All Department Publications

Found 99 results
Author [ Title(Desc)] Type Year
Filters: Author is David M Lynn  [Clear All Filters]
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A
Lynn DM, Anderson DG, Putnam D, Langer R. Accelerated discovery of synthetic transfection vectors: parallel synthesis and screening of a degradable polymer library. J Am Chem Soc. 2001;123(33):8155-6.
Aytar BS, Muller JPE, Golan S, Hata S, Takahashi H, Kondo Y, Talmon Y, Abbott NL, Lynn DM. Addition of ascorbic acid to the extracellular environment activates lipoplexes of a ferrocenyl lipid and promotes cell transfection. Journal of Controlled Release. 2012;157:249-259.
Liu X, Yang JW, Lynn DM. Addition of "Charge-Shifting" side chains to linear poly(ethyleneimine) enhances cell transfection efficiency. Biomacromolecules. 2008;9:2063-2071.
Zhang J, Fredin NJ, Lynn DM. Apparent dewetting of ultrathin multilayered polyelectrolyte films incubated in aqueous environments. Langmuir. 2007;23:11603-11610.
Saurer EM, Jewell CM, Kuchenreuther JM, Lynn DM. Assembly of erodible, DNA-containing thin films on the surfaces of polymer microparticles: Toward a layer-by-layer approach to the delivery of DNA to antigen-presenting cells. Acta Biomaterialia. 2009;5:913-924.
Sun B, Jewell CM, Fredin NJ, Lynn DM. Assembly of multilayered films using well-defined, end-labeled poly(acrylic acid): Influence of molecular weight on exponential growth in a synthetic weak polyelectrolyte system. Langmuir. 2007;23:8452-8459.
Buck ME, Lynn DM. Azlactone-functionalized polymers as reactive platforms for the design of advanced materials: Progress in the last ten years. Polym. Chem. 2012;3:66-80.
Sun B, Liu X, Buck ME, Lynn DM. Azlactone-functionalized polymers as reactive templates for parallel polymer synthesis: synthesis and screening of a small library of cationic polymers in the context of DNA delivery. Chemical Communications. 2010;46:2016-2018.
B
Gelman MA, Weisblum B, Lynn DM, Gellman SH. Biocidal activity of polystyrenes that are cationic by virtue of protonation. Org Lett. 2004;6(4):557-60.
C
Bechler SL, Lynn DM. Characterization of Degradable Polyelectrolyte Multilayers Fabricated Using DNA and a Fluorescently-Labeled Poly(beta-amino ester): Shedding Light on the Role of the Cationic Polymer in Promoting Surface-Mediated Gene Delivery. Biomacromolecules. 2012;13:542-552.
Fredin NJ, Flessner RM, Jewell CM, Bechler SL, Buck ME, Lynn DM. Characterization of Nanoscale Transformations in Polyelectrolyte Multilayers Fabricated From Plasmid DNA Using Laser Scanning Confocal Microscopy in Combination With Atomic Force Microscopy. Microscopy Research and Technique. 2010;73:834-844.
Sun B, Flessner RM, Saurer EM, Jewell CM, Fredin NJ, Lynn DM. Characterization of pH-induced changes in the morphology of polyelectrolyte multilayers assembled from poly(allylamine) and low molecular weight poly(acrylic acid). Journal of Colloid and Interface Science. 2011;355:431-441.
Pizzey CL, Jewell CM, Hays ME, Lynn DM, Abbott NL, Kondo Y, Golan S, Talmon Y. Characterization of the Nanostructure of Complexes Formed by a Redox-Active Cationic Lipid and DNA. The Journal of Physical Chemistry B. 2008;112:5849-5857.
Liu X, Yang JW, Miller AD, Nack EA, Lynn DM. Charge-Shifting Cationic Polymers That Promote Self-Assembly and Self-Disassembly with DNA. Macromolecules. 2005;38:7907-7914.
Jewell CM, Hays ME, Kondo Y, Abbott NL, Lynn DM. Chemical Activation of Lipoplexes Formed from DNA and a Redox-Active, Ferrocene-Containing Cationic Lipid. Bioconjugate Chemistry. 2008;19:2120-2128.
Buck ME, Breitbach AS, Belgrade SK, Blackwell HE, Lynn DM. Chemical Modification of Reactive Multilayered Films Fabricated from Poly(2-alkenyl azlactone)s: Design of Surfaces that Prevent or Promote Mammalian Cell Adhesion and Bacterial Biofilm Growth. Biomacromolecules. 2009;10:1564-1574.
