Chemistry Newsletter

	UNIVERSITY OF WISCONSIN-MADISON DEPARTMENT OF CHEMISTRY NEWSLETTER
XXXVI - No. 36	November 26th, 2012

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2012 Dates of Finance/Department Meetings
Department/Executive Committee Meetings - Tuesdays - 1:30 PM - Room 9341 Chemistry

Finance Committee Meetings - Tuesdays - 1:30 PM - Room 1130

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SEMINARS
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Monday, December 3rd, 2012 - 2012-2013 X-Ray Superuser Seminar, 12:00 p.m., Room 1220 in the new Biochemical Sciences Building on Henry Mall. Katrina Forest lab - Presenter and title TBA.
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Friday, December 7th , 2012 - ECT Seminar, 12:00 p.m., 1025 Engineering Centers Building. Mercedes Ruiz, ECT Graduate Student.
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Friday, December 14th , 2012 - ECT Seminar, 12:00 p.m., 1025 Engineering Centers Building. Thomas Kuech, ECT Graduate Student.
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Monday, February 4th, 2012 - 2012-2013 X-Ray Superuser Seminar, 12:00 p.m., Room 1220 in the new Biochemical Sciences Building on Henry Mall. Yongna Xing lab - Presenter and title TBA.
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Monday, March 4th, 2012 - 2012-2013 X-Ray Superuser Seminar, 12:00 p.m., Room 1220 in the new Biochemical Sciences Building on Henry Mall. Jim Keck lab - Presenter and title TBA.
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Monday, April 1st, 2012 - 2012-2013 X-Ray Superuser Seminar, 12:00 p.m., Room 1220 in the new Biochemical Sciences Building on Henry Mall. Sam Butcher lab - Presenter and title TBA.
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Monday, May 6th, 2012 - 2012-2013 X-Ray Superuser Seminar, 12:00 p.m., Room 1220 in the new Biochemical Sciences Building on Henry Mall. Presenter and title TBA.
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RECENT PUBLICATIONS
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Chemical oxidation of a redox-active, ferrocene-containing cationic lipid: Influence on interactions with DNA and characterization in the context of cell transfection.
Aytar, BS; Muller, JPE; Golan, S; Kondo, Y; Talmon, Y; Abbott, NL; Lynn, DM*.
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 387 56-64; 10.1016/j.jcis.2012.07.083 DEC 1 2012.
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Catalyst-Controlled Regioselectivity in the Synthesis of Branched Conjugated Dienes via Aerobic Oxidative Heck Reactions.
Zheng, CW; Wang, D; Stahl, SS*.
Journal of the American Chemical Society, 134 (40):16496-16499; 10.1021/ja307371w OCT 10 2012.
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Visible Light Photocatalysis of [2+2] Styrene Cycloadditions by Energy Transfer.
Lu, Z; Yoon, TP*.
Angewandte Chemie-international Edition, 51 (41):10329-10332; 10.1002/anie.201204835 2012.
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Spectroscopic and computational studies of matrix-isolated iso-CXBr3 (X = F, Cl, Br): Structure, properties, and photochemistry of substituted iso-tribromomethanes.
George, L; Kalume, A; Reid, SA; Esselman, BJ; McMahon, RJ*.
JOURNAL OF MOLECULAR STRUCTURE, 1025 61-68; SI 10.1016/j.molstruc.2011.12.018 OCT 10 2012.
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Electrophilic aryl C-H amination by dimetal nitrides: correlating electronic structure with reactivity.
Timmer, GH; Berry, JF*.
CHEMICAL SCIENCE, 3 (10):3038-3052; 10.1039/c2sc20688a 2012.
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Cobalt analogs of Ru-based water oxidation catalysts: overcoming thermodynamic instability and kinetic lability to achieve electrocatalytic O-2 evolution.
Rigsby, ML; Mandal, S; Nam, W; Spencer, LC; Llobet, A; Stahl, SS*.
CHEMICAL SCIENCE, 3 (10):3058-3062; 10.1039/c2sc20755a 2012.
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Deconvolution of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry isotope patterns to determine ratios of A-type to B-type interflavan bonds in cranberry proanthocyanidins.
Feliciano, RP; Krueger, CG; Shanmuganayagam, D; Vestling, MM*; Reed, JD.
FOOD CHEMISTRY, 135 (3):1485-1493; 10.1016/j.foodchem.2012.05.102 DEC 1 2012.
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Natural bond orbital analysis: A critical overview of relationships to alternative bonding perspectives.
Weinhold, F*.
JOURNAL OF COMPUTATIONAL CHEMISTRY, 33 (30):2363-2379; 10.1002/jcc.23060 NOV 15 2012.
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Natural bond critical point analysis: Quantitative relationships between natural bond orbital-based and QTAIM-based topological descriptors of chemical bonding.
Weinhold, F*.
JOURNAL OF COMPUTATIONAL CHEMISTRY, 33 (30):2440-2449; 10.1002/jcc.23057 NOV 15 2012.
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What Is Happening When the Blue Bottle Bleaches: An Investigation of the Methylene Blue-Catalyzed Air Oxidation of Glucose.
Anderson, L; Wittkopp, SM; Painter, CJ; Liegel, JJ; Schreiner, R*; Bell, JA; Shakhashiri, BZ*.
JOURNAL OF CHEMICAL EDUCATION, 89 (11):1425-1431; 10.1021/ed200511d NOV 2012.
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Implementation of the Solvent Macromolecule Boundary Potential and Application to Model and Realistic Enzyme Systems.
Zienau, J; Cui, Q*.
JOURNAL OF PHYSICAL CHEMISTRY B, 116 (41):12522-12534; 10.1021/jp308218m OCT 18 2012.
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Effect of Polydispersity on Diffusion in Random Obstacle Matrices.
Cho, HW; Kwon, G; Sung, BJ; Yethiraj, A*.
PHYSICAL REVIEW LETTERS, 109 (15):10.1103/PhysRevLett.109.155901 OCT 12 2012.
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Attenuation of Quorum Sensing in the Pathogen Acinetobacter baumannii Using Non-native N-Acyl Homoserine Lactones.
Stacy, DM; Welsh, MA; Rather, PN; Blackwell, HE*.
ACS CHEMICAL BIOLOGY, 7 (10):1719-1728; 10.1021/cb300351x OCT 2012.
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Copyright © 2012 Thomson ISI
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THE INDUSTRIAL INTERNSHIP PROGRAM AT THE UNIVERSITY OF OREGON
Earn a master's degree and a paycheck. The industrial internship program at the University of Oregon. What is it? A master's program in chemistry or applied physics featuring concentrated classroom and laboratory instruction with 9-month paid internship.
What Makes It Special? You can earn between $2,500 and $5,400 per month during the internship. Approximately 90% of interns receive regular job offers. The majority of our students finish in one year. Academic Requirements? A bachelor's degree in one of the following: Chemistry; Biochemistry; Physics and Chemical, Electrical, or Mechanical Engineering.
For more information on this program, please go to this website: http://internship.uoregon.edu.
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EMPLOYMENT OPPORTUNITIES
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Kensey Nash, Regenerating Medicine. Chemistry Lab Technician I. Webite for job description and application process: http://www.kenseynash.com/careers/job/chemistry-lab-technician-I. Purpose: Assure that Kensey Nash products are of consistent and high quality by: Assuming responsibility for duties related to the synthesis, development, scale-up, testing and/or manufacturing of polymers, medical device materials, products or technologies in compliance with applicable regulatory standards.
Principal Duties:

• Assist with product development and in the transition of development products and projects through chemical synthesis and purification.
• Execute DOE's and test protocols required to evaluate parameters of new and existing chemical processes.
• Tabulate data and summarize results based on completed experiments and/or tests.
• Interface with supporting groups and labs that are active in product development, product testing and process development.
• Develop a fundamental understanding of applicable chemical and application tests.
• Maintain project documentation in accordance with GMP requirements. (i.e.   Design History File).
• Maintain a detailed laboratory notebook and accord records according to GLP guidelines.
• Actively participate in organizing laboratory, stocking laboratory supplies, and helping to establish safety-oriented protocols.
• Perform other duties as assigned by the supervisor.

Research:

• Synthesize, purify, and isolate intermediate and final products suitable for application testing or medical device fabrication.
• Conduct experiments related to evaluating new technologies, polymers, biomaterials for medical implants or devices.
• Support engineers in evaluating of new material formulations.

Process:

• Assist in establishing standard operating procedures for chemical processes (synthesis and purification) of new products.
• Assist in the creation of process routers, drawings and other written documentation in accordance with GMP requirements to support commercial manufacturing.
• Design and/or specify tooling and equipment necessary for the development of polymer processes.
• Update operating procedures as necessary.

Abilities/Knowledge:

• Good written and oral communications skills.
• Basic math, and chemistry skills.
• Ability to function as part of a team.
• Computer literacy (e.g. MS Word, MS Excel, email).
• Ability to work safely in an industrial environment.
• Mechanical intuition a plus.

Education: Associates Degree or Bachelors degree (or equivalent experience) in Chemical Engineering, Chemistry or related field.
Experience: 0-2 years experience in organic synthesis, purification, process development, and/or manufacturing of polymeric materials or a related industry.
Working Conditions: Will be required to spend a significant amount of time in production areas and R&D labs. Will be required to handle lab chemicals and other potentially hazardous materials and wear appropriate safety attire (lab coat, gloves, goggles, mask, respirator etc.). Some office work will be required.
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FACULTY POSITIONS/TEMPORARY FACULTY/ACADEMIC POSITIONS
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NONE FOR THIS NEWSLETTER
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POSTDOCTORAL POSITIONS AND/OR JOBS
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University of Kansas/Haskell, IRACDA Postdoctoral Program. Two positions are available at the University of Kansas through the NIH-Institutional Research and Academic Career Development Award (IRACDA) program. This comprehensive program offers three years of support to outstanding candidates seeking postdoctoral research training along with an opportunity to obtain some mentored teaching experience in a four-year tribal college in preparation for an academic career. Postdoctoral research training is provided under the guidance of one of the faculty mentors listed on the IRACDA website, who represent a broad range of disciplines including organic chemistry, medicinal chemistry, pharmaceutical chemistry, pharmacology/toxicology, chemical biology, biochemistry, molecular/cellular biology, genetics, and evolutionary biology. The program is administered by the KU School of Pharmacy and the Office for Diversity in Science Training at the University of Kansas and is partnered with Haskell Indian Nations University, a local Bureau of Indian A affairs university. The starting salary range for trainees is $40,560 per year, along with excellent fringe benefits and an allowance for research supplies and travel to an annual IRACDA meeting. Applicants must have a Ph.D. in chemistry, biology, or a related field and have no more than two years of previous postdoctoral experience. Groups currently underrepresented in the sciences are especially encouraged to apply. This grant requires that candidates appointed under this program be U.S. citizens, noncitizen nationals, or permanent residents. Special interest in developing a career in academic science with an emphasis in teaching and research at an institution that serves underrepresented minorities, experience working with minority students, demonstrated ability working in a team based environment, and excellent oral and written communication skills are preferred. Applicants are asked to review the list of KU faculty members participating as mentors and their areas of research. The list can be found at http://www2.ku.edu/~iracda/apply/. Other KU faculty members of interest to the applicant may be considered. Applicants should contact one or more potential mentors about applying for the positions and the research opportunities available in the mentor's program. To apply, complete the online application and attach a curriculum vitae and a cover letter that outlines your career goals and how the experiences you will have through the program will assist you in achieving those goals. A letter from an IRACDA mentor indicating his/her willingness to provide guidance and support in your development of an academic career, particularly your training in all aspects of high quality research, and two original letters of reference should be mailed to: Peggy Williams, Continuing Education Building, 1515 St Andrews Dr, Lawrence, KS 66047 or sent by email to: pwilliam@ku.edu. Review of applications begins on April 1, 2013 for appointments beginning approximately August 1, 2013, and continues until positions are filled.
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Reminder: Postdoc Fellowship Position Closes this Friday
EMSL is accepting applications for its William R. Wiley Postdoctoral Fellowship for 2013. The position closes Nov. 30, 2012. The fellowship recipient will serve a one-year term, with the possibility of it being renewed for a total of three years, and will receive an annual salary of $70,000. An additional $20,000 may be made available for research support and travel. EMSL launched the postdoctoral fellowship in 2010 and since then has named three recipients. To hear from the first-ever Wiley postdoctoral fellow, watch Ken Lopata talk with EMSL Director Allison Campbell about his experience at EMSL. The Wiley postdoctoral fellowship was established to attract high-performing PhD scientists who have the potential to become full-time scientific staff at EMSL.
Information on how to apply, selection criteria and the selection process is online at: http://www.emsl.pnl.gov/news/awards/post_doc.jsp.
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Merck Research Laboratories. Postdoctoral Research Fellow - Translational Molecular Imaging. Agent-POS000116. Merck is a global health care leader with a diversified portfolio of prescription medicines, vaccines and consumer health products, as well as animal health products. Today, we are building a new kind of healthcare company - one that is ready to help create a healthier future for all of us. Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you'll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career. Be a part of the legacy: MRL Postdoctoral Research Fellow Program. The Merck Research Laboratories (MRL) Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery. Translational molecular imaging agent Postdoctoral Fellow. As a postdoctoral fellow in Imaging and Medicinal Chemistry you will advance molecular imaging by leveraging Merck's expertise in drug discovery and development, developing multi-therapeutic area translational imaging tools and establishing a proof of concept for rapid prototyping of target affinity and imaging-driven in vivo labeling of physiological and pathophysiological processes. Responsibilities include but are not limited to:

• Evaluation of the imaging, synthesis and medicinal chemistry literature for relevant chemical precedent.
• Data mining of Merck's compound collection and pharmacology data in the design of translational molecular imaging tools.
• Synthesis and characterization of molecular imaging agents working closely with project teams and biological, pharmacokinetic and imaging assays.
• Advancement of imaging agent discovery and qualification platforms for rapid prototyping.

Education Minimum Requirement:

• PhD in Synthetic Organic Chemistry or related field.
• Required Experience and Skills.
• Design and implementation of diverse small molecule organic synthesis.
• Purification and spectroscopic (NMR, MS) characterization of organic compounds.

Applications is on-line at: http://www.merck.com/research/fellow/home.html.
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Please submit all newsletter information or address changes to: goldade@chem.wisc.edu or 262-0293. Thanks.
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DETAILS ARE AVAILABLE IN ROOM 1146.
NEXT NEWSLETTER IS ON DECEMBER 3rd, 2012