All Faculty and Research Staff Publications

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2013
Chae PS, Wander MJ, Cho KH, Laible PD, Gellman SH. Carbohydrate-containing Triton X-100 analogues for membrane protein solubilization and stabilization. Molecular Biosystems. 2013 ;9:626-629.
Shin YH, Mortenson DE, Satyshur KA, Forest KT, Gellman SH. Differential Impact of beta and gamma Residue Preorganization on alpha/beta/gamma-Peptide Helix Stability in Water. Journal of the American Chemical Society. 2013 ;135:8149-8152.
Chakraborty S, Liu RH, Lemke JJ, Hayouka Z, Welch RA, Weisblum B, Masters KS, Gellman SH. Effects of Cyclic vs Acyclic Hydrophobic Subunits on the Chemical Structure and Biological Properties of Nylon-3 Copolymers. Acs Macro Letters. 2013 ;2:753-756.
Giuliano MW, Maynard SJ, Almeida AM, Reidenbach AG, Guo L, Ulrich EC, Guzei IA, Gellman SH. Evaluation of a Cyclopentane-Based gamma-Amino Acid for the Ability to Promote alpha/gamma-Peptide Secondary Structure. Journal of Organic Chemistry. 2013 ;78:12351-12361.
Hayouka Z, Mortenson DE, Kreitler DF, Weisblum B, Forest KT, Gellman SH. Evidence for Phenylalanine Zipper-Mediated Dimerization in the X-ray Crystal Structure of a Magainin 2 Analogue. Journal of the American Chemical Society. 2013 ;135:15738-15741.
Mortenson DE, Kreitler DF, Yun HG, Gellman SH, Forest KT. Evidence for small-molecule-mediated loop stabilization in the structure of the isolated Pin1 WW domain. Acta Crystallographica Section D-Biological Crystallography. 2013 ;69:2506-2512.
Chae PS, Rana RR, Gotfryd K, Rasmussen SGF, Kruse AC, Cho KH, Capaldi S, Carlsson E, Kobilka B, Loland CJ, et al. Glucose-Neopentyl Glycol (GNG) amphiphiles for membrane protein study. Chemical Communications. 2013 ;49:2287-2289.
Hayouka Z, Chakraborty S, Liu RH, Boersma MD, Weisblum B, Gellman SH. Interplay among Subunit Identity, Subunit Proportion, Chain Length, and Stereochemistry in the Activity Profile of Sequence-Random Peptide Mixtures. Journal of the American Chemical Society. 2013 ;135:11748-11751.
Chae PS, Kruse AC, Gotfryd K, Rana RR, Cho KH, Rasmussen SGF, Bae HE, Chandra R, Gether U, Guan L, et al. Novel Tripod Amphiphiles for Membrane Protein Analysis. Chemistry-A European Journal. 2013 ;19:15645-15651.
Liu RH, Chen XY, Gellman SH, Masters KS. Nylon-3 Polymers That Enable Selective Culture of Endothelial Cells. Journal of the American Chemical Society. 2013 ;135:16296-16299.
Liu RH, Chen XY, Hayouka Z, Chakraborty S, Falk SP, Weisblum B, Masters KS, Gellman SH. Nylon-3 Polymers with Selective Antifungal Activity. Journal of the American Chemical Society. 2013 ;135:5270-5273.
Arnold U, Huck BR, Gellman SH, Raines RT. Protein prosthesis: beta-peptides as reverse-turn surrogates. Protein Science. 2013 ;22:274-279.
Kusaka R, Zhang D, Walsh PS, Gord JR, Fisher BF, Gellman SH, Zwier TS. Role of Ring-Constrained gamma-Amino Acid Residues in alpha/gamma-Peptide Folding: Single-Conformation UV and IR Spectroscopy. Journal of Physical Chemistry A. 2013 ;117:10847-10862.
Choi SH, Ivancic M, Guzei IA, Gellman SH. Structural Characterization of Peptide Oligomers Containing (1R,2S)-2-Aminocyclohexanecarboxylic Acid (cis-ACHC). European Journal of Organic Chemistry. 2013 :3464-3469.
Smith BJ, Lee EF, Checco JW, Evangelista M, Gellman SH, Fairlie DW. Structure-Guided Rational Design of α/β-Peptide Foldamers with High Affinity for BCL-2 Family Prosurvival Proteins. Chembiochem. 2013 ;14:1564-1572.
2012
Gellman SH. Biologically active nylon-3 copolymers. Polymer Preprints. 2012 ;53:366-367.
