All Faculty and Research Staff Publications

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2004
Woll MG, Gellman SH. Backbone thioester exchange: A new approach to evaluating higher order structural stability in polypeptides. Journal of the American Chemical Society. 2004 ;126:11172-11174.
Gelman MA, Weisblum B, Lynn DM, Gellman SH. Biocidal activity of polystyrenes that are cationic by virtue of protonation. Organic Letters. 2004 ;6:557-560.
Langenhan JM, Gellman SH. Effects of alternative side chain pairings and reverse turn sequences on antiparallel sheet structure in beta-peptide hairpins. Organic Letters. 2004 ;6:937-940.
Lai JR, Fisk JD, Weisblum B, Gellman SH. Hydrophobic core repacking in a coiled-coil dimer via phage display: Insights into plasticity and specificity at a protein-protein interface. Journal of the American Chemical Society. 2004 ;126:10514-10515.
Peelen TJ, Chi YG, English EP, Gellman SH. Synthesis of 4,4-disubstituted 2-aminocyclopentanecarboxylic acid derivatives and their incorporation into 12-helical beta-peptides. Organic Letters. 2004 ;6:4411-4414.
Hayen A, Schmitt MA, Ngassa FN, Thomasson KA, Gellman SH. Two helical conformations from a single foldamer backbone: "Split personality" in short alpha/beta-peptides. Angewandte Chemie-International Edition. 2004 ;43:505-510.
Schmitt MA, Weisblum B, Gellman SH. Unexpected relationships between structure and function in alpha,beta-peptides: Antimicrobial foldamers with heterogeneous backbones. Journal of the American Chemical Society. 2004 ;126:6848-6849.
2003
Park JS, Lee HS, Lai JR, Kim BM, Gellman SH. Accommodation of alpha-substituted residues in the beta-peptide 12-helix: Expanding the range of substitution patterns available to a foldamer scaffold. Journal of the American Chemical Society. 2003 ;125:8539-8545.
Schinnerl M, Murray JK, Langenhan JM, Gellman SH. Asymmetric synthesis of a new helix-forming beta-amino acid: trans-4-aminopiperidine-3-carboxylic acid. European Journal of Organic Chemistry. 2003 :721-726.
Eldred SE, Stone DA, Gellman SH, Stahl SS. Catalytic transamidation under moderate conditions. Journal of the American Chemical Society. 2003 ;125:3422-3423.
Potocky TB, Menon AK, Gellman SH. Cytoplasmic and nuclear delivery of a TAT-derived peptide and a beta-peptide after endocytic uptake into HeLa cells. Journal of Biological Chemistry. 2003 ;278:50188-50194.
Lee H-S, Park J-S, Kim BM, Gellman SH. Efficient Synthesis of Enantiomerically Pure β2-Amino Acids via Chiral Isoxazolidinones. Journal of Organic Chemistry. 2003 ;68:1575-1578.
Raguse TL, Lai JR, Gellman SH. Environment-independent 14-helix formation in short beta-peptides: Striking a balance between shape control and functional diversity. Journal of the American Chemical Society. 2003 ;125:5592-5593.
Syud FA, Stanger HE, Mortell HS, Espinosa JF, Fisk JD, Fry CG, Gellman SH. Influence of strand number on antiparallel beta-sheet stability in designed three- and four-stranded beta-sheets. Journal of Molecular Biology. 2003 ;326:553-568.
Epand RF, Umezawa N, Porter EA, Gellman SH, Epand RM. Interactions of the antimicrobial beta-peptide beta-17 with phospholipid vesicles differ from membrane interactions of magainins. European Journal of Biochemistry. 2003 ;270:1240-1248.
Bruckner AM, Chakraborty P, Gellman SH, Diederichsen U. Molecular architecture with functionalized beta-peptide helices. Angewandte Chemie-International Edition. 2003 ;42:4395-4399.
Langenhan JM, Guzei IA, Gellman SH. Parallel sheet secondary structure in beta-peptides. Angewandte Chemie-International Edition. 2003 ;42:2402-2405.
Langenhan JM, Gellman SH. Preparation of protected syn-alpha,beta-dialkyl beta-amino acids that contain polar side chain functionality. Journal of Organic Chemistry. 2003 ;68:6440-6443.
Lai JR, Gellman SH. Reinvestigation of the proposed folding and self-association of the Neuropeptide Head Activator. Protein Science. 2003 ;12:560-566.
Huck BR, Fisk JD, Guzei IA, Carlson HA, Gellman SH. Secondary Structural Preferences of 2,2-Disubstituted Pyrrolidine-4-carboxylic Acid Oligomers: β-Peptide Foldamers that Cannot Form Internal Hydrogen Bonds. Journal of the American Chemical Society. 2003 ;125:9035-9037.
Gelman MA, Richter S, Cao H, Umezawa N, Gellman SH, Rana TM. Selective binding of TAR RNA by a tat-derived beta-peptide. Organic Letters. 2003 ;5:3563-3565.
Gellman SH. Structure and function in b-peptide foldamers. Polymer Preprints. 2003 ;44:461.
Bruckner AM, Garcia M, Marsh A, Gellman SH, Diederichsen U. Synthesis of novel nucleo-beta-amino acids and nucleobase-functionalized beta-peptides. European Journal of Organic Chemistry. 2003 :3555-3561.
2002
Espinosa JF, Syud FA, Gellman SH. Analysis of the factors that stabilize a designed two-stranded antiparallel beta-sheet. Protein Science. 2002 ;11:1492-1505.
Gellman SH. Beta-peptide foldamers show biomedical potential. sp2. 2002 ;1:30-31.
