Expand Menu
Facilitating Discovery of Prion Disease Biomarkers by Quantitative Glycoproteomics
Tue, 11/27/2012 - 11:49am — root
| Title | Facilitating Discovery of Prion Disease Biomarkers by Quantitative Glycoproteomics |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Wei, X, Herbst, A, Schmidt, JR, Aikent, J, Li, LJ |
| Journal | Lc Gc North America |
| Volume | 27 |
| Pagination | 154-+ |
| Date Published | Feb |
| Accession Number | ISI:000263662200006 |
| Keywords | apolipoprotein-e, astrocytes, cells, Chemistry, Analytical, chromatography, Mass-spectrometry, proteins, proteomics, scrapie |
| Abstract | Currently, there is a lack of a sensitive and reliable premortem diagnostic test for prion diseases. Here we examine mass spectrometry (MS)-based methods to search for protein biomarkers of prion diseases from plasma samples. Dynamic range of detection is increased by glycoprotein enrichment and multidimensional separations. By utilizing isotopic labeling, quantitative information of a panel of biomarker candidates is obtained. |
Contact Us
1101 University Avenue
Madison, WI 53706
Phone: 608.262.1483
Email: chemdept@chem.wisc.edu
Get Directions
