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A mechanical nanomembrane detector for time-of-flight mass spectrometry.
| Title | A mechanical nanomembrane detector for time-of-flight mass spectrometry. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Park, J, Qin, H, Scalf, M, Hilger, RT, Westphall, MS, Smith, LM, Blick, RH |
| Journal | Nano Lett |
| Volume | 11 |
| Issue | 9 |
| Pagination | 3681-4 |
| Date Published | 2011 Sep 14 |
| ISSN | 1530-6992 |
| Keywords | algorithms, Animals, Biophysics, Biosensing Techniques, Cattle, Humans, Immunoglobulin G, ions, Models, Statistical, nanoparticles, Nanotechnology, Oscillometry, Serum Albumin, Bovine, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization |
| Abstract | We describe here a new principle for ion detection in time-of-flight (TOF) mass spectrometry in which an impinging ion packet excites mechanical vibrations in a silicon nitride (Si(3)N(4)) nanomembrane. The nanomembrane oscillations are detected by means of time-varying field emission of electrons from the mechanically oscillating nanomembrane. Ion detection is demonstrated in the MALDI-TOF analysis of proteins varying in mass from 5729 (insulin) to 150,000 (Immunoglobulin G) daltons. The detector response agrees well with the predictions of a thermomechanical model in which the impinging ion packet causes a nonuniform temperature distribution in the nanomembrane, exciting both fundamental and higher order oscillations. |
| DOI | 10.1021/nl201645u |
| Custom 1 | |
| Alternate Journal | Nano Lett. |
| PubMed ID | 21806063 |
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