Zhang J, Markiewicz MJ, Mowery BP, Weisblurn B, Stahl SS, Gellman SH. C-Terminal Functionalization of Nylon-3 Polymers: Effects of C-Terminal Groups on Antibacterial and Hemolytic Activities. Biomacromolecules. 2012 ;13:323-331.
Steinkruger JD, Bartlett GJ, Hadley EB, Fay L, Woolfson DN, Gellman SH. The d '-d-d ' Vertical Triad Is Less Discriminating Than the a '-a-a ' Vertical Triad in the Antiparallel Coiled-Coil Dimer Motif. Journal of the American Chemical Society. 2012 ;134:2626-2633.
Johnson LM, Mortenson DE, Yun HG, Horne WS, Ketas TJ, Lu M, Moore JP, Gellman SH. Enhancement of alpha-Helix Mimicry by an alpha/beta-Peptide Foldamer via Incorporation of a Dense Ionic Side-Chain Array. Journal of the American Chemical Society. 2012 ;134:7317-7320.
Boersma MD, Haase HS, Peterson-Kaufman KJ, Lee EF, Clarke OB, Colman PM, Smith BJ, Horne SW, Fairlie DW, Gellman SH. Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain. Journal of the American Chemical Society. 2012 ;134:315-323.
Liu RH, Vang KZ, Kreeger PK, Gellman SH, Masters KS. Experimental and computational analysis of cellular interactions with nylon-3-bearing substrates. Journal of Biomedical Materials Research Part A. 2012 ;100A:2750-2759.
Haase HS, Peterson-Kaufman KJ, Levengood SKL, Checco JW, Murphy WL, Gellman SH. Extending Foldamer Design beyond alpha-Helix Mimicry: alpha/beta-Peptide Inhibitors of Vascular Endothelial Growth Factor Signaling. Journal of the American Chemical Society. 2012 ;134:7652-7655.
Zhang JH, Markiewicz MJ, Weisblum B, Stahl SS, Gellman SH. Functionally Diverse Nylon-3 Copolymers from Readily Accessible beta-Lactams. Acs Macro Letters. 2012 ;1:714-717.
Guo L, Zhang WC, Guzei IA, Spencer LC, Gellman SH. Helical secondary structures in 2:1 and 1:2 alpha/gamma-peptide foldamers. Tetrahedron. 2012 ;68:4413-4417.
Chae PS, Rasmussen SGF, Rana RR, Gotfryd K, Kruse AC, Manglik A, Cho KH, Nurva S, Gether U, Guan L, et al. A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins. Chemistry-A European Journal. 2012 ;18:9485-9490, S9485/1-S9485/25.
Guo L, Zhang WC, Guzei IA, Spencer LC, Gellman SH. New Preorganized gamma-Amino Acids as Foldamer Building Blocks. Organic Letters. 2012 ;14:2582-2585.
Woys AM, Almeida AM, Wang L, Chiu CC, McGovern M, de Pablo JJ, Skinner JL, Gellman SH, Zanni MT. Parallel beta-Sheet Vibrational Couplings Revealed by 2D IR Spectroscopy of an Isotopically Labeled Macrocycle: Quantitative Benchmark for the Interpretation of Amyloid and Protein Infrared Spectra. Journal of the American Chemical Society. 2012 ;134:19118-19128.
Almeida AM, Li R, Gellman SH. Parallel β-Sheet Secondary Structure Is Stabilized and Terminated by Interstrand Disulfide Cross-Linking. Journal of the American Chemical Society. 2012 ;134:75-78.
Liu RH, Masters KS, Gellman SH. Polymer Chain Length Effects on Fibroblast Attachment on Nylon-3-Modified Surfaces. Biomacromolecules. 2012 ;13:1100-1105.
Mortenson DE, Satyshur KA, Guzei IA, Forest KT, Gellman SH. Quasiracemic Crystallization as a Tool To Assess the Accommodation of Noncanonical Residues in Nativelike Protein Conformations. Journal of the American Chemical Society. 2012 ;134:2473-2476.
Buchanan EG, James, William H. III, Choi SH, Guo L, Gellman SH, Mueller CW, Zwier TS. Single-conformation infrared spectra of model peptides in the amide I and amide II regions: Experiment-based determination of local mode frequencies and inter-mode coupling. Journal of Chemical Physics. 2012 ;137:094301/1-094301/16.
