All Faculty and Research Staff Publications

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2014
Giuliano MW, Maynard SJ, Almeida AM, Guo L, Guzei IA, Spencer LC, Gellman SH. A gamma-Amino Acid That Favors 12/10-Helical Secondary Structure in alpha/gamma-Peptides. Journal of the American Chemical Society. 2014 ;136:15046-15053.
Chae PS, Cho KH, Wander MJ, Bae HE, Gellman SH, Laible PD. Hydrophobic variants of ganglio-tripod amphiphiles for membrane protein manipulation. Biochimica Et Biophysica Acta-Biomembranes. 2014 ;1838:278-286.
Chae PS, Sadaf A, Gellman SH. Hydrophobic Variations of N-Oxide Amphiphiles for Membrane Protein Manipulation: Importance of Non-hydrocarbon Groups in the Hydrophobic Portion. Chemistry-an Asian Journal. 2014 ;9:110-116.
Lee MR, Raman N, Gellman SH, Lynn DM, Palecek SP. Hydrophobicity and Helicity Regulate the Antifungal Activity of 14-Helical beta-Peptides. ACS Chemical Biology. 2014 ;9:1613-1621.
Cho KH, Bae HE, Das M, Gellman SH, Chae PS. Improved Glucose-Neopentyl Glycol (GNG) Amphiphiles for Membrane Protein Solubilization and Stabilization. Chemistry-an Asian Journal. 2014 ;9:632-638.
Gord JR, Walsh PS, Fisher BF, Gellman SH, Zwier TS. Mimicking the First Turn of an alpha-Helix with an Unnatural Backbone: Conformation-Specific IR and UV Spectroscopy of Cyclically Constrained beta/gamma-Peptides. Journal of Physical Chemistry B. 2014 ;118:8246-8256.
Maynard SJ, Almeida AM, Yoshimi Y, Gellman SH. New Charge-Bearing Amino Acid Residues That Promote beta-Sheet Secondary Structure. Journal of the American Chemical Society. 2014 ;136:16683-16688.
Johnson LM, Barrick S, Hager MV, McFedries A, Homan EA, Rabaglia ME, Keller MP, Attie AD, Saghatelian A, Bisello A, et al. A Potent alpha/beta-Peptide Analogue of GLP-1 with Prolonged Action in Vivo. Journal of the American Chemical Society. 2014 ;136:12848-12851.
Liu RH, Chen XY, Falk SP, Mowery BP, Karlsson AJ, Weisblum B, Palecek SP, Masters KS, Gellman SH. Structure-Activity Relationships among Antifungal Nylon-3 Polymers: Identification of Materials Active against Drug-Resistant Strains of Candida albicans. Journal of the American Chemical Society. 2014 ;136:4333-4342.
Liu RH, Suarez JM, Weisblum B, Gellman SH, McBride SM. Synthetic Polymers Active against Clostridium difficile Vegetative Cell Growth and Spore Outgrowth. Journal of the American Chemical Society. 2014 ;136:14498-14504.
Chakraborty S, Liu RH, Hayouka Z, Chen XY, Ehrhardt J, Lu Q, Burke E, Yan YQ, Weisblum B, Wong GCL, et al. Ternary Nylon-3 Copolymers as Host-Defense Peptide Mimics: Beyond Hydrophobic and Cationic Subunits. Journal of the American Chemical Society. 2014 ;136:14530-14535.
Liu RH, Chen XY, Chakraborty S, Lemke JJ, Hayouka Z, Chow C, Welch RA, Weisblum B, Masters KS, Gellman SH. Tuning the Biological Activity Profile of Antibacterial Polymers via Subunit Substitution Pattern. Journal of the American Chemical Society. 2014 ;136:4410-4418.
Lee MW, Chakraborty S, Schmidt NW, Murgai R, Gellman SH, Wong GCL. Two interdependent mechanisms of antimicrobial activity allow for efficient killing in nylon-3-based polymeric mimics of innate immunity peptides. Biochimica Et Biophysica Acta-Biomembranes. 2014 ;1838:2269-2279.
Laaser JE, Skoff DR, Ho JJ, Joo Y, Serrano AL, Steinkruger JD, Gopalan P, Gellman SH, Zanni MT. Two-Dimensional Sum-Frequency Generation Reveals Structure and Dynamics of a Surface-Bound Peptide. Journal of the American Chemical Society. 2014 ;136:956-962.
2013
Johnson LM, Gellman SH. alpha-Helix Mimicry with alpha/beta-Peptides. In: Keating AE Vol. 523. ; 2013. pp. 407-429.
