All Faculty and Research Staff Publications

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Potocky TB, Silvius J, Menon AK, Gellman SH. HeLa cell entry by guanidinium-rich β-peptides: importance of specific cation-cell surface interactions. Chembiochem. 2007 ;8:917-926.
Choi SH, Guzei IA, Gellman SH. Helical secondary structures in alpha/beta-peptides by crystallographic characterization. Biopolymers. 2007 ;88:607-607.
Horne SW, Price JL, Keck JL, Gellman SH. Helix Bundle Quaternary Structure from α/β-Peptide Foldamers. Journal of the American Chemical Society. 2007 ;129:4178-4180.
Price JL, Home WS, Gellman SH. Heterogeneous helix-bundle quaternary structure formed by alpha/beta-peptide foldamers and alpha-peptides. Biopolymers. 2007 ;88:568-568.
Schmitt MA, Weisblum B, Gellman SH. Interplay among folding, sequence, and lipophilicity in the antibacterial and hemolytic activities of alpha/beta-peptides. Journal of the American Chemical Society. 2007 ;129:417-428.
Pomerantz WC, Pizzey C, Yuwono V, Paramanov S, Hartgerink J, Gellman SH, Abbott NL. Lyotropic liquid crystals from designed helical beta peptides. Biopolymers. 2007 ;88:570-570.
Mowery BP, Lee SE, Kissounko DA, Epand RF, Epand RM, Weisblum B, Stahl SS, Gellman SH. Mimicry of antimicrobial host-defense peptides by random copolymers. Journal of the American Chemical Society. 2007 ;129:15474-15476.
Lee M-R, Raguse TL, Schinnerl M, Pomerantz WC, Wang X, Wipf P, Gellman SH. Origins of the high 14-helix propensity of cyclohexyl-rigidified residues in β-peptides. Organic Letters. 2007 ;9:1801-1804.
Murray JK, Gellman SH. Parallel synthesis of peptide libraries using microwave irradiation. Nature Protocols. 2007 ;2:624-631.
Chi Y, English EP, Pomerantz WC, Horne SW, Joyce LA, Alexander LR, Fleming WS, Hopkins EA, Gellman SH. Practical synthesis of enantiomerically pure beta(2)-amino acids via proline-catalyzed diastereoselective aminomethylation of aldehydes. Journal of the American Chemical Society. 2007 ;129:6050-6055.
Pomerantz WC, Cadwell KD, Hsu Y-J, Gellman SH, Abbott NL. Sequence dependent behavior of amphiphilic beta-peptides on gold surfaces. Chemistry of Materials. 2007 ;19:4436-4441.
Cornilescu G, Hadley EB, Woll MG, Markley JL, Gellman SH, Cornilescu CC. Solution structure of a small protein containing a fluorinated side chain in the core. Protein Science. 2007 ;16:14-19.
Murray JK, Gellman SH. Targeting protein-protein interactions: Lessons from p53/MDM2. Biopolymers. 2007 ;88:657-686.
Hadley EB, Witek AM, Freire F, Peoples AJ, Gellman SH. Thermodynamic analysis of β-sheet secondary structure by backbone thioester exchange. Angewandte Chemie-International Edition. 2007 ;46:7056-7059.
Kissounko DA, Hoerter JM, Guzei IA, Cui Q, Gellman SH, Stahl SS. Ti-IV-mediated reactions between primary amines and secondary carboxamides: Amidine formation versus transamidation. Journal of the American Chemical Society. 2007 ;129:1776-1783.
Pal S, Wu J, Murray JK, Gellman SH, Wozniak MA, Keely PJ, Boyer ME, Gomez TM, Hasso SM, Fallon JF, et al. An antiangiogenic neurokinin-B/thromboxane A2 regulatory axis. Journal of Cell Biology. 2006 ;174:1047-1058.
Karlsson AJ, Pomerantz WC, Weisblum B, Gellman SH, Palecek SP. Antifungal activity from 14-helical β-peptides. Journal of the American Chemical Society. 2006 ;128:12630-12631.
Hadley EB, Gellman SH. An antiparallel alpha-helical coiled-coil model system for rapid assessment of side-chain recognition at the hydrophobic interface. Journal of the American Chemical Society. 2006 ;128:16444-16445.
Chi Y, Gellman SH. Enantioselective Organocatalytic Aminomethylation of Aldehydes: A Role for Ionic Interactions and Efficient Access to β2-Amino Acids. Journal of the American Chemical Society. 2006 ;128:6804-6805.
Pomerantz WC, Abbott NL, Gellman SH. Lyotropic Liquid Crystals from Designed Helical β-Peptides. Journal of the American Chemical Society. 2006 ;128:8730-8731.
Hoerter JM, Otte KM, Gellman SH, Stahl SS. Mechanism of Al-III-catalyzed transamidation of unactivated secondary carboxamides. Journal of the American Chemical Society. 2006 ;128:5177-5183.
Murray JK, Gellman SH. Microwave-assisted parallel synthesis of a 14-helical beta-peptide library. Journal of Combinatorial Chemistry. 2006 ;8:58-65.
Schmitt MA, Choi SH, Guzei IA, Gellman SH. New helical foldamers: Heterogeneous backbones with 1 : 2 and 2 : 1 alpha :beta-amino acid residue patterns. Journal of the American Chemical Society. 2006 ;128:4538-4539.
