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Total synthesis of Tamiflu:
Reference: Ishikawa, H.; Suzuki, T.; Hayashi, Y. ACIEE 2009, 48, 1307 DOI
Keywords: ConjAdd M-SR • CarboxEster → CarboxAcid • ConjAdd Enamine • Vinyl-NO2+Enamine(asymm) • ConjAdd Nitronate • Nitronate+EnoateEster • HWE → EnoateEster • CarboxAcid → CarboxCl • CarboxCl → CarboxAzide • Curtius • C-CO2H → C-N • Nitro → Amine • Dehydrosulfenylation → EnoateEster •
Reagents: Pyrrolidine • Chloroacetate • Carbonate, cesium • Thiol. tolyl • Acetic acid, trifluoro • Oxalyl chloride • DMF (solvent) • Azide, sodium • Acetic anhydride • SiMe3-Cl • NH3 • Carbonate, potassium • Chiral catalyst •

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