Chae PS, Wander MJ, Cho KH, Laible PD, Gellman SH. Carbohydrate-containing Triton X-100 analogues for membrane protein solubilization and stabilization. Molecular Biosystems. 2013 ;9:626-629.
Shin YH, Mortenson DE, Satyshur KA, Forest KT, Gellman SH. Differential Impact of beta and gamma Residue Preorganization on alpha/beta/gamma-Peptide Helix Stability in Water. Journal of the American Chemical Society. 2013 ;135:8149-8152.
Chakraborty S, Liu RH, Lemke JJ, Hayouka Z, Welch RA, Weisblum B, Masters KS, Gellman SH. Effects of Cyclic vs Acyclic Hydrophobic Subunits on the Chemical Structure and Biological Properties of Nylon-3 Copolymers. Acs Macro Letters. 2013 ;2:753-756.
Giuliano MW, Maynard SJ, Almeida AM, Reidenbach AG, Guo L, Ulrich EC, Guzei IA, Gellman SH. Evaluation of a Cyclopentane-Based gamma-Amino Acid for the Ability to Promote alpha/gamma-Peptide Secondary Structure. Journal of Organic Chemistry. 2013 ;78:12351-12361.
Hayouka Z, Mortenson DE, Kreitler DF, Weisblum B, Forest KT, Gellman SH. Evidence for Phenylalanine Zipper-Mediated Dimerization in the X-ray Crystal Structure of a Magainin 2 Analogue. Journal of the American Chemical Society. 2013 ;135:15738-15741.
Mortenson DE, Kreitler DF, Yun HG, Gellman SH, Forest KT. Evidence for small-molecule-mediated loop stabilization in the structure of the isolated Pin1 WW domain. Acta Crystallographica Section D-Biological Crystallography. 2013 ;69:2506-2512.
Chae PS, Rana RR, Gotfryd K, Rasmussen SGF, Kruse AC, Cho KH, Capaldi S, Carlsson E, Kobilka B, Loland CJ, et al. Glucose-Neopentyl Glycol (GNG) amphiphiles for membrane protein study. Chemical Communications. 2013 ;49:2287-2289.
Hayouka Z, Chakraborty S, Liu RH, Boersma MD, Weisblum B, Gellman SH. Interplay among Subunit Identity, Subunit Proportion, Chain Length, and Stereochemistry in the Activity Profile of Sequence-Random Peptide Mixtures. Journal of the American Chemical Society. 2013 ;135:11748-11751.
Chae PS, Kruse AC, Gotfryd K, Rana RR, Cho KH, Rasmussen SGF, Bae HE, Chandra R, Gether U, Guan L, et al. Novel Tripod Amphiphiles for Membrane Protein Analysis. Chemistry-A European Journal. 2013 ;19:15645-15651.
Liu RH, Chen XY, Gellman SH, Masters KS. Nylon-3 Polymers That Enable Selective Culture of Endothelial Cells. Journal of the American Chemical Society. 2013 ;135:16296-16299.
Liu RH, Chen XY, Hayouka Z, Chakraborty S, Falk SP, Weisblum B, Masters KS, Gellman SH. Nylon-3 Polymers with Selective Antifungal Activity. Journal of the American Chemical Society. 2013 ;135:5270-5273.
Arnold U, Huck BR, Gellman SH, Raines RT. Protein prosthesis: beta-peptides as reverse-turn surrogates. Protein Science. 2013 ;22:274-279.
Kusaka R, Zhang D, Walsh PS, Gord JR, Fisher BF, Gellman SH, Zwier TS. Role of Ring-Constrained gamma-Amino Acid Residues in alpha/gamma-Peptide Folding: Single-Conformation UV and IR Spectroscopy. Journal of Physical Chemistry A. 2013 ;117:10847-10862.
Choi SH, Ivancic M, Guzei IA, Gellman SH. Structural Characterization of Peptide Oligomers Containing (1R,2S)-2-Aminocyclohexanecarboxylic Acid (cis-ACHC). European Journal of Organic Chemistry. 2013 :3464-3469.
Smith BJ, Lee EF, Checco JW, Evangelista M, Gellman SH, Fairlie DW. Structure-Guided Rational Design of α/β-Peptide Foldamers with High Affinity for BCL-2 Family Prosurvival Proteins. Chembiochem. 2013 ;14:1564-1572.
2012
Gellman SH. Biologically active nylon-3 copolymers. Polymer Preprints. 2012 ;53:366-367.
