Department of Chemistry Newsletter for 05/01/2017

XLI - No. 5 May 1st, 2017

2017 Dates of Finance/Department Meetings
Department/Executive Committee Meetings - Tuesdays - 1:30 PM - Room 9341 Chemistry


Finance Committee Meetings - Tuesdays - 1:30 PM - Room 1130

May 2 May 16


Tuesday, May 2nd, 2017 - Physical Seminar, 11:00 am, 1315 Chemistry. "Physical Chemistry Graduate Student Award Talks"
Wednesday, May 3rd, 2017 - Inorganic Seminar, 3:30 pm, Room 1315 Chemistry. Prof. Nathaniel Szymczak, University of Michigan "Inorganic Meloche seminar -Moving Beyond the Metal: Assisted Small Molecule Activation"
Thursday, May 4th, 2017 - Analytical, Chemical Biology Seminar, 12:15 pm, 1315 Chemistry (Seminar Hall). Nick Riley, Coon research group at UW-Madison "Activated ion electron transfer dissociation and global profiling of the glycoproteome"
Thursday, May 4th, 2017 - Chemical Biology, Organic Seminar, 2:30 pm, 1315 Chemistry (Seminar Hall). Dr. Michael Shultz, Novartis Institutes for BioMedical Research "Novartis Chemical Sciences Lectureship "Improving the Plausibility of Success in Drug Discovery with Inefficient Metrics""
Thursday, May 4th, 2017 - Chemical Biology, Organic Seminar, 3:30 pm, Chemistry Seminar Hall #1315. Prof. Wilfred van der Donk, University of Illinois "Novartis Chemical Sciences Lectureship "Biosynthesis and Engineering of Cyclic Peptide Antibiotics""
Friday, May 5th, 2017 - Chemical Biology Seminar, 3:30 pm, Room 105 Psychology Building. Prof. Peter Schultz, Scripps Research Institute "McElvain Seminar: New Opportunities at the Interface of Chemistry and Biology--From Stem Cells to the Genetic Code"
Tuesday, May 9th, 2017 - General Conference/Meeting, 1:30 pm, 9341 Chemistry. "Department Meeting"
Wednesday, May 10th, 2017 - Inorganic Seminar, 3:30 pm, Room 1315 Chemistry. Prof. Eric Hegg, Michigan State University "Inorganic seminar -TBD"
Friday, May 12th, 2017 - General Special Event, 3:00 pm, TBD. UW-Madison Department of Chemistry, "Chemistry Graduation Celebration"
Tuesday, May 16th, 2017 - General, Chemical Biology Seminar, 1:30 pm, 1315 Chemistry (Seminar Hall). 4th year Chem Bio Students, University of Wisconsin-Madison "5th Annual Chem Bio Seminar Day"
Wednesday, May 17th, 2017 - Inorganic Seminar, 3:30 pm, Room 1315 Chemistry. Prof. Christopher Cummins, MIT "Inorganic McElvain seminar -TBD"
Tuesday, May 23rd, 2017 - Organic Special Event, 8:30 am, Chemistry Seminar Hall #1315. 4th Year Organic Students, UW-Madison "4th Year Organic Student Research Seminar"
Thursday, June 15th, 2017 to Friday, June 16th, 2017 - General Career Services, 9:00 am, "P&G sponsored Career Workshop"
Wednesday, July 26th, 2017 to Friday, July 28th, 2017 - General Career Services, 8:00 am, "PfLAGS"

Improving data quality and preserving HCD-generated reporter ions with EThcD for isobaric tag-based quantitative proteomics and proteome-wide PTM studies.
Yu, Q; Shi, XD; Feng, Y; Kent, KC; Li, LJ*.
ANALYTICA CHIMICA ACTA, 968 40-49; 10.1016/j.aca.2017.03.003 MAY 22 2017.
In-crystal reaction cycle of a toluene-bound diiron hydroxylase.
Acheson, JF; Bailey, LJ; Brunold, TC*; Fox, BG.
NATURE, 544 (7649):191-+; 10.1038/nature21681 APR 13 2017.
Mechanism of transcription initiation and promoter escape by E. coli RNA polymerase.
Henderson, KL; Felth, LC; Molzahn, CM; Shkel, I; Wang, S; Chhabra, M; Ruff, EF; Bieter, L; Kraft, JE; Record, MT*.
Proceedings of the National Academy of Sciences of the United States of America, 114 (15):E3032-E3040; 10.1073/pnas.1618675114 APR 11 2017.
Broadband 2D electronic spectrometer using white light and pulse shaping: noise and signal evaluation at 1 and 100 kHz.
Kearns, NM; Mehlenbacher, RD; Jones, AC; Zanni, MT*.
OPTICS EXPRESS, 25 (7):7869-7883; 10.1364/OE.25.007869 APR 3 2017.

