All Faculty and Research Staff Publications

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2010
Dohm MT, Mowery BP, Czyzewski AM, Stahl SS, Gellman SH, Barron AE. Biophysical Mimicry of Lung Surfactant Protein B by Random Nylon-3 Copolymers. Journal of the American Chemical Society. 2010 ;132:7957-7967.
Choi SH, Guzei IA, Spencer LC, Gellman SH. Crystallographic Characterization of 12-Helical Secondary Structure in beta-Peptides Containing Side Chain Groups. Journal of the American Chemical Society. 2010 ;132:13879-13885.
Chae PS, Guzei IA, Gellman SH. Crystallographic Characterization of N-Oxide Tripod Amphiphiles. Journal of the American Chemical Society. 2010 ;132:1953-1959.
Price JL, Hadley EB, Steinkruger JD, Gellman SH. Detection and Analysis of Chimeric Tertiary Structures by Backbone Thioester Exchange: Packing of an α Helix against an α/β-Peptide Helix. Angewandte Chemie-International Edition. 2010 ;49:368-371, S368/1-S368/79.
Guo L, Almeida AM, Zhang W, Reidenbach AG, Choi SH, Guzei IA, Gellman SH. Helix formation in preorganized β/γ-peptide foldamers: Hydrogen-bond analogy to the α-helix without α-amino acid residues. Journal of the American Chemical Society. 2010 ;132:7868-7869.
Segman S, Lee M-R, Vaiser V, Gellman SH, Rapaport H. Highly Stable Pleated-Sheet Secondary Structure in Assemblies of Amphiphilic alpha/beta-Peptides at the Air-Water Interface. Angewandte Chemie-International Edition. 2010 ;49:716-719.
Zhang J, Gellman SH, Stahl SS. Kinetics of Anionic Ring-Opening Polymerization of Variously Substituted beta-Lactams: Homopolymerization and Copolymerization. Macromolecules. 2010 ;43:5618-5626.
James WH, Baquero EE, Choi SH, Gellman SH, Zwier TS. Laser Spectroscopy of Conformationally Constrained alpha/beta-Peptides: Ac-ACPC-Phe-NHMe and Ac-Phe-ACPC-NHMe. Journal of Physical Chemistry A. 2010 ;114:1581-1591.
Thiele CM, Pomerantz WC, Abbott NL, Gellman SH. Lyotropic liquid crystalline phases from helical beta-peptides as alignment media. Chemical Communications. 2010 ;47:502-504.
Chae PS, Rasmussen SGF, Rana RR, Gotfryd K, Chandra R, Goren MA, Kruse AC, Nurva S, Loland CJ, Pierre Y, et al. Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins. Nature Methods. 2010 ;7:1003-U90.
Karlsson AJ, Flessner RM, Gellman SH, Lynn DM, Palecek SP. Polyelectrolyte Multilayers Fabricated from Antifungal beta-Peptides: Design of Surfaces that Exhibit Antifungal Activity Against Candida albicans. Biomacromolecules. 2010 ;11:2321-2328.
Steinkruger JD, Woolfson DN, Gellman SH. Side-Chain Pairing Preferences in the Parallel Coiled-Coil Dimer Motif: Insight on Ion Pairing between Core and Flanking Sites. Journal of the American Chemical Society. 2010 ;132:7586-7588.
Price JL, Horne SW, Gellman SH. Structural Consequences of beta-Amino Acid Preorganization in a Self-Assembling alpha/beta-Peptide: Fundamental Studies of Foldameric Helix Bundles. Journal of the American Chemical Society. 2010 ;132:12378-12387.
Chae PS, Gotfryd K, Pacyna J, Miercke LJW, Rasmussen SGF, Robbins RA, Rana RR, Loland CJ, Kobilka B, Stroud R, et al. Tandem Facial Amphiphiles for Membrane Protein Stabilization. Journal of the American Chemical Society. 2010 ;132:16750-16752.
Chae PS, Laible PD, Gellman SH. Tripod amphiphiles for membrane protein manipulation. Molecular Biosystems. 2010 ;6:89-94.