Aytar BS, Muller JPE, Golan S, Kondo Y, Talmon Y, Abbott NL, Lynn DM. Chemical oxidation of a redox-active, ferrocene-containing cationic lipid: Influence on interactions with DNA and characterization in the context of cell transfection. Journal of Colloid and Interface Science. 2012;387:56-64.
Manna U, Broderick AH, Lynn DM. Chemical Patterning and Physical Refinement of Reactive Superhydrophobic Surfaces. Advanced Materials. 2012;24:4291-+.
Vázquez E, Dewitt DM, Hammond PT, Lynn DM. Construction of hydrolytically-degradable thin films via layer-by-layer deposition of degradable polyelectrolytes. J Am Chem Soc. 2002;124(47):13992-3.
Wood KC, Chuang HF, Batten RD, Lynn DM, Hammond PT. Controlling interlayer diffusion to achieve sustained, multiagent delivery from layer-by-layer thin films. Proceedings of the National Academy of Sciences of the United States of America. 2006;103:10207.
Broderick AH, Manna U, Lynn DM. Covalent Layer-by-Layer Assembly of Water-Permeable and Water-Impermeable Polymer Multilayers on Highly Water-Soluble and Water-Sensitive Substrates. Chemistry of Materials. 2012;24:1786-1795.
Broderick AH, Lynn DM. Covalent Layer-by-Layer Assembly Using Reactive Polymers. In: Functional Polymers by Post-Polymerization Modification: Concepts, Practical Guidelines, and Applications. Functional Polymers by Post-Polymerization Modification: Concepts, Practical Guidelines, and Applications. Wiley-VCH; 2012. pp. 371-406.
D
Lynn DM, Anderson DG, Akinc AB, Langer R. Degradable Poly(b-amino ester)s for Gene Delivery. In: Polymeric Gene Delivery: Principles and Applications. Polymeric Gene Delivery: Principles and Applications. CRC Press; 2004. pp. 227-241.
Lynn DM, Langer R. Degradable poly(beta-amino esters): Synthesis, characterization, and self-assembly with plasmid DNA. Journal of the American Chemical Society. 2000;122:10761-10768.
Flessner RM, Jewell CM, Anderson DG, Lynn DM. Degradable Polyelectrolyte Multilayers that Promote the Release of siRNA. Langmuir. 2011;27:7868-7876.
Saurer EM, Yamanouchi D, Liu B, Lynn DM. Delivery of plasmid DNA to vascular tissue in vivo using catheter balloons coated with polyelectrolyte multilayers. Biomaterials. 2011;32:610-618.
Bechler SL, Lynn DM. Design and Synthesis of a Fluorescently End-Labeled Poly(beta-amino ester): Application to the Characterization of Degradable Polyelectrolyte Multilayers. Journal of Polymer Science Part a-Polymer Chemistry. 2011;49:1572-1581.
Kinsinger MI, Buck ME, Campos F, Lynn DM, Abbott NL. Dynamic Ordering Transitions of Liquid Crystals Driven by Interfacial Complexes Formed between Polyanions and Amphiphilic Polyamines. Langmuir. 2008;24:13231-13236.
E
Zelikin AN, Lynn DM, Farhadi J, Martin I, Shastri V, Langer R. Erodible conducting polymers for potential biomedical applications. Angew Chem Int Ed Engl. 2002;41(1):141-4.
Zhang JT, Fredin NJ, Lynn DM. Erosion of multilayered films fabricated from degradable polyamines: Characterization and evidence in support of a mechanism that involves polymer hydrolysis. Journal of Polymer Science Part a-Polymer Chemistry. 2006;44:5161.
F
Broderick AH, Azarin SM, Buck ME, Palecek SP, Lynn DM. Fabrication and Selective Functionalization of Amine-Reactive Polymer Multi layers on Topographically Patterned Microwell Cell Culture Arrays. Biomacromolecules. 2011;12:1998-2007.
Saurer EM, Flessner RM, Buck ME, Lynn DM. Fabrication of covalently crosslinked and amine-reactive microcapsules by reactive layer-by-layer assembly of azlactone-containing polymer multilayers on sacrificial microparticle templates. Journal of Materials Chemistry. 2011;21:1736-1745.
Broderick AH, Carter MCD, Lockett MR, Smith LM, Lynn DM. Fabrication of Oligonucleotide and Protein Arrays on Rigid and Flexible Substrates Coated with Reactive Polymer Multilayers. ACS Applied Materials & Interfaces. 2013;5:351-359.