Zhang J, Markiewicz MJ, Mowery BP, Weisblurn B, Stahl SS, Gellman SH. C-Terminal Functionalization of Nylon-3 Polymers: Effects of C-Terminal Groups on Antibacterial and Hemolytic Activities. Biomacromolecules. 2012 ;13:323-331.
Steinkruger JD, Bartlett GJ, Hadley EB, Fay L, Woolfson DN, Gellman SH. The d '-d-d ' Vertical Triad Is Less Discriminating Than the a '-a-a ' Vertical Triad in the Antiparallel Coiled-Coil Dimer Motif. Journal of the American Chemical Society. 2012 ;134:2626-2633.
Johnson LM, Mortenson DE, Yun HG, Horne WS, Ketas TJ, Lu M, Moore JP, Gellman SH. Enhancement of alpha-Helix Mimicry by an alpha/beta-Peptide Foldamer via Incorporation of a Dense Ionic Side-Chain Array. Journal of the American Chemical Society. 2012 ;134:7317-7320.
Boersma MD, Haase HS, Peterson-Kaufman KJ, Lee EF, Clarke OB, Colman PM, Smith BJ, Horne SW, Fairlie DW, Gellman SH. Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain. Journal of the American Chemical Society. 2012 ;134:315-323.
Liu RH, Vang KZ, Kreeger PK, Gellman SH, Masters KS. Experimental and computational analysis of cellular interactions with nylon-3-bearing substrates. Journal of Biomedical Materials Research Part A. 2012 ;100A:2750-2759.
Haase HS, Peterson-Kaufman KJ, Levengood SKL, Checco JW, Murphy WL, Gellman SH. Extending Foldamer Design beyond alpha-Helix Mimicry: alpha/beta-Peptide Inhibitors of Vascular Endothelial Growth Factor Signaling. Journal of the American Chemical Society. 2012 ;134:7652-7655.
Zhang JH, Markiewicz MJ, Weisblum B, Stahl SS, Gellman SH. Functionally Diverse Nylon-3 Copolymers from Readily Accessible beta-Lactams. Acs Macro Letters. 2012 ;1:714-717.
Guo L, Zhang WC, Guzei IA, Spencer LC, Gellman SH. Helical secondary structures in 2:1 and 1:2 alpha/gamma-peptide foldamers. Tetrahedron. 2012 ;68:4413-4417.
Chae PS, Rasmussen SGF, Rana RR, Gotfryd K, Kruse AC, Manglik A, Cho KH, Nurva S, Gether U, Guan L, et al. A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins. Chemistry-A European Journal. 2012 ;18:9485-9490, S9485/1-S9485/25.
Guo L, Zhang WC, Guzei IA, Spencer LC, Gellman SH. New Preorganized gamma-Amino Acids as Foldamer Building Blocks. Organic Letters. 2012 ;14:2582-2585.
Woys AM, Almeida AM, Wang L, Chiu CC, McGovern M, de Pablo JJ, Skinner JL, Gellman SH, Zanni MT. Parallel beta-Sheet Vibrational Couplings Revealed by 2D IR Spectroscopy of an Isotopically Labeled Macrocycle: Quantitative Benchmark for the Interpretation of Amyloid and Protein Infrared Spectra. Journal of the American Chemical Society. 2012 ;134:19118-19128.
Almeida AM, Li R, Gellman SH. Parallel β-Sheet Secondary Structure Is Stabilized and Terminated by Interstrand Disulfide Cross-Linking. Journal of the American Chemical Society. 2012 ;134:75-78.
Liu RH, Masters KS, Gellman SH. Polymer Chain Length Effects on Fibroblast Attachment on Nylon-3-Modified Surfaces. Biomacromolecules. 2012 ;13:1100-1105.
Mortenson DE, Satyshur KA, Guzei IA, Forest KT, Gellman SH. Quasiracemic Crystallization as a Tool To Assess the Accommodation of Noncanonical Residues in Nativelike Protein Conformations. Journal of the American Chemical Society. 2012 ;134:2473-2476.
Buchanan EG, James, William H. III, Choi SH, Guo L, Gellman SH, Mueller CW, Zwier TS. Single-conformation infrared spectra of model peptides in the amide I and amide II regions: Experiment-based determination of local mode frequencies and inter-mode coupling. Journal of Chemical Physics. 2012 ;137:094301/1-094301/16.
Steinkruger JD, Bartlett GJ, Woolfson DN, Gellman SH. Strong Contributions from Vertical Triads to Helix-Partner Preferences in Parallel Coiled Coils. Journal of the American Chemical Society. 2012 ;134:15652-15655.

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