2009
Zhang JH, Kissounko DA, Lee SE, Gellman SH, Stahl SS. Access to Poly-beta-Peptides with Functionalized Side Chains and End Groups via Controlled Ring-Opening Polymerization of beta-Lactams. Journal of the American Chemical Society. 2009 ;131:1589-1597.
Miller CA, Gellman SH, Abbott NL, de Pablo JJ. Association of Helical beta-Peptides and their Aggregation Behavior from the Potential of Mean Force in Explicit Solvent. Biophysical Journal. 2009 ;96:4349-4362.
Stephenson NA, Zhu J, Gellman SH, Stahl SS. Catalytic Transamidation Reactions Compatible with Tertiary Amide Metathesis under Ambient Conditions. Journal of the American Chemical Society. 2009 ;131:10003-10008.
Choi SH, Guzei IA, Spencer LC, Gellman SH. Crystallographic Characterization of Helical Secondary Structures in 2:1 and 1:2 alpha/beta-Peptides. Journal of the American Chemical Society. 2009 ;131:2917-2924.
Karlsson AJ, Pomerantz WC, Neilsen KJ, Gellman SH, Palecek SP. Effect of Sequence and Structural Properties on 14-Helical beta-Peptide Activity against Candida albicans Planktonic Cells and Biofilms. ACS Chemical Biology. 2009 ;4:567-579.
Lee EF, Sadowsky JD, Smith BJ, Czabotar PE, Peterson-Kaufman KJ, Colman PM, Gellman SH, Fairlie WD. High-Resolution Structural Characterization of a Helical alpha/beta-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-x(L). Angewandte Chemie-International Edition. 2009 ;48:4318-4322.
Pomerantz WC, Hadley EB, Fry CG, Gellman SH. In situ monitoring of backbone thioester exchange by 19F NMR. Chembiochem. 2009 ;10:2177-2181.
James, William H. III, Muller CW, Buchanan EG, Nix MGD, Guo L, Roskop L, Gordon MS, Slipchenko LV, Gellman SH, Zwier TS. Intramolecular Amide Stacking and Its Competition with Hydrogen Bonding in a Small Foldamer. Journal of the American Chemical Society. 2009 ;131:14243-14245.
Freire F, Gellman SH. Macrocyclic design strategies for small, stable parallel β-sheet scaffolds. Journal of the American Chemical Society. 2009 ;131:7970-7972.
Lee M-R, Stahl SS, Gellman SH, Masters KS. Nylon-3 Copolymers that Generate Cell-Adhesive Surfaces Identified by Library Screening. Journal of the American Chemical Society. 2009 ;131:16779-16789.
Lu D, Windsor MA, Gellman SH, Keck JL. Peptide Inhibitors Identify Roles for SSB C-Terminal Residues in SSB/Exonuclease I Complex Formation. Biochemistry. 2009 ;48:6764-6771.
Muller MM, Windsor MA, Pomerantz WC, Gellman SH, Hilvert D. A Rationally Designed Aldolase Foldamer. Angewandte Chemie-International Edition. 2009 ;48:922-925.
James WH, Baquero EE, Shubert VA, Choi SH, Gellman SH, Zwier TS. Single-Conformation and Diastereomer Specific Ultraviolet and Infrared Spectroscopy of Model Synthetic Foldamers: alpha/beta-Peptides. Journal of the American Chemical Society. 2009 ;131:6574-6590.
Guo L, Chi Y, Almeida AM, Guzei IA, Parker BK, Gellman SH. Stereospecific synthesis of conformationally constrained γ-amino acids: New foldamer building blocks that support helical secondary structure. Journal of the American Chemical Society. 2009 ;131:16018-16020.
Horne WS, Johnson LM, Ketas TJ, Klasse PJ, Lu M, Moore JP, Gellman SH. Structural and biological mimicry of protein surface recognition by alpha/beta-peptide foldamers. Proceedings of the National Academy of Sciences of the United States of America. 2009 ;106:14751-14756.
Mowery BP, Lindner AH, Weisblum B, Stahl SS, Gellman SH. Structure-activity Relationships among Random Nylon-3 Copolymers That Mimic Antibacterial Host-Defense Peptides. Journal of the American Chemical Society. 2009 ;131:9735-9745.
Giuliano MW, Horne SW, Gellman SH. An α/β-peptide helix bundle with a pure β3-amino acid core and a distinctive quaternary structure. Journal of the American Chemical Society. 2009 ;131:9860-9861.
2008
Pizzey CL, Pomerantz WC, Sung B-J, Yuwono VM, Gellman SH, Hartgerink JD, Yethiraj A, Abbott NL. Characterization of nanofibers formed by self-assembly of β-peptide oligomers using small angle x-ray scattering. Journal of Chemical Physics. 2008 ;129:095103/1-095103/8.
Vaz E, Pomerantz WC, Geyer M, Gellman SH, Brunsveld L. Comparison of design strategies for promotion of β-peptide 14-helix stability in water. Chembiochem. 2008 ;9:2254-2259.
Choi SH, Guzei IA, Spencer LC, Gellman SH. Crystallographic characterization of helical secondary structures in alpha/beta-peptides with 1 : 1 residue alternation. Journal of the American Chemical Society. 2008 ;130:6544-6550.
Freire F, Fisk JD, Peoples AJ, Ivancic M, Guzei IA, Gellman SH. Diacid Linkers That Promote Parallel β-Sheet Secondary Structure in Water. Journal of the American Chemical Society. 2008 ;130:7839-7841.
Miller CA, Hernandez-Ortiz JP, Abbott NL, Gellman SH, De Pablo JJ. Dipole-induced self-assembly of helical β-peptides. Journal of Chemical Physics. 2008 ;129:015102/1-015102/10.
Hoerter JM, Otte KM, Gellman SH, Cui Q, Stahl SS. Discovery and mechanistic study of Al-III-catalyzed transamidation of tertiary amides. Journal of the American Chemical Society. 2008 ;130:647-654.
Pomerantz WC, Grygiel TLR, Lai JR, Gellman SH. Distinctive circular dichroism signature for 14-helix-bundle formation by β-peptides. Organic Letters. 2008 ;10:1799-1802.
Epand RF, Mowery BP, Lee SE, Stahl SS, Lehrer RI, Gellman SH, Epand RM. Dual mechanism of bacterial lethality for a cationic sequence-random copolymer that mimics host-defense antimicrobial peptides. Journal of Molecular Biology. 2008 ;379:38-50.
Chi Y, Guo L, Kopf NA, Gellman SH. Enantioselective organocatalytic Michael addition of aldehydes to nitroethylene: efficient access to γ2-amino acids. Journal of the American Chemical Society. 2008 ;130:5608-5609.
Zhu X, Koenig P, Gellman SH, Yethiraj A, Cui Q. Establishing Effective Simulation Protocols for β- and α/β-Peptides. II. Molecular Mechanical (MM) Model for a Cyclic β-Residue. Journal of Physical Chemistry B. 2008 ;112:5439-5448.
Murray JK, Sadowsky JD, Scalf M, Smith LM, Tomita Y, Gellman SH. Exploration of structure - Activity relationships among foldamer ligands for a specific protein binding site via parallel and split-and-mix library synthesis. Journal of Combinatorial Chemistry. 2008 ;10:204-215.
Peterson KJ, Sadowsky JD, Scheef EA, Pal S, Kourentzi KD, Willson RC, Bresnick EH, Sheibani N, Gellman SH. A fluorescence polarization assay for identifying ligands that bind to vascular endothelial growth factor. Analytical Biochemistry. 2008 ;378:8-14.
Horne WS, Gellman SH. Foldamers with Heterogeneous Backbones. Accounts of Chemical Research. 2008 ;41:1399-1408.
Chae PS, Wander MJ, Bowling AP, Laible PD, Gellman SH. Glycotripod amphiphiles for solubilization and stabilization of a membrane-protein superassembly: importance of branching in the hydrophilic portion. Chembiochem. 2008 ;9:1706-1709.

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