All Department Publications

Found 72 results
Author Title Type [ Year(Asc)]
Filters: Author is Blackwell, H. E.  [Clear All Filters]
2011
Palmer AG, Streng E, Blackwell HE. Attenuation of Virulence in Pathogenic Bacteria Using Synthetic Quorum-Sensing Modulators under Native Conditions on Plant Hosts. ACS Chemical Biology [Internet]. 2011;6:1348-1356. Available from: http://pubs.acs.org/doi/abs/10.1021/cb200298g
Crapster AJ, Stringer JR, Guzei IA, Blackwell HE. Design and Conformational Analysis of Peptoids Containing N-Hydroxy Amides Reveals a Unique Sheet-Like Secondary Structure. Biopolymers. 2011;96:604-616.
McInnis CE, Blackwell HE. Design, synthesis, and biological evaluation of abiotic, non-lactone modulators of LuxR-type quorum sensing. Bioorganic & Medicinal Chemistry. 2011;19:4812-4819.
Stringer JR, Crapster AJ, Guzei IA, Blackwell HE. Extraordinarily Robust Polyproline Type I Peptoid Helices Generated via the Incorporation of α-Chiral Aromatic N-1-Naphthylethyl Side Chains. Journal of the American Chemical Society [Internet]. 2011;133:15559-15567. Available from: http://pubs.acs.org/doi/abs/10.1021/ja204755p
Stringer JR, Bowman MD, Weisblum B, Blackwell HE. Improved Small-Molecule Macroarray Platform for the Rapid Synthesis and Discovery of Antibacterial Chalcones. ACS Combinatorial Science. 2011;13:175-180.
Blackwell HE, Fuqua C. Introduction to Bacterial Signals and Chemical Communication. Chemical Reviews. 2011;111:1-3.
Lindemann A, Pessi G, Schaefer AL, Mattmann ME, Christensen QH, Kessler A, Hennecke H, Blackwell HE, Greenberg PE, Harwood CS. Isovaleryl-homoserine lactone, an unusual branched-chain quorum-sensing signal from the soybean symbiont Bradyrhizobium japonicum. Proceedings of the National Academy of Sciences of the United States of America. 2011;108:16765-16770.
Mattmann ME, Shipway PM, Heth NJ, Blackwell HE. Potent and Selective Synthetic Modulators of a Quorum Sensing Repressor in Pseudomonas aeruginosa Identified from Second-Generation Libraries of N-Acylated L-Homoserine Lactones. Chembiochem. 2011;12:942-949.
Palmer AG, Streng E, Jewell KA, Blackwell HE. Quorum Sensing in Bacterial Species that Use Degenerate Autoinducers Can Be Tuned by Using Structurally Identical Non-native Ligands. Chembiochem. 2011;12:138-147.
Breitbach AS, Broderick AH, Jewell CM, Gunasekaran S, Lin Q, Lynn DM, Blackwell HE. Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: Gradual release enhances activity. Chem. Commun. [Internet]. 2011;47:370-372. Available from: http://dx.doi.org/10.1039/C0CC02316G
Praneenararat T, Beary TMJ, Breitbach AS, Blackwell HE. Synthesis and application of an N-acylated L-homoserine lactone derivatized affinity matrix for the isolation of quorum sensing signal receptors. Bioorganic & Medicinal Chemistry Letters. 2011;21:5054-5057.
McInnis CE, Blackwell HE. Thiolactone modulators of quorum sensing revealed through library design and screening. Bioorganic & Medicinal Chemistry. 2011;19:4820-4828.
2009
Buck ME, Breitbach AS, Belgrade SK, Blackwell HE, Lynn DM. Chemical Modification of Reactive Multilayered Films Fabricated from Poly(2-alkenyl azlactone)s: Design of Surfaces that Prevent or Promote Mammalian Cell Adhesion and Bacterial Biofilm Growth. Biomacromolecules. 2009;10:1564-1574.
Campbell J, Blackwell HE. Efficient Construction of Diketopiperazine Macroarrays Through a Cyclative-Cleavage Strategy and Their Evaluation as Luminescence Inhibitors in the Bacterial Symbiont Vibrio fischeri. Journal of Combinatorial Chemistry. 2009;11:1094-1099.
Praneenararat T, Geske GD, Blackwell HE. Efficient Synthesis and Evaluation of Quorum-Sensing Modulators Using Small Molecule Macroarrays. Organic Letters. 2009;11:4600-4603.
Campbell J, Lin Q, Geske GD, Blackwell HE. New and Unexpected Insights into the Modulation of LuxR-Type Quorum Sensing by Cyclic Dipeptides. ACS Chemical Biology. 2009;4:1051-1059.