Bell Laboratories, Inc. Analytical Chemist.
Status: Salaried
Job Function: Perform quantitative method development, validation and analyses to support a chemical manufacturing facility.
Reports To: Chemistry Manager
     •    Perform analytical method development, validation and quantitation of small molecules using UPLC
          / MS.
     •    Develop high-throughput methods for the extraction of small molecules from solid matrices.
     •    Perform quantitative analysis of gases using a GC with Headspace Analyzer.
     •    Assist in developing qualitative methods for routine UPLC / MS usage by chemistry team.
     •    Maintain laboratory equipment and confidently troubleshoot analytical instrumentation.
     •    Review and evaluate data, write reports and robust protocols for smooth operation of laboratory
     •    Keep and maintain a meticulous laboratory notebook with transparent scientific reasoning.
     •    Assist in the creation of well-written, accurate, and timely reports to company management.
     •    Solve complex analytical problems as well as recommend/implement continuous laboratory
     •    Recognize errors, identify root causes, and recommend process improvements
     •    With minimal supervision, safely and effectively develop, establish, and validate analytical testing
          methodologies used to control raw materials, production intermediates, and final products.
     •    Provide timely analytical services using other techniques such as HPLC, GC, Microwave and Karl
          Fischer titration to cross-functional groups within the organization.
     •    Act as Study Director in support of new product development within compliance of Good Laboratory
          Practice (GLP) guidelines.
Education: Ph.D. in Analytical Chemistry with 0-3 years' experience or M.S. in Analytical Chemistry with 7-10 years' experience preferred.
Experience: Must include practical hands-on experience with the qualitative and quantitative analysis of small molecule pharmaceuticals. Must have hands-on and demonstrated expertise in creating quantitative analysis methods using GC, HPLC, LCMS and UPLC instrumentation. Knowledge and usage of Empower software is desirable.
Qualifications: Must demonstrate expertise in theory and application of LC-MS to develop quantitative analyses of small molecules embedded within a sample matrix. Must display strong analytical reasoning and communication skills in areas outside of Analytical Chemistry. A working knowledge of computer and work processing/spreadsheet programs, more JMP statistical discovery software is desired. Familiarity with Waters instrumentation a plus.
Contact: Chris Thomas, Chemistry Manager, Bell Laboratories, Direct: 608-906-8171, e-mail:
Bruker BioSpin is looking for a Pharma Market Manager for the US, to gather market insights and participate in the design, development and implementation of an integrated, focused and on-going program of solutions targeting the Pharma market. The successful candidate will work in close collaboration with the sales, marketing, and marcom teams to ensure the success of Pharma products in the market. If interested, find out more at: @

Truckee Meadows Community College (TMCC), located in Reno, Nevada is seeking applicants for a tenure-track Chemistry Instructor. The successful applicant for this position will be responsible for teaching lower-division, university-transferable courses and will be instructing students both in the classroom and lab settings, on field trips (as necessary), and in online courses. The main teaching responsibilities for this position are General Chemistry 1 and 2 and non-majors Chemistry.
Some perks include: excellent colleagues, teaching focused environment (tenure based on teaching/service), small class sizes (capped at 28), good salary/affordable city, and located in a beautiful region with easy access to mountains (skiing, hiking, Lake Tahoe, Yosemite NP).
Apply online at:

