All Faculty and Research Staff Publications

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2018
Eddinger GA, Gellman SH. Differential Effects of beta(3)- versus beta(2)-Amino Acid Residues on the Helicity and Recognition Properties of Bim BH3-Derived alpha/beta-Peptides. Angewandte Chemie-International Edition. 2018 ;57:13829-13832.
Mortenson DE, Kreitler DF, Thomas NC, Guzei IA, Gellman SH, Forest KT. Evaluation of -Amino Acid Replacements in Protein Loops: Effects on Conformational Stability and Structure. Chembiochem. 2018 ;19:604-612.
Girvin ZC, Gellman SH. Exploration of Diverse Reactive Diad Geometries for Bifunctional Catalysis via Foldamer Backbone Variation. Journal of the American Chemical Society. 2018 ;140:12476-12483.
Shin YH, Gellman SH. Impact of Backbone Pattern and Residue Substitution on Helicity in alpha/beta/gamma-Peptides. Journal of the American Chemical Society. 2018 ;140:1394-1400.
Rank LA, Walsh NM, Lim FY, Gellman SH, Keller NP, Hull CM. Peptide-Like Nylon-3 Polymers with Activity against Phylogenetically Diverse, Intrinsically Drug-Resistant Pathogenic Fungi. Msphere. 2018 ;3.
Liu S, Cheloha RW, Watanabe T, Gardella TJ, Gellman SH. Receptor selectivity from minimal backbone modification of a polypeptide agonist. Proceedings of the National Academy of Sciences of the United States of America. 2018 ;115:12383-12388.
Fisher BF, Hong SH, Gellman SH. Thermodynamic Scale of beta-Amino Acid Residue Propensities for an alpha-Helix-like Conformation. Journal of the American Chemical Society. 2018 ;140:9396-9399.
2017
Rank LA, Walsh NM, Liu RH, Lim FY, Bok JW, Huang MW, Keller NP, Gellman SH, Hull CM. A Cationic Polymer That Shows High Antifungal Activity against Diverse Human Pathogens. Antimicrobial Agents and Chemotherapy. 2017 ;61.
Hager MV, Clydesdale L, Gellman SH, Sexton PM, Wootten D. Characterization of signal bias at the GLP-1 receptor induced by backbone modification of GLP-1. Biochemical Pharmacology. 2017 ;136:99-108.
Cheloha RW, Chen BM, Kumar NN, Watanabe T, Thorne RG, Li LJ, Gardella TJ, Gellman SH. Development of Potent, Protease-Resistant Agonists of the Parathyroid Hormone Receptor with Broad beta Residue Distribution. Journal of Medicinal Chemistry. 2017 ;60:8816-8833.
Fisher BF, Hong SH, Gellman SH. Helix Propensities of Amino Acid Residues via Thioester Exchange. Journal of the American Chemical Society. 2017 ;139:13292-13295.
Lee MR, Raman N, Gellman SH, Lynn DM, Palecek SP. Incorporation of beta-Amino Acids Enhances the Antifungal Activity and Selectivity of the Helical Antimicrobial Peptide Aurein 1.2. ACS Chemical Biology. 2017 ;12:2975-2980.
MacDonald MJ, Cornejo NR, Gellman SH. Inhibition of Ice Recrystallization by Nylon-3 Polymers. Acs Macro Letters. 2017 ;6:695-699.
Checco JW, Gellman SH. Iterative Nonproteinogenic Residue Incorporation Yields alpha/beta-Peptides with a Helix-Loop-Helix Tertiary Structure and High Affinity for VEGF. Chembiochem. 2017 ;18:291-299.
Wang CX, Ma CKD, Yeon H, Wang XG, Gellman SH, Abbott NL. Nonadditive Interactions Mediated by Water at Chemically Heterogeneous Surfaces: Nonionic Polar Groups and Hydrophobic Interactions. Journal of the American Chemical Society. 2017 ;139:18536-18544.
Thomas NC, Bartlett GJ, Woolfson DN, Gellman SH. Toward a Soluble Model System for the Amyloid State. Journal of the American Chemical Society. 2017 ;139:16434-16437.
2016
Cheloha RW, Watanabe T, Dean T, Gellman SH, Gardella TJ. Backbone Modification of a Parathyroid Hormone Receptor-1 Antagonist/Inverse Agonist. ACS Chemical Biology. 2016 ;11:2752-2762.
Hager MV, Johnson LM, Wootten D, Sexton PM, Gellman SH. beta-Arrestin-Biased Agonists of the GLP-1 Receptor from beta-Amino Acid Residue Incorporation into GLP-1 Analogues. Journal of the American Chemical Society. 2016 ;138:14970-14979.
Walsh PS, Dean JC, McBurney C, Kang H, Gellman SH, Zwier TS. Conformation-specific spectroscopy of capped glutamine-containing peptides: role of a single glutamine residue on peptide backbone preferences. Physical Chemistry Chemical Physics. 2016 ;18:11306-11322.
Kreitler DF, Mortenson DE, Forest KT, Gellman SH. Effects of Single alpha-to-beta Residue Replacements on Structure and Stability in a Small Protein: Insights from Quasiracemic Crystallization. Journal of the American Chemical Society. 2016 ;138:6498-6505.
