Copper(II)-mediated oxidative cyclization of enamides to oxazoles

TitleCopper(II)-mediated oxidative cyclization of enamides to oxazoles
Publication TypeJournal Article
Year of Publication2012
AuthorsWendlandt, AE, Stahl, SS
JournalOrganic & Biomolecular Chemistry
Volume10
Pagination3866-3870
Type of ArticleArticle
ISBN Number1477-0520
Accession NumberWOS:000303166500011
Keywords2,5-disubstituted oxazoles, Bond formation, c-h, copper-catalyzed synthesis, Coupling reactions, efficient synthesis, mild conditions, n-heterocycles, one-pot synthesis, terminal alkynes
Abstract

The copper(II)-mediated oxidative cyclization of enamides to oxazoles is reported. A range of 2,5-disubstituted oxazoles were prepared in moderate to good yields in two steps from simple amide and alkyne precursors.

Short TitleOrg. Biomol. Chem