Lai JR, Huck BR, Weisblum B, Gellman SH. Design of non-cysteine-containing antimicrobial beta-hairpins: Structure-activity relationship studies with linear protegrin-1 analogues. Biochemistry. 2002 ;41:12835-12842.
Raguse TL, Lai JR, Gellman SH. Evidence that the beta-peptide 14-Helix is Stabilized by beta(3)-residues with side-chain branching adjacent to the beta-carbon atom. Helvetica Chimica Acta. 2002 ;85:4154-4164.
Knight SMG, Umezawa N, Lee HS, Gellman SH, Kay BK. A fluorescence polarization assay for the identification of inhibitors of the p53-DM2 protein-protein interaction. Analytical Biochemistry. 2002 ;300:230-236.
Porter EA, Weisblum B, Gellman SH. Mimicry of host-defense peptides by unnatural oligomers: Antimicrobial beta-peptides. Journal of the American Chemical Society. 2002 ;124:7324-7330.
Gellman SH, Woolfson DN. Mini-proteins Trp the light fantastic. Nature Structural Biology. 2002 ;9:408-410.
Gellman SH, Raines RT. Model systems - This year's model - Editorial overview. Current Opinion in Chemical Biology. 2002 ;6:727-728.
Arnold U, Hinderaker MP, Nilsson BL, Huck BR, Gellman SH, Raines RT. Protein prosthesis: A semisynthetic enzyme with a beta-peptide reverse turn. Journal of the American Chemical Society. 2002 ;124:8522-8523.
Hilario J, Kubelka J, Syud FA, Gellman SH, Keiderling TA. Spectroscopic characterization of selected β-sheet hairpin models. Biopolymers. 2002 ;61:233-236.
Woll MG, Fisk JD, LePlae PR, Gellman SH. Stereoselective synthesis of 3-substituted 2-aminocyclopentanecarboxylic acid derivatives and their incorporation into short 12-helical beta-peptides that fold in water. Journal of the American Chemical Society. 2002 ;124:12447-12452.
Raguse TL, Porter EA, Weisblum B, Gellman SH. Structure-activity studies of 14-helical antimicrobial beta-peptides: Probing the relationship between conformational stability and antimicrobial potency. Journal of the American Chemical Society. 2002 ;124:12774-12785.
Porter EA, Wang XF, Schmitt MA, Gellman SH. Synthesis and 12-helical secondary structure of beta-peptides containing (2R,3R)-aminoproline. Organic Letters. 2002 ;4:3317-3319.
LePlae PR, Fisk JD, Porter EA, Weisblum B, Gellman SH. Tolerance of acyclic residues in the beta-peptide 12-helix: Access to diverse side-chain arrays for biological applications. Journal of the American Chemical Society. 2002 ;124:6820-6821.
Umezawa N, Gelman MA, Haigis MC, Raines RT, Gellman SH. Translocation of a beta-peptide across cell membranes. Journal of the American Chemical Society. 2002 ;124:368-369.
2001
Cheng RP, Gellman SH, DeGrado WF. beta-peptides: From structure to function. Chemical Reviews. 2001 ;101:3219-3232.
McKay SL, Haptonstall B, Gellman SH. Beyond the hydrophobic effect: Attractions involving heteroaromatic rings in aqueous solution. Journal of the American Chemical Society. 2001 ;123:1244-1245.
Lee HS, Syud FA, Wang XF, Gellman SH. Diversity in short beta-peptide 12-helices: High-resolution structural analysis in aqueous solution of a hexamer containing sulfonylated pyrrolidine residues. Journal of the American Chemical Society. 2001 ;123:7721-7722.
Lee HS, LePlae PR, Porter EA, Gellman SH. An efficient route to either enantiomer of orthogonally protected trans-3-aminopyrrolidine-4-carboxylic acid. Journal of Organic Chemistry. 2001 ;66:3597-3599.
LePlae PR, Umezawa N, Lee HS, Gellman SH. An efficient route to either enantiomer of trans-2-aminocyclopentanecarboxylic acid. Journal of Organic Chemistry. 2001 ;66:5629-5632.
Langenhan JM, Fisk JD, Gellman SH. Evaluation of hydrogen bonding complementarity between a secondary sulfonamide and an alpha-amino acid residue. Organic Letters. 2001 ;3:2559-2562.
Espinosa JF, Munoz V, Gellman SH. Interplay between hydrophobic cluster and loop propensity in beta-hairpin formation. Journal of Molecular Biology. 2001 ;306:397-402.
Syud FA, Stanger HE, Gellman SH. Interstrand side chain-side chain interactions in a designed beta-hairpin: Significance of both lateral and diagonal pairings. Journal of the American Chemical Society. 2001 ;123:8667-8677.
Stanger HE, Syud FA, Espinosa JF, Giriatt I, Muir T, Gellman SH. Length-dependent stability and strand length limits in antiparallel beta-sheet secondary structure. Proceedings of the National Academy of Sciences of the United States of America. 2001 ;98:12015-12020.
Fisk JD, Gellman SH. A parallel beta-sheet model system that folds in water. Journal of the American Chemical Society. 2001 ;123:343-344.
Woll MG, Lai JR, Guzei IA, Taylor SJC, Smith MEB, Gellman SH. Parallel sheet secondary structure in gamma-peptides. Journal of the American Chemical Society. 2001 ;123:11077-11078.
Arnold U, Hinderaker MP, Nilsson BL, Huck BR, Gellman SH, Raines RT. Semisynthesis of proteins containing nonnatural modules. Biochemistry. 2001 ;40:8627-8628.

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