Alteration of Membrane Compositional Asymmetry by LiCoO2 Nanosheets

TitleAlteration of Membrane Compositional Asymmetry by LiCoO2 Nanosheets
Publication TypeJournal Article
Year of Publication2015
AuthorsDogangun, M, Hang, MN, Troiano, JM, McGeachy, AC, Melby, ES, Pedersen, JA, Hamers, RJ, Geiger, FM
JournalAcs Nano
Volume9
Pagination8755-8765
Date PublishedSep
Type of ArticleArticle
ISBN Number1936-0851
KeywordsChemistry, Multidisciplinary, Chemistry, Physical, FACILE SYNTHESIS, FREQUENCY VIBRATIONAL SPECTROSCOPY, FUNCTIONAL-GROUP, generation, GOLD, LITHIUM-ION BATTERIES, MASS-SPECTROMETRY, Materials Science, Multidisciplinary, nano-bio interface, NANOPARTICLES, Nanoscience &, Nanotechnology, phospholipid bilayer asymmetry, PHOSPHOLIPID FLIP-FLOP, secondary ion mass spectrometry, silica/water interfaces, sum-frequency, SUPPORTED LIPID-BILAYERS, transbilayer movement, TRANSMEMBRANE PEPTIDES
Abstract

Given the projected massive presence of redox-active nanomaterials in the next generation of consumer electronics and electric vehicle batteries, they are likely to eventually come in contact with cell membranes, with biological consequences that are currently not known. Here, we present nonlinear optical studies showing that lithium nickel manganese cobalt oxide nanosheets carrying a negative zeta-potential have no discernible consequences for lipid alignment and interleaflet composition in supported lipid bilayers formed from zwitterionic and negatively charged lipids. In contrast, lithiated and delithiated LiCoO2 nanosheets having positive and neutral zeta-potentials, respectively, alter the compositional asymmetry of the two membrane leaflets, and bilayer asymmetry remains disturbed even after rinsing. The insight that some cobalt oxide nanoformulations induce alterations to the compositional asymmetry in idealized model membranes may represent an important step toward assessing the biological consequences of their predicted widespread use.

DOI10.1021/acsnano.5b01440