Professor Adam R. Urbach, is writing to announce the availability of a funded postdoctoral position in his laboratory, available to start as early as August of 2017. This position is especially well suited to those individuals interested in pursuing a tenure-track faculty position at a primarily undergraduate institution (PUI). Trinity University, a private liberal arts institution in San Antonio, Texas, is well known for the quality of its undergraduate chemistry program. Our rigorous coursework, access to state-of-the-art facilities, and intensive undergraduate research experiences prepare our students for the best post-graduate opportunities. This postdoc position is designed specifically for professional growth in scholarship, teaching, and management with particular attention paid to the skills necessary to succeed in a tenure-track position at a PUI. The postdoc will collaborate extensively with me on idea generation, grant writing, project design, project implementation, manuscript writing, student recruiting and training, and laboratory management. Teaching opportunities will include a combination of formal lecturing, lab instruction, course development, and mentoring of undergraduate research students.
His research group explores fundamental and applied supramolecular chemistry related to the molecular recognition of peptides, proteins, and DNA by synthetic compounds in aqueous solution. We are interested in the fundamental principles that guide recognition in natural and synthetic systems, as well as the development of applications in chemical biology and materials science. His laboratory is located in a new, state-of-the-art facility and is currently funded by grants from the National Science Foundation and the Welch Foundation. Qualified candidates will have good communication skills, a strong interest in both teaching and research, the ability and motivation to work independently and in small teams, and a demonstrated technical background in synthetic organic chemistry, supramolecular chemistry, medicinal chemistry, biophysical chemistry, nano/materials chemistry, or molecular biology.
This position includes a competitive salary and full benefits. Interested applicants should send an email to: including, as a single PDF file, a cover letter, CV, and list of references. Applications will be accepted immediately, and review will continue until the position is filled.
The chair of the Analytical Chemistry Academic Contacts Committee (ACACC) at Eli Lilly and Company, wants to reach out about a post-doc position and encourage any qualified candidates to apply. It is an open post-doc position for a fixed term of 2 years in Eli Lilly and Company's  small molecule development organization.  It focuses on development of advanced analytical technology and methods for rapid and automated analysis of active pharmaceutical ingredients in a variety of drug product formulations. For more see:
The Cyclotron Research Group at the University of Wisconsin, Madison seeks candidates for two postdoctoral research positions in radionuclide production. The Cyclotron Research Group is responsible for a wide variety of scientific endeavors related to the application of radionuclides for basic science, industrial, and medical use. The Group operates two research facilities on the Madison campus, each centered around its own low-energy cyclotron and associated radiochemistry and radiobiology laboratories.
Position 1:
For the first position, a PhD in physics, radiochemistry, nuclear chemistry, nuclear engineering or a closely related field is required. The chosen candidate will be responsible for the design and conduct of experiments to make new measurements of fundamental nuclear data, including nuclear excitation functions for charged and neutral particles. Travel will be required for several such experiments and is expected for durations of up to three weeks up to four times annually.
The most desirable candidates will have experience knowledge in one or several of the following topics: charged and neutral particle transport, accelerator and nuclear reaction physics (beam optics, target thermodynamics), gamma and beta spectrometry, monte carlo computational codes (e.g., MCNP, GEANT), radiochemical separations, and radionuclide production. Familiarity with analysis toolkits used for computational problems in physical fields is also desirable (e.g., ROOT, python, Fortran, C++). Experience working with mega-electronvolt OR kilowatt-scale charged particle accelerators, handling radioactive material, high vacuum systems, RF instrumentation, and scintillation-based detector systems is particularly desirable.
Position 2:
For the second position, a PhD in chemistry, biochemistry, radiobiology, or a closely related field is required. The chosen candidate will be responsible for experiments working to apply novel electron- and alpha-emitting radionuclides to the utilization of targeted molecular agents for diagnosis and therapy of human disease, examining the radiobiological potential of multiple radionuclides in both in vitro and in vivo models.
The most desirable candidates will have experience working in radiation environments, especially accelerator and radiochemistry facilities, and in the routine use of fume hoods, biosafety cabinets, laminar air flow environments, and hot cells. Experience with radiochemical separations, especially those seeking the isolation of no-carrier-added radionuclides, is also highly desired. Desireable candidates may also have experience in the growth and analysis of cellular samples, including the use of a variety of commercial kits for staining analysis, spectrofluorometry, flow cytometry, and significant experience in aseptic techniques, preferably with BSL-2 level organisms.
Job Requirements of Both Positions:
     •    Record of technical excellence and achievement as demonstrated through publications, reports,
          presentations at national or international meetings and independent research in relevant disciplines.
     •    Record of effective written and oral communication skills as evidenced by internal and/or external
          interactions, seminars, briefings, presentations, funding proposals, and/or publications.
     •    Demonstrated commitment to quality research, technical and scientific excellence, professional
          integrity, and personal initiative.
     •    Ability to work within the context of a team, synthesizing large amounts of technical information to
          accomplish shared objectives in a productive, collaborative fashion.
Term of Position: 1-3 years. Applicants should provide a cover letter of interest in the position and a curriculum vitae detailing specific experience as it applies to the required and desired criteria of this job ad. Please submit materials and/or address inquiries to
Contact: Jonathan Engle, Assistant Professor, University of Wisconsin Department of Medical Physics, B1303 WIMR Cyclotron Laboratory, 1111 Highland Avenue, Madison, WI 53705, Cell: (505) 695-6203, Laboratory: (608) 263-5805.
Please submit all newsletter information or address changes to: or 262-0293. Thanks.