MacDonald MJ, Lavis LD, Hilvert D, Gellman SH. Evaluation of the Ser-His Dipeptide, a Putative Catalyst of Amide and Ester Hydrolysis. Organic Letters. 2016 ;18:3518-3521.
Fisher BF, Gellman SH. Impact of γ-Amino Acid Residue Preorganization on α/γ-Peptide Foldamer Helicity in Aqueous Solution. Journal of the American Chemical Society. 2016 ;138:10766-10769.
Walsh PS, Blodgett KN, McBurney C, Gellman SH, Zwier TS. Inherent Conformational Preferences of Ac-Gln-Gln-NHBn: Sidechain Hydrogen Bonding Supports a β-Turn in the Gas Phase. Angewandte Chemie - International Edition. 2016 ;55:14618-14622.
Ma CD, Acevedo-Velez C, Wang C, Gellman SH, Abbott NL. Interaction of the Hydrophobic Tip of an Atomic Force Microscope with Oligopeptides Immobilized Using Short and Long Tethers. Langmuir. 2016 ;32:2985-95.
Choi H, Chakraborty S, Liu RH, Gellman SH, Weisshaar JC. Single-Cell, Time-Resolved Antimicrobial Effects of a Highly Cationic, Random Nylon-3 Copolymer on Live Escherichia coli. ACSChemical Biology. 2016 ;11:113-120.
Checco JW, Gellman SH. Targeting recognition surfaces on natural proteins with peptidic foldamers. Current Opinion in Structural Biology. 2016 ;39:96-105.
2015
Checco JW, Lee EF, Evangelista M, Sleebs NJ, Rogers K, Pettikiriarachchi A, Kershaw NJ, Eddinger GA, Belair DG, Wilson JL, et al. alpha/beta-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells. Journal of the American Chemical Society. 2015 ;137:11365-11375.
Cheloha RW, Sullivan JA, Wang T, Sand JM, Sidney J, Sette A, Cook ME, Suresh M, Gellman SH. Consequences of Periodic alpha-to-beta(3) Residue Replacement for Immunological Recognition of Peptide Epitopes. ACS Chemical Biology. 2015 ;10:844-854.
Hovakeemian SG, Liu RH, Gellman SH, Heerklotz H. Correlating antimicrobial activity and model membrane leakage induced by nylon-3 polymers and detergents. Soft Matter. 2015 ;11:6840-6851.
Fisher BF, Guo L, Dolinar BS, Guzei IA, Gellman SH. Heterogeneous H-Bonding in a Foldamer Helix. Journal of the American Chemical Society. 2015 ;137:6484-6487.
Mortenson DE, Steinkruger JD, Kreitler DF, Perroni DV, Sorenson GP, Huang L, Mittal R, Yun HG, Travis BR, Mahanthappa MK, et al. High-resolution structures of a heterochiral coiled coil. Proceedings of the National Academy of Sciences of the United States of America. 2015 ;112:13144-13149.
Kung VM, Cornilescu G, Gellman SH. Impact of Strand Number on Parallel beta-Sheet Stability. Angewandte Chemie-International Edition. 2015 ;54:14336-14339.
Ma CD, Wang CX, Acevedo-Velez C, Gellman SH, Abbott NL. Modulation of hydrophobic interactions by proximally immobilized ions. Nature. 2015 ;517:347-U443.
Liu RH, Chen XY, Falk SP, Masters KS, Weisblum B, Gellman SH. Nylon-3 Polymers Active against Drug-Resistant Candida albicans Biofilms. Journal of the American Chemical Society. 2015 ;137:2183-2186.
Demizu Y, Oba M, Okitsu K, Yamashita H, Misawa T, Tanaka M, Kurihara M, Gellman SH. A preorganized beta-amino acid bearing a guanidinium side chain and its use in cell-penetrating peptides. Organic & Biomolecular Chemistry. 2015 ;13:5617-5620.
Cheloha RW, Gellman SH, Vilardaga JP, Gardella TJ. PTH receptor-1 signalling-mechanistic insights and therapeutic prospects. Nature Reviews Endocrinology. 2015 ;11:712-724.
Hayouka Z, Thomas NC, Mortenson DE, Satyshur KA, Weisblum B, Forest KT, Gellman SH. Quasiracemate Crystal Structures of Magainin 2 Derivatives Support the Functional Significance of the Phenylalanine Zipper Motif. Journal of the American Chemical Society. 2015 ;137:11884-7.
Peterson-Kaufman KJ, Haase HS, Boersma MD, Lee EF, Fairlie DW, Gellman SH. Residue-Based Preorganization of BH3-Derived α/β-Peptides: Modulating Affinity, Selectivity and Proteolytic Susceptibility in α-Helix Mimics. ACS Chemical Biology. 2015 ;10:1667-1675.
Nadithe V, Liu RH, Killinger BA, Movassaghian S, Kim NH, Moszczynska AB, Masters KS, Gellman SH, Merkel OM. Screening Nylon-3 Polymers, a New Class of Cationic Amphiphiles, for siRNA Delivery. Mol Pharm. 2015 ;12:362-374.
Checco JW, Kreitler DF, Thomas NC, Belair DG, Rettko NJ, Murphy WL, Forest KT, Gellman SH. Targeting diverse protein-protein interaction interfaces with alpha/beta-peptides derived from the Z-domain scaffold. Proceedings of the National Academy of Sciences of the United States of America. 2015 ;112:4552-4557.

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