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Functionally Diverse Nylon-3 Copolymers from Readily Accessible beta-Lactams
Tue, 11/27/2012 - 11:23am — root
| Title | Functionally Diverse Nylon-3 Copolymers from Readily Accessible beta-Lactams |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Zhang, JH, Markiewicz, MJ, Weisblum, B, Stahl, SS, Gellman, SH |
| Journal | Acs Macro Letters |
| Volume | 1 |
| Pagination | 714-717 |
| Date Published | Jun |
| Type of Article | Article |
| ISBN Number | 2161-1653 |
| Accession Number | WOS:000305320600014 |
| Keywords | antibacterial, antimicrobial polymers, conformational-analysis, de-novo design, derivatives, hemolytic activities, host-defense peptides, resistance, Ring-opening polymerization, Side-chains |
| Abstract | A new family of beta-lactams is described that enables anionic ring-opening polymerization (AROP) to prepare nylon-3 materials bearing diverse appended functionality, including carboxylic acid, thiol, hydroxyl, and secondary amine groups. Nylon-3 copolymers generated with the new beta-lactams are shown to display distinctive self-assembly behavior and biological properties. |
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