English EP, Chumanov RS, Gellman SH, Compton T. Rational development of beta-peptide inhibitors of human cytomegalovirus entry. Journal of Biological Chemistry. 2006 ;281:2661-2667.
Epand RF, Schmitt MA, Gellman SH, Epand RM. Role of membrane lipids in the mechanism of bacterial species selective toxicity by two α/β-antimicrobial peptides. Biochim. Biophys. Acta, Biomembr. 2006 ;1758:1343-1350.
Lai JR, Epand RF, Weisblum B, Epand RM, Gellman SH. Roles of salt and conformation in the biological and physicochemical behavior of protegrin-1 and designed analogues: Correlation of antimicrobial, hemolytic, and lipid bilayer-perturbing activities. Biochemistry. 2006 ;45:15718-15730.
Woll MG, Hadley EB, Mecozzi S, Gellman SH. Stabilizing and destabilizing effects of phenylalanine -> F-5-phenylalanine mutations on the folding of a small protein. Journal of the American Chemical Society. 2006 ;128:15932-15933.
Gellman SH. Structure and function in foldamers. Pept. Sci. 2006 ;43rd:72.
Fisk JD, Schmitt MA, Gellman SH. Thermodynamic Analysis of Autonomous Parallel β-Sheet Formation in Water. Journal of the American Chemical Society. 2006 ;128:7148-7149.
Rathore N, Gellman SH, de Pablo JJ. Thermodynamic stability of beta-peptide helices and the role of cyclic residues. Biophysical Journal. 2006 ;91:3425-3435.
Murray JK, Gellman SH. Application of microwave irradiation to the synthesis of 14-helical beta-peptides. Organic Letters. 2005 ;7:1517-1520.
Espinosa JF, Syud FA, Gellman SH. An autonomously folding beta-hairpin derived from the human YAP65 WW domain: Attempts to define a minimum ligand-binding motif. Biopolymers. 2005 ;80:303-311.
Epand RF, Schmitt MA, Gellman SH, Sen A, Auger M, Hughes DW, Epand RM. Bacterial species selective toxicity of two isomeric alpha/beta-peptides: Role of membrane lipids. Molecular Membrane Biology. 2005 ;22:457-469.
Sadowsky JD, Schmitt MA, Lee HS, Umezawa N, Wang SM, Tomita Y, Gellman SH. Chimeric (alpha/beta plus alpha)-peptide ligands for the BH3-recognition cleft of Bcl-x(L): Critical role of the molecular scaffold in protein surface recognition. Journal of the American Chemical Society. 2005 ;127:11966-11968.
Theisen MJ, Potocky TB, D. McQuade T, Gellman SH, Chiu ML. Crystallization of bacteriorhodopsin solubilized by a tripod amphiphile. Biochimica et Biophysica Acta, Proteins and Proteomics. 2005 ;1751:213-216.
Chi YG, Gellman SH. Diphenylprolinol methyl ether: A highly enantioselective catalyst for Michael addition of aldehydes to simple enones. Organic Letters. 2005 ;7:4253-4256.
Potocky TB, Menon AK, Gellman SH. Effects of conformational stability and geometry of guanidinium display on cell entry by beta-peptides. Journal of the American Chemical Society. 2005 ;127:3686-3687.
Eldred SE, Pancost MR, Otte KM, Rozema D, Stahl SS, Gellman SH. Effects of side chain configuration and backbone spacing on the gene delivery properties of lysine-derived cationic polymers. Bioconjugate Chemistry. 2005 ;16:694-699.
Murray JK, Farooqi B, Sadowsky JD, Scalf M, Freund WA, Smith LM, Chen JD, Gellman SH. Efficient synthesis of a beta-peptide combinatorial library with microwave irradiation. Journal of the American Chemical Society. 2005 ;127:13271-13280.
Chi Y, Peelen TJ, Gellman SH. A rapid 1H NMR assay for enantiomeric excess of α-substituted aldehydes. Organic Letters. 2005 ;7:3469-3472.
Schmitt MA, Choi SH, Guzei IA, Gellman SH. Residue requirements for helical folding in short alpha/beta-peptides: Crystallographic characterization of the 11-helix in an optimized sequence. Journal of the American Chemical Society. 2005 ;127:13130-13131.
Gilbert PUPA, Schmitt MA, Gellman SH. Spectromicroscopy at the organic-inorganic interface in biominerals. American Journal of Science. 2005 ;305:673-686.
Gellman SH. Structure and function in foldamers. Polymer Preprints. 2005 ;46:169.
Huck BR, Gellman SH. Synthesis of 2,2-disubstituted pyrrolidine-4-carboxylic acid derivatives and their incorporation into beta-peptide oligomers. Journal of Organic Chemistry. 2005 ;70:3353-3362.
Kissounko DA, Guzei IA, Gellman SH, Stahl SS. Titanium(IV)-mediated conversion of carboxamides to amidines and implications for catalytic transamidation. Organometallics. 2005 ;24:5208-5210.
Porter EA, Weisblum B, Gellman SH. Use of parallel synthesis to probe structure-activity relationships among 12-helical beta-peptides: Evidence of a limit on antimicrobial activity. Journal of the American Chemical Society. 2005 ;127:11516-11529.
Gelman MA, Gellman SH. Using constrained b-amino acid residues to control b-peptide shape and function. Enantioselective Synthesis of b-Amino Acids (2nd Edition). 2005 :527-591.