Expand Menu
Nonenzymatic Polymerization of Ubiquitin: Single-Step Synthesis and Isolation of Discrete Ubiquitin Oligomers.
Sat, 12/01/2012 - 11:06am — ldowdall
| Title | Nonenzymatic Polymerization of Ubiquitin: Single-Step Synthesis and Isolation of Discrete Ubiquitin Oligomers. |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Trang, VH, Valkevich, EM, Minami, S, Chen, Y-C, Ge, Y, Strieter, ER |
| Journal | Angew Chem Int Ed Engl |
| Date Published | 2012 Nov 19 |
| ISSN | 1521-3773 |
| Abstract | Linked: A method based on thiol-ene chemistry enables the synthesis and purification of ubiquitin oligomers with ≥4 units. This approach, which employs free-radical polymerization, can be applied towards the synthesis of homogeneous Lys6-linked ubiquitin oligomers currently inaccessible by enzymatic methods. By using these chains, one can study their roles in the ubiquitin proteasome system and the DNA damage response pathway. |
| DOI | 10.1002/anie.201207171 |
| Custom 1 | |
| Alternate Journal | Angew. Chem. Int. Ed. Engl. |
| PubMed ID | 23161800 |
Contact Us
1101 University Avenue
Madison, WI 53706
Phone: 608.262.1483
Email: chemdept@chem.wisc.edu
Get Directions
