All Faculty and Research Staff Publications

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Wright G, Higgin JJ, Raines RT, Steenbergen C, Murphy E. Activation of the prolyl hydroxylase oxygen-sensor results in induction of GLUT1, heme oxygenase-1, and nitric-oxide synthase proteins and confers protection from metabolic inhibition to cardiomyocytes. Journal of Biological Chemistry. 2003 ;278:20235-20239.
Park C, Raines RT. Catalysis by ribonuclease A is limited by the rate of substrate association. Biochemistry. 2003 ;42:3509-3518.
Woycechowsky KJ, Hook BA, Raines RT. Catalysis of protein folding by an immobilized small-molecule dithiol. Biotechnology Progress. 2003 ;19:1307-1314.
Dickson KA, Dahlberg CL, Raines RT. Compensating effects on the cytotoxicity of ribonuclease A variants. Archives of Biochemistry & Biophysics. 2003 ;415:172-177.
Matousek J, Soucek J, Slavik T, Tomanek M, Lee JE, Raines RT. Comprehensive comparison of the cytotoxic activities of onconase and bovine seminal ribonuclease. Comparative Biochemistry & Physiology. 2003 :343-356.
Lee JE, Raines RT. Contribution of active-site residues to the function of onconase, a ribonuclease with antitumoral activity. Biochemistry. 2003 ;42:11443-11450.
Plainkum P, Fuchs SM, Wiyakrutta S, Raines RT. Creation of a zymogen. Nature Structural Biology. 2003 ;10:115-119.
Woycechowsky KJ, Raines RT. The CXC motif: A functional mimic of protein disulfide isomerase. Biochemistry. 2003 ;42:5387-5394.
Jenkins CL, Bretscher LE, Guzei IA, Raines RT. Effect of 3-hydroxyproline residues on collagen stability. Journal of the American Chemical Society. 2003 ;125:6422-6427.
Hinderaker MP, Raines RT. An electronic effect on protein structure. Protein Science. 2003 ;12:1188-1194.
Smith BD, Soellner MB, Raines RT. Potent inhibition of ribonuclease A by oligo(vinylsulfonic acid). Journal of Biological Chemistry. 2003 ;278:20934-20938.
Nilsson BL, Hondal RJ, Soellner MB, Raines RT. Protein assembly by orthogonal chemical ligation methods. Journal of the American Chemical Society. 2003 ;125:5268-5269.
Arnold U, Hinderaker MP, Koditz J, Golbik R, Ulbrich-Hofmann R, Raines RT. Protein prosthesis: A nonnatural residue accelerates folding and increases stability. Journal of the American Chemical Society. 2003 ;125:7500-7501.
Haigis MC, Kurten EL, Raines RT. Ribonuclease inhibitor as an intracellular sentry. Nucleic Acids Research. 2003 ;31:1024-1032.
Haigis MC, Raines RT. Secretory ribonucleases are internalized by a dynamin-independent endocytic pathway. Journal of Cell Science. 2003 ;116:313-324.
Soellner MB, Dickson KA, Nilsson BL, Raines RT. Site-specific protein immobilization by Staudinger ligation. Journal of the American Chemical Society. 2003 ;125:11790-11791.
Hodges JA, Raines RT. Stereoelectronic effects on collagen stability: The dichotomy of 4-fluoroproline diastereomers. Journal of the American Chemical Society. 2003 ;125:9262-9263.
Higgin JJ, Yakovlev GI, Mitkevich VA, Makarov AA, Raines RT. Zinc(II)-mediated inhibition of a ribonuclease by an N-hydroxyurea nudeotide. Bioorganic & Medicinal Chemistry Letters. 2003 ;13:409-412.
DeRider ML, Wilkens SJ, Waddell MJ, Bretscher LE, Weinhold F, Raines RT, Markley JL. Collagen stability: Insights from NMR spectroscopic and hybrid density functional computational investigations of the effect of electronegative substituents on prolyl ring conformations. Journal of the American Chemical Society. 2002 ;124:2497-2505.
Haigis MC, Haag ES, Raines RT. Evolution of ribonuclease inhibitor by exon duplication. Molecular Biology & Evolution. 2002 ;19:959-963.
Abel RL, Haigis MC, Park C, Raines RT. Fluorescence assay for the binding of ribonuclease A to the ribonuclease inhibitor protein. Analytical Biochemistry. 2002 ;306:100-107.
Park SH, Raines RT. Genetic screen to dissect protein-protein interactions: ribonuclease inhibitor-ribonuclease A as a model system. Methods. 2002 ;28:346-352.