Jewell CM, Hays ME, Kondo Y, Abbott NL, Lynn DM. Ferrocene-containing cationic lipids for the delivery of DNA: oxidation state determines transfection activity. J Control Release. 2006;112(1):129-38.
Abbott NL, Jewell CM, Hays ME, Kondo Y, Lynn DM. Ferrocene-containing cationic lipids: influence of redox state on cell transfection. J Am Chem Soc. 2005;127(33):11576-7.
Little SR, Lynn DM, Puram SV, Langer R. Formulation and characterization of poly (beta amino ester) microparticles for genetic vaccine delivery. J Control Release. 2005;107(3):449-62.
Buck ME, Lynn DM. Free-Standing and Reactive Thin Films Fabricated by Covalent Layer-by-Layer Assembly and Subsequent Lift-Off of Azlactone-Containing Polymer Multilayers. Langmuir. 2010;26:16134-16140.
Buck ME, Lynn DM. Functionalization of Fibers Using Azlactone-Containing Polymers: Layer-by-Layer Fabrication of Reactive Thin Films on the Surfaces of Hair and Cellulose-Based Materials. ACS Applied Materials & Interfaces. 2010;2:1421-1429.
Tocce EJ, Broderick AH, Murphy KC, Liliensiek SJ, Murphy CJ, Lynn DM, Nealey PF. Functionalization of reactive polymer multilayers with RGD and an antifouling motif: RGD density provides control over human corneal epithelial cell-substrate interactions. J Biomed Mater Res A. 2012;100(1):84-93.
H
Berry D, Lynn DM, Berry E, Sasisekharan R, Langer R. Heparin localization and fine structure regulate Burkitt's lymphoma growth. Biochem Biophys Res Commun. 2006;348(3):850-6.
I
Kinsinger MI, Buck ME, Abbott NL, Lynn DM. Immobilization of Polymer-Decorated Liquid Crystal Droplets on Chemically Tailored Surfaces. Langmuir. 2010;26:10234-10242.
Broderick AH, Lockett MR, Buck ME, Yuan Y, Smith LM, Lynn DM, Ruthers Mh MIEVP. In situ Synthesis of Oligonucleotide Arrays on Surfaces Coated with Crosslinked Polymer Multilayers. Chemistry of Materials. 2012;24:938-945.
Muller JPE, Aytar BS, Kondo Y, Lynn DM, Abbott NL. Incorporation of DOPE into lipoplexes formed from a ferrocenyl lipid leads to inverse hexagonal nanostructures that allow redox-based control of transfection in high serum. Soft Matter. 2012;8:2608-2619.
Golan S, Aytar BS, Muller JPE, Kondo Y, Lynn DM, Abbott NL, Talmon Y. Influence of biological media on the structure and behavior of ferrocene-containing cationic lipid/DNA complexes used for DNA delivery. Langmuir. 2011;27(11):6615-21.
Golan S, Aytar BS, Muller JPE, Kondo Y, Lynn DM, Abbott NL, Talmont Y. Influence of Biological Media on the Structure and Behavior of Ferrocene-Containing Cationic Lipid/DNA Complexes Used for DNA Delivery. Langmuir. 2011;27:6615-6621.
Tocce EJ, Liliensiek SJ, Broderick AH, Jiang Y, Murphy KC, Murphy CJ, Lynn DM, Nealey PF. The influence of biomimetic topographical features and the extracellular matrix peptide RGD on human corneal epithelial contact guidance. Acta Biomater. 2013;9(2):5040-51.
L
Kinsinger MI, Buck ME, Meli M-V, Abbott NL, Lynn DM. Langmuir films of flexible polymers transferred to aqueous/liquid crystal interfaces induce uniform azimuthal alignment of the liquid crystal. Journal of Colloid and Interface Science. 2010;341:124-135.
Saurer EM, Flessner RM, Sullivan SP, Prausnitz MR, Lynn DM. Layer-by-Layer Assembly of DNA- and Protein-Containing Films on Microneedles for Drug Delivery to the Skin. Biomacromolecules. 2010;11:3136-3143.
Buck ME, Zhang J, Lynn DM. Layer-by-layer assembly of reactive ultrathin films mediated by click-type reactions of poly(2-alkenyl azlactone)s. Advanced Materials. 2007;19:3951-+.
Buck ME, Lynn DM. Layer-by-Layer Fabrication of Covalently Crosslinked and Reactive Polymer Multilayers Using Azlactone-Functionalized Copolymers: A Platform for the Design of Functional Biointerfaces. Advanced Engineering Materials. 2011;13:B343-B352.

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