image

Total synthesis of Vineomycinone B2, Methyl Ester:
Reference: Tius, M. A.; Gu, X. Q.; Gomez-Galeno, J. J. Am. Chem. Soc. 1990, 112, 8188–8189. DOI
Keywords: O-SiMe2tBu → O-H • O-MOM → O-H • Pd/Zn-Vinyl+Aryl-X • Negishi coupling • Li/H → Li-Vinyl • Li-Vinyl → Zn-Vinyl • Hydrogenation EnolEther • Li/H → Li-Aryl • Li-Aryl → Sn-Aryl • Pd/Sn-Aryl+Allyl-X • Stille coupling • Cu-Me+EnoateEster • Anthraquinone synthesis •
Reagents: BuLi(tert) • ZnCl2 • PPh3 • BH3CN-Na+ • HCl • BuLi(n) • SnBu3-Cl • Pd2(dba)3 • LiCuMe2 • Permanganate, silver • HCl, MeOH •

Syntheses Home