Jenkins CL, Raines RT. Insights on the conformational stability of collagen. Natural Product Reports. 2002 ;19:49-59.
Haigis MC, Kurten EL, Abel RL, Raines RT. KFERQ sequence in ribonuclease A-mediated cytotoxicity. Journal of Biological Chemistry. 2002 ;277:11576-11581.
Gellman SH, Raines RT. Model systems - This year's model - Editorial overview. Current Opinion in Chemical Biology. 2002 ;6:727-728.
Arnold U, Hinderaker MP, Nilsson BL, Huck BR, Gellman SH, Raines RT. Protein prosthesis: A semisynthetic enzyme with a beta-peptide reverse turn. Journal of the American Chemical Society. 2002 ;124:8522-8523.
Leland PA, Staniszewski KE, Park C, Kelemen BR, Raines RT. The ribonucleolytic activity of angiogenin. Biochemistry. 2002 ;41:1343-1350.
Hondal RJ, Raines RT. Semisynthesis of proteins containing selenocysteine. Protein Sensors And Reactive Oxygen Species, Pt A. 2002 ;347:70-83.
Soellner MB, Nilsson BL, Raines RT. Staudinger ligation of alpha-azido acids retains stereochemistry. Journal of Organic Chemistry. 2002 ;67:4993-4996.
Umezawa N, Gelman MA, Haigis MC, Raines RT, Gellman SH. Translocation of a beta-peptide across cell membranes. Journal of the American Chemical Society. 2002 ;124:368-369.
Sevcik J, Urbanikova L, Leland PA, Raines RT. X-ray structure of two crystalline forms of a Streptomycete ribonuclease with cytotoxic activity. Journal of Biological Chemistry. 2002 ;277:47325-47330.
Abel R, Hondal RJ, Raines RT. Active-site variants of ribonuclease A. Biochemistry. 2001 ;40:8647-8647.
Leland PA, Raines RT. Cancer chemotherapy - ribonucleases to the rescue. Chemistry & Biology. 2001 ;8:405-413.
Jardine AM, Leonidas DD, Jenkins JL, Park C, Raines RT, Acharya KR, Shapiro R. Cleavage of 3 ',5 '-pyrophosphate-linked dinucleotides by ribonuclease A and angiogenin. Biochemistry. 2001 ;40:10262-10272.
Bretscher LE, Jenkins CL, Taylor KM, DeRider ML, Raines RT. Conformational stability of collagen relies on a stereoelectronic effect. Journal of the American Chemical Society. 2001 ;123:777-778.
Chandran SS, Taylor KM, Raines RT. Contribution of individual modules of a leucine-rich repeat protein to its affinity for other proteins. Biochemistry. 2001 ;40:8615-8616.
Kersteen EA, Raines RT. Contribution of tertiary amides to the conformational stability of collagen triple helices. Biopolymers. 2001 ;59:24-28.
Park C, Schultz LW, Raines RT. Contribution of the active site histidine residues of ribonuclease A to nucleic acid binding. Biochemistry. 2001 ;40:4949-4956.
Leland PA, Staniszewski KE, Kim BM, Raines RT. Endowing human pancreatic ribonuclease with toxicity for cancer cells. Journal of Biological Chemistry. 2001 ;276:43095-43102.
Park C, Kelemen BR, Klink TA, Sweeney RY, Behlke MA, Eubanks SR, Raines RT. Fast, facile, hypersensitive assays for ribonucleolytic activity. In: Vol. 341. San Diego: Academic Press Inc; 2001. pp. 81-94.
Klink TA, Vicentini AM, Hofsteenge J, Raines RT. High-level soluble production and characterization of porcine ribonuclease inhibitor. Protein Expression & Purification. 2001 ;22:174-179.
Nilsson BL, Kiessling LL, Raines RT. High-yielding Staudinger ligation of a phosphinothioester and azide to form a peptide. Organic Letters. 2001 ;3:9-12.
Park C, Raines RT. Quantitative analysis of the effect of salt concentration on enzymatic catalysis. Journal of the American Chemical SocietyJournal of the American Chemical Society. 2001 ;123:11472-11479.
Plainkum P, Fuchs SM, Raines RT. A ribonuclease zymogen as a chemotherapeutic for malaria. FASEB Journal. 2001 ;15:A538-A538.
Lee JWE, Raines RT. Role of lysine residues in the active site of onconase. Biochemistry. 2001 ;40:8627-8627.