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Aerobic Oxidative Coupling of o-Xylene: Discovery of 2-Fluoropyridine as a Ligand to Support Selective Pd-Catalyzed C-H Functionalization
Tue, 11/27/2012 - 11:52am — root
| Title | Aerobic Oxidative Coupling of o-Xylene: Discovery of 2-Fluoropyridine as a Ligand to Support Selective Pd-Catalyzed C-H Functionalization |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Izawa, Y, Stahl, SS |
| Journal | Advanced Synthesis & Catalysis |
| Volume | 352 |
| Pagination | 3223-3229 |
| Date Published | Dec |
| Accession Number | ISI:000285397800022 |
| Keywords | aerobic oxidation, aromatic-compounds, biphenyl, bond activation, C-H activation, Chemistry, Applied, Chemistry, Organic, Complexes, direct arylation, industrial chemistry, mechanism, methyl benzoate, molecular-oxygen, oxidation, oxidative coupling, palladium, palladium(ii) acetate, unactivated arenes |
| Abstract | An improved method for the direct oxidative coupling of o-xylene could provide streamlined access to an important monomer used in polyimide resins. The use of 2-fluoropyridine as a ligand has been found to enable unprecedented levels of chemo- and regioselectivity in this palladium-catalyzed aerobic oxidative coupling reaction. Preliminary insights have been obtained into the origin of the effectiveness of 2-fluoropyridine as a ligand. |
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