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Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: Gradual release enhances activity
Tue, 11/27/2012 - 11:03am — root
| Title | Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: Gradual release enhances activity |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Breitbach, AS, Broderick, AH, Jewell, CM, Gunasekaran, S, Lin, Q, Lynn, DM, Blackwell, HE |
| Journal | Chemical Communications |
| Volume | 47 |
| Pagination | 370-372 |
| Accession Number | ISI:000285068300077 |
| Keywords | Acylated homoserine lactones, Chemistry, Multidisciplinary, communication, drug, Gram-negative bacteria, microspheres, Pseudomonas-aeruginosa, therapies, tissue, to-cell, virulence |
| Abstract | We demonstrate an approach to the surface-mediated release of a synthetic N-acylated L-homoserine lactone (AHL) modulator of bacterial quorum sensing (QS). AHL released gradually from thin films of poly(lactide-co-glycolide) (PLG) is shown to activate QS in the model symbiont Vibrio fischeri at levels that exceed those promoted by direct solution-based administration. |
| Short Title | Chem. Commun |
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