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Total synthesis of Vibralactone:
Reference: Zhou, Q.; Snider, B. B. J. Org. Chem. 2008, 73, 8049-8056. DOI
Keywords: CarboxEster → CarboxAcid • Iodolactonization • Enal → Allyl-OH • CompRed-Aldehyde/Lactone+B-H • Birch alkylation • CarboxEster enolate+Alkyl-X • Alkyl-X+Enolate • EnolEther → Ketone • Ketone → Alkyl-OH • Felkin-Anh • Ozonolysis • Aldol-enamine → Enal • Reductive elimination - X/OR • Protecting group - Ene • Lactone-4 • Felkin-Anh Chelation •
Reagents: Iodide, lithium • Allyl-Br • HCl, MeOH • Hydroxide, potassium • I2, KI • O3 • PPh3 • O3 • PPh3 • Acetic acid, trifluoro • Acetic acid, trifluoro • Zn° • TsCl, Py • BH4-Na+ • Zn(BH4)2

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