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Synthesis of Cyclic Enones via Direct Palladium-Catalyzed Aerobic Dehydrogenation of Ketones
Tue, 11/27/2012 - 11:52am — root
| Title | Synthesis of Cyclic Enones via Direct Palladium-Catalyzed Aerobic Dehydrogenation of Ketones |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Diao, T, Stahl, SS |
| Journal | Journal of the American Chemical Society |
| Volume | 133 |
| Pagination | 14566-14569 |
| Date Published | Sep |
| Accession Number | WOS:000295148100026 |
| Keywords | alcohol, aldehydes, alpha,beta-unsaturated carbonyl-compounds, c-h, chemistry, functionalization, ITO Y, 1978, JOURNAL OF ORGANIC CHEMISTRY, V43, P1011, molecular-oxygen, organoselenium reagents, oxidation, palladium(ii)-catalyzed oxidation, saegusa oxidation, selective oxidation, silyl enol ethers, Trost BM, 2010, CHEMISTRY-A EUROPEAN JOURNAL, V16, P6265, VRIES JG, 2007, HDB HOMOGENEOUS HYDR, |
| Abstract | alpha,beta-Unsaturated carbonyl compounds are versatile intermediates in the synthesis of pharmaceuticals and biologically active compounds. Here, we report the discovery and application of Pd(DMSO)(2)(TFA)(2) as a catalyst for direct dehydrogenation of cydohexanones and other cyclic ketones to the corresponding enones, using O(2) as the oxidant. The substrate scope includes heterocyclic ketones and several natural-product precursors. |
| Short Title | J. Am. Chem. Soc. |
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