How can a single second sphere amino acid substitution cause reduction midpoint potential changes of hundreds of millivolts?

TitleHow can a single second sphere amino acid substitution cause reduction midpoint potential changes of hundreds of millivolts?
Publication TypeJournal Article
Year of Publication2007
AuthorsYikilmaz, E, Porta, J, Grove, LE, Vahedi-Faridi, A, Bronshteyn, Y, Brunold, TC, Borgstahl, GEO, Miller, A-F
JournalJournal of the American Chemical Society
Volume129
Pagination9927-9940
Date PublishedAug
Accession NumberISI:000248708500024