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Total synthesis of Vibralactone:
Reference: Zhou, Q.; Snider, B. B. J. Org. Chem. 2008, 73, 8049-8056. DOI
Keywords: CarboxEster -> CarboxAcid • Iodolactonization • Enal -> Allyl-OH • CompRed-Aldehyde/Lactone+B-H • Birch alkylation • CarboxEster enolate+Alkyl-X • Enolether -> Ketone • Ketone -> Alkyl-OH • Ozonolysis • Aldol-enamine -> Enal • Reductive elimination - X/OR • Protecting group - Ene • Lactone-4 •
Reagents: K°/NH3 • Iodide, lithium • Allyl-Br • HCl, MeOH • Hydroxide, potassium • I2, KI • O3 • PPh3 • O3 • PPh3 • Acetic acid, trifluoro • Acetic acid, trifluoro • TsCl, Py • BH4-Na+ • Zn(BH4)2

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