Campbell J, Lin Q, Geske GD, Blackwell HE. New and Unexpected Insights into the Modulation of LuxR-Type Quorum Sensing by Cyclic Dipeptides. ACS Chemical Biology [Internet]. 2009;4:1051-1059. Available from: http://pubs.acs.org/doi/abs/10.1021/cb900165y
Gorske BC, Stringer JR, Bastian BL, Fowler SA, Blackwell HE. New Strategies for the Design of Folded Peptoids Revealed by a Survey of Noncovalent Interactions in Model Systems. Journal of the American Chemical Society [Internet]. 2009;131:16555-16567. Available from: http://pubs.acs.org/doi/abs/10.1021/ja907184g
Fowler SA, Blackwell HE. Structure-function relationships in peptoids: Recent advances toward deciphering the structural requirements for biological function. Organic & Biomolecular Chemistry. 2009;7:1508-1524.
Fowler SA, Luechapanichkul R, Blackwell HE. Synthesis and Characterization of Nitroaromatic Peptoids: Fine Tuning Peptoid Secondary Structure through Monomer Position and Functionality. Journal of Organic Chemistry. 2009;74:1440-1449.
2007
Chan YY, Bian HS, Tan TMC, Mattmann ME, Geske GD, Igarashi J, Hatano T, Suga H, Blackwell HE, Chua KL. Control of quorum sensing by a Burkholderia pseudomallei multidrug efflux pump. Journal of Bacteriology. 2007;189:4320-4324.
Guzei IA, Spencer LC, Lin Q, Blackwell HE. {ıt N}-{(Amino{\-}carbon{\-}yl)[(ıt S})-4-nitro{\-}benz{\-}yl]meth{\-}yl}-ıt N}-{[(ıt R})-cyclo{\-}hexyl](cyclo{\-}hexylamino{\-}carbon{\-}yl)meth{\-}yl}propanamide methanol solvate}. Acta Crystallographica Section E [Internet]. 2007;63:o1892–o1894. Available from: http://dx.doi.org/10.1107/S1600536807012299
Gorske BC, Bastian BL, Geske GD, Blackwell HE. Local and tunable n ->pi* interactions regulate amide isomerism in the peptoid backbone. Journal of the American Chemical Society. 2007;129:8928-+.
Geske GD, O'Neill JC, Miller DM, Mattmann ME, Blackwell HE. Modulation of bacterial quorum sensing with synthetic ligands: Systematic evaluation of N-acylated homoserine lactones in multiple species and new insights into their mechanisms of action. Journal of the American Chemical Society. 2007;129:13613-13625.
Geske GD, O'Neill JC, Blackwell HE. N-phenylacetanoyl-L-homoserine lactones can strongly antagonize or superagonize quorum sensing in. ACS Chemical Biology. 2007;2:315-U1.
Bowman MD, O'Neill JC, Stringer JR, Blackwell HE. Rapid identification of antibacterial agents effective against Staphylococcus aureus using small-molecule macroarrays. Chemistry & Biology. 2007;14:351-357.
O'Neill JC, Blackwell HE. Solid-phase and microwave-assisted syntheses of 2,5-diketopiperazines: Small molecules with great potential. Combinatorial Chemistry & High Throughput Screening. 2007;10:857-876.
2006
Bowman MD, Jacobson MM, Blackwell HE. Discovery of Fluorescent Cyanopyridine and Deazalumazine Dyes Using Small Molecule Macroarrays. Organic Letters [Internet]. 2006;8:1645-1648. Available from: http://pubs.acs.org/doi/abs/10.1021/ol0602708
Bowman MD, Jacobsen M, Pujanauski BG, Blackwell HE. Efficient synthesis of small molecule macroarrays: optimization of the macroarray synthesis platform and examination of microwave and conventional heating methods. Tetrahedron [Internet]. 2006;62:4715 - 4727. Available from: http://www.sciencedirect.com/science/article/pii/S0040402006002699
Blackwell HE. Hitting the SPOT: small-molecule macroarrays advance combinatorial synthesis. Current Opinion in Chemical Biology [Internet]. 2006;10:203 - 212. Available from: http://www.sciencedirect.com/science/article/pii/S1367593106000639
Gorske BC, Blackwell HE. Interception of quorum sensing in Staphylococcus aureus: a new niche for peptidomimetics. Org. Biomol. Chem. [Internet]. 2006;4:1441-1445. Available from: http://dx.doi.org/10.1039/B517681F
Guzei IA, Gorske BC, Blackwell HE. {ıt N}-[1-(Penta{\-}fluoro{\-}phenyl){\-}ethyl]{\-}acetamide}. Acta Crystallographica Section C [Internet]. 2006;62:o286–o288. Available from: http://dx.doi.org/10.1107/S0108270106012121
Hollenbeck JJ, Wixson EN, Geske GD, Dodge MW, Tseng AT, Clauss AD, Blackwell HE. A New Model for Transitioning Students from the Undergraduate Teaching Laboratory to the Research Laboratory. The Evolution of an Intermediate Organic Synthesis Laboratory Course. Journal of Chemical Education [Internet]. 2006;83:1835. Available from: http://pubs.acs.org/doi/abs/10.1021/ed083p1835
Hollenbeck JJ, Wixson EN, Geske GD, Dodge MW, Tseng TA, Clauss AD, Blackwell HE. A new model for transitioning students from the undergraduate teaching laboratory to the research laboratory - The evolution of an intermediate organic synthesis laboratory course. Journal of Chemical Education. 2006;83:1835.

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