B. R. Borlee, G. D. Geske, C. J. Robinson, H. E. Blackwell, and J. Handelsman. “Quorum-Sensing Signals in the Microbial Community of the Cabbage White Butterfly Larval Midgut.” submitted for publication.
S. A. Fowler, D. M. Stacy, and H. E. Blackwell. “Design and Synthesis of Macrocyclic Peptomers as Mimics of a Quorum Sensing Signal from Staphylococcus aureus.” Org. Lett. 2008, 10, 2329-2332.
DOI 10.1021/ol800908h
M. E. Mattmann, G. D. Geske, G. A. Worzalla, J. R. Chandler, K. J. Sappington, E. P. Greenberg, and H. E. Blackwell. “Synthetic Ligands that Activate and Inhibit a Quorum-Sensing Regulator in Pseudomonas aeruginosa.” Bioorg. Med. Chem. Lett. 2008, 18, 3072-3075.
DOI 10.1016/j.bmcl.2007.11.095
Grant D. Geske, Jennifer C. O’Neill, David M. Miller, Margrith E. Mattmann, Qi Lin, Rachel J. Wezeman, and Helen E. Blackwell. “Comparative Analysis of N-Acyl Homoserine Lactones Reveals Unique Structural Features that Dictate Their Ability to Activate or Inhibit Quorum Sensing.” ChemBioChem. 2008, 9, 389-400.
DOI 10.1002/cbic.200700551
Grant D. Geske, Jennifer C. O’Neill, David M. Miller, Margrith E. Mattmann, and Helen E. Blackwell. “Modulation of Bacterial Quorum Sensing: Systematic Evaluation of N-Acylated Homoserine Lactones in Multiple Species and New Insights into Their Mechanism of Action.” J. Am. Chem. Soc. 2007, 129, 13613-13625.
DOI 10.1021/ja074135h
Ilia A. Guzei, Lara C. Spencer, Qi Lin, and Helen E. Blackwell. “N-{(Aminocarbonyl)[(S)-4-itrobenzyl]methyl}-N- {[(R)-cyclohexyl](cyclohexylaminocarbonyl)methyl}propanamide methanol solvate.” Acta Cryst. 2007, E63, 1892-1894.
DOI 10.1107/S1600536807012299
Matthew D. Bowman, Jennifer C. O’Neill, Joseph R. Stringer, and Helen E. Blackwell. “Rapid Identification of Antibacterial Agents Effective Against Staphylococcus aureus Using Small Molecule Macroarrays.” Chem. Biol. 2007, 14, 351-357.
DOI 10.1016/j.chembiol.2007.03.006
Ying Ying Chan, Hau Sheng Bian, Theresa May Chin Tan, Margrith E. Mattmann, Grant D. Geske, Jin Igarashi, Tomomi Hatano, Hiroaki Suga, Helen E. Blackwell, and Kim Lee Chau. “ Control of Quorum Sensing by a Burkholderia pseudomallei Multidrug Efflux Pump.” J. Bacteriol. 2007, 189, 4320-4324.
DOI 10.1128/JB.00003-07
Grant D. Geske, Jennifer C. O’Neill, and Helen E. Blackwell. “N-Phenylacetanoyl-L-Homoserine Lactones Can Strongly Antagonize or Super-Agonize Quorum Sensing in Vibrio fischeri.” ACS Chem. Biol. 2007, 2, 315-320.
DOI 10.1021/cb700036x
Benjamin C. Gorske, Brent L. Bastian, Grant D. Geske, and Helen E. Blackwell. “Local and Tunable n --> p * Interactions Regulate Amide Isomerism in the Peptoid Backbone.” J. Am. Chem. Soc. 2007, 129 , 8928-8929.
DOI 10.1021/ja07130l
Qi Lin and Helen E. Blackwell. “Rapid Synthesis of Diketopiperazine Macroarrays via Ugi Four-Component Reactions.” Chem. Commun. 2006, 2884-2886.
DOI 10.1039/b604329a
Benjamin C. Gorske and Helen E. Blackwell. “Tuning Peptoid Secondary Structure with Pentafluoroaromatic Functionality: A New Design Paradigm for the Construction of Discretely Folded Peptoid Structures.” J. Am. Chem. Soc. 2006, 128, 14378-14387.