Steinkruger JD, Bartlett GJ, Woolfson DN, Gellman SH. Strong Contributions from Vertical Triads to Helix-Partner Preferences in Parallel Coiled Coils. Journal of the American Chemical Society. 2012 ;134:15652-15655.
2011
Johnson LM, Horne SW, Gellman SH. Broad Distribution of Energetically Important Contacts across an Extended Protein Interface. Journal of the American Chemical Society. 2011 ;133:10038-10041.
Guo L, Zhang W, Reidenbach AG, Giuliano MW, Guzei IA, Spencer LC, Gellman SH. Characteristic Structural Parameters for the gamma-Peptide 14-Helix: Importance of Subunit Preorganization. Angewandte Chemie-International Edition. 2011 ;50:5843-5846.
James WH, Buchanan EG, Guo L, Gellman SH, Zwier TS. Competition between Amide Stacking and Intramolecular H Bonds in γ-Peptide Derivatives: Controlling Nearest-Neighbor Preferences. Journal of Physical Chemistry A. 2011 ;115:11960-11970.
Rasmussen SGF, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, et al. Crystal structure of the beta(2) adrenergic receptor-Gs protein complex. Nature. 2011 ;477:549-U311.
James WH, Buchanan EG, Muller CW, Dean JC, Kosenkov D, Slipchenko LV, Guo L, Reidenbach AG, Gellman SH, Zwier TS. Evolution of Amide Stacking in Larger γ-Peptides: Triamide H-Bonded Cycles. Journal of Physical Chemistry A. 2011 ;115:13783-13798.
Selao TT, Branca R, Chae PS, Lehtio J, Gellman SH, Rasmussen SGF, Nordlund S, Noren A. Identification of Chromatophore Membrane Protein Complexes Formed under Different Nitrogen Availability Conditions in Rhodospirillum rubrum. Journal of Proteome Research. 2011 ;10:2703-2714.
Freire F, Almeida AM, Fisk JD, Steinkruger JD, Gellman SH. Impact of Strand Length on the Stability of Parallel-β-Sheet Secondary Structure. Angewandte Chemie-International Edition. 2011 ;50:8735-8738, S8735/1-S8735/28.
Pomerantz WC, Yuwono VM, Drake R, Hartgerink JD, Abbott NL, Gellman SH. Lyotropic Liquid Crystals Formed from ACHC-Rich beta-Peptides. Journal of the American Chemical Society. 2011 ;133:13604-13613.
Segman-Magidovich S, Lee M-R, Vaiser V, Struth B, Gellman SH, Rapaport H. Sheet-Like Assemblies of Charged Amphiphilic α/β-Peptides at the Air-Water Interface. Chemistry-A European Journal. 2011 ;17:14857-14866, S14857/1-S14857/6.
Buchanan EG, James, William H. III, Gutberlet A, Dean JC, Guo L, Gellman SH, Zwier TS. Single-conformation spectroscopy and population analysis of model gamma-peptides: New tests of amide stacking. Faraday Discussions. 2011 ;150:209-226.
Acevedo-Velez C, Andre G, Dufrene YF, Gellman SH, Abbott NL. Single-Molecule Force Spectroscopy of beta-Peptides That Display Well-Defined Three-Dimensional Chemical Patterns. Journal of the American Chemical Society. 2011 ;133:3981-3988.
Lee EF, Smith BJ, Horne SW, Mayer KN, Evangelista M, Colman PM, Gellman SH, Fairlie DW. Structural Basis of Bcl-x(L) Recognition by a BH3-Mimetic alpha/beta-Peptide Generated by Sequence-Based Design. Chembiochem. 2011 ;12:2025-2032.
Sawada T, Gellman SH. Structural Mimicry of the alpha-Helix in Aqueous Solution with an Isoatomic alpha/beta/gamma-Peptide Backbone. Journal of the American Chemical Society. 2011 ;133:7336-7339.
Rosenbaum DM, Zhang C, Lyons JA, Holl R, Aragao D, Arlow DH, Rasmussen SGF, Choi H-J, DeVree BT, Sunahara RK, et al. Structure and function of an irreversible agonist-beta(2) adrenoceptor complex. Nature. 2011 ;469:236-U129.
Rasmussen SGF, Choi H-J, Fung JJ, Pardon E, Casarosa P, Chae PS, DeVree BT, Rosenbaum DM, Thian FS, Kobilka TS, et al. Structure of a nanobody-stabilized active state of the beta(2) adrenoceptor. Nature. 2011 ;469:175-U59.

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