1997 ;119:11719-11720.
Yang J, Christianson LA, Gellman SH. Energetic superiority of two-center over three-center (bifurcated) hydrogen bonds in solution. FASEB Journal. 1997 ;11:A1324-A1324.
Gellman SH, Cowburn D, McDonnell JM. Hairpin turns. Chemical & Engineering News. 1997 ;75:6-6.
McQuade DT, McKay SL, Powell DR, Gellman SH. Indifference to hydrogen bonding in a family of secondary amides. Journal of the American Chemical Society. 1997 ;119:8528-8532.
Haque TS, Gellman SH. Insights on beta-hairpin stability in aqueous solution from peptides with enforced type I' and type II' beta-turns. Journal of the American Chemical Society. 1997 ;119:2303-2304.
Gellman SH. Introduction: Molecular Recognition. Chemical Reviews (Washington, D. C.). 1997 ;97:1231-1232.
Gardner RR, Christianson LA, Gellman SH. Quantitative analysis of hydrophobically induced folding in a minimal model system. Journal of the American Chemical Society. 1997 ;119:5041-5042.
Appella DH, Christianson LA, Klein DA, Powell DR, Huang XL, Barchi JJ, Gellman SH. Residue-based control of helix shape in beta-peptide oligomers. Nature. 1997 ;387:381-384.
Gardner RR, Gellman SH. Secondary effects in flexible hydrogen bonding networks. Tetrahedron. 1997 ;53:9881-9890.
Holmgren SK, Savage PB, Desper JM, Schladetzky KD, Powell DR, Gellman SH. Steric control of oxidation selectivity in macrocyclic phosphine oxide-dithioethers. Tetrahedron. 1997 ;53:12249-12262.
1996
Rozema D, Gellman SH. Artificial chaperone-assisted refolding of carbonic anhydrase B. Journal of Biological Chemistry. 1996 ;271:3478-3487.
Rozema D, Gellman SH. Artificial chaperone-assisted refolding of denatured-reduced lysozyme: Modulation of the competition between renaturation and aggregation. Biochemistry. 1996 ;35:15760-15771.
Appella DH, Christianson LA, Karle IL, Powell DR, Gellman SH. beta-peptide foldamers: Robust Helix formation in a new family of beta-amino acid oligomers. Journal of the American Chemical Society. 1996 ;118:13071-13072.
Gellman SH, Haque TS, Newcomb LF. New evidence that the hydrophobic effect and dispersion are not major driving forces for nucleotide base stacking. Biophysical Journal. 1996 ;71:3523-3525.
Schenck HL, Dado GP, Gellman SH. Redox-triggered secondary structure changes in the aggregated states of a designed methionine-rich peptide. Journal of the American Chemical Society. 1996 ;118:12487-12494.
Haque TS, Little JC, Gellman SH. Stereochemical requirements for beta-hairpin formation: Model studies with four-residue peptides and depsipeptides. Journal of the American Chemical Society. 1996 ;118:6975-6985.
Powell DR, Hanson PE, Gellman SH. (Z)-2-(Benzoyl-aci-nitro)-2-phenylacetonitrile. Acta Crystallographica - Section C - Crystal Structure Communications. 1996 ;C52:2945-2946.

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