How innocent is thallium(I)? Corrected formulations of Tl2Pd14(CO)(9)(PMe3)(11) PF6 (2) and TlPd9(CO)(9)(PPh3)(6) PF6 clusters previously reported as corresponding Au2Pd14 and AuPd9 clustersParallel Reaction Monitoring for High Resolution and High Mass Ac

Two previously reported cationic clusters, Au2Pd14 (1-Me) and AuPd9 (2-Ph), obtained by similar reactions of CO/PR3-ligated Pd(0) clusters with AuCl(PR3') in the presence of TlPF6 are shown to be [Tl2Pd14(CO)(9)(PMe3)(11)](2+) (1a-Me) and [TlPd9(CO)(9)(PPh3)(6)](+) (2a-Ph), respectively. These clusters ([PF6](-) counterion) were prepared without the presence of gold by reactions of either Pd-10(CO)(12)(PMe3)(6) or Pd-10(CO)(12)(PPh3)(6) with TlPF6 and characterized crystallographically and spectroscopically.Selected reaction monitoring on a triple quadrupole mass spectrometer is currently experiencing a renaissance within the proteomics community for its, as yet, unparalleled ability to characterize and quantify a set of proteins reproducibly, completely, and with high sensitivity. Given the immense benefit that high resolution and accurate mass instruments have brought to the discovery proteomics field, we wondered if highly accurate mass measurement capabilities could be leveraged to provide benefits in the targeted proteomics domain as well. Here, we propose a new targeted proteomics paradigm centered on the use of next generation, quadrupole-equipped high resolution and accurate mass instruments: parallel reaction monitoring (PRM). In PRM, the third quadrupole of a triple quadrupole is substituted with a high resolution and accurate mass mass analyzer to permit the parallel detection of all target product ions in one, concerted high resolution mass analysis. We detail th!