DOI 10.1021/ja065248o
Jessica J. Hollenbeck, Emily N. Wixson, Grant D. Geske, Matthew W. Dodge, T. Andrew Tseng, Allen D. Clauss and Helen E. Blackwell. “A Model for Transitioning Students from the Undergraduate Teaching Lab to the Research Laboratory: The Evolution of an Intermediate Organic Synthesis Laboratory Course.” J. Chem. Educ. 2006, 83, 1835-1843. View PDF
Ilia A. Guzei, Benjamin C. Gorske, and Helen E. Blackwell. “N-(1-Pentafluorophenyl-ethyl)-acetamide.” Acta Cryst. 2006, C62, o286-o288.
DOI 10.1107/S0108270106012121
Matthew D. Bowman, Megan M. Jacobson, Brian G. Pujanauski, and Helen E. Blackwell. “Efficient Synthesis of Small Molecule Macroarrays: Optimization of the Macroarray Synthesis Platform and Examination of Microwave and Conventional Heating Methods.” Tetrahedron (Symposium-in-Print on Microwaves in Organic Chemistry) 2006, 62, 4715-4727.
DOI 10.1016/j.tet.2006.02.083
Matthew D. Bowman, Megan M. Jacobson, and Helen E. Blackwell. “Discovery of Fluorescent Cyanopyridine and Deazalumazine Dyes using Small Molecule Macroarrays.” Org. Lett. 2006, 8, 1645-1648.
DOI 10.1021/ol0602708
Qi Lin, Jennifer C. O’Neill, and Helen E. Blackwell. “Small Molecule Macroarray Construction via Ugi Four-Component Reactions.” Org. Lett. 2005, 7, 4455-4458.
DOI 10.1021/ol051684o
Grant D. Geske, Rachel J. Wezeman, Adam P. Seigel, and Helen E. Blackwell. “Small Molecule Inhibitors of Bacterial Quorum Sensing and Biofilm Formation.” J. Am. Chem. Soc. 2005, 127, 12762-12763.
DOI 10.1021/ja0530321
Benjamin C. Gorske, Sarah A. Jewell, Emily J. Guerard, and Helen E. Blackwell. “ Expedient Synthesis and Design Strategies for New Peptoid Construction.” Org. Lett. 2005, 7, 1521-1524.
DOI 10.1021/ol0502984
Matthew D. Bowman, Ryan C. Jeske, and Helen E. Blackwell. “Microwave-Accelerated SPOT-Synthesis on Cellulose Supports.” Org. Lett. 2004, 6, 2019-2022.
DOI 10.1021/ol049313f
Review Articles and Commentaries (Peer Reviewed)
G. D. Geske, J. C. O’Neill and H. E. Blackwell. “Expanding Dialogues: From Natural Autoinducers to Non-Natural Analogues that Modulate Quorum Sensing in Gram-Negative Bacteria.” Chemical Society Reviews, 2008, 37, 1432-1447.
DOI 10.1039/B703021P
Jennifer C. O’Neill and Helen E. Blackwell. “Solid-Phase and Microwave-Assisted Syntheses of 2,5-Diketopiperazines: Small Molecules with Great Potential.” Comb. Chem. High Throughput Screen. 2007, 10, 857-876.
Helen E. Blackwell. “Hitting the SPOT: Small molecule macroarrays advance combinatorial synthesis.” Curr. Opin. Chem. Biol. 2006, 10, 203-212.
DOI 10.1016/j.cbpa.2006.04.026
Benjamin C. Gorske and Helen E. Blackwell. “Interception of Quorum Sensing in Staphylococcus aureus: A New Niche for Peptidomimetics.” Org. Biomol. Chem. 2006, 4 , 1441-1445.
DOI 10.1039/b517681f
Helen E. Blackwell. “Bacterial Crowd Control with Iron.” Chem. Biol. 2005, 12, 721-723.
DOI 10.1016/j.chembiol.2005.07.001
Helen E. Blackwell and Yunde Zhao. “Chemical Genetic Approaches to Plant Biology.” Plant Physiology 2003, 133, 448-455.
DOI 10.1104/pp.103.031138
Helen E. Blackwell. “Out of the Oil Bath and Into the Oven – Microwave-assisted Combinatorial Chemistry Heats Up.” Org. Biomol. Chem. 2003, 1, 1251-1255.
DOI